Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59845 | Target Info | |||
| Target Name | Serine/threonine PP1-alpha (PPP1CA) | ||||
| Synonyms |
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase 1alpha; PPP1A; PP-1A
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| Target Type | Successful Target | ||||
| Gene Name | PPP1CA | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(Methylsulfonyl)benzenesulfonic acid 3-methyl-5-[3-(guanidinooxy)propoxy]phenyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL37637; SCHEMBL7649320; BDBM50126635; [3-[3-(diaminomethylideneamino)oxypropoxy]-5-methylphenyl] 2-methylsulfonylbenzenesulfonate; 3-[3-({[(Z)-amino(imino)methyl]amino}oxy)ethoxy]-5-methylphenyl 2-methylsulfonylbenzenesulfonate; 3-[3-({[(Z)-amino(imino)methyl]amino}oxy)propoxy]-5-methylphenyl 2-methylsulfonylbenzenesulfonate
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| Activity |
Ki ~ 67000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4210922
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Investigative | Compound Info | ||
| Synonyms |
BDBM50453860
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| Activity |
IC50 = 253500 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1495-8. | ||||
| REF 2 | Microcystins: Synthesis and structure-activity relationship studies toward PP1 and PP2A. Bioorg Med Chem. 2018 Mar 15;26(6):1118-1126. | ||||
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