Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T64795 | Target Info | |||
| Target Name | Voltage-gated calcium channel alpha Cav3.1 (CACNA1G) | ||||
| Synonyms |
Voltage-gated calcium channel alpha subunit Cav3.1; Voltage-dependent T-type calcium channel; NBR13; Cav3.1c; CACNA1G
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| Target Type | Successful Target | ||||
| Gene Name | CACNA1G | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(4-Chlorobenzyl)-N-[2-(dimethylamino)ethyl]-4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227432; MLS001201043; HMS2862B22; BDBM50197631; ZINC20645360; AKOS002077896; MCULE-4967786063; SMR000564268; SR-01000562879; SR-01000562879-1
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| Activity |
IC50 = 53500 nM
|
[1] | |||
| Compound Name |
Methyl 2-(4-bromophenyl)-2-isopropyl-5-(4-(2-methoxyphenyl)piperazin-1-yl)pentanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL513338; SCHEMBL1890199; BDBM50262239; methyl 2-(4-bromophenyl)-5-[4-(2-methoxyphenyl)piperazin-1-yl]-2-propan-2-ylpentanoate
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| Activity |
IC50 = 95040 nM
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[2] | |||
| Compound Name |
N-((4-Phenyl-2-propyloxazol-5-yl)methyl)-3-(4-p-tolylpiperazin-1-yl)propan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171953; BDBM50321409; 3-[4-(4-methylphenyl)piperazin-1-yl]-N-[(4-phenyl-2-propyl-1,3-oxazol-5-yl)methyl]propan-1-amine
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| Activity |
IC50 = 130010 nM
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[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 3D pharmacophore based virtual screening of T-type calcium channel blockers. Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. | ||||
| REF 2 | Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4424-7. | ||||
| REF 3 | Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4219-22. | ||||
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