Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T55689 | Target Info | |||
| Target Name | Hormone sensitive lipase (LIPE) | ||||
| Synonyms |
Hormone-sensitive lipase; HSL
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | LIPE | ||||
| Biochemical Class | Carboxylic ester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Methylsulfanyl-3-((E)-styryl)-[1,2,4]triazole-1-carboxylic acid dimethylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339995; BDBM50138752; N,N-dimethyl-5-(methylthio)-3-styryl-1H-1,2,4-triazole-1-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(3-(4-Chlorophenyl)-5-(hexylthio)-1H-1,2,4-triazol-1-yl)(morpholino)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337486; BDBM50138754; [3-(4-Chloro-phenyl)-5-hexylsulfanyl-[1,2,4]triazol-1-yl]-morpholin-4-yl-methanone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-Hexylsulfanyl-3-p-tolyl-[1,2,4]triazole-1-carboxylic acid dimethylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336276; BDBM50138738; 5-(hexylthio)-N,N-dimethyl-3-p-tolyl-1H-1,2,4-triazole-1-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
[3-(4-Chloro-phenyl)-5-hexylsulfanyl-[1,2,4]triazol-1-yl]-piperidin-1-yl-methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335158; BDBM50138756
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Dimethyl-carbamic Acid 4-(3,5-dichloro pyridin-2-yloxy)-phenyl Ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239207; SCHEMBL5648599; BDBM50224145; [4-(3,5-dichloropyridin-2-yl)oxyphenyl] N,N-dimethylcarbamate; dimethyl-carbamic acid 4-(3,5-dichloro-pyridin-2-yloxy)-phenyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
8a-Tert-Butoxymethyl-6-furan-2-yl-1,4-dioxo-2-(4-phenyl-butyl)-octahydro-pyrrolo[1,2-a]pyrazine-7-carboxylic acid phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL275272; BDBM50125742
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[3] | |||
| Compound Name |
5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,2,4]triazole-1-carboxylic acid dimethylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130478; BDBM50138759; N,N-dimethyl-5-(methylthio)-3-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole-1-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
8a-Benzyloxymethyl-2-(2-cyclohex-1-enyl-ethyl)-6-furan-2-yl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazine-7-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL14225; BDBM50125737
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Methylsulfanyl-3-(4-trifluoromethoxy-phenyl)-[1,2,4]triazole-1-carboxylic acid methyl-phenyl-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131051; BDBM50138751; N-methyl-5-(methylthio)-N-phenyl-3-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole-1-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase. J Med Chem. 2004 Jan 15;47(2):400-10. | ||||
| REF 2 | Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects. J Med Chem. 2007 Nov 1;50(22):5449-56. | ||||
| REF 3 | Pyrrolopyrazinedione-based inhibitors of human hormone-sensitive lipase. J Med Chem. 2003 Mar 27;46(7):1120-2. | ||||
| REF 4 | Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials. J Med Chem. 2015 Aug 27;58(16):6448-55. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.