Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66538 | Target Info | |||
| Target Name | Calcium-activated potassium channel KCa1.1 (KCNMA1) | ||||
| Synonyms |
hSlo; Slowpoke homolog; Slo1; Slo-alpha; Slo homolog; SLO; MaxiK; Maxi K channel; KCa1.1; KCNMA; K(VCA)alpha; Calcium-activated potassium channel, subfamily M subunit alpha-1; Calcium-activated potassium channel subunit alpha-1; BKCA alpha; BK channel
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| Target Type | Clinical trial Target | ||||
| Gene Name | KCNMA1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(2-Oxo-5-phenyl-3H-benzimidazol-1-yl)-2H-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468707; BDBM50412620; 5-(2,3-Dihydro-5-phenyl-2-oxo-1H-benzimidazole-1-yl)-1H-1,2,3-triazole-4-carboxamide
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| Activity |
IC50 = 54954.09 nM
|
[1] | |||
| Compound Name |
5-(5-Chlorobenzotriazol-1-yl)-2H-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466204; BDBM50412619
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| Activity |
IC50 = 54954.09 nM
|
[1] | |||
| Compound Name |
5-[3-[3-(Trifluoromethyl)phenyl]ureido]-1H-1,2,3-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL446913; BDBM50412621
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| Activity |
IC50 = 79432.82 nM
|
[1] | |||
| Compound Name |
5-(5-Methyl-2-oxo-3H-benzimidazol-1-yl)-2H-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468913; BDBM50412623
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| Activity |
IC50 = 93325.43 nM
|
[1] | |||
| Compound Name |
5-(5-Fluorobenzotriazol-1-yl)-2H-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL449320; BDBM50412622
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| Activity |
IC50 = 93325.43 nM
|
[1] | |||
| Compound Name |
5-(2-Nitroanilino)-2H-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503117; BDBM50412624
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| Activity |
IC50 = 104712.85 nM
|
[1] | |||
| Compound Name |
5-(Benzotriazol-1-yl)-2H-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL505582; BDBM50412625
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| Activity |
IC50 = 112201.85 nM
|
[1] | |||
| Compound Name |
5-(5-Methoxybenzotriazol-1-yl)-2H-triazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499448; BDBM50412626
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| Activity |
IC50 = 154881.66 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | QSAR studies on BK channel activators. Bioorg Med Chem. 2009 Jan 1;17(1):319-25. | ||||
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