Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T61622 | Target Info | |||
| Target Name | Angiotensinogenase renin (REN) | ||||
| Synonyms |
Renin; Angiotensinogenase
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| Target Type | Successful Target | ||||
| Gene Name | REN | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 69 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Iboctadekin + rituximab
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|
Phase 1 | Compound Info | ||
| Synonyms |
Pepstatin A; 26305-03-3; Pepstatine; Ahpatinin C; UNII-V6Y2T27Q1U; MLS002222329; Iva-Val-Val-Sta-Ala-Sta-OH; V6Y2T27Q1U; CHEMBL296588; 39324-30-6; FAXGPCHRFPCXOO-LXTPJMTPSA-N; C34H63N5O9; NCGC00161670-06; Pepstatin (nonspecific); DSSTox_RID_81334; DSSTox_CID_26095; DSSTox_GSID_46095; CCRIS 3603; Pepstatina; Pepstatinum; Pepstatin (VAN); Ia Quinidine
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|
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| Activity |
IC50 = 92000 nM
|
[1] | |||
| Compound Name |
GRASSYSTATIN A
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|
Investigative | Compound Info | ||
| Synonyms |
Grassystatin A; CHEMBL567893; GTPL8674
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
1-N-[(2S,3R)-4-Amino-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL225442; BDBM16410; hydroxyethylamine containing compound 11
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-(N-methylpropane-2-sulfonamido)-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL162970; BDBM16413; hydroxyethylamine containing compound 14
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-N-[(2S,3R)-4-(Ethylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376072; BDBM16411; hydroxyethylamine containing compound 12
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[(1S,2R)-1-Benzyl-3-(cyclopropylamino)-2-hydroxypropyl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]isophthalamide
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|
Investigative | Compound Info | ||
| Synonyms |
BACE-1 INHIBITOR; CHEMBL378225; beta-Secretase Inhibitor IV; Merck-3; Isophthalamide Derivative 24; SCHEMBL4567212; 5-Substituted isophthalamide, 1; BDBM16034; ZINC14960423; NCGC00386495-01; hydroxyethylamine (HEA) derived inhibitor 1; Q27455765; L-000384950
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-N-[(2S,3R)-4-(Tert-butylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(N-methylmethanesulfonamido)benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL266891; BDBM16412; hydroxyethylamine containing compound 13
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-N-[(2S,3R)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[(dimethylsulfamoyl)(methyl)amino]-3-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376277; BDBM16414; hydroxyethylamine containing compound 15
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-N-[(2S)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-1-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-(methanesulfonamido)benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL222209
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-N-[(2S)-4-(Cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-1-N-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221454
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(4-Chloro-phenyl)-3-(4-methoxy-benzyloxy)-piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413256; SCHEMBL6041925; BDBM50077683; 4-(4-chlorophenyl)-3-[(4-methoxyphenyl)methoxy]piperidine
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|
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
2-Oxo-4-cyclohexyl-3-[[N-(benzyloxycarbonyl)-L-leucyl]amino]butanoic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL310140; BDBM50406976
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|
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| Activity |
IC50 = 52000 nM
|
[6] | |||
| Compound Name |
[(S)-1-((1S,2R,3S)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93724; BDBM50281237
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| Activity |
IC50 = 52000 nM
|
[7] | |||
| Compound Name |
5-(1-Adamantyl)-2-amino-5-(4-methoxyphenyl)-3-methylimidazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL584694; SCHEMBL4599012
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|
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| Activity |
IC50 = 53300 nM
|
[8] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-4-cyclohexyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL151836; BDBM50022875
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|
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| Activity |
IC50 = 55000 nM
|
[9] | |||
| Compound Name |
2-Amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4-methoxy-3-methylphenyl)-1-methyl-1H-imidazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL567688; SCHEMBL3535649; BDBM50303716; 2-amino-5-(4-fluoro-3-pyrimidin-5-ylphenyl)-5-(4-methoxy-3-methylphenyl)-3-methylimidazol-4-one
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| Activity |
IC50 = 57600 nM
|
[8] | |||
| Compound Name |
Acetyl-NH-val-cyclohexyl-CH2[nch2choh]CH2-benzyl-val-NH-acetyl
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|
Investigative | Compound Info | ||
| Synonyms |
cgp 53820; Cgp-53820; cgp53820; BDBM201; CHEMBL94797; DTXSID20164214; 203976-EP2277867A2; 203976-EP2280003A2; Q27458615
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| Activity |
IC50 ~ 58000 nM
|
[10] | |||
| Compound Name |
(2R,4S,5S)-5-Amino-N-butyl-4-hydroxy-9-[3-(hydroxymethyl)phenyl]-2,7,7-trimethylnonanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL43522; BDBM50287363; (2R,4S,5S)-5-Amino-4-hydroxy-9-(3-hydroxymethyl-phenyl)-2,7,7-trimethyl-nonanoic acid butylamide
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| Activity |
IC50 = 58000 nM
|
[11] | |||
| Compound Name |
5-(1-Adamantyl)-2-amino-5-(4-methoxy-3-methylphenyl)-3-methylimidazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL584284; SCHEMBL4599017
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|
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| Activity |
IC50 = 59500 nM
|
[8] | |||
| Compound Name |
4-{(2R,3S,4S)-4-[(S)-2-((S)-2-Tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(3H-imidazol-4-yl)-propionylamino]-2,3-dihydroxy-6-methyl-heptanoylamino}-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435737; BDBM50286816
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|
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| Activity |
IC50 = 63000 nM
|
[12] | |||
| Compound Name |
Pro-Phe-His-Statine-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL286958; BDBM50022979
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|
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| Activity |
IC50 = 68000 nM
|
[13] | |||
| Compound Name |
2-[2-(2-{[7-(2-Tert-Butoxycarbonylamino-3-phenyl-propionyl)-6-methyl-5-oxo-1-oxa-4,7-diaza-cyclododecane-3-carbonyl]-amino}-3-methyl-butyrylamino)-3-methyl-pentanoylamino]-3-(3H-imidazol-4-yl)-propionic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97865; BDBM50022867
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|
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| Activity |
IC50 = 69000 nM
|
[14] | |||
| Compound Name |
Methyl (2S)-3-(1H-imidazol-5-yl)-2-[[(2S,3S)-3-methyl-2-[[(2S)-3-methyl-2-[[(3R,6S)-6-methyl-7-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]-5-oxo-1-oxa-4,7-diazacyclododec-3-yl]methylamino]butanoyl]amino]pentanoyl]amino]propanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204331; BDBM50400809
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|
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| Activity |
IC50 = 69000 nM
|
[15] | |||
| Compound Name |
(4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylamino)-propionylamino]-6-hydroxy-4-isobutylcarbamoyl-8-phenyl-octanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157575; BDBM50139111
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|
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| Activity |
Ki = 73600 nM
|
[16] | |||
| Compound Name |
(2R,4S,5S)-5-Amino-N-butyl-4-hydroxy-9-[4-(hydroxymethyl)phenyl]-2,7,7-trimethylnonanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40202; BDBM50287369; (2R,4S,5S)-5-Amino-4-hydroxy-9-(4-hydroxymethyl-phenyl)-2,7,7-trimethyl-nonanoic acid butylamide
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|
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| Activity |
IC50 = 79000 nM
|
[11] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;dihydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216389; BDBM50224559
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|
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| Activity |
Ki = 80000 nM
|
[17] | |||
| Compound Name |
(2R)-N-[(2R)-1-[[(2R)-1-(2,2-Dimethylpropylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-2-(hydroxymethyl)-4-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL12373; BDBM50391339
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| Activity |
IC50 = 80000 nM
|
[18] | |||
| Compound Name |
His-Leu-Leu-Val-Phe-OCH3
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL27307; CHEMBL545396; BDBM50027891
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|
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| Activity |
Ki = 80000 nM
|
[19] | |||
| Compound Name |
2-Amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL566200; SCHEMBL3533042; BDBM50303719; 2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-(3-pyridin-3-ylphenyl)imidazol-4-one; rac-2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one
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| Activity |
IC50 = 93400 nM
|
[8] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[(5-amino-3-hydroxy-7-methyloctanoyl)amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL545630
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|
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| Activity |
Ki = 95000 nM
|
[17] | |||
| Compound Name |
(2R,4S,5S)-5-Amino-4-hydroxy-2,7-dimethyl-octanoic acid butylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41508; SCHEMBL4045732; BDBM50287367
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|
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-Methoxy-5-[1-(3-methoxypropyl)-3,4-dihydro-2H-quinolin-7-yl]pyridin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077961; BDBM50268113
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| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-Ethyl-4-(furan-2-ylmethylamino)-2-methyl-N-piperidin-4-ylpyrimidine-5-carboxamide;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953971; BDBM50195231
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| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(4-{[4-(Cyclohexylamino)-1-(3-Fluorophenyl)-2-Oxo-1,3,8-Triazaspiro[4.5]dec-3-En-8-Yl]methyl}phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL592583; CHEMBL495087; BDBM25361; Spiropiperidine Iminohydantoin, 16; Q27465375
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| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
4-(Furan-2-ylmethylamino)-N,2-dimethyl-N-piperidin-3-ylpyrimidine-5-carboxamide;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926340; BDBM50195234
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| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Propan-2-yl 2-hydroxy-3-[[3-(1H-imidazol-5-yl)-2-[[4-morpholin-4-yl-2-(naphthalen-1-ylmethyl)-4-oxobutanoyl]amino]propanoyl]amino]-5-methylhexanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348587; Kri-1230; Kri 1230; ACMC-20mapa; CTK4A4824; DTXSID80910158; BDBM50022531
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| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
Methyl (3S,4S)-3-hydroxy-4-[[(2S)-2-[[(3S,4S)-3-hydroxy-4-[[(2R)-3-(1H-indol-3-yl)-2-[[(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoyl]amino]-6-methylheptanoyl]amino]propanoyl]amino]-6-methylheptanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3349556; BDBM50226298
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| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
Phe-Statine-Ile-Phe-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL23991; BDBM50022975
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S,3R,5S)-5-((1S,3R)-3-Butylcarbamoyl-1-hydroxy-butyl)-3-methyl-2-phenyl-pyrrolidine-1-carboxylic acid benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL296767; BDBM50282790
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| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2R,4S,5S)-5-Amino-N-butyl-4-hydroxy-6-[(4-methoxyphenyl)sulfonyl-propan-2-ylamino]-2-methylhexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL551279; BDBM50298202; (2R,4S,5S)-5-amino-N-butyl-4-hydroxy-6-(N-isopropyl-4-methoxyphenylsulfonamido)-2-methylhexanamide
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| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
Pro-Phe-His-Phe-Phe-Val-Tyr-Lys-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL406111; BDBM50022985
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| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
Ac-Ftr-Pro-Phe-His-Phe-Phe-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217629; BDBM50022839
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| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-[(1R,2S)-1,3-Dicyclohexyl-1-hydroxypropan-2-yl]-2-[8-(2-methylpropyl)-6-phenyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2115170; BDBM50406415
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| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Di-Tert-Butyl {iminobis[(2s,3s)-3-Hydroxy-1-Phenylbutane-4,2-Diyl]}biscarbamate
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Investigative | Compound Info | ||
| Synonyms |
BMS-182193; BMS-182193, BMS-182,193; Aminodiol deriv. 9a; BDBM914; CHEMBL47476; BMS-186318 analog 1; DTXSID50167112; Q27451037; di-tert-butyl {iminobis[(2S,3R)-3-hydroxy-1-phenylbutane-4,2-diyl]}biscarbamate
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| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
Methyl (2S)-3-(1H-imidazol-5-yl)-2-[[(2S,3S)-3-methyl-2-[[(2S)-3-methyl-2-[[(3R,6S)-6-methyl-7-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]-5-oxo-1,4,7-oxadiazecan-3-yl]methylamino]butanoyl]amino]pentanoyl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204332; BDBM50400814
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Boc-His-Pro[CH2O]Phe-His-Sta-Ile-AMP
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407901; BDBM50022898
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|
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| Activity |
IC50 = 100000 nM
|
[30] | |||
| Compound Name |
Hexanoic acid, 2-hydroxy-3-((3-(1H-imidazol-4-yl)-2-((2-(1-naphthalenylmethyl)-1,4-dioxo-4-((2-phenylethyl)amino)butyl)amino)-1-oxopropyl)amino)-5-methyl-, methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
Kri 1177; Kri-1177; CHEMBL159462; ACMC-20m7zz; DTXSID50909377; BDBM50022526
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| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
Ac-His-Phe-Ftr-Phe-Phe-Val-Ftr-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370339; BDBM50022857
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Pro-Phe-His-delta-ornithine-Val-Tyr-Lys-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371819; BDBM50022973
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|
||||
| Activity |
IC50 = 100000 nM
|
[13] | |||
| Compound Name |
2-[2-(2-{[7-(2-Tert-Butoxycarbonylamino-3-phenyl-propionyl)-6-methyl-5-oxo-[1,4,7]oxadiazecane-3-carbonyl]-amino}-3-methyl-butyrylamino)-3-methyl-pentanoylamino]-3-(3H-imidazol-4-yl)-propionic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445118; BDBM50022868
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||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Methyl (3S,4S)-3-hydroxy-4-[[(2S)-2-[[(3S,4S)-3-hydroxy-4-[[(2S)-3-(1H-indol-3-yl)-2-[[(2R)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoyl]amino]propanoyl]amino]-6-methylheptanoyl]amino]propanoyl]amino]-6-methylheptanoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3349794; BDBM50226308
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
{1-[3-({1-[2-(1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-methyl)-oxiranyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL352937; BDBM50016050
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
Tert-butyl N-[(Z,2S)-6-[[(4S)-1-[[(2S)-1-(benzylamino)-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-6-oxo-1-phenylhex-3-en-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL355625; BDBM50016065
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
[(1S,2S,4R)-4-Butylcarbamoyl-2-hydroxy-1-((S)-2-methyl-3-phenyl-propyl)-pentyl]-carbamic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430578; BDBM50282788
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S)-1-[(2R)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1-formylindol-3-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420276
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3R)-5-((1S,3R)-3-Butylcarbamoyl-1-hydroxy-butyl)-3-methyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL47403; BDBM50282789
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-[(2S)-1-Cyclohexyl-3-hydroxyheptan-2-yl]-2-(6-methyl-8-propyl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73980; BDBM50012931
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
CID 56834949
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934295; SCHEMBL7915400; BDBM50360723
Click to Show/Hide
|
||||
| Activity |
IC50 = 106000 nM
|
[32] | |||
| Compound Name |
5-(1H-Indol-7-yl)-4,6-dimethylpyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093580; BDBM50268092
Click to Show/Hide
|
||||
| Activity |
IC50 = 124000 nM
|
[20] | |||
| Compound Name |
(3S)-3-Hydroxy-6-methyl-N-[(2S)-1-(3-methylbutylamino)-1-oxopropan-2-yl]-4-[[(2R)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]heptanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL113257; BDBM50028312
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[33] | |||
| Compound Name |
(S)-N-[(S)-4-((S,R)-Butylsulfamoyl)-1-cyclohexylmethyl-2,3-dihydroxy-butyl]-3-(3H-imidazol-4-yl)-2-(2-phenyl-ethanesulfonylamino)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL92179; BDBM50281240
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[7] | |||
| Compound Name |
Boc-Pro[CH2O]Phe-His-Sta-Ile-AMP
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL347572; BDBM50022909
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[30] | |||
| Compound Name |
N-(3-{1-Hydroxy-2-[1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-ethylamino}-1-isopropyl-2-oxo-3-phenyl-propyl)-3-methyl-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL325506; BDBM50028314
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[33] | |||
| Compound Name |
N-[(5R,14R)-5-Amino-5-methyl-16-oxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248699; BDBM50212178
Click to Show/Hide
|
||||
| Activity |
IC50 = 144000 nM
|
[34] | |||
| Compound Name |
2-(2-{5-[2-Amino-3-(3H-imidazol-4-yl)-propionylamino]-7-methyl-oct-3-enoylamino}-3-methyl-butyrylamino)-3-phenyl-propionic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287176; BDBM50027898
Click to Show/Hide
|
||||
| Activity |
Ki = 146000 nM
|
[19] | |||
| Compound Name |
Boc-Trp-Trp-Sta-Ala-Sta-OMe
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3142766; CHEMBL348101; BDBM50022516
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[24] | |||
| Compound Name |
N-[(5R,14R)-5-Amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400530; BDBM50212180
Click to Show/Hide
|
||||
| Activity |
IC50 = 169000 nM
|
[34] | |||
| Compound Name |
(2R)-6-Amino-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-2-[[(2R)-1-[(2S)-3-(1H-imidazol-5-yl)-2-[[(2R)-pyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1790121; BDBM50367715
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[35] | |||
| Compound Name |
Pro-His-Pro-Phe-Arg-Phe-Phe-Val-Tyr-Lys
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386402; BDBM50022992
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 71 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
oxazine 89
Click to Show/Hide
|
Clinical trial | Compound Info | ||
| Synonyms |
CHEMBL2347208; N-{3-[(4s,6s)-2-Amino-4-Methyl-6-(Trifluoromethyl)-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-Carboxamide; oxazine 89; GTPL6944; SCHEMBL15991481; BDBM50432601; 1HL
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[36] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-hydroxy-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372727; BDBM50367081
Click to Show/Hide
|
||||
| Activity |
Ki = 230000 nM
|
[37] | |||
| Compound Name |
2-{2-[2-(2-Hydroxy-4-methyl-pentanoylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371226; BDBM50028493
Click to Show/Hide
|
||||
| Activity |
Ki = 230000 nM
|
[38] | |||
| Compound Name |
Phenyl-substituted sulfonamides, 6a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL487288; BDBM32384
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
Iso-butyl-substituted sulfonamide, 9a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521590; BDBM32390
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
Phenyl-substituted sulfonamides, 6c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL487494; BDBM32386
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
Phenyl-substituted sulfonamides, 6f
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510829; BDBM32389
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
N,N'-(Iminodiethane-2,1-Diyl)bis[4-Amino-N-(2-Methylpropyl)benzenesulfonamide]
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490184; BDBM32391; iso-butyl-substituted sulfonamide, 9b; Q27462569
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
Phenyl-substituted sulfonamides, 6e
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505405; BDBM32388
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
Carboxamide, 12b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL488104; BDBM32393; N-benzyl-N-[3-[2-[benzyl-(2-phenylacetyl)amino]ethylamino]propyl]-2-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
N,N'-(Iminodiethane-2,1-diyl)bis(4-amino-N-benzylbenzenesulfonamide)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519079; BDBM32387; phenyl-substituted sulfonamides, 6d; Q27462568; LJH
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
Phenyl-substituted sulfonamides, 6b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521384; BDBM32385
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[39] | |||
| Compound Name |
4-(2-{4-[2-(2-Tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(3H-imidazol-4-yl)-propionylamino]-3-hydroxy-6-methyl-heptanoylamino}-propionylamino)-3-hydroxy-6-methyl-heptanoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90896; BDBM50025903
Click to Show/Hide
|
||||
| Activity |
IC50 = 270000 nM
|
[24] | |||
| Compound Name |
2-[(5R,14R)-5-Amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(20),7,9,11(22),17(21),18-hexaen-19-yl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401180; BDBM50212189
Click to Show/Hide
|
||||
| Activity |
IC50 = 275000 nM
|
[34] | |||
| Compound Name |
2-{2-[2-(2-Hydroxy-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371230; BDBM50028491
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[38] | |||
| Compound Name |
5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5,6,7,8-Tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidin-4-ylamine; 5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-amine; CHEMBL1836471; 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine; 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamine; [1]Benzothieno[2,3-d]pyrimidine, 4-amino-5,6,7,8-tetrahydro-; (1)Benzothieno(2,3-d)pyrimidine, 4-amino-5,6,7,8-tetrahydro-; 5,6,7,8-tetrahydrobenzo[b]thiopheno[2,3-d]pyrimidine-4-ylamine; 5,6,7,8-TETRAHYDRO-BENZO(4,5)THIENO(2,3-D)PYRIMIDIN-4-YLAMINE; NSC86899; Oprea1_485936; Oprea1_610205; SCHEMBL16751404; CTK1D6227; ZINC78174; DTXSID30293029; 5,6,7,8-Tetrahydro[1]benzothieno-[2,3-d]pyrimidin-4-amine; HMS1679H04; ALBB-018433; BBL007900; BDBM50354357; CCG-52656; MFCD00203885; NSC-86899; RSC001992; SBB015197; STK271042; AKOS000115978; MCULE-7316157732; ST014640; AB0062472; V6202; EN300-02901; W-6678; AG-205/05254028; SR-01000468064; [1]Benzothieno[2, 4-amino-5,6,7,8-tetrahydro-; SR-01000468064-1; SR-01000468064-2; Z56757217; F0239-0907; 5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine #; 5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-amine; Pyrimido[4,5-b]benzothiophen-1-amine, 6,7,8,9-tetrahydro-; [1]Benzothieno[2,3-d]pyrimidin-4-amine, 5,6,7,8-tetrahydro-; [1]Benzothino[2,3-d]pyrimidine, 4-amino-5,6,7,8-tetrahydro-; 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-ylamine; 8-thia-4,6-diazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6-tetraen-3-amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[40] | |||
| Compound Name |
Furfurylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
furan-2-ylmethanamine; 2-(Aminomethyl)furan; 2-Furfurylamine; 2-Furanmethylamine; 2-Aminomethylfuran; 2-FURANMETHANAMINE; Furanmethanamine; 2-Furylmethylamine; (2-Furylmethyl)amine; USAF Q-1; Methylamine, 1-(2-furyl)-; 2-Furylmethanamine; Furfuryl amine; UNII-86GAN59F7R; NSC 49136; NSC 61168; .alpha.-Furfurylamine; (furan-2-yl)methanamine; MFCD00003258; 1-(furan-2-yl)methanamine; 86GAN59F7R; 1-(2-furyl)methylamine; CHEMBL3561633; Furfurylamine, 99+%; WLN: T5OJ B1Z; alpha-Furfurylamine; EINECS 210-536-9; UN2526; BRN 0001614; furylmethylamine; AI3-25428; 2-furylmethlamine; 2-aminomethyl-furan; 2-furanylmethanamine; 2-furanylmethylamine; 2-furylmethyl amine; furan-2-methylamine; Furan-2-yhnethylamine; Furan-2-ylmethylamine; PubChem6967; 2-Furylmethanamine #; furan-2-ylmethaneamine; (2-Furanylmethyl)amine; ACMC-20aj1o; (furan-2-yl)methylamine; 1-(2-furyl)methanamine; Furfurylamine, >=99%; C-furan-2-yl-methylamine; EC 210-536-9; DSSTox_CID_30867; DSSTox_GSID_52295; 5-18-09-00541 (Beilstein Handbook Reference); KSC354I1J; DTXSID6052295; CTK2F4414; KS-00000W2H; NSC49136; NSC61168; STR00639; ZINC1681227; Tox21_304050; ANW-75610; BBL011620; BDBM50195324; NSC-49136; NSC-61168; SBB004376; STL163341; AKOS000119304; MCULE-8280847881; NE10272; PS-9340; UN 2526; VZ34690; NCGC00357257-01; SC-05782; CS-0015389; F0091; FT-0626583; ST45026773; EN300-17953; Furfurylamine [UN2526] [Flammable liquid]; 10.14272/DDRPCXLAQZKBJP-UHFFFAOYSA-N.1; 133869-EP2277848A1; 133869-EP2281563A1; 133869-EP2292606A1; 133869-EP2295420A1; doi:10.14272/DDRPCXLAQZKBJP-UHFFFAOYSA-N.1; Q5509528; W-109579; F2190-0395
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[40] | |||
| Compound Name |
(2R,3R,4S)-N-Butyl-5-cyclohexyl-2,3-dihydroxy-4-[3-(1H-imidazol-5-yl)propylamino]pentane-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90402; BDBM50281239
Click to Show/Hide
|
||||
| Activity |
IC50 = 310000 nM
|
[7] | |||
| Compound Name |
N-Ac-Trp(CHO)-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413362; BDBM50022906
Click to Show/Hide
|
||||
| Activity |
IC50 = 330000 nM
|
[30] | |||
| Compound Name |
(3S)-4-Acetyl-3-hydroxy-6-methyl-N-[(2R)-1-(3-methylbutylamino)-1-oxopropan-2-yl]heptanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL113917; BDBM50028316; 4-Acetyl-3-hydroxy-6-methyl-heptanoic acid [1-(3-methyl-butylcarbamoyl)-ethyl]-amide
Click to Show/Hide
|
||||
| Activity |
IC50 > 330000 nM
|
[33] | |||
| Compound Name |
(3S)-3-Hydroxy-6-methyl-4-(3-methylbutanoylamino)-N-[(2R)-1-(3-methylbutylamino)-1-oxopropan-2-yl]heptanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112794; BDBM50028311
Click to Show/Hide
|
||||
| Activity |
IC50 > 330000 nM
|
[33] | |||
| Compound Name |
3-Hydroxy-6-methyl-4-{3-methyl-2-[3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-heptanoic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL115380; BDBM50028319
Click to Show/Hide
|
||||
| Activity |
IC50 > 330000 nM
|
[33] | |||
| Compound Name |
3-Hydroxy-6-methyl-4-[3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-heptanoic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL112016; BDBM50028317
Click to Show/Hide
|
||||
| Activity |
IC50 > 330000 nM
|
[33] | |||
| Compound Name |
His-Sta-Leu-Phe-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103365; BDBM50022858
Click to Show/Hide
|
||||
| Activity |
IC50 = 370000 nM
|
[27] | |||
| Compound Name |
2-[2-(5-Amino-7-methyl-oct-3-enoylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26248; BDBM50027899
Click to Show/Hide
|
||||
| Activity |
Ki = 400000 nM
|
[19] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-[[(2S,3R)-1-cyclohexyl-3-hydroxy-4-oxoheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL81202; BDBM50406980
Click to Show/Hide
|
||||
| Activity |
IC50 = 420000 nM
|
[6] | |||
| Compound Name |
Boc-His-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL265970; BDBM50022897
Click to Show/Hide
|
||||
| Activity |
IC50 = 440000 nM
|
[30] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2R,3S,8S)-3,8-diamino-2-hydroxy-5,10-dimethyl-7-oxoundecanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203568
Click to Show/Hide
|
||||
| Activity |
Ki = 440000 nM
|
[37] | |||
| Compound Name |
(2R,3R,4S)-4-Amino-N-butyl-5-cyclohexyl-2,3-dihydroxypentane-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91556; BDBM50281232; (2R,3R,4S)-4-Amino-5-cyclohexyl-2,3-dihydroxy-pentane-1-sulfonic acid butylamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 470000 nM
|
[7] | |||
| Compound Name |
3-{2-[(5-Aminopentyl)amino]-2-oxoethoxy}-5-({[1-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl phenylmethanesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
oxyacetamide 5; CHEMBL426717; SCHEMBL4586113; BDBM16046; L-124,671; Q27453495
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[41] | |||
| Compound Name |
Leu-Leu-Val-Phe-OCH3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25842; BDBM50027897
Click to Show/Hide
|
||||
| Activity |
Ki = 500000 nM
|
[19] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S,3S,8S)-3,8-diamino-2-hydroxy-5,10-dimethyl-7-oxoundecanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203572
Click to Show/Hide
|
||||
| Activity |
Ki = 520000 nM
|
[37] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-hydroxy-2-phenylacetyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143511
Click to Show/Hide
|
||||
| Activity |
Ki = 530000 nM
|
[38] | |||
| Compound Name |
N-Ac-His-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263293; BDBM50022899
Click to Show/Hide
|
||||
| Activity |
IC50 = 550000 nM
|
[30] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-hydroxy-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350377
Click to Show/Hide
|
||||
| Activity |
Ki = 600000 nM
|
[38] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-hydroxy-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143514
Click to Show/Hide
|
||||
| Activity |
Ki = 670000 nM
|
[38] | |||
| Compound Name |
(2R,3R,4S)-N-Butyl-5-cyclohexyl-2,3-dihydroxy-4-(4-methylpentylamino)pentane-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94252; BDBM50281227; (2R,3R,4S)-5-Cyclohexyl-2,3-dihydroxy-4-(4-methyl-pentylamino)-pentane-1-sulfonic acid butylamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 680000 nM
|
[7] | |||
| Compound Name |
Methyl (2R)-2-[[(2R)-2-[[5-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-7-methyloctanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216383; BDBM50224558
Click to Show/Hide
|
||||
| Activity |
Ki = 740000 nM
|
[17] | |||
| Compound Name |
Chembl539498
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216382; BDBM50027890
Click to Show/Hide
|
||||
| Activity |
Ki = 900000 nM
|
[17] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-3-amino-2-hydroxy-5-methylhexanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203567
Click to Show/Hide
|
||||
| Activity |
Ki = 960000 nM
|
[37] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143510
Click to Show/Hide
|
||||
| Activity |
Ki = 980000 nM
|
[38] | |||
| Compound Name |
Pro-His-Pro-Phe-His-5-amino-valeric acid-Ile-Phe-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371836; BDBM50022969
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[13] | |||
| Compound Name |
Boc-Trp(CHO)-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437229; BDBM50022901
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[30] | |||
| Compound Name |
(S)-2-Amino-N-[4-((S,R,R)-butylsulfamoyl)-1-cyclohexylmethyl-2,3-dihydroxy-butyl]-3-(3H-imidazol-4-yl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90659; BDBM50281244
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
N-((1S,2R,3R)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-3-(3H-imidazol-4-yl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL327891; SCHEMBL7278517; BDBM50281230
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
N-((1S,2R,3R)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94013; SCHEMBL9634502; BDBM50281221
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
4-Methyl-pentanoic acid ((1S,2R,3S)-4-butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL91299; SCHEMBL9014908; BDBM50281228
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(2S,3R,4R)-5-(Butylsulfamoyl)-1-cyclohexyl-3,4-dihydroxypentan-2-yl]-2-hydroxy-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330018; BDBM50281243
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
4-Methoxy-N-{4-[(3R,4R)-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-benzyl}-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417673; BDBM50077681; 3alpha-(2-Naphthylmethoxy)-4beta-[4-(4-methoxybenzoylaminomethyl)phenyl]piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[42] | |||
| Compound Name |
N-((1S,2R,3S)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL90415; BDBM50281235
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
4-Methyl-pentanoic acid ((1S,2R,3R)-4-butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93516; SCHEMBL7282313; BDBM50281224
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(2S,3R,4S)-5-(Butylsulfamoyl)-1-cyclohexyl-3,4-dihydroxypentan-2-yl]-2-hydroxy-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330573; BDBM50281236
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
2-{2-[2-(2-Amino-4-methyl-pentanoylamino)-acetylamino]-3-methyl-butyrylamino}-3-phenyl-propionic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL287206; Leu-Gly-Val-Phe-OCH3; BDBM50027895
Click to Show/Hide
|
||||
| Activity |
Ki = 1000000 nM
|
[19] | |||
| Compound Name |
N-((1S,2R,3S)-4-Butylsulfamoyl-1-cyclohexylmethyl-2,3-dihydroxy-butyl)-3-(3H-imidazol-4-yl)-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93587; SCHEMBL7281536; BDBM50281241
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-N-[(2S,3R,4R)-5-(butylsulfamoyl)-1-cyclohexyl-3,4-dihydroxypentan-2-yl]-4-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL93697; BDBM50281225
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[7] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2R,3S)-3-amino-2-hydroxy-5-methylhexanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346373; BDBM50028528
Click to Show/Hide
|
||||
| Activity |
Ki = 1010000 nM
|
[37] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1204164
Click to Show/Hide
|
||||
| Activity |
Ki = 1140000 nM
|
[37] | |||
| Compound Name |
Methyl (2R)-2-[[(2R)-2-[(5-amino-3-hydroxy-7-methyloctanoyl)amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558204
Click to Show/Hide
|
||||
| Activity |
Ki = 1180000 nM
|
[17] | |||
| Compound Name |
(3S,4S)-4-(4-Chloro-phenyl)-3-(4-methoxy-benzyloxy)-piperidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL31997; SCHEMBL6042777; BDBM50077670; 3beta-(4-Methoxybenzyloxy)-4alpha-(4-chlorophenyl)piperidine; (3S,4S)-4-(4-chlorophenyl)-3-[(4-methoxyphenyl)methoxy]piperidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[42] | |||
| Compound Name |
(2S)-N-[(2R)-1-(2,2-Dimethylpropylamino)-1-oxo-3-phenylpropan-2-yl]-N'-[(2S)-1-hydroxy-4-methylpentan-2-yl]-2-(1H-imidazol-5-ylmethyl)propanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL12246; BDBM50391338
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[18] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2R)-2-[[(2R,3S)-3-amino-2-hydroxy-5-methylhexanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1203573
Click to Show/Hide
|
||||
| Activity |
Ki = 1520000 nM
|
[37] | |||
| Compound Name |
N-(2,3-Seco-olean-12-en-28-oyl)-D-valine acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575697; BDBM50298418
Click to Show/Hide
|
||||
| Activity |
IC50 > 1663000 nM
|
[43] | |||
| Compound Name |
Methyl (2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-hydroxy-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350378
Click to Show/Hide
|
||||
| Activity |
Ki = 1780000 nM
|
[38] | |||
| Compound Name |
(3S,4As,6aR,7S,8R,10aR,10bS,12aS)-7-(carboxymethyl)-8-(2-carboxypropan-2-yl)-3,7,10a,10b,12a-pentamethyl-6-oxo-1,2,4,4a,6a,8,9,10,11,12-decahydrochrysene-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574282; BDBM50298419
Click to Show/Hide
|
||||
| Activity |
IC50 > 1935000 nM
|
[43] | |||
| Compound Name |
(1R,2R,4Ar,4bS,6aS,10aR,12aR)-1-(carboxymethyl)-2-(2-carboxypropan-2-yl)-1,4a,4b,9,9-pentamethyl-3,4,5,6,7,8,10,10a,12,12a-decahydro-2H-chrysene-6a-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573822; BDBM50298420
Click to Show/Hide
|
||||
| Activity |
IC50 > 1990000 nM
|
[43] | |||
| Compound Name |
2,3-Seco-lupa-20(29)-en-2,3,28-trioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573333; BDBM50298414
Click to Show/Hide
|
||||
| Activity |
IC50 > 1991000 nM
|
[43] | |||
| Compound Name |
(1R,2R,4Ar,4bS,6aS,9R,10S,10aS,12aR)-1-(carboxymethyl)-2-(2-carboxypropan-2-yl)-1,4a,4b,9,10-pentamethyl-2,3,4,5,6,7,8,9,10,10a,12,12a-dodecahydrochrysene-6a-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575187; BDBM50298415
Click to Show/Hide
|
||||
| Activity |
IC50 > 1991000 nM
|
[43] | |||
| Compound Name |
16beta-Hydroxy-2,3-seco-lup-20(29)-en-2,3-dioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573101; BDBM50298416
Click to Show/Hide
|
||||
| Activity |
IC50 > 2046000 nM
|
[43] | |||
| Compound Name |
2,3-Seco-lup-20(29)-en-2,3-dioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL578646; BDBM50298417
Click to Show/Hide
|
||||
| Activity |
IC50 > 2117000 nM
|
[43] | |||
| Compound Name |
2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435650; BDBM50028527
Click to Show/Hide
|
||||
| Activity |
Ki = 2440000 nM
|
[37] | |||
| Compound Name |
Boc-Pro[CH2O]Phe-His-Sta-Ile-Phe-OCH3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL347694; BDBM50022904
Click to Show/Hide
|
||||
| Activity |
IC50 = 2500000 nM
|
[30] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction. J Med Chem. 1990 Oct;33(10):2707-14. | ||||
| REF 2 | Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47. | ||||
| REF 3 | Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1). J Med Chem. 2004 Dec 16;47(26):6447-50. | ||||
| REF 4 | Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position. Bioorg Med Chem. 2013 Nov 1;21(21):6665-73. | ||||
| REF 5 | Direct renin inhibitors as a new therapy for hypertension. J Med Chem. 2010 Nov 11;53(21):7490-520. | ||||
| REF 6 | Activated ketone based inhibitors of human renin. J Med Chem. 1993 Aug 20;36(17):2431-47. | ||||
| REF 7 | Diol sulfonamides: A potent and novel class of inhibitors of human renin. Bioorg Med Chem Lett. 1993 Dec;3(12):2739-44. | ||||
| REF 8 | Design and synthesis of 5,5'-disubstituted aminohydantoins as potent and selective human beta-secretase (BACE1) inhibitors. J Med Chem. 2010 Feb 11;53(3):1146-58. | ||||
| REF 9 | New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site. J Med Chem. 1988 Mar;31(3):532-9. | ||||
| REF 10 | Novel pseudosymmetric inhibitors of HIV-1 protease. Bioorg Med Chem Lett. 1993 Dec;3(12):2837-42. | ||||
| REF 11 | Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3-P1)-moieties. A novel strategy towards small non-peptide renin inhibitors. Bioorg Med Chem Lett. 1996 Jul 9;6(13):1589-94. | ||||
| REF 12 | Synthesis of alpha-hydroxy statine through a facially selective osmylation of a chiral alpha-amido crotonate. Bioorg Med Chem Lett. 1995 May 4;5(9):949-52. | ||||
| REF 13 | Analysis of structure-activity relationships in renin substrate analogue inhibitory peptides. J Med Chem. 1987 Aug;30(8):1287-95. | ||||
| REF 14 | Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen. J Med Chem. 1988 Feb;31(2):284-95. | ||||
| REF 15 | Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J Med Chem. 2011 Apr 14;54(7):1961-2004. | ||||
| REF 16 | Rational design and synthesis of selective BACE-1 inhibitors. Bioorg Med Chem Lett. 2004 Feb 9;14(3):601-4. | ||||
| REF 17 | Inhibition of renin by angiotensinogen peptide fragments containing the hydroxy amino acid residue 5-amino-3-hydroxy-7-methyloctanoic acid. J Med Chem. 1983 Oct;26(10):1457-62. | ||||
| REF 18 | Retro-Inverso Tripeptide Renin Inhibitors. Bioorg Med Chem Lett. 1992 Sep;2(9):1089-92. | ||||
| REF 19 | Inhibition of renin by substrate analogue inhibitors containing the olefinic amino acid 5(S)-amino-7-methyl-3(E)-octenoic acid. J Med Chem. 1984 Oct;27(10):1351-4. | ||||
| REF 20 | Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations. Bioorg Med Chem. 2017 Aug 1;25(15):3947-3963. | ||||
| REF 21 | Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors. Bioorg Med Chem. 2016 Nov 15;24(22):5771-5780. | ||||
| REF 22 | Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase. J Med Chem. 2008 Oct 23;51(20):6259-62. | ||||
| REF 23 | New human renin inhibitors containing an unnatural amino acid, norstatine. J Med Chem. 1988 Apr;31(4):701-4. | ||||
| REF 24 | Pepstatin analogues as novel renin inhibitors. J Med Chem. 1986 Jul;29(7):1152-9. | ||||
| REF 25 | Design and synthesis of a prototypical non-peptidic inhibitor model for the enzme renin. Bioorg Med Chem Lett. 1994 Jul 21;4(14):1697-702. | ||||
| REF 26 | The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4863-7. | ||||
| REF 27 | Design, structure-activity, and molecular modeling studies of potent renin inhibitory peptides having N-terminal Nin-For-Trp (Ftr): angiotensinogen congeners modified by P1-P1' Phe-Phe, Sta, Leu psi[CH(OH)CH2]Val or leu psi[CH2NH]Val substitutions. J Med Chem. 1988 Jan;31(1):18-30. | ||||
| REF 28 | 1,2,4-Triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity. 1. Synthesis and biological properties of alkyl alcohol and statine derivatives. J Med Chem. 1990 Sep;33(9):2326-34. | ||||
| REF 29 | Aminodiol HIV protease inhibitors. 1. Design, synthesis, and preliminary SAR. J Med Chem. 1994 Jun 10;37(12):1758-68. | ||||
| REF 30 | Renin inhibitors containing psi[CH2O] pseudopeptide inserts. J Med Chem. 1988 Mar;31(3):671-7. | ||||
| REF 31 | Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites. J Med Chem. 1990 Feb;33(2):838-45. | ||||
| REF 32 | Discovery of pyrrolidine-based -secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency. Bioorg Med Chem Lett. 2012 Jan 1;22(1):240-4. | ||||
| REF 33 | Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin. J Med Chem. 1980 Jan;23(1):27-33. | ||||
| REF 34 | Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4057-61. | ||||
| REF 35 | Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine, Leu psi [CH2S]Val, or Leu psi [CH2SO]Val at the P1-P1' cleavage site. J Med Chem. 1988 Jul;31(7):1377-82. | ||||
| REF 36 | beta-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. | ||||
| REF 37 | Renin inhibitors. Substitution of the leucyl residues of Leu-Leu-Val-Phe-OCH3 with 3-amino-2-hydroxy-5-methylhexanoic acid. J Med Chem. 1982 May;25(5):605-10. | ||||
| REF 38 | N-(alpha-Hydroxyalkanoyl) derivatives of Leu-Val-Phe-OCH3 as inhibitors of renin. J Med Chem. 1980 Jun;23(6):666-9. | ||||
| REF 39 | Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors. Bioorg Med Chem. 2008 Sep 15;16(18):8574-86. | ||||
| REF 40 | Novel approach of fragment-based lead discovery applied to renin inhibitors. Bioorg Med Chem. 2016 Nov 15;24(22):6066-6074. | ||||
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