Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T58449 | Target Info | |||
| Target Name | Cyclin-dependent kinase 7 (CDK7) | ||||
| Synonyms |
TFIIH basal transcription factor complex kinase subunit; Serine/threonine-protein kinase 1; P39 Mo15; MO15; Cell division protein kinase 7; CDKN7; CDK-activating kinase 1; CDK-activating kinase; CAK1; CAK; 39 kDa protein kinase
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| Target Type | Clinical trial Target | ||||
| Gene Name | CDK7 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
JNJ-10198409
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Investigative | Compound Info | ||
| Synonyms |
JNJ-10198409; 627518-40-5; PDGFR Tyrosine Kinase Inhibitor IV; PDGF Receptor Tyrosine Kinase Inhibitor IV; CHEMBL120077; N-(3-fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine; 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine; ZDNURMVOKAERHZ-UHFFFAOYSA-N; SCHEMBL3088170; GTPL6020; CTK8E8807; jnj10198409; DTXSID70430890; MolPort-009-019-131; HMS3650O03; HMS3229I11; ZINC13677843; BDBM50179207; AKOS030525202; RWJ 540973; CCG-206773; NCGC00343986-02; RT-014973; KB-274227; SR-01000946814
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| Activity |
IC50 = 56700 nM
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[1] | |||
| Compound Name |
3-(Indol-2-yl)indazole 10
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374940; SCHEMBL5058860; BDBM12120; n,n-dimethyl-3-[5-(morpholin-4-ylmethyl)-1h-indol-2-yl]-1h-indazole-6-carboxamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73. | ||||
| REF 2 | 3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6049-53. | ||||
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