Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62193 | Target Info | |||
| Target Name | Aromatic-L-amino-acid decarboxylase (DDC) | ||||
| Synonyms |
DOPA decarboxylase; AADC
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|
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| Target Type | Successful Target | ||||
| Gene Name | DDC | ||||
| Biochemical Class | Carbon-carbon lyase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
8-Methoxy-5-methylphenanthridin-5-ium-2-ol;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323160; BDBM50017577
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| Activity |
IC50 = 120000 nM
|
[1] | |||
| Compound Name |
2,8-Dimethoxy-5-methylphenanthridin-5-ium;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323151; BDBM50017576
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| Activity |
IC50 = 190000 nM
|
[1] | |||
| Compound Name |
Sanguinarium Chloride
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Investigative | Compound Info | ||
| Synonyms |
SANGUINARINE CHLORIDE; Viadent; Sanguinarine (chloride); Sanguinarine chloride hydrate; Sanguinarine hydrochloride; UNII-B8Z8J4400H; CHEMBL490129; 5578-73-4 (chloride); B8Z8J4400H; Pseudochelerythrine chloride;Sanguinarium chloride; MFCD00012126; Sanguinarine, chloride; Sanguinarium chloride [USAN:INN]; SANGUINARINECHLORIDE; SR-01000075650; Chelerythrine Chloride,(S); SCHEMBL43290; CTK5A4180; HY-N0052A; DTXSID30971158; HMS3263M18; Sanguinarium chloride (USAN/INN); Tox21_501108; AKOS024457036; CCG-212462; CS-4784; LP01108; KS-0000003G; NCGC00094379-01; NCGC00094379-02; NCGC00261793-01; AK546775; DB-052796; EU-0101108; FT-0603674; D05799; S 5890; Sanguinarine chloride hydrate, >=98% (HPLC); Q-100647; SR-01000075650-2; Q27274521; 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride; 13-Methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i] phenanthridinium chloride
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|
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| Activity |
IC50 = 200000 nM
|
[1] | |||
| Non Binders of This Target (in total, 12 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
chelerythrine
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|
Investigative | Compound Info | ||
| Synonyms |
broussonpapyrine; cheleritrine; chelerythrine hydroxide; toddalin
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| Activity |
IC50 = 1280000 nM
|
[1] | |||
| Compound Name |
Phenanthridinium, 5-methyl-, chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288322; 5-methylphenanthridin-5-ium chloride; N-Methylphenanthridinium chloride; SCHEMBL11496936; DTXSID20983801; BDBM50017565; NSC174126; NSC-174126
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| Activity |
IC50 = 400000 nM
|
[1] | |||
| Compound Name |
2-Fluoro-8-methoxy-5-methylphenanthridin-5-ium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288327; BDBM50017573
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| Activity |
IC50 = 570000 nM
|
[1] | |||
| Compound Name |
8-Methoxy-2,5-dimethylphenanthridin-5-ium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288329; BDBM50017575
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| Activity |
IC50 = 600000 nM
|
[1] | |||
| Compound Name |
2-Chloro-8-methoxy-5-methylphenanthridin-5-ium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288328; BDBM50017574
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|
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| Activity |
IC50 = 930000 nM
|
[1] | |||
| Compound Name |
8-Methoxy-5-methylphenanthridin-5-ium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288326; BDBM50017572
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| Activity |
IC50 = 950000 nM
|
[1] | |||
| Compound Name |
2,8,9-Trimethoxy-5-methylphenanthridin-5-ium;chloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323153; BDBM50017571
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|
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| Activity |
IC50 = 1170000 nM
|
[1] | |||
| Compound Name |
Nitidine
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Investigative | Compound Info | ||
| Synonyms |
(1,3)Benzodioxolo(5,6-c)phenanthridinium, 2,3-dimethoxy-12-methyl-; UNII-933301178Z; NCIMech_000542; Neuro_000081; 2,3-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium; NSC 146397; 933301178Z; [1,3]Benzodioxolo[5,6-c]phenanthridinium, 2,3-dimethoxy-12-methyl-; AC1L1IB4; CHEMBL176008; SCHEMBL8014101; CTK5C8373; DTXSID60218846; ZINC898732; BDBM50017566; CCG-35985; AKOS015904022; NCGC00482764-03; NCI60_000995; FT-0686666; N2626; C09595; Q15425772; [1,3]Dioxolo[4',5':4,5]benzo[1,2-c]phenanthridinium,2,3-dimethoxy-12-methyl-; 2,3-Dimethoxy-12-methyl-9H-phenanthridino[4',3'-2,1]benzo[4,5-d]1,3-dioxolane
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|
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| Activity |
IC50 = 1340000 nM
|
[1] | |||
| Compound Name |
2-Chloro-8,9-dimethoxy-5-methylphenanthridin-5-ium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288324; BDBM50017569
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|
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| Activity |
IC50 = 1390000 nM
|
[1] | |||
| Compound Name |
8,9-Dimethoxy-2,5-dimethylphenanthridin-5-ium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288325; BDBM50017570
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|
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| Activity |
IC50 = 1490000 nM
|
[1] | |||
| Compound Name |
2-Fluoro-8,9-dimethoxy-5-methylphenanthridin-5-ium;chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3288323; BDBM50017568
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|
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| Activity |
IC50 = 2690000 nM
|
[1] | |||
| Compound Name |
8,9-Dimethoxy-5-methylphenanthridin-5-ium chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3248107; DTXSID90611048; BDBM50017567; NSC273819; NSC-273819; Phenanthridinium,9-dimethoxy-5-methyl-, chloride
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|
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| Activity |
IC50 = 3500000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis of 5-methyl phenanthridium derivatives: a new class of human DOPA decarboxylase inhibitors. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2712-6. | ||||
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