Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59881 | Target Info | |||
| Target Name | Vasopressin V1b receptor (V1BR) | ||||
| Synonyms |
Vasopressin V3 receptor; Vasopressin V(1b) Receptor; VPR3; V1bR; Antidiuretic hormone receptor 1b; AVPR3; AVPR V3; AVPR V1b
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| Target Type | Successful Target | ||||
| Gene Name | AVPR1B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
OPC-51803
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Discontinued in Phase 1 | Compound Info | ||
| Synonyms |
SOU-003; 2-[1-[2-Chloro-4-(1-pyrrolidinyl)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepin-5(R)-yl]-N-isopropylacetamide
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
CID 11569672
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL196603; SCHEMBL3931222; BDBM50416840
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| Activity |
Ki ~ 50118.72 nM
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[2] | |||
| Compound Name |
N-[2-[3-[2-(Cyclopropylmethylamino)-2-oxoethyl]-4-oxo-2-phenylquinazolin-6-yl]oxyethyl]-3-(4-hydroxyphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1224609; BDBM50325828
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-(Cyclopropylmethyl)-2-(6-hydroxy-4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1224610; SCHEMBL3125153; BDBM50325829; N-(cyclopropylmethyl)-2-(6-hydroxy-4-oxo-2-phenylquinazolin-3-yl)acetamide; N-cyclopropylmethyl-2-(6-hydroxy-4-oxo-2-phenyl-4H-quinazolin-3-yl)acetamide
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-[6-(6-Aminohexoxy)-4-oxo-2-phenylquinazolin-3-yl]-N-(cyclopropylmethyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1223630; BDBM50325835; 2-(6-(6-aminohexyloxy)-4-oxo-2-phenylquinazolin-3(4H)-yl)-N-(cyclopropylmethyl)acetamide
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692. | ||||
| REF 2 | Oral oxytocin antagonists. J Med Chem. 2010 Sep 23;53(18):6525-38. | ||||
| REF 3 | Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5394-7. | ||||
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