Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T56051 | Target Info | |||
| Target Name | Ubiquitin thioesterase L1 (UCHL1) | ||||
| Synonyms |
Ubiquitin thiolesterase L1; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin carboxy-terminal hydrolase L1; UCH-L1; PGP9.5; PGP 9.5; Neuron cytoplasmic protein 9.5
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| Target Type | Preclinical Target | ||||
| Gene Name | UCHL1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione
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Investigative | Compound Info | ||
| Synonyms |
4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor; 4,5,6,7-tetrachloroindene-1,3-dione; 4,5,6,7-Tetrachloroindane-1,3-dione; compound 6 [PMID: 17948018]; 1H-Indene-1,3(2H)-dione, 4,5,6,7-tetrachloro-; Maybridge1_006552; Ubiquitin Thiolesterase L3 Inhibitor; Ubiquitin C-Terminal Esterase L3 Inhibitor; Ubiquitin C-Terminal Hydrolase L3 Inhibitor; 4,5,6,7-tetrachloro-2H-indene-1,3-dione; C9H2Cl4O2; GTPL8660; SCHEMBL5819833; CHEMBL1241028; CTK4G5564; HMS560B18; DTXSID80369561; HMS3653C11; BCP29983; TCID, >=98% (HPLC); ANW-73173; CCG-51207; MFCD00239209; RW3397; s7140; SBB054653; AKOS016008550; ZINC100004134; MCULE-6723746718; QC-2393; 4,5,6,7-Tetrachloro indane-1,3-dione; AC-33082; HY-18638; DB-005319; CS-0011637; FT-0617124; SW219230-1; X5659; A20530; 675T139; 1H-Indene-1,3(2H)-dione,4,5,6,7-tetrachloro-; J-018051; SR-01000640519-1; Q27076782; F9995-1817; 4,5,6,7-tetrachloro-2-hydrocyclopenta[1,2-a]benzene-1,3-dione; UCH 23;UCH23;UCH-23;UCH-L3 Inhibitor;4,5,6,7-tetrachloroindan-1,3-dione
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| Activity |
IC50 = 75000 nM
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[1] | |||
| Compound Name |
5-(4-Butylphenyl)-4-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241766; BDBM50326015
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| Activity |
IC50 = 126000 nM
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[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Menadione
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Approved | Compound Info | ||
| Synonyms |
menadione; 58-27-5; Vitamin K3; 2-Methyl-1,4-naphthoquinone; Menaphthone; 2-methylnaphthalene-1,4-dione; 2-Methylnaphthoquinone; Thyloquinone; Panosine; Klottone; Kayquinone; Kappaxin; Kayklot; Kolklot; 2-Methyl-1,4-naphthalenedione; Menaphthon; Menadion; Kipca; Kanone; Mitenone; Kativ-G; Kaergona; Aquinone; Prokayvit; Mitenon; Koaxin; Kaykot; Kareon; Hemodal; Aquakay; Synkay; Karcon; K-Thrombyl; K-Vitan; Kipca-Oil Soluble; Juva-K; Vitamin K2(0); Vitamin K0; Menaquinone 0; Vitamin K 3; Menaphtone; Menadionum; 2-Methyl-1,4-naphthochinon; Usaf; Aquakay; Klottone;Koaxin; Memodol; Methylnaphthoquinone; Vicasol; Menadione semiquinone; M0373; VK3; Kappaxan (VAN); Kappaxin (TN); Kipca, oil soluble; Menadione (K3); Menadione (USP); Menadione [USAN:BAN]; Usaf ek-5185; Vitamin-K3; Methyl-1,4-naphthalenedione; Methyl-1,4-naphthoquinone; Vitamin K3 : 2-Methyl-1,4-naphthoquinone; 1,4-Naphthalenedione, 2-methyl-,radical ion(1-); 2-Methyl-1,4-naftochinon; 2-Methyl-1,4-naftochinon [Czech]; 2-Methyl-1,4-naphthochinon [German]; 2-methyl-1,4-naphthoquinone, 5; 3-Methyl-1,4-naphthoquinone; Ascorbic acid/menadione; Triglycyl-lysine-vasopressin
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| Activity |
IC50 = 290000 nM
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[1] | |||
| Compound Name |
Chembl4129140
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3709928; BDBM50271098; 3-acetyl-2-(4-bromophenyl)-1-[2-(3,4-dichlorophenyl)ethyl]-4-hydroxy-2H-pyrrol-5-one
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| Activity |
IC50 > 200000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol. 2007 Nov;3(11):697-705. | ||||
| REF 2 | Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem. 2018 Jan 25;61(2):422-443. | ||||
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