Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T62266 | Target Info | |||
| Target Name | Indoleamine 2,3-dioxygenase 2 (IDO2) | ||||
| Synonyms |
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1; Indoleamine 2,3-dioxygenase-like protein 1; INDOL1; IDO-2
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| Target Type | Patented-recorded Target | ||||
| Gene Name | IDO2 | ||||
| Biochemical Class | Oxygenase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
NLG8189
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Phase 2/3 | Compound Info | ||
| Synonyms |
1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189
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| Activity |
IC50 = 148900 nM
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[1] | |||
| Compound Name |
1-methyl-L-tryptophan
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Preclinical | Compound Info | ||
| Synonyms |
1-L-MT; 1-LMT
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| Activity |
IC50 = 56900 nM
|
[1] | |||
| Compound Name |
2-Fluoroindolo[2,1-b]quinazoline-6,12-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3086870; SCHEMBL9100993; CTK7C1374; BDBM50442995
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| Activity |
IC50 = 56800 nM
|
[1] | |||
| Compound Name |
9-Chloroindolo[2,1-b]quinazoline-6,12-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1276265; NSC349855; SCHEMBL9101860; DTXSID20319722; BDBM50442990; NSC-349855
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| Activity |
IC50 = 67900 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
amg-1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3342402; N-(1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetamide; BAS 06591295; AC1LLIU7; GTPL8227; SCHEMBL20313457; MolPort-000-220-791; ZINC801901; STL305655; BDBM50030791; AKOS000657540; MCULE-5294683561; ST50049773; Z56882059; N-(2H-1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}acetamide; 496023-55-3; N-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)-2-[5-(4-methylphenyl)(1,3-thiazolino[3,2- d]1,2,4-triazol-3-ylthio)]acetamide
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| Activity |
IC50 > 250000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-179. | ||||
| REF 2 | Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy. Eur J Med Chem. 2018 Jan 1;143:656-669. | ||||
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