Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T58741 | Target Info | |||
| Target Name | Voltage-gated sodium channel alpha Nav1.6 (SCN8A) | ||||
| Synonyms |
Voltage-gated sodium channel subunit alpha Nav1.6; Sodium channel protein type VIII subunit alpha; Sodium channel protein type 8 subunit alpha; SCN8A
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| Target Type | Clinical trial Target | ||||
| Gene Name | SCN8A | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CID 53239561
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236329; SCHEMBL1768494; BDBM50008745
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
N-[[5-[1-(2-Imidazol-1-ylethyl)indazol-3-yl]-1,2,4-oxadiazol-3-yl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3236343; SCHEMBL1768467; BDBM50008746; N-((5-(1-(2-(1H-imidazol-1-yl)ethyl)-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methyl)benzamide; N-[5-[1-[2-(1H-Imidazole-1-yl)ethyl]-1H-indazole-3-yl]-1,2,4-oxadiazole-3-ylmethyl]benzamide
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Imidazol-1-ylethylindazole voltage-gated sodium channel ligands are neuroprotective during optic neuritis in a mouse model of multiple sclerosis. J Med Chem. 2014 Apr 10;57(7):2942-52. | ||||
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