Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59679 | Target Info | |||
| Target Name | 5-HT 4 receptor (HTR4) | ||||
| Synonyms |
Serotonin receptor 4; 5-hydroxytryptamine receptor 4; 5-HT4 receptor; 5-HT4; 5-HT-4
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| Target Type | Successful Target | ||||
| Gene Name | HTR4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[2-Hydroxy-3-methyl-4-[[4-[4-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]phenyl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899832; SCHEMBL3163790; BDBM50207400
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| Activity |
Ki > 6310000 nM
|
[1] | |||
| Compound Name |
5-Methoxy-N-piperidin-4-yl-1H-indole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL558757; BDBM50414677
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| Activity |
EC50 = 100000000 nM
|
[2] | |||
| Compound Name |
5-Methoxy-N-(2-piperazin-1-ylethyl)-1H-indole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL553688; BDBM50414678
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| Activity |
EC50 = 100000000 nM
|
[2] | |||
| Compound Name |
n-(4-Piperidinylmethyl)-1-isopropyl-1h-3 indazolecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL552796; SCHEMBL4410253; BDBM50414669; N-(piperidin-4-ylmethyl)-1-propan-2-ylindazole-3-carboxamide
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| Activity |
EC50 = 100000000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache. Bioorg Med Chem Lett. 2017 Jan 15;27(2):323-328. | ||||
| REF 2 | A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists. J Med Chem. 2009 Sep 10;52(17):5330-43. | ||||
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