Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67102 | Target Info | |||
| Target Name | Cathepsin D (CTSD) | ||||
| Synonyms |
CPSD; CD
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | CTSD | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 258 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
verubecestat
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|
Phase 3 | Compound Info | ||
| Synonyms |
example 25 (US8940748)
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Resveratrol
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|
Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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| Activity |
IC50 = 138000 nM
|
[2] | |||
| Compound Name |
PF-06751979
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|
Phase 1 | Compound Info | ||
| Synonyms |
ZLZUHACSRMOLLV-RAALSFIWSA-N; 1818339-66-0; UNII-1Y0Y126GUG; 1Y0Y126GUG; US9315520, Example 1; CHEMBL3952064; US9315520, Example 2; US9315520, Comparator 1; SCHEMBL17162186; BDBM223395; HY-112157; CS-0043501; US9315520, 1; N-(2-((4aR,6S,8aR)-2-Amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano(3,4-d)(1,3)thiazin-8a-yl)thiazol-4-yl)-5-(difluoromethoxy)pyridine-2-carboxamide; N-{2-[(4aR,6S,8aR)-2-Amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-1,3-thiazol-4-yl}-5-(difluoromethoxy)pyridine-2-carb
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| Activity |
IC50 ~ 95300 nM
|
[1] | |||
| Compound Name |
Iboctadekin + rituximab
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|
Phase 1 | Compound Info | ||
| Synonyms |
Pepstatin A; 26305-03-3; Pepstatine; Ahpatinin C; UNII-V6Y2T27Q1U; MLS002222329; Iva-Val-Val-Sta-Ala-Sta-OH; V6Y2T27Q1U; CHEMBL296588; 39324-30-6; FAXGPCHRFPCXOO-LXTPJMTPSA-N; C34H63N5O9; NCGC00161670-06; Pepstatin (nonspecific); DSSTox_RID_81334; DSSTox_CID_26095; DSSTox_GSID_46095; CCRIS 3603; Pepstatina; Pepstatinum; Pepstatin (VAN); Ia Quinidine
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5,5-Diphenyl-2-iminohydantoin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291784; 5,5-Diphenyl-2-iminohydantoin; SCHEMBL4237550; 2-amino-3-methyl-5,5-diphenyl-3,5-dihydro-imidazol-4-one; BDBM50300229; 26975-80-4; 2-Imino-3-methyl-5,5-diphenylimidazolidin-4-one; 2-Imino-3-methyl-5,5-diphenyl-imidazolidin-4-one; 1-methyl-4,4-diphenyl-4,5-dihydro-1H-imidazol-2-amine
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2,3-difluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688766; SCHEMBL16049478; BDBM171712; US9085576, 342
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| Activity |
IC50 = 50550 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688651; SCHEMBL16041765; BDBM171587; US9085576, 221
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|
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| Activity |
IC50 = 51050 nM
|
[5] | |||
| Compound Name |
2-Amino-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]-7-[4-(5-phenylpentyl)phenyl]quinazolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763900; BDBM50145186
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| Activity |
IC50 = 52000 nM
|
[6] | |||
| Compound Name |
8-(3-Benzylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566977; SCHEMBL3457576; BDBM50300727; 8-(3-benzylphenyl)-8-phenyl-3,4-dihydro-2H-imidazo[1,5-a]pyrimidin-6-amine
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| Activity |
IC50 = 52500 nM
|
[7] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[[1-(trifluoromethyl)cyclopropyl]methylamino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688803; SCHEMBL16077322; BDBM171750; US9085576, 376
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|
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| Activity |
IC50 = 52900 nM
|
[5] | |||
| Compound Name |
(S)-2-Amino-4-(4-(difluoromethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1271343; SCHEMBL2795258; BDBM50329518; WAY-264116; (5S)-2-amino-5-[4-(difluoromethoxy)phenyl]-3-methyl-5-phenylimidazol-4-one
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| Activity |
IC50 = 53000 nM
|
[8] | |||
| Compound Name |
(5R)-2-Amino-5-(2-cyclohexylethyl)-5-[[(1S,3R)-3-(cyclopropylmethylamino)cyclohexyl]methyl]-3-methylimidazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354249; SCHEMBL7531303; BDBM50036575
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|
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| Activity |
Ki = 53300 nM
|
[9] | |||
| Compound Name |
2-Amino-3-[[(2S)-oxolan-2-yl]methyl]-7-phenylquinazolin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764744; BDBM50139143
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| Activity |
IC50 = 53400 nM
|
[6] | |||
| Compound Name |
Hydroxyethylamine derivative, 16
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500555; SCHEMBL5222095; BDBM29761
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| Activity |
IC50 = 53700 nM
|
[10] | |||
| Compound Name |
(S)-2-Amino-4-(2,6-diethylpyridin-4-yl)-4-(3-(2-fluoropyridin-3-yl)phenyl)-1-methyl-1H-imidazol-5(4H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL598290; SCHEMBL4964150; BDBM50310150
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| Activity |
IC50 = 54000 nM
|
[11] | |||
| Compound Name |
2-[2-(1-Adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-[(2S)-2-hydroxypropyl]carbamimidoyl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258315; SCHEMBL4485362; BDBM50372248
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|
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| Activity |
IC50 = 54100 nM
|
[12] | |||
| Compound Name |
2-[2-(1-Adamantyl)-5-phenylpyrrol-1-yl]-N-(N'-cyclohexylcarbamimidoyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404256; BDBM50372244
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| Activity |
IC50 = 54200 nM
|
[12] | |||
| Compound Name |
(4S,6S)-4-[5-[(7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3975091; SCHEMBL15990998; BDBM214810; US9296734, 11
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|
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| Activity |
IC50 = 54400 nM
|
[13] | |||
| Compound Name |
2-Amino-3-methyl-5-(1-methylpyrazol-4-yl)-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824133; SCHEMBL3583089; BDBM50352855
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|
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| Activity |
IC50 = 54400 nM
|
[4] | |||
| Compound Name |
Hydroxy ethylamine (HEA), 15
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|
Investigative | Compound Info | ||
| Synonyms |
BMCL193664 Compound 5; CHEMBL399656; SCHEMBL5220378; BDBM26780
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|
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| Activity |
IC50 = 56230 nM
|
[14] | |||
| Compound Name |
(1R,2R,6R)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688762; SCHEMBL16041374; BDBM171708; US9085576, 338
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|
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| Activity |
IC50 = 56550 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-(fluoromethyl)-1,3-oxazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683914; SCHEMBL16042014; BDBM171534; US9085576, 168
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|
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| Activity |
IC50 = 56750 nM
|
[5] | |||
| Compound Name |
(8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trifluoromethoxy)phenyl]-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL584509; SCHEMBL4060868; BDBM50300719
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|
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| Activity |
IC50 = 56900 nM
|
[7] | |||
| Compound Name |
(4Ar,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127097; BDBM50448530
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|
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| Activity |
IC50 = 57000 nM
|
[15] | |||
| Compound Name |
(1R,4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)-1-methylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127078; SCHEMBL9931039; BDBM50448529
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|
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| Activity |
IC50 = 57000 nM
|
[15] | |||
| Compound Name |
(2S,4S,5S)-5-[[(2S)-2-[(3R)-3-Benzyl-4-(4-methylpiperazine-1-carbonyl)-2-oxopiperazin-1-yl]hexanoyl]amino]-6-cyclohexyl-N-[2-(dimethylamino)ethyl]-4-hydroxy-2-propan-2-ylhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419942; BDBM50084640
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| Activity |
IC50 = 58000 nM
|
[16] | |||
| Compound Name |
Tricyclic hydroxyethylamine (HEA) derivative, 8f
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562554; SCHEMBL5930456; BMCL193669 Compound 28; BDBM26512
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| Activity |
IC50 = 58880 nM
|
[17] | |||
| Compound Name |
3-Ethyl-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide;formic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL493984; SCHEMBL5930086
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| Activity |
IC50 = 58880 nM
|
[18] | |||
| Compound Name |
2,2-Dimethyl-6-pyrimidin-5-ylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL427982; CHEMBL2349466
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| Activity |
IC50 = 59798 nM
|
[19] | |||
| Compound Name |
N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217068; 1H-Pyrrole-1-acetamide,N-(aminoiminomethyl)-2,5-diphenyl-; Acylguanidine, 7a; SCHEMBL4472723; SCHEMBL8269481; BDBM16751; N-(diaminomethylidene)-2-(2,5-diphenylpyrrol-1-yl)acetamide; ZINC14962105; DB06930; n-[2-(2,5-diphenyl-pyrrol-1-yl)-acetyl]guanidine; Q27095835; N-carbamimidoyl-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide; (N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-acetamide); N-(diaminomethylidene)-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
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| Activity |
IC50 = 60000 nM
|
[20] | |||
| Compound Name |
(4Ar,6S,8aS)-8a-(2,4-difluorophenyl)-6-ethyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414709; BDBM50078323
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| Activity |
IC50 = 63000 nM
|
[21] | |||
| Compound Name |
8-(3,4-Diethoxyphenyl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL566978; BDBM50300715
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| Activity |
IC50 = 63400 nM
|
[7] | |||
| Compound Name |
(5R)-2-Amino-5-[[(1S,3R)-3-(cyclohexylamino)cyclohexyl]methyl]-5-(2-cyclohexylethyl)-3-methylimidazol-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354251; SCHEMBL7533016; BDBM50036577
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| Activity |
Ki = 63500 nM
|
[9] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[1-(4-Chlorophenyl)cyclopropyl]methylamino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688797; SCHEMBL16077315; BDBM171744; US9085576, 370
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| Activity |
IC50 = 63600 nM
|
[5] | |||
| Compound Name |
Chembl4214785
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Investigative | Compound Info | ||
| Synonyms |
BDBM50452878
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| Activity |
IC50 ~ 64000 nM
|
[1] | |||
| Compound Name |
(4S)-4-[5-[[[1-(Difluoromethyl)cyclopropyl]amino]methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4062728; BDBM50259959
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| Activity |
IC50 = 65500 nM
|
[22] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688649; SCHEMBL16040656; BDBM171585; US9085576, 219; US9085576, 222
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| Activity |
IC50 = 65800 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[(1R)-1-(5-Chloropyridin-2-yl)-2,2,2-trifluoroethyl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693238; SCHEMBL16026317; BDBM171797; US9085576, 422
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| Activity |
IC50 = 68200 nM
|
[5] | |||
| Compound Name |
3-[(4As,10R,10aS)-2'-amino-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-8-yl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127099; SCHEMBL9882589; BDBM50448528
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| Activity |
IC50 = 69000 nM
|
[15] | |||
| Compound Name |
2-Amino-4-(3-chlorophenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL578410; SCHEMBL4236948; BDBM50303728; 2-amino-5-(3-chlorophenyl)-3-methyl-5-phenylimidazol-4-one
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| Activity |
IC50 = 69180 nM
|
[23] | |||
| Compound Name |
8-(4-Methoxyphenyl)-8-(3-(pyrimidin-5-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL582828; SCHEMBL4066453; BDBM50300721; 8-(4-methoxyphenyl)-8-(3-pyrimidin-5-ylphenyl)-3,4-dihydro-2H-imidazo[1,5-a]pyrimidin-6-amine
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| Activity |
IC50 = 69500 nM
|
[7] | |||
| Compound Name |
N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976114; BDBM220790; US9296759, 55; US9296759, 56
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| Activity |
IC50 = 69900 nM
|
[24] | |||
| Compound Name |
US9315520, Example 45
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972449; SCHEMBL17162352; BDBM223400; US9315520, 45
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| Activity |
IC50 ~ 70300 nM
|
[1] | |||
| Compound Name |
Chembl4227924
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Investigative | Compound Info | ||
| Synonyms |
BDBM50461486
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| Activity |
IC50 = 71000 nM
|
[2] | |||
| Compound Name |
1-[[5-[(4S)-2-Amino-4-methyl-5,6-dihydro-1,3-thiazin-4-yl]-2,4-difluorophenyl]methylamino]cyclopropane-1-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077211; BDBM50259960
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| Activity |
IC50 = 71800 nM
|
[22] | |||
| Compound Name |
CID 73507167
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414707; SCHEMBL15630348; BDBM50078349
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| Activity |
IC50 ~ 72000 nM
|
[1] | |||
| Compound Name |
Chembl4280656
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Investigative | Compound Info | ||
| Activity |
IC50 = 72000 nM
|
[25] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-(5-prop-1-ynylpyridin-3-yl)phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693245; SCHEMBL16041670; BDBM171804; US9085576, 429; US9085576, 431
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| Activity |
IC50 = 72850 nM
|
[5] | |||
| Compound Name |
2-[2-(1-Adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(2,3-dihydroxypropyl)carbamimidoyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL401832; SCHEMBL4496969; BDBM50372247
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| Activity |
IC50 = 73500 nM
|
[12] | |||
| Compound Name |
(4Ar,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1,3-oxazol-2-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422235; SCHEMBL15369976; BDBM148173; US8962616, 1
Click to Show/Hide
|
||||
| Activity |
IC50 = 74900 nM
|
[26] | |||
| Compound Name |
Sulfonamide tricyclic analogue, 12
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562290; SCHEMBL5930171; BDBM29801
Click to Show/Hide
|
||||
| Activity |
IC50 = 75500 nM
|
[27] | |||
| Compound Name |
2-Amino-5-(1-ethylpyrazol-4-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824134; SCHEMBL7884941; BDBM50352856
Click to Show/Hide
|
||||
| Activity |
IC50 = 75800 nM
|
[4] | |||
| Compound Name |
(4As,10R,10aS)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127095; SCHEMBL9933098; BDBM50448519
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[15] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[(1R)-1-(5-Chloropyridin-2-yl)ethyl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688805; SCHEMBL16042052; BDBM171752; US9085576, 378
Click to Show/Hide
|
||||
| Activity |
IC50 = 77400 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(3-cyclopropylprop-2-ynoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688678; SCHEMBL16041224; BDBM171616; US9085576, 250
Click to Show/Hide
|
||||
| Activity |
IC50 = 77500 nM
|
[5] | |||
| Compound Name |
CID 56682314
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824362; SCHEMBL3572513; BDBM50352851; (5R)-2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methyl-5-(5-propanoylthiophen-3-yl)imidazol-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 78400 nM
|
[4] | |||
| Compound Name |
8-(3-(Pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL584521; SCHEMBL4069358; BDBM50300725
Click to Show/Hide
|
||||
| Activity |
IC50 = 78700 nM
|
[7] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(3-methylidenecyclobutyl)methylamino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688802; SCHEMBL16077319; BDBM171749; US9085576, 375
Click to Show/Hide
|
||||
| Activity |
IC50 = 78850 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[[7-(trifluoromethyl)pyrido[3,2-d]pyrimidin-4-yl]amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688792; SCHEMBL16077321; BDBM171739; US9085576, 449
Click to Show/Hide
|
||||
| Activity |
IC50 = 79350 nM
|
[5] | |||
| Compound Name |
(4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylamino)-propionylamino]-6-hydroxy-4-isobutylcarbamoyl-8-phenyl-octanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL157575; BDBM50139111
Click to Show/Hide
|
||||
| Activity |
Ki = 79700 nM
|
[28] | |||
| Compound Name |
(4Ar,6R,8aS)-8a-(2,4-difluorophenyl)-6-(fluoromethyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414701; SCHEMBL14716501; BDBM142394; J3.522.164F; US8933221, 4; Q27454179
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 81000 nM
|
[21] | |||
| Compound Name |
US9085576, 2b-rac
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693256; SCHEMBL16040184; BDBM171816; US9085576, 2b-B
Click to Show/Hide
|
||||
| Activity |
IC50 = 81300 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683868; SCHEMBL16045137; BDBM171482; US9085576, 116
Click to Show/Hide
|
||||
| Activity |
IC50 = 81884 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[(1R)-5-Bromo-2,3-dihydro-1H-inden-1-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688810; SCHEMBL16042237; BDBM171758; US9085576, 384
Click to Show/Hide
|
||||
| Activity |
IC50 = 82550 nM
|
[5] | |||
| Compound Name |
CID 73507165
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414700; SCHEMBL15630477; BDBM50078320
Click to Show/Hide
|
||||
| Activity |
IC50 = 83100 nM
|
[21] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[(7S)-3-Bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688807; SCHEMBL16040825; BDBM171754; US9085576, 380; US9085576, 381
Click to Show/Hide
|
||||
| Activity |
IC50 = 83300 nM
|
[5] | |||
| Compound Name |
(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[[(1S,2R)-2-phenylcyclopropyl]methylamino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688799; SCHEMBL16077323; BDBM171746; US9085576, 372
Click to Show/Hide
|
||||
| Activity |
IC50 = 85450 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chloro-5-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683890; BDBM171506; US9085576, 140
Click to Show/Hide
|
||||
| Activity |
IC50 = 86900 nM
|
[5] | |||
| Compound Name |
Hydroxy ethylamine (HEA), 22
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254485; SCHEMBL5220916; BDBM26787
Click to Show/Hide
|
||||
| Activity |
IC50 = 87100 nM
|
[14] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-bromo-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917597; BDBM220857; US9296759, 120
Click to Show/Hide
|
||||
| Activity |
IC50 = 88300 nM
|
[24] | |||
| Compound Name |
8-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688773; SCHEMBL16077299; BDBM171719; US9085576, 349; US9085576, 351
Click to Show/Hide
|
||||
| Activity |
IC50 = 88357 nM
|
[5] | |||
| Compound Name |
CID 66683659
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349471; SCHEMBL429086; BDBM50432509; (4R)-2,2-dimethyl-6-pyrimidin-5-ylspiro[1,3-dihydronaphthalene-4,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 88464 nM
|
[19] | |||
| Compound Name |
2-Amino-7-[4-(4-phenylbutyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763489; BDBM50145183
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[6] | |||
| Compound Name |
CID 73507384
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414708; SCHEMBL15630354; BDBM50078324
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 91400 nM
|
[21] | |||
| Compound Name |
Chembl4228633
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461477
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[2] | |||
| Compound Name |
8-(3-Propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL583887; SCHEMBL3458204; BDBM50300708; 8-(3-propylphenyl)-8-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-imidazo[1,5-a]pyrimidin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 93700 nM
|
[7] | |||
| Compound Name |
N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922902; SCHEMBL17162434; BDBM223332; US9315520, 19
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 95000 nM
|
[1] | |||
| Compound Name |
(4S)-4-[5-[(1-Bicyclo[1.1.1]pentanylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102593; BDBM50259974
Click to Show/Hide
|
||||
| Activity |
IC50 = 95300 nM
|
[22] | |||
| Compound Name |
8-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-8-(3-(2-fluoropyridin-3-yl)phenyl)-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL566969; SCHEMBL4073994; BDBM50300716
Click to Show/Hide
|
||||
| Activity |
IC50 = 95300 nM
|
[7] | |||
| Compound Name |
(4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-thiazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127098; BDBM50448527
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[15] | |||
| Compound Name |
N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3941301; SCHEMBL17162334; BDBM223323; US9315520, 10
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 96700 nM
|
[1] | |||
| Compound Name |
Chembl4217023
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452884
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 97000 nM
|
[1] | |||
| Compound Name |
N-[(5R,14R)-5-Amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400530; BDBM50212180
Click to Show/Hide
|
||||
| Activity |
IC50 = 97000 nM
|
[29] | |||
| Compound Name |
US9315520, Example 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967984; SCHEMBL17162233; BDBM223396; US9315520, 7
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 97000 nM
|
[1] | |||
| Compound Name |
(4r)-2'-Amino-6-Bromo-1',2,2-Trimethyl-2,3-Dihydrospiro[chromene-4,4'-Imidazol]-5'(1'h)-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349610; SCHEMBL1981997; BDBM50432508; Q27452218; 2'-amino-6-bromo-1',2,2-trimethylspiro[chroman-4,4'-imidazol]-5'(1'H)-one; 2'-amino-6-bromo-2,2,3'-trimethylspiro[3H-chromene-4,5'-imidazole]-4'-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 97740 nM
|
[19] | |||
| Compound Name |
Chembl4229013
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461479
Click to Show/Hide
|
||||
| Activity |
IC50 = 98000 nM
|
[2] | |||
| Compound Name |
Chembl4204215
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452880
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 98000 nM
|
[1] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683822; SCHEMBL16041629; BDBM171429; US9085576, 63
Click to Show/Hide
|
||||
| Activity |
IC50 = 99750 nM
|
[5] | |||
| Compound Name |
(4S)-4-[5-(Ethylaminomethyl)-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061944; BDBM50259963
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Chembl4225481
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(2S)-5-(Diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-(2-phenylethylamino)heptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]benzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344268
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Chembl4209994
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452873
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[(1R,3S)-3-[[(4R)-2-Amino-4-(2-cyclohexylethyl)-1-methyl-5-oxoimidazol-4-yl]methyl]cyclohexyl]-3-(4-chlorophenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354257; SCHEMBL8187867; BDBM50036602
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(4S)-4-[5-[(Cyclopropylmethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064148; BDBM50259971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-1-(2,3-dihydro-1H-inden-2-ylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344264
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2R,3S)-2-hydroxy-1-[(3-methoxyphenyl)methylamino]-4-methylpentan-3-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254273
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(4-{[4-(Cyclohexylamino)-1-(3-Fluorophenyl)-2-Oxo-1,3,8-Triazaspiro[4.5]dec-3-En-8-Yl]methyl}phenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL592583; CHEMBL495087; BDBM25361; Spiropiperidine Iminohydantoin, 16; Q27465375
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2-Amino-7-[4-(3-methylbutyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764738; BDBM50145783
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(4S,5R)-4-(2,4-Difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414704; BDBM50078350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3S,4S)-4-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[(2-phenylmethoxyacetyl)amino]pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344269
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(4Ar,8aS)-8a-(2,4-difluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414706; SCHEMBL14716712; BDBM142369; BDBM142391; US8933221, 1; US8933221, 10; Q27454178; (4aR,8aS)-8a-(2,4-difluorophenyl)-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[(3,3,3-trifluoropropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084170; BDBM50259955
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-Acetyl-5,8-dibromo-2-(4-bromophenylamino)quinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470707; SCHEMBL20094427; BDBM50249605
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[[(3R)-3-methoxypyrrolidin-1-yl]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073296; BDBM50259975
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Chembl4225038
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461480
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[[(1,1,1-trifluoro-2-methylpropan-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094377; BDBM50259954
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-[2-(4-chlorophenyl)ethylamino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344266
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]pentanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344151; BDBM50099148
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Benzyl N-[(2S)-6-amino-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344156; BDBM50099239
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(E)-N-((1S,3S)-1-Benzyl-2-hydroxy-3-{(2-pyridin-2-yl-ethyl)-[2-(2,4,6-trichloro-phenoxy)-acetyl]-amino}-propyl)-3-(2,6-dichloro-phenyl)-acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283862; BDBM50110935
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[32] | |||
| Compound Name |
Chembl4214603
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452885
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[[[3-(trifluoromethyl)oxetan-3-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080380; BDBM50259961
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-Amino-4-(4-methoxyphenyl)-4-[3-(3-pyridinyl)phenyl]-2-oxazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177312; SCHEMBL7862652; BDBM50398316; J3.603.265K; 4-(4-methoxyphenyl)-4-(3-pyridin-3-ylphenyl)-5H-1,3-oxazol-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
Benzyl N-[(2S)-5-amino-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344155; BDBM50099238
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Chembl4203347
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452876
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(4S,5S)-4-(2,4-Difluorophenyl)-5-(methoxymethyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414703; BDBM50078351
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[[[(2R)-1,1,1-trifluoropropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061602; BDBM50259970
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(5R)-2-Amino-5-(2-cyclohexylethyl)-3-methyl-5-[[(3R)-1-pentylpiperidin-3-yl]methyl]imidazol-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353634; BDBM50036593
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(4s,6r)-4-[2,4-Difluoro-5-({[1-(Trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-Dimethyl-5,6-Dihydro-4h-1,3-Thiazin-2-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088234; BDBM50259962; P6M
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[(2,2,2-trifluoroethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086633; BDBM50259949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[(3-methoxypropylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064708; BDBM50259967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Chembl4209354
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452881
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[[(5-methylpyridin-2-yl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091480; BDBM50259976
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-Amino-4-(4-methoxyphenyl)-4-[3-(5-pyrimidinyl)phenyl]-2-oxazoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177313; SCHEMBL7867664; BDBM50398315; J3.603.264B; 4-(4-methoxyphenyl)-4-(3-pyrimidin-5-ylphenyl)-5H-1,3-oxazol-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
(4As,7aS)-7a-(2,4-difluorophenyl)-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414705; BDBM50078352
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl) 3-chlorobenzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586133
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
Chembl4226994
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17169038; BDBM50462002; 0B5
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
2-Amino-7-[4-(2-cyclohexylethyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764518; BDBM50145785
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[[methyl(2,2,2-trifluoroethyl)amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104527; BDBM50259969
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-Tert-butyl-4-(furan-2-ylmethylamino)-N-(2-methylpropyl)-N-[(3S)-piperidin-3-yl]pyrimidine-5-carboxamide;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916240; SCHEMBL2897126; BDBM50195224
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
(S)-3-((4-(6-Methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl)methyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1272322; BDBM50330180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Chembl4226007
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL18636679; BDBM50462004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
3-Acetyl-8-chloro-2-(4-chlorophenylamino)-6-nitroquinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492175; BDBM50250152; 3-acetyl-8-chloro-2-(4-chloroanilino)-6-nitro-1H-quinolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2e,5r)-5-(2-Cyclohexylethyl)-5-{[(1s,3r)-3-(Cyclopentylamino)cyclohexyl]methyl}-2-Imino-3-Methylimidazolidin-4-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354250; SCHEMBL7531458; BDBM50036574; Q27453888
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
Z-FF-Fmk
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2368566; Z-Phe-PheCH2F; Z-Phe-Phe-fluoromethyl ketone; SCHEMBL18328618; EX-A3847; BDBM50491472; MFCD03453604; ZINC25667985; Z-Phe-Phe-fluoromethyl ketone, >=98% (TLC), solid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Acetyl-6-chloro-2-(2-chloro-4-methylphenylamino)-8-nitroquinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521771; BDBM50250190
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(4Ar,6R,8aS)-8a-(2,4-difluoro-5-{[(2,2,2-trifluoroethyl)amino]methyl}phenyl)-6-(fluoromethyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3673194; SCHEMBL15783597; BDBM160666; US9045498, 8
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Chembl4212046
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452875
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-cyclohexyl-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344154; BDBM50099237
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Chembl4203860
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452883
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4229080
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461478
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(4S)-4-[5-[(Dimethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100140; BDBM50259965
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-Acetyl-8-bromo-5-chloro-2-(4-chlorophenylamino)quinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513042; KSI-3716; SCHEMBL19821437; BDBM50249606; HY-12703; CS-0012282
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL582044; Imidazo[1,5-a]pyrimidin-6-amine,2,3,4,8-tetrahydro-8,8-diphenyl-; SCHEMBL3456304; BDBM50300710; Imidazo[1,5-a]pyrimidin-6-amine, 2,3,4,8-tetrahydro-8,8-diphenyl-; ZINC34657615; Q27454410; 8,8-diphenyl-3,4-dihydro-2H-imidazo[1,5-a]pyrimidin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4228400
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461476
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl)-3-chlorobenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586130
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(cyclohexylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344157; BDBM50099240
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Chembl4227851
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17169379; BDBM50462008
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
Tert-butyl (3R)-3-[[(4R)-2-amino-4-(2-cyclohexylethyl)-1-methyl-5-oxoimidazol-4-yl]methyl]piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353631; BDBM50036598
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(4S)-4-[5-[(2,2-Difluoroethylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066885; BDBM50259950
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[(propan-2-ylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083698; BDBM50259964
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
4-Acetamido-N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL271231; BDBM50373801
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(5R)-2-Amino-5-(2-cyclohexylethyl)-3-methyl-5-[[(3R)-piperidin-3-yl]methyl]imidazol-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353633; BDBM50036588
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
3-Acetyl-5,8-dichloro-2-(2,4-dichlorophenylamino)quinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471915; SCHEMBL22003072; BDBM50249607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(4S)-4-[5-[(Cyclopropylamino)methyl]-2,4-difluorophenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085715; BDBM50259957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Hydroxy ethylamine (HEA), 19
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399862; SCHEMBL5221191; BDBM26784
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-(4-amino-4-oxobutyl)-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344153; BDBM50099236
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Chembl4225394
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50461470
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(1,1-Dioxothiazinan-2-yl)-5-(ethylamino)-N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]benzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493807; SCHEMBL5217651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
3-Acetyl-8-chloro-2-(2,4-dibromophenylamino)-5-methylquinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523822; SCHEMBL20094464; BDBM50249659
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-[2-(4-chlorophenyl)ethyl-methylamino]-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[[[(2R)-1-methoxypropan-2-yl]amino]methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084653; BDBM50259968
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-oxo-butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94762; BDBM50045683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
Chembl4213486
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL15482946; TQR0573; BDBM50457586; J3.591.428E; (S)-N-(3-(2-amino-6-(fluoromethyl)-4-methyl-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(5R)-2-Amino-5-(2-cyclohexylethyl)-3-methyl-5-[[(3S)-piperidin-3-yl]methyl]imidazol-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3353632; BDBM50036590
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
(3S,4S)-4-[[(2S)-2-[[(2S)-2-(Benzenesulfonamido)-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344270
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(3S,4S)-4-[[(2S)-2-[[(2S)-2-(Benzylsulfonylamino)-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344271
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
3-Acetyl-2-(4-tert-butylphenylamino)-8-chloro-6-nitroquinolin-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521636; BDBM50250153; 3-acetyl-2-(4-tert-butylanilino)-8-chloro-6-nitro-1H-quinolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4207711
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50452882
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Benzyl N-[(2S)-1-[[(2S)-1-[[(3S,4S)-1-(benzylamino)-3-hydroxy-6-methyl-1-oxoheptan-4-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344262
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
CID 9821383
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CA-074; CA 074; CHEMBL490920; MFCD00797531; Cathepsin B Inhibitor III; PrNH-tES-Ile-Pro-OH; epoxysuccinyl derivative CA074; SCHEMBL4323476; BDBM16509; CA074; ZINC3927825; AKOS024458382; CS-7886; HY-103350; (L-3-trans-(Propylcarbamyl)oxirane-2-carbonyl)-L-isoleucyl-L-proline; N-{[(2S,3S)-3-(propylcarbamoyl)oxiran-2-yl]carbonyl}-L-isoleucyl-L-proline
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Benzyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-(1-phenylethylamino)heptan-4-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(4S)-4-[2,4-Difluoro-5-[(2-methoxyethylamino)methyl]phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092406; BDBM50259966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(3S,4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-N-[(2S)-1-amino-1-oxopropan-2-yl]-3-hydroxy-6-methylheptanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[[(1R,2R)-2-phenylcyclopropyl]methylamino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688798; SCHEMBL16077317; BDBM171745; US9085576, 371
Click to Show/Hide
|
||||
| Activity |
IC50 = 102350 nM
|
[5] | |||
| Compound Name |
8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluoroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688794; SCHEMBL16042345; BDBM171741; US9085576, 367
Click to Show/Hide
|
||||
| Activity |
IC50 = 102630 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688688; SCHEMBL16041769; BDBM171626; US9085576, 260
Click to Show/Hide
|
||||
| Activity |
IC50 = 103950 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-(5-((3-Chloro-1,7-naphthyridin-8-yl)amino)-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3949268; SCHEMBL15991391; BDBM214983; US9296734, 176
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[13] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[(7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688771; SCHEMBL16077298; BDBM171717; US9085576, 347
Click to Show/Hide
|
||||
| Activity |
IC50 = 105750 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-7'-(3,6-dihydro-2H-pyran-5-yl)-5'-fluorospiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976447; BDBM220842; US9296759, 106
Click to Show/Hide
|
||||
| Activity |
IC50 = 106500 nM
|
[24] | |||
| Compound Name |
6-o-Tolylquinolin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1821803; 2-Quinolinamine, 6-(2-methylphenyl)-; SCHEMBL1767713; 6-(2-methylphenyl)quinolin-2-amine; BDBM50351914
Click to Show/Hide
|
||||
| Activity |
IC50 = 108000 nM
|
[41] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683799; SCHEMBL16043973; BDBM171405; US9085576, 39
Click to Show/Hide
|
||||
| Activity |
IC50 = 109250 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683811; SCHEMBL16047582; BDBM171417; US9085576, 51
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916872; SCHEMBL15991215; BDBM214974; US9296734, 167
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-(4-phenylpyridin-2-yl)oxyphenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961455; SCHEMBL15990763; BDBM214903; US9296734, 102
Click to Show/Hide
|
||||
| Activity |
IC50 = 114000 nM
|
[13] | |||
| Compound Name |
(1R,5S,6R)-5-[5-[[4-Chloro-1-(difluoromethyl)pyrazol-3-yl]methylamino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688801; SCHEMBL16077324; BDBM171748; US9085576, 374
Click to Show/Hide
|
||||
| Activity |
IC50 = 115500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683793; SCHEMBL16040641; BDBM171399; US9085576, 33
Click to Show/Hide
|
||||
| Activity |
IC50 = 116000 nM
|
[5] | |||
| Compound Name |
(S)-2-Amino-4-(4-(2-fluoroethoxy)phenyl)-1-methyl-4-phenyl-1H-imidazol-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269918; BDBM50329522
Click to Show/Hide
|
||||
| Activity |
IC50 = 116710 nM
|
[8] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-oxocyclobutane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688686; SCHEMBL16041970; BDBM171624; US9085576, 258
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[5] | |||
| Compound Name |
(4Ar,10R,10aR)-8-(5-chloropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127092; SCHEMBL9932592; BDBM50448526
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[15] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965633; BDBM220850; US9296759, 113
Click to Show/Hide
|
||||
| Activity |
IC50 = 120100 nM
|
[24] | |||
| Compound Name |
(1R,5S,6R)-5-(5-((Cyclobutylmethyl)amino)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688795; SCHEMBL16906354; BDBM171742; US9085576, 368
Click to Show/Hide
|
||||
| Activity |
IC50 = 121000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688704; SCHEMBL16042118; BDBM171645; US9085576, 279
Click to Show/Hide
|
||||
| Activity |
IC50 = 123500 nM
|
[5] | |||
| Compound Name |
8-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluoroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688793; SCHEMBL16026328; BDBM171740; US9085576, 366
Click to Show/Hide
|
||||
| Activity |
IC50 = 127610 nM
|
[5] | |||
| Compound Name |
5-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934911; SCHEMBL15991032; BDBM214904; US9296734, 103
Click to Show/Hide
|
||||
| Activity |
IC50 = 129000 nM
|
[13] | |||
| Compound Name |
Chembl4288556
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2372269; (4S)-3'-chloro-7'-(5-fluoropyridin-3-yl)spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-c]pyridine]-2-amine; (S)-3-chloro-7-(5-fluoropyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[25] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-chloro-5-fluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926258; SCHEMBL15990889; BDBM215047; US9296734, 238
Click to Show/Hide
|
||||
| Activity |
IC50 = 131000 nM
|
[13] | |||
| Compound Name |
(7R)-7-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688828; SCHEMBL16026315; BDBM171779; US9085576, 404
Click to Show/Hide
|
||||
| Activity |
IC50 = 131500 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895059; BDBM220785; US9296759, 52
Click to Show/Hide
|
||||
| Activity |
IC50 = 132000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-(6-fluoroquinolin-2-yl)phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934218; SCHEMBL15991524; BDBM214917; US9296734, 116
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 133000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(5-((3-Chloro-1,7-naphthyridin-8-yl)amino)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906250; SCHEMBL15991018; BDBM214807; US9296734, 8; US9296734, 22
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 133000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-(7-fluoroquinolin-2-yl)phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899615; SCHEMBL15991209; BDBM214918; US9296734, 117
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 133000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937966; BDBM220859; US9296759, 122
Click to Show/Hide
|
||||
| Activity |
IC50 = 133000 nM
|
[24] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979006; BDBM220854; US9296759, 117
Click to Show/Hide
|
||||
| Activity |
IC50 = 133000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-(5-((6-Chloro-4-phenylpyridin-2-yl)oxy)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965566; SCHEMBL15990839; BDBM215043; US9296734, 235
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 133000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959106; BDBM220801; US9296759, 69
Click to Show/Hide
|
||||
| Activity |
IC50 = 133000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-[5-[[3-(2-Cyclopropylethynyl)-5-fluoro-1,7-naphthyridin-8-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946502; SCHEMBL15999903; BDBM214853; US9296734, 54
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 133000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[5-[(3-Chloro-5-fluoro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940322; SCHEMBL15990985; BDBM214818; US9296734, 19
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 133000 nM
|
[13] | |||
| Compound Name |
N-[6-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoropyridin-2-yl]-5-isocyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688756; BDBM171700; US9085576, 330; US9085576, 331
Click to Show/Hide
|
||||
| Activity |
IC50 = 139000 nM
|
[5] | |||
| Compound Name |
(4As,10R,10aS)-8-(5-chloropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127073; SCHEMBL9882611; BDBM50448525
Click to Show/Hide
|
||||
| Activity |
IC50 = 140000 nM
|
[15] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[(7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688776; SCHEMBL16077302; BDBM171723; US9085576, 353
Click to Show/Hide
|
||||
| Activity |
IC50 = 141050 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683851; SCHEMBL16077267; BDBM171461; US9085576, 95
Click to Show/Hide
|
||||
| Activity |
IC50 = 143000 nM
|
[5] | |||
| Compound Name |
4-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]pyrido[3,2-d]pyrimidine-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688817; SCHEMBL16049126; BDBM171767; US9085576, 393
Click to Show/Hide
|
||||
| Activity |
IC50 = 147000 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3927120; BDBM220808; US9296759, 74
Click to Show/Hide
|
||||
| Activity |
IC50 = 147000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-phenylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688715; SCHEMBL16043679; BDBM171657; US9085576, 291
Click to Show/Hide
|
||||
| Activity |
IC50 = 148000 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3927382; SCHEMBL15991445; BDBM214864; US9296734, 65
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[13] | |||
| Compound Name |
8-(3-Tert-butylphenyl)-8-phenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL583213; BDBM50300723
Click to Show/Hide
|
||||
| Activity |
IC50 = 150100 nM
|
[7] | |||
| Compound Name |
N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3968517; BDBM220775; US9296759, 48
Click to Show/Hide
|
||||
| Activity |
IC50 = 151500 nM
|
[24] | |||
| Compound Name |
(1R,5S,6R)-5-[5-[(6-Chloro-1-benzofuran-3-yl)amino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688811; BDBM171759; US9085576, 385
Click to Show/Hide
|
||||
| Activity |
IC50 = 153000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683808; SCHEMBL16042379; BDBM171414; US9085576, 48; US9085576, 142
Click to Show/Hide
|
||||
| Activity |
IC50 = 154000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683867; SCHEMBL16042145; BDBM171480; US9085576, 114
Click to Show/Hide
|
||||
| Activity |
IC50 = 158500 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902076; BDBM220858; US9296759, 121
Click to Show/Hide
|
||||
| Activity |
IC50 = 158800 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688619; SCHEMBL16041889; BDBM171554; US9085576, 188
Click to Show/Hide
|
||||
| Activity |
IC50 = 159000 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917445; BDBM220799; US9296759, 67
Click to Show/Hide
|
||||
| Activity |
IC50 = 159800 nM
|
[24] | |||
| Compound Name |
(4As,10R,10aS)-8-(5-fluoropyridin-3-yl)-4a-methylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127074; BDBM50448524
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[15] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-1,3-benzoxazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3905256; SCHEMBL15991424; BDBM214830; US9296734, 30
Click to Show/Hide
|
||||
| Activity |
IC50 = 162000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970753; BDBM220852; US9296759, 115
Click to Show/Hide
|
||||
| Activity |
IC50 = 162100 nM
|
[24] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[3-(5-Chloropyridin-2-yl)oxetan-3-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688757; SCHEMBL16077292; BDBM171702; US9085576, 332
Click to Show/Hide
|
||||
| Activity |
IC50 = 163000 nM
|
[5] | |||
| Compound Name |
N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(trifluoromethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947194; SCHEMBL17162240; BDBM223333; US9315520, 20
Click to Show/Hide
|
||||
| Activity |
IC50 = 163600 nM
|
[1] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683843; SCHEMBL16042535; BDBM171453; US9085576, 87
Click to Show/Hide
|
||||
| Activity |
IC50 = 164500 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(5-fluoro-3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688791; SCHEMBL16077311; BDBM171738; US9085576, 448
Click to Show/Hide
|
||||
| Activity |
IC50 = 169000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(2-cyclopropylethynyl)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693224; SCHEMBL16041683; BDBM171782; US9085576, 407
Click to Show/Hide
|
||||
| Activity |
IC50 = 169850 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-(6-prop-1-ynylpyridin-3-yl)phenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911790; SCHEMBL15991586; BDBM214914; US9296734, 113
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[13] | |||
| Compound Name |
(4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)spiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127094; SCHEMBL9932259; BDBM50448520
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[15] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-4-chloro-2-(fluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688744; SCHEMBL16040820; BDBM171688; US9085576, 444
Click to Show/Hide
|
||||
| Activity |
IC50 = 171000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683806; SCHEMBL16040650; BDBM171412; US9085576, 46
Click to Show/Hide
|
||||
| Activity |
IC50 = 173500 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-7'-(3,6-dihydro-2H-pyran-4-yl)-5'-fluorospiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932872; SCHEMBL16109657; BDBM220847; US9296759, 60
Click to Show/Hide
|
||||
| Activity |
IC50 = 173600 nM
|
[24] | |||
| Compound Name |
(1R,5S,6R)-5-(5-(((5-Chloropyridin-2-yl)methyl)amino)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688804; SCHEMBL16906369; BDBM171751; US9085576, 377
Click to Show/Hide
|
||||
| Activity |
IC50 = 177000 nM
|
[5] | |||
| Compound Name |
[4-[3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-2-(5-prop-1-ynylpyridin-3-yl)phenyl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693247; BDBM171807; US9085576, 432
Click to Show/Hide
|
||||
| Activity |
IC50 = 177690 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3968748; BDBM220798; US9296759, 66
Click to Show/Hide
|
||||
| Activity |
IC50 = 179300 nM
|
[24] | |||
| Compound Name |
N-(2'-Amino-1',2,2-trimethyl-5'-oxospiro[3H-chromene-4,4'-imidazole]-6-yl)-5-methylfuran-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2349609; BDBM50432532
Click to Show/Hide
|
||||
| Activity |
IC50 = 180420 nM
|
[19] | |||
| Compound Name |
N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688750; SCHEMBL16042578; BDBM171694; US9085576, 324
Click to Show/Hide
|
||||
| Activity |
IC50 = 182000 nM
|
[5] | |||
| Compound Name |
N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948443; SCHEMBL16108932; BDBM220812; US9296759, 78
Click to Show/Hide
|
||||
| Activity |
IC50 = 184000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-(fluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688732; SCHEMBL16041421; BDBM171674; US9085576, 308
Click to Show/Hide
|
||||
| Activity |
IC50 = 186000 nM
|
[5] | |||
| Compound Name |
(3R)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]oxolane-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688681; SCHEMBL16041821; BDBM171619; US9085576, 253
Click to Show/Hide
|
||||
| Activity |
IC50 = 188000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3904149; SCHEMBL15990814; BDBM215026
Click to Show/Hide
|
||||
| Activity |
IC50 = 188500 nM
|
[13] | |||
| Compound Name |
(1R,2S,6R)-2-[5-(Cyclopropylmethylamino)-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688806; SCHEMBL16043251; BDBM171753; US9085576, 379
Click to Show/Hide
|
||||
| Activity |
IC50 = 188500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,3,3-trifluoropropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688679; SCHEMBL16041924; BDBM171617; US9085576, 251
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683854; SCHEMBL16041534; BDBM171466; US9085576, 100
Click to Show/Hide
|
||||
| Activity |
IC50 = 190500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683818; SCHEMBL16042531; BDBM171424; US9085576, 58; US9085576, 64
Click to Show/Hide
|
||||
| Activity |
IC50 = 191000 nM
|
[5] | |||
| Compound Name |
8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688775; SCHEMBL16077305; BDBM171722; US9085576, 352
Click to Show/Hide
|
||||
| Activity |
IC50 = 192210 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-chloro-5-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955707; SCHEMBL15991460; BDBM215046; US9296734, 237
Click to Show/Hide
|
||||
| Activity |
IC50 = 194000 nM
|
[13] | |||
| Compound Name |
(1R,2S,6R)-2-[5-(6-Chloro-1,3-benzoxazol-2-yl)-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693242; SCHEMBL16042541; BDBM171801; US9085576, 426
Click to Show/Hide
|
||||
| Activity |
IC50 = 195650 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-(hydroxymethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688820; SCHEMBL16040231; BDBM171770; US9085576, 396
Click to Show/Hide
|
||||
| Activity |
IC50 = 197500 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891240; BDBM220836; US9296759, 101
Click to Show/Hide
|
||||
| Activity |
IC50 = 197600 nM
|
[24] | |||
| Compound Name |
Chembl4211913
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17162229; US9605007, Example 5; BDBM312940
Click to Show/Hide
|
||||
| Activity |
IC50 = 197600 nM
|
[1] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[42] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 530 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
oxazine 89
Click to Show/Hide
|
Clinical trial | Compound Info | ||
| Synonyms |
CHEMBL2347208; N-{3-[(4s,6s)-2-Amino-4-Methyl-6-(Trifluoromethyl)-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-Carboxamide; oxazine 89; GTPL6944; SCHEMBL15991481; BDBM50432601; 1HL
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[43] | |||
| Compound Name |
(4Ar,10R,10aR)-8-pyrimidin-5-ylspiro[3,4,4a,10a-tetrahydro-1H-pyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127096; SCHEMBL9931890; BDBM50448522
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
N-[(2S,3R)-4-[[1-(4-Tert-butyl-1,3-oxazol-2-yl)cyclopropyl]amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1257775; BDBM50328058
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[44] | |||
| Compound Name |
2-Amino-7-phenyl-3-[(4-phenyloxolan-2-yl)methyl]quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765557; BDBM50145779
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[6] | |||
| Compound Name |
(4Ar,10R,10aR)-8-(2-fluoropyridin-3-yl)-10a-methylspiro[1,3,4,4a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127082; SCHEMBL9931381; BDBM50448554
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
(4As,10R,10aS)-4a-methyl-8-pyrimidin-5-ylspiro[1,3,4,10a-tetrahydropyrano[4,3-b]chromene-10,4'-5H-1,3-oxazole]-2'-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127076; SCHEMBL9931767; BDBM50448555
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[15] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976045; SCHEMBL15990772; BDBM214831; US9296734, 31
Click to Show/Hide
|
||||
| Activity |
IC50 = 202000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683809; SCHEMBL16043048; BDBM171415; US9085576, 49
Click to Show/Hide
|
||||
| Activity |
IC50 = 202000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-phenylprop-2-ynamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688690; SCHEMBL16041743; BDBM171628; US9085576, 262
Click to Show/Hide
|
||||
| Activity |
IC50 = 203500 nM
|
[5] | |||
| Compound Name |
8-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688770; SCHEMBL16041921; BDBM171716; US9085576, 346
Click to Show/Hide
|
||||
| Activity |
IC50 = 204890 nM
|
[5] | |||
| Compound Name |
(7S)-7-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688826; SCHEMBL16043743; BDBM171777; US9085576, 402
Click to Show/Hide
|
||||
| Activity |
IC50 = 205500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683873; SCHEMBL16077271; BDBM171487; US9085576, 121
Click to Show/Hide
|
||||
| Activity |
IC50 = 206000 nM
|
[5] | |||
| Compound Name |
(4S)-4-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluoroanilino]-3,4-dihydro-2H-pyrano[3,2-b]pyridine-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688809; BDBM171757; US9085576, 383
Click to Show/Hide
|
||||
| Activity |
IC50 = 206000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688647; SCHEMBL16041827; BDBM171583; US9085576, 217
Click to Show/Hide
|
||||
| Activity |
IC50 = 206030 nM
|
[5] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-6-chlorobenzo[d]oxazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944240; SCHEMBL15991020; BDBM214829; US9296734, 29
Click to Show/Hide
|
||||
| Activity |
IC50 = 210000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903132; BDBM220853; US9296759, 116
Click to Show/Hide
|
||||
| Activity |
IC50 = 210700 nM
|
[24] | |||
| Compound Name |
N-[6-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688747; SCHEMBL16043968; BDBM171691; US9085576, 321
Click to Show/Hide
|
||||
| Activity |
IC50 = 212500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683861; SCHEMBL16042403; BDBM171473; US9085576, 107
Click to Show/Hide
|
||||
| Activity |
IC50 = 213000 nM
|
[5] | |||
| Compound Name |
N-[6-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683860; SCHEMBL16044054; BDBM171472; US9085576, 106
Click to Show/Hide
|
||||
| Activity |
IC50 = 216000 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3914230; BDBM220800; US9296759, 68
Click to Show/Hide
|
||||
| Activity |
IC50 = 217000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methoxyphenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683894; SCHEMBL16041526; BDBM171511; US9085576, 145
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[5] | |||
| Compound Name |
2-Amino-7-[4-(2-phenylethyl)phenyl]-3-[[(2S,5R)-5-phenyloxolan-2-yl]methyl]quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763442; BDBM50145787
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[6] | |||
| Compound Name |
(4S,6S)-4-(2-Fluoro-5-(5-(prop-1-yn-1-yl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906965; SCHEMBL15990777; BDBM214905; US9296734, 104
Click to Show/Hide
|
||||
| Activity |
IC50 = 220000 nM
|
[13] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloropyridine-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693237; SCHEMBL16026316; BDBM171796; US9085576, 421
Click to Show/Hide
|
||||
| Activity |
IC50 = 223500 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926305; BDBM220849; US9296759, 112
Click to Show/Hide
|
||||
| Activity |
IC50 = 223500 nM
|
[24] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-hydroxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959278; BDBM220841; US9296759, 105
Click to Show/Hide
|
||||
| Activity |
IC50 = 225000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(cyclohexylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693232; SCHEMBL16042721; BDBM171791; US9085576, 416
Click to Show/Hide
|
||||
| Activity |
IC50 = 228150 nM
|
[5] | |||
| Compound Name |
8-[[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]amino]-5-fluoro-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925020; SCHEMBL15991366; BDBM214888; US9296734, 89
Click to Show/Hide
|
||||
| Activity |
IC50 = 229000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-morpholin-4-ylspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960345; BDBM220846; US9296759, 110
Click to Show/Hide
|
||||
| Activity |
IC50 = 229500 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683905; SCHEMBL16041246; BDBM171524; US9085576, 158
Click to Show/Hide
|
||||
| Activity |
IC50 = 230500 nM
|
[5] | |||
| Compound Name |
N-Phenyl-2-(1-(3,4,5-trimethoxybenzoyl)naphthalen-2-yloxy)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378015; BDBM50189984
Click to Show/Hide
|
||||
| Activity |
IC50 = 231500 nM
|
[45] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[4-Chloro-1-(difluoromethyl)pyrazol-3-yl]methylamino]-2-fluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688800; SCHEMBL16077318; BDBM171747; US9085576, 373
Click to Show/Hide
|
||||
| Activity |
IC50 = 234000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-(difluoromethyl)-1,3-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683899; SCHEMBL16077274; BDBM171516; US9085576, 150
Click to Show/Hide
|
||||
| Activity |
IC50 = 238370 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683801; SCHEMBL16045874; BDBM171407; US9085576, 41
Click to Show/Hide
|
||||
| Activity |
IC50 = 238440 nM
|
[5] | |||
| Compound Name |
(1S,5R,6S)-5-(5-(6-Chlorobenzo[d]oxazol-2-yl)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693241; SCHEMBL16041579; BDBM171800; US9085576, 425
Click to Show/Hide
|
||||
| Activity |
IC50 = 240270 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688661; SCHEMBL16041450; BDBM171599; US9085576, 233
Click to Show/Hide
|
||||
| Activity |
IC50 = 243500 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-3'-bromospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3978473; SCHEMBL16108528; BDBM220769; US9296759, 34
Click to Show/Hide
|
||||
| Activity |
IC50 = 245100 nM
|
[24] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[5-(4-fluorophenyl)-1H-1,2,4-triazol-3-yl]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693259; SCHEMBL16026137; BDBM171820; US9085576, 440
Click to Show/Hide
|
||||
| Activity |
IC50 = 249590 nM
|
[5] | |||
| Compound Name |
NB-360 free base
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NB-360; CHEMBL3261067; 1262857-73-7 (free base); NB-360 HCl; SCHEMBL360548; GTPL9822; NB360; BCP30332; BDBM50012653; HY-124322; CS-0086203; NB 360 HCl pound>>NB360 HCl pound>>NB-360 Hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[1] | |||
| Compound Name |
(1R,2S,6R)-2-[2-Chloro-5-[(3-chloro-1,7-naphthyridin-8-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688782; SCHEMBL16077307; BDBM171729; US9085576, 359
Click to Show/Hide
|
||||
| Activity |
IC50 = 251180 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-bromo-3-(difluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3639875; SCHEMBL16042527; BDBM171656; US9085576, 290
Click to Show/Hide
|
||||
| Activity |
IC50 = 251500 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930557; BDBM220817; US9296759, 83
Click to Show/Hide
|
||||
| Activity |
IC50 = 255000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683795; SCHEMBL16042499; BDBM171401; US9085576, 35
Click to Show/Hide
|
||||
| Activity |
IC50 = 255770 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908554; BDBM220821; US9296759, 87
Click to Show/Hide
|
||||
| Activity |
IC50 = 256400 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683791; SCHEMBL16042521; BDBM171396; US9085576, 30; US9085576, 123
Click to Show/Hide
|
||||
| Activity |
IC50 = 257250 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683855; SCHEMBL16041359; BDBM171467; US9085576, 101
Click to Show/Hide
|
||||
| Activity |
IC50 = 258460 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683847; SCHEMBL16041754; BDBM171457; US9085576, 91
Click to Show/Hide
|
||||
| Activity |
IC50 = 260000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688628; SCHEMBL16041987; BDBM171563; US9085576, 197
Click to Show/Hide
|
||||
| Activity |
IC50 = 260500 nM
|
[5] | |||
| Compound Name |
2-N'-(3-Ethoxypyridin-2-yl)-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2,2'-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937998; BDBM220793; US9296759, 33
Click to Show/Hide
|
||||
| Activity |
IC50 = 262500 nM
|
[24] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[(8S)-3-Bromo-5,6,7,8-tetrahydroquinolin-8-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688808; SCHEMBL16043852; BDBM171756; US9085576, 382
Click to Show/Hide
|
||||
| Activity |
IC50 = 263000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972147; SCHEMBL15991066; BDBM215028
Click to Show/Hide
|
||||
| Activity |
IC50 = 263000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-3'-cyclopropyl-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986979; BDBM220788; US9296759, 54
Click to Show/Hide
|
||||
| Activity |
IC50 = 269400 nM
|
[24] | |||
| Compound Name |
(2S)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-(4-chlorophenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688680; SCHEMBL16077285; BDBM171618; US9085576, 252
Click to Show/Hide
|
||||
| Activity |
IC50 = 270500 nM
|
[5] | |||
| Compound Name |
N-[5-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683829; SCHEMBL16077266; BDBM171439; US9085576, 73
Click to Show/Hide
|
||||
| Activity |
IC50 = 274500 nM
|
[5] | |||
| Compound Name |
N-[(5R,14R)-5-Amino-5-methyl-16-oxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7,9,11(22),17,19-hexaen-19-yl]-N-propylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248699; BDBM50212178
Click to Show/Hide
|
||||
| Activity |
IC50 = 275000 nM
|
[29] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloro-3-(hydroxymethyl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693235; SCHEMBL16042049; BDBM171794; US9085576, 419
Click to Show/Hide
|
||||
| Activity |
IC50 = 275500 nM
|
[5] | |||
| Compound Name |
N-(3-Amino-12-oxa-4-thia-2-azatricyclo[4.4.3.01,6]tridec-2-en-8-yl)-3-chlorobenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586132
Click to Show/Hide
|
||||
| Activity |
IC50 = 277000 nM
|
[34] | |||
| Compound Name |
N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688752; SCHEMBL16041548; BDBM171696; US9085576, 326
Click to Show/Hide
|
||||
| Activity |
IC50 = 279000 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688769; SCHEMBL16048392; BDBM171715; US9085576, 345
Click to Show/Hide
|
||||
| Activity |
IC50 = 282000 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-(2,3-Difluoro-5-((3-methoxypyridin-2-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3973710; SCHEMBL15990926; BDBM215039; US9296734, 231
Click to Show/Hide
|
||||
| Activity |
IC50 = 282000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683830; SCHEMBL16043991; BDBM171440; US9085576, 74
Click to Show/Hide
|
||||
| Activity |
IC50 = 282500 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960890; SCHEMBL15991485; BDBM214995; US9296734, 188
Click to Show/Hide
|
||||
| Activity |
IC50 = 286000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688729; SCHEMBL16041874; BDBM171671; US9085576, 305
Click to Show/Hide
|
||||
| Activity |
IC50 = 287990 nM
|
[5] | |||
| Compound Name |
(1S,2R,6S)-2-[2,6-Difluoro-3-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688777; SCHEMBL16077303; BDBM171724; US9085576, 354
Click to Show/Hide
|
||||
| Activity |
IC50 = 292000 nM
|
[5] | |||
| Compound Name |
N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688635; SCHEMBL16041771; BDBM171570; US9085576, 204
Click to Show/Hide
|
||||
| Activity |
IC50 = 293500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688734; SCHEMBL16040687; BDBM171677; US9085576, 311
Click to Show/Hide
|
||||
| Activity |
IC50 = 293790 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984506; BDBM220840; US9296759, 104
Click to Show/Hide
|
||||
| Activity |
IC50 = 294500 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chloro-1-propan-2-ylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683907; SCHEMBL16043846; BDBM171527; US9085576, 161
Click to Show/Hide
|
||||
| Activity |
IC50 = 294980 nM
|
[5] | |||
| Compound Name |
1,4-Di(carbazol-9-yl)butane-2,3-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059104; BDBM50388761
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
1,3-Di(9H-carbazol-9-yl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059101; Oprea1_519606; Oprea1_705300; SCHEMBL14889275; 1,3-di(9-carbazolyl)-2-propanol; ZINC2273012; BDBM50388758; STK545854; AKOS003598568; MCULE-2939813280; 1,3-Bis(9H-carbazole-9-yl)-2-propanol
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
1-(4-Benzylphenoxy)-3-(2-chlorophenyl)sulfanylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059624; BDBM50388748
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
Chembl4215837
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17162189; US9605007, Example 4; BDBM312938
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
(2R)-1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058869; BDBM50388751
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
N-(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl)-5-fluoropyridine-2-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586137
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[34] | |||
| Compound Name |
1-Carbazol-9-yl-4-naphthalen-2-ylsulfanylbutan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058875; BDBM50388756
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
1-(2-Chlorophenyl)sulfanyl-3-(7-ethylindol-1-yl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059330; BDBM50388745
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
N'-(1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-yl)ethane-1,2-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058872; BDBM50388754
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
N-[(1R,4S,6S,7S)-9-Amino-12-oxa-8-thia-10-azatricyclo[5.3.3.01,6]tridec-9-en-4-yl]-3-chlorobenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586131
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[34] | |||
| Compound Name |
Chembl4204163
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17162208; BDBM312934
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
1-Naphthalen-2-ylsulfanyl-3-(2-phenylindol-1-yl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059613; BDBM50388747
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
9-(3-Naphthalen-2-ylsulfanylpropyl)carbazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058867; BDBM50388749
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
1-Carbazol-9-yl-3-(2-fluorophenyl)sulfanylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059596; BDBM50388766
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
(2S)-1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058868; BDBM50388750
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
N-[2-[(4Ar,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(trifluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917530; SCHEMBL17162390; BDBM223330; US9315520, 17
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
1-Carbazol-9-yl-3-naphthalen-2-ylsulfanylpropan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059601; BDBM50388746
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
4-Carbazol-9-yl-1-naphthalen-2-ylsulfanylbutan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2058874; BDBM50388743
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
1-(2-Chlorophenyl)sulfanyl-3-(1,2,3,4-tetrahydrocarbazol-9-yl)propan-2-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2059593; BDBM50388744
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[46] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683844; SCHEMBL16042322; BDBM171454; US9085576, 88
Click to Show/Hide
|
||||
| Activity |
IC50 = 301500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-(2-cyclopropylethynyl)-1,3-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683900; SCHEMBL16042430; BDBM171517; US9085576, 151
Click to Show/Hide
|
||||
| Activity |
IC50 = 302500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683816; SCHEMBL16042004; BDBM171422; US9085576, 56
Click to Show/Hide
|
||||
| Activity |
IC50 = 302760 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688634; SCHEMBL16044638; BDBM171569; US9085576, 203
Click to Show/Hide
|
||||
| Activity |
IC50 = 303020 nM
|
[5] | |||
| Compound Name |
Chembl4279064
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 = 310000 nM
|
[25] | |||
| Compound Name |
N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688637; SCHEMBL16041960; BDBM171572; US9085576, 206
Click to Show/Hide
|
||||
| Activity |
IC50 = 310790 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloro-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893104; BDBM220856; US9296759, 119
Click to Show/Hide
|
||||
| Activity |
IC50 = 311000 nM
|
[24] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3973477; BDBM220818; US9296759, 84
Click to Show/Hide
|
||||
| Activity |
IC50 = 312700 nM
|
[24] | |||
| Compound Name |
(1R,5S,6R)-5-[5-[4-(2-Cyclopropylethynyl)pyrazol-1-yl]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693250; SCHEMBL16077347; BDBM171810; US9085576, 435
Click to Show/Hide
|
||||
| Activity |
IC50 = 315500 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-(2-Fluoro-5-((4-phenylpyridin-2-yl)amino)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906242; SCHEMBL15991148; BDBM214916; US9296734, 115
Click to Show/Hide
|
||||
| Activity |
IC50 = 316000 nM
|
[13] | |||
| Compound Name |
(2R)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]oxolane-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688672; SCHEMBL16041089; BDBM171610; US9085576, 244
Click to Show/Hide
|
||||
| Activity |
IC50 = 318540 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[3-Chloro-2-fluoro-5-[(2-propan-2-yloxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688780; SCHEMBL16041838; BDBM171727; US9085576, 357
Click to Show/Hide
|
||||
| Activity |
IC50 = 322620 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906344; BDBM220776; US9296759, 49
Click to Show/Hide
|
||||
| Activity |
IC50 = 323000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-1-(4-chlorophenyl)cyclobutane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688674; SCHEMBL16042024; BDBM171612; US9085576, 246
Click to Show/Hide
|
||||
| Activity |
IC50 = 323700 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-morpholin-4-ylspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947150; BDBM220843; US9296759, 107
Click to Show/Hide
|
||||
| Activity |
IC50 = 326400 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688665; SCHEMBL16043577; BDBM171603; US9085576, 237
Click to Show/Hide
|
||||
| Activity |
IC50 = 326910 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-phenoxyacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688684; SCHEMBL16042083; BDBM171622; US9085576, 256
Click to Show/Hide
|
||||
| Activity |
IC50 = 331000 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-2-fluoro-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935967; BDBM220811; US9296759, 77
Click to Show/Hide
|
||||
| Activity |
IC50 = 331100 nM
|
[24] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683817; SCHEMBL16041212; BDBM171423; US9085576, 57
Click to Show/Hide
|
||||
| Activity |
IC50 = 332730 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688727; SCHEMBL16041945; BDBM171669; US9085576, 303
Click to Show/Hide
|
||||
| Activity |
IC50 = 334880 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897373; BDBM220774; US9296759, 47
Click to Show/Hide
|
||||
| Activity |
IC50 = 334900 nM
|
[24] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683792; SCHEMBL16026308; BDBM171397; US9085576, 31; US9085576, 32
Click to Show/Hide
|
||||
| Activity |
IC50 = 339220 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947677; SCHEMBL16109391; BDBM220779; US9296759, 45
Click to Show/Hide
|
||||
| Activity |
IC50 = 341500 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683882; SCHEMBL16042382; BDBM171497; US9085576, 131
Click to Show/Hide
|
||||
| Activity |
IC50 = 342490 nM
|
[5] | |||
| Compound Name |
Methyl 4-[[3-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]carbamoyl]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693251; SCHEMBL17071775; BDBM171811; US9085576, 436
Click to Show/Hide
|
||||
| Activity |
IC50 = 343180 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[[3-(2-Cyclopropylethynyl)-5-fluoro-1,7-naphthyridin-8-yl]amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693225; SCHEMBL16041969; BDBM171783; US9085576, 408
Click to Show/Hide
|
||||
| Activity |
IC50 = 346950 nM
|
[5] | |||
| Compound Name |
N-[5-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683831; SCHEMBL16077265; BDBM171441; US9085576, 75
Click to Show/Hide
|
||||
| Activity |
IC50 = 347610 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688629; SCHEMBL16042591; BDBM171564; US9085576, 198
Click to Show/Hide
|
||||
| Activity |
IC50 = 348840 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3973815; SCHEMBL16109617; BDBM220777; US9296759, 32
Click to Show/Hide
|
||||
| Activity |
IC50 = 350200 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683872; SCHEMBL16041455; BDBM171486; US9085576, 120
Click to Show/Hide
|
||||
| Activity |
IC50 = 351420 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-(hydroxymethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688813; SCHEMBL16045125; BDBM171761; US9085576, 387
Click to Show/Hide
|
||||
| Activity |
IC50 = 352100 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688728; SCHEMBL16041851; BDBM171670; US9085576, 304
Click to Show/Hide
|
||||
| Activity |
IC50 = 354980 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-1'-fluoro-3'-pyridin-3-ylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-fluoropyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908041; BDBM220804; US9296759, 72
Click to Show/Hide
|
||||
| Activity |
IC50 = 357900 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(3-cyclopropylprop-2-ynoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693227; SCHEMBL16906361; BDBM171786; US9085576, 411
Click to Show/Hide
|
||||
| Activity |
IC50 = 359770 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-3'-cyclopropyl-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3905117; SCHEMBL16109850; BDBM220787; US9296759, 40
Click to Show/Hide
|
||||
| Activity |
IC50 = 360000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-2-ylmethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683918; SCHEMBL16042303; BDBM171538; US9085576, 172
Click to Show/Hide
|
||||
| Activity |
IC50 = 360350 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945386; BDBM220822; US9296759, 88
Click to Show/Hide
|
||||
| Activity |
IC50 = 361600 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688654; SCHEMBL16042536; BDBM171592; US9085576, 226
Click to Show/Hide
|
||||
| Activity |
IC50 = 363000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683797; SCHEMBL16043046; BDBM171403; US9085576, 37
Click to Show/Hide
|
||||
| Activity |
IC50 = 364120 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688740; SCHEMBL16043510; BDBM171684; US9085576, 318
Click to Show/Hide
|
||||
| Activity |
IC50 = 370020 nM
|
[5] | |||
| Compound Name |
N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688638; SCHEMBL16041946; BDBM171573; US9085576, 207
Click to Show/Hide
|
||||
| Activity |
IC50 = 370200 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-methyl-1,3-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683912; SCHEMBL16042305; BDBM171532; US9085576, 166
Click to Show/Hide
|
||||
| Activity |
IC50 = 372960 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683841; SCHEMBL16042486; BDBM171451; US9085576, 85
Click to Show/Hide
|
||||
| Activity |
IC50 = 373100 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683858; SCHEMBL16041195; BDBM171470; US9085576, 104
Click to Show/Hide
|
||||
| Activity |
IC50 = 374140 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683804; SCHEMBL16041582; BDBM171410; US9085576, 44
Click to Show/Hide
|
||||
| Activity |
IC50 = 376160 nM
|
[5] | |||
| Compound Name |
(2R)-N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-methoxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688685; SCHEMBL16040827; BDBM171623; US9085576, 257
Click to Show/Hide
|
||||
| Activity |
IC50 = 376540 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-5'-fluoro-7'-(oxan-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919324; SCHEMBL16109680; BDBM220837; US9296759, 61
Click to Show/Hide
|
||||
| Activity |
IC50 = 378500 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683826; SCHEMBL16044594; BDBM171436; US9085576, 70
Click to Show/Hide
|
||||
| Activity |
IC50 = 378870 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[2-(1H-indol-5-yl)ethynyl]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921212; SCHEMBL15990974; BDBM214932; US9296734, 131
Click to Show/Hide
|
||||
| Activity |
IC50 = 381000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-2-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683911; SCHEMBL16041578; BDBM171531; US9085576, 165
Click to Show/Hide
|
||||
| Activity |
IC50 = 383220 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-(4-prop-1-ynylpyrazol-1-yl)phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693249; SCHEMBL16042022; BDBM171809; US9085576, 434
Click to Show/Hide
|
||||
| Activity |
IC50 = 385600 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945996; SCHEMBL15991463; BDBM215015; US9296734, 207
Click to Show/Hide
|
||||
| Activity |
IC50 = 385600 nM
|
[13] | |||
| Compound Name |
(S)-3-Chloro-1-fluoro-N7-(3-methylpyridin-2-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazine]-2',7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967607; SCHEMBL14823717; BDBM220792; US9296759, 41
Click to Show/Hide
|
||||
| Activity |
IC50 = 386300 nM
|
[24] | |||
| Compound Name |
N-[5-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688659; SCHEMBL16041253; BDBM171597; US9085576, 231
Click to Show/Hide
|
||||
| Activity |
IC50 = 389590 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966981; SCHEMBL15991253; BDBM215016; US9296734, 208
Click to Show/Hide
|
||||
| Activity |
IC50 = 393600 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3,5-dichloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923385; SCHEMBL15991121; BDBM214979
Click to Show/Hide
|
||||
| Activity |
IC50 = 394000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683902; SCHEMBL16042385; BDBM171519; US9085576, 153; US9085576, 157
Click to Show/Hide
|
||||
| Activity |
IC50 = 395990 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3939821; SCHEMBL15991064; BDBM214869; US9296734, 70
Click to Show/Hide
|
||||
| Activity |
IC50 = 397000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]phenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688691; SCHEMBL16041972; BDBM171629; US9085576, 263; US9085576, 265
Click to Show/Hide
|
||||
| Activity |
IC50 = 397000 nM
|
[5] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-(cyclopropylethynyl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693222; SCHEMBL16041997; BDBM171780; US9085576, 405
Click to Show/Hide
|
||||
| Activity |
IC50 = 398530 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688785; SCHEMBL16077313; BDBM171732; US9085576, 362
Click to Show/Hide
|
||||
| Activity |
IC50 = 399580 nM
|
[5] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(cyclopropylethynyl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979325; SCHEMBL15991359; BDBM214964; US9296734, 158
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(Fluoromethyl)-4-(2-fluoro-5-pyridin-2-yloxyphenyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986682; SCHEMBL15991450; BDBM214902; US9296734, 101
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899000; SCHEMBL16109303; BDBM220806
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
8-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluoroanilino]-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961045; SCHEMBL15990959; BDBM214987; US9296734, 180
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
8-[[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]amino]-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892989; SCHEMBL15991430; BDBM214876; US9296734, 77
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952111; BDBM220797; US9296759, 65
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-(6-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-fluoropyridin-2-yl)-3-chloro-5-(trifluoromethyl)-picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917242; SCHEMBL15990835; BDBM214880; US9296734, 81
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-2,4-difluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683834; SCHEMBL16041825; BDBM171444; US9085576, 78
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-3,5-dichloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3949737; SCHEMBL15991164; BDBM214867; US9296734, 68
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944050; SCHEMBL16109619; BDBM220830; US9296759, 62
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964372; SCHEMBL15991584; BDBM214997; US9296734, 190
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-1-methyl-6-oxopyridin-3-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3928092; SCHEMBL15991375; BDBM214953; US9296734, 148
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-5'-fluoro-7'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3973933; BDBM220829; US9296759, 95
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-6-chloro-3-methylimidazo[1,2-a]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925462; SCHEMBL15990861; BDBM214805; US9296734, 6
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-isocyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938934; BDBM214992; US9296734, 185
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
6-[2-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]ethynyl]-N-methylpyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925243; SCHEMBL15990878; BDBM214927
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(trifluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688648; SCHEMBL16077283; BDBM171584; US9085576, 218
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922952; BDBM220825; US9296759, 91
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894188; BDBM220851; US9296759, 114
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2,3-difluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913444; SCHEMBL15990785; BDBM214967; US9296734, 161
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
8-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluoroanilino]-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902460; SCHEMBL15991025; BDBM214968; US9296734, 162
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683876; SCHEMBL16040877; BDBM171491; US9085576, 125
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dimethoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683840; SCHEMBL16042919; BDBM171450; US9085576, 84
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921965; SCHEMBL15990885; BDBM214866; US9296734, 67
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-1-methyl-6-oxopyridin-3-yl]-5-isocyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923394; BDBM214955; US9296734, 150
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-3'-bromospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-4-chloro-2-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3962806; SCHEMBL16108868; BDBM220782; US9296759, 37
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3,6-dihydro-2H-pyridine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961630; SCHEMBL15991686; BDBM214924; US9296734, 123
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-3-chloro-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915277; SCHEMBL15990981; BDBM214868; US9296734, 69
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[5-[(1S,2R,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688758; SCHEMBL16077293; BDBM171703; US9085576, 333; US9085576, 335
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683839; SCHEMBL16041464; BDBM171449; US9085576, 83
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[5-[[3-(2-Cyclopropylethynyl)-1,7-naphthyridin-8-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970713; SCHEMBL15991318; BDBM214854; US9296734, 55
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3975637; BDBM220832; US9296759, 97
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930384; SCHEMBL15991006; BDBM214842; US9296734, 42
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
2-N'-(3-Ethoxypyridin-2-yl)-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2,2'-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966650; BDBM220795; US9296759, 31
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929911; SCHEMBL15991074; BDBM214994; US9296734, 187
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[5-(4-Bromo-6-chloropyridin-2-yl)oxy-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952503; SCHEMBL15999915; BDBM214899; US9296734, 98
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(5-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-3-chloro-5-cyanopicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958391; SCHEMBL15991269; BDBM214865; US9296734, 66
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3941417; SCHEMBL15990967; BDBM214966; US9296734, 160
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944783; SCHEMBL15991235; BDBM214975; US9296734, 168
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890449; BDBM220826; US9296759, 92
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688824; SCHEMBL16041678; BDBM171775; US9085576, 450
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(difluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964525; SCHEMBL15990792; BDBM214841; US9296734, 41
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
2-[2-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]ethynyl]-N-methylpyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915749; SCHEMBL15991127; BDBM214930; US9296734, 129
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913972; BDBM220823; US9296759, 89
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-chloro-5-(trifluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961329; SCHEMBL15991140; BDBM214843; US9296734, 44
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluoro-5-methylphenyl)-5-(difluoromethyl)-3-methylpicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923927; SCHEMBL15991737; BDBM215024; US9296734, 216
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-1-methyl-6-oxopyridin-3-yl]-5-isocyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898875; BDBM214954; US9296734, 149
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(5-((7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino)-2-fluoro-3-methylphenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940796; SCHEMBL15990909; BDBM215038; US9296734, 230
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-fluoropicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985357; SCHEMBL15991742; BDBM215012; US9296734, 205
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3962966; BDBM220827; US9296759, 93
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910114; BDBM220802; US9296759, 70
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3,5-dichloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688642; SCHEMBL16041930; BDBM171577; US9085576, 211
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[5-[(3-Chloro-5-fluoro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688784; SCHEMBL16077312; BDBM171731; US9085576, 361
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-5'-fluoro-7'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971440; BDBM220844; US9296759, 108
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966149; SCHEMBL15990855; BDBM214863; US9296734, 64
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972152; SCHEMBL15990929; BDBM214981; US9296734, 174
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913825; BDBM220831; US9296759, 96
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3928397; SCHEMBL15991738; BDBM215027; US9296734, 219
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,2S,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693257; SCHEMBL16041479; BDBM171817; US9085576, 2b-A
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-4-prop-2-ynoxypiperidine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951840; SCHEMBL15991097; BDBM214921; US9296734, 120
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977981; SCHEMBL15991437; BDBM214860; US9296734, 61
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893892; SCHEMBL15149804; BDBM214839; US9296734, 39
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924457; BDBM220773; US9296759, 46
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3951561; SCHEMBL15991604; BDBM214846; US9296734, 47
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-fluoro-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688731; SCHEMBL16042482; BDBM171673; US9085576, 307
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3936327; SCHEMBL15991296; BDBM214862; US9296734, 63
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972614; SCHEMBL15991551; BDBM215033
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(oxolan-3-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693229; SCHEMBL17068983; BDBM171788; US9085576, 413
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(1,3-oxazol-2-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3968912; SCHEMBL15990782; BDBM214845; US9296734, 46
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945149; SCHEMBL15991261; BDBM214881; US9296734, 82
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-cyano-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3914410; SCHEMBL15990790; BDBM215042
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-chloro-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926914; SCHEMBL15990957; BDBM215041; US9296734, 233
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(5-(6-Ethynylpyridin-3-yl)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948514; SCHEMBL15990820; BDBM214913; US9296734, 112
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[6-[(1S,2R,6S)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688749; SCHEMBL16044081; BDBM171693; US9085576, 323
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[5-[(1S,5R,6S)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688760; SCHEMBL16077295; BDBM171706; US9085576, 336
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-(5-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-5-cyano-3-methylpicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923890; SCHEMBL15991014; BDBM214944; US9296734, 140
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(5-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)-5-chloropicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915000; SCHEMBL15991071; BDBM214943; US9296734, 139
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683863; SCHEMBL16077269; BDBM171475; US9085576, 109
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-chloro-3-methylpicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920732; SCHEMBL15990757; BDBM214803; US9296734, 4
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3901027; SCHEMBL15991270; BDBM214980; US9296734, 173
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896202; SCHEMBL15990737; BDBM214802; US9296734, 3
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
6-((3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)ethynyl)nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952931; SCHEMBL15991243; BDBM214926; US9296734, 125
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6R)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4115023; SCHEMBL15990865; BDBM214824; US9296734, 25
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979722; SCHEMBL16109590; BDBM220780; US9296759, 42
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
(1S,2R,6S)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688763; SCHEMBL16026327; BDBM171709; US9085576, 339
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[2,3-Difluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911484; SCHEMBL16002794; BDBM214986; US9296734, 179
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[(2-methylpyrazolo[3,4-c]pyridin-7-yl)amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688781; SCHEMBL16077306; BDBM171728; US9085576, 358
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926156; SCHEMBL15990874; BDBM215004; US9296734, 197
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[5-(5-Chloro-3-fluoropyridin-2-yl)oxy-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952065; SCHEMBL15990962; BDBM214896; US9296734, 95
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933312; SCHEMBL15991876; BDBM215023; US9296734, 215
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(cyclopropylmethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3974975; SCHEMBL15991452; BDBM214837; US9296734, 37
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(1S,2S,6S)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688761; SCHEMBL16014082; BDBM171707; US9085576, 337
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
4-[[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]amino]pyrido[3,2-d]pyrimidine-7-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3982006; SCHEMBL15991007; BDBM214874; US9296734, 75
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966313; SCHEMBL15991409; BDBM215000; US9296734, 193
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952809; SCHEMBL16109436; BDBM220768; US9296759, 63
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908654; BDBM220855; US9296759, 118
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-chloro-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948355; SCHEMBL15991094; BDBM215030; US9296734, 222
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948791; BDBM220834; US9296759, 99
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976955; BDBM220778; US9296759, 50
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-[5-[(3-Chloro-1,7-naphthyridin-8-yl)amino]-2-fluoropyridin-3-yl]-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953251; SCHEMBL15990958; BDBM214875; US9296734, 76
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890269; SCHEMBL16109355; BDBM220783; US9296759, 39
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960610; SCHEMBL15991240; BDBM214835; US9296734, 35
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898955; SCHEMBL15990868; BDBM214963; US9296734, 157
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-bromopicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958580; SCHEMBL15990859; BDBM214851; US9296734, 52
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-{3-[(4s,6s)-2-Amino-4-(Fluoromethyl)-6-(Trifluoromethyl)-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2347187; SCHEMBL15142874; BDBM50432603; Q27452080
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922335; SCHEMBL15991169; BDBM214976
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-4-chloro-2-fluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908016; BDBM220810; US9296759, 76
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(6S)-2-Amino-4-(difluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957666; BDBM214935; US9296734, 134
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896886; SCHEMBL15990882; BDBM215035; US9296734, 227
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977392; SCHEMBL15991394; BDBM214847; US9296734, 48
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-3'-chlorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3974459; BDBM220813; US9296759, 79
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-(2-Fluoro-5-(pyrazin-2-yloxy)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3983343; SCHEMBL15991067; BDBM214892; US9296734, 92
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(1R,2S,6R)-2-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688764; SCHEMBL16041375; BDBM171710; US9085576, 340
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891152; SCHEMBL15991062; BDBM215022
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-chloro-5-cyano-2-pyridinecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3954148; SCHEMBL15142713; BDBM214832; US9296734, 32
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966080; SCHEMBL15991567; BDBM214838; US9296734, 38
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[5-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688658; SCHEMBL16040835; BDBM171596; US9085576, 230
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[6-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3949134; SCHEMBL15991447; BDBM214938
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(Fluoromethyl)-4-(2-fluoro-5-pyrimidin-2-yloxyphenyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985595; SCHEMBL15991438; BDBM214909; US9296734, 108
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683819; SCHEMBL16041669; BDBM171425; US9085576, 59; US9085576, 65
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929456; SCHEMBL15152239; BDBM214826; US9296734, 26; US9296734, 60
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688669; SCHEMBL16042505; BDBM171607; US9085576, 241
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
2-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenoxy]-N-methylpyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971100; SCHEMBL15991185; BDBM214897; US9296734, 96
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891585; SCHEMBL15991050; BDBM214834; US9296734, 34
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-chloro-5-(difluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924932; SCHEMBL15990735; BDBM214840; US9296734, 40
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-5'-fluoro-7'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937992; BDBM220838; US9296759, 102
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]phenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688692; SCHEMBL16041975; BDBM171630; US9085576, 264
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
Methyl 2-[3-[(4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenoxy]pyridine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3912456; SCHEMBL15991051; BDBM214907; US9296734, 106
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683838; SCHEMBL16041819; BDBM171448; US9085576, 82
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3927002; SCHEMBL15990946; BDBM214962
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Aminospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909521; SCHEMBL16109586; BDBM220781; US9296759, 36
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
N-(6-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-fluoropyridin-2-yl)-5-chloropicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961673; SCHEMBL15990887; BDBM214882; US9296734, 83
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
5'-Fluoro-7'-methoxy-2-N'-(3-phenylmethoxypyridin-2-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2,2'-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891797; BDBM220794; US9296759, 57
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935479; SCHEMBL15991294; BDBM215001; US9296734, 194
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-bromo-3-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937663; SCHEMBL15990996; BDBM214855; US9296734, 56
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966377; BDBM220784; US9296759, 51
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957970; SCHEMBL15152282; BDBM214848; US9296734, 49
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[(7-isocyanopyrido[3,2-d]pyrimidin-4-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943162; BDBM214822; US9296734, 23
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyanopyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688722; SCHEMBL16041219; BDBM171664; US9085576, 298
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893463; SCHEMBL16139659; BDBM220767
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683815; SCHEMBL16041971; BDBM171421; US9085576, 55; US9085576, 60
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[3-fluoro-4-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960749; SCHEMBL15991165; BDBM214910; US9296734, 109
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(3-((1S,5R,6S)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688746; SCHEMBL16041476; BDBM171690; US9085576, 319
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903880; SCHEMBL15991351; BDBM214861; US9296734, 62
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[5-[[2-(Difluoromethyl)-[1,3]thiazolo[5,4-d]pyrimidin-7-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926622; SCHEMBL15991453; BDBM214820; US9296734, 21
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[(7-methoxypyrido[3,2-d]pyrimidin-4-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966600; SCHEMBL15991440; BDBM214812; US9296734, 13
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3904830; BDBM220833; US9296759, 98
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942282; SCHEMBL15991322; BDBM214811; US9296734, 12
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980947; BDBM220796; US9296759, 64
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897411; SCHEMBL15149973; BDBM214804; US9296734, 5
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,3-dimethylbut-1-ynyl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898979; BDBM220816; US9296759, 82
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[2-Amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902974; BDBM220828; US9296759, 94
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-4-yl)spiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3978732; BDBM220839; US9296759, 103
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895635; BDBM220809; US9296759, 75
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953730; SCHEMBL15991348; BDBM214965; US9296734, 159
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(2-Fluoro-5-(6-((trimethylsilyl)ethynyl)pyridin-3-yl)phenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971064; SCHEMBL15991451; BDBM214912; US9296734, 111
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]cyclohexanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688667; SCHEMBL16040477; BDBM171605; US9085576, 239
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-{3-[(1R,5S,6R)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693258; SCHEMBL16040186; BDBM171819; US9085576, 320
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-4-chloro-1-propan-2-ylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898408; SCHEMBL15991467; BDBM214870; US9296734, 71
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688697; SCHEMBL16042302; BDBM171637; US9085576, 271; US9085576, 276
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935940; SCHEMBL15991338; BDBM214960; US9296734, 154
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-3-methylimidazo[1,2-a]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964122; SCHEMBL15991232; BDBM214806; US9296734, 7
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-(5-((7-Chloropyrido[3,2-d]pyrimidin-4-yl)amino)-2-fluoropyridin-3-yl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911117; SCHEMBL15991637; BDBM214873; US9296734, 74
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911798; SCHEMBL15990964; BDBM214801; US9296734, 2
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688821; SCHEMBL16043932; BDBM171771; US9085576, 397
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-5'-fluoro-7'-hydroxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938375; SCHEMBL16109681; BDBM220845; US9296759, 109
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
N-(3-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-4-methoxypiperidine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908739; SCHEMBL15991081; BDBM214920; US9296734, 119
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
3-((1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluoro-N-((S)-1-methoxypropan-2-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693243; SCHEMBL16043912; BDBM171802; US9085576, 427
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[5-[[2-(Difluoromethyl)pyrazolo[3,4-c]pyridin-7-yl]amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908807; SCHEMBL16002683; BDBM214819; US9296734, 20
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980894; SCHEMBL15990999; BDBM214833; US9296734, 33
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Benzamido-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957032; SCHEMBL15990746; BDBM214827; US9296734, 27
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3949245; BDBM220803; US9296759, 71
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-(5-Amino-2-fluoropyridin-3-yl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909660; SCHEMBL15991308; BDBM214941; US9296734, 138
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-3-chloro-5-(difluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956483; SCHEMBL15991183; BDBM215005; US9296734, 198
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3968489; SCHEMBL15990803; BDBM214993; US9296734, 186
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carbothioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952727; SCHEMBL15991139; BDBM214889; US9296734, 90
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-3'-chloro-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948764; SCHEMBL16109493; BDBM220772; US9296759, 38
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986646; SCHEMBL15990949; BDBM214849; US9296734, 50
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-chloro-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957556; SCHEMBL15991096; BDBM215002; US9296734, 195
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683836; SCHEMBL16041584; BDBM171446; US9085576, 80
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-[4-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955892; SCHEMBL15991005; BDBM214900; US9296734, 99
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-3'-cyclopropylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921606; BDBM220815; US9296759, 81
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965056; SCHEMBL15991234; BDBM214808; US9296734, 9
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-(2-Amino-3'-cyclopropyl-1'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971627; BDBM220786; US9296759, 53
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[24] | |||
| Compound Name |
8-((5-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-fluoropyridin-3-yl)amino)-5-fluoro-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958521; SCHEMBL15990864; BDBM214877; US9296734, 78
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(methoxymethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683837; SCHEMBL16042269; BDBM171447; US9085576, 81
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3904438; SCHEMBL15991323; BDBM214961; US9296734, 155
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950676; BDBM220824; US9296759, 90
Click to Show/Hide
|
||||
| Activity |
IC50 = 400800 nM
|
[24] | |||
| Compound Name |
N-[5-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688759; SCHEMBL16077294; BDBM171704; US9085576, 334
Click to Show/Hide
|
||||
| Activity |
IC50 = 401920 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683901; SCHEMBL16014098; BDBM171518; US9085576, 152; US9085576, 155
Click to Show/Hide
|
||||
| Activity |
IC50 = 403830 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-chloro-5-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933535; SCHEMBL15990816; BDBM215045; US9296734, 236
Click to Show/Hide
|
||||
| Activity |
IC50 = 407900 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963996; BDBM220819; US9296759, 85
Click to Show/Hide
|
||||
| Activity |
IC50 = 411100 nM
|
[24] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892657; SCHEMBL15991456; BDBM215018; US9296734, 210
Click to Show/Hide
|
||||
| Activity |
IC50 = 416000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-1-ynylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688737; SCHEMBL16042707; BDBM171680; US9085576, 314
Click to Show/Hide
|
||||
| Activity |
IC50 = 420550 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688733; SCHEMBL16045138; BDBM171675; US9085576, 309; US9085576, 310
Click to Show/Hide
|
||||
| Activity |
IC50 = 421050 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910073; SCHEMBL15990862; BDBM214982; US9296734, 175
Click to Show/Hide
|
||||
| Activity |
IC50 = 424000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]isoquinoline-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688633; SCHEMBL16043897; BDBM171568; US9085576, 202
Click to Show/Hide
|
||||
| Activity |
IC50 = 430210 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-3'-cyclopropylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl)-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970199; BDBM220807; US9296759, 73
Click to Show/Hide
|
||||
| Activity |
IC50 = 432500 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-chloro-3-methylimidazo[1,2-a]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683825; SCHEMBL16042061; BDBM171435; US9085576, 69
Click to Show/Hide
|
||||
| Activity |
IC50 = 439580 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688815; SCHEMBL16044658; BDBM171764; US9085576, 390
Click to Show/Hide
|
||||
| Activity |
IC50 = 441280 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(difluoromethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688735; SCHEMBL16040844; BDBM171678; US9085576, 312
Click to Show/Hide
|
||||
| Activity |
IC50 = 441810 nM
|
[5] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloropyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688689; SCHEMBL16041520; BDBM171627; US9085576, 261
Click to Show/Hide
|
||||
| Activity |
IC50 = 444000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chlorophenyl]-5-chloro-3-(fluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688741; SCHEMBL16043374; BDBM171685; US9085576, 441
Click to Show/Hide
|
||||
| Activity |
IC50 = 444190 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-5-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683916; SCHEMBL16044604; BDBM171536; US9085576, 170
Click to Show/Hide
|
||||
| Activity |
IC50 = 444850 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688724; SCHEMBL16043049; BDBM171666; US9085576, 300
Click to Show/Hide
|
||||
| Activity |
IC50 = 447110 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-1-(4-chlorophenyl)cyclopropane-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688673; SCHEMBL16043040; BDBM171611; US9085576, 245
Click to Show/Hide
|
||||
| Activity |
IC50 = 447240 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,3-dimethylbut-1-ynyl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3936498; BDBM220820; US9296759, 86
Click to Show/Hide
|
||||
| Activity |
IC50 = 452300 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-(Fluoromethyl)-4-[2-fluoro-5-[5-(1,3,4-oxadiazol-2-yl)pyridin-3-yl]phenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924137; SCHEMBL15991505; BDBM214919; US9296734, 118
Click to Show/Hide
|
||||
| Activity |
IC50 = 454000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688645; SCHEMBL16041968; BDBM171580; US9085576, 214
Click to Show/Hide
|
||||
| Activity |
IC50 = 459300 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-6-chloro-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683814; SCHEMBL16077262; BDBM171420; US9085576, 54
Click to Show/Hide
|
||||
| Activity |
IC50 = 459520 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,6S)-3-Amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(4-hydroxy-4-methylpent-2-ynoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683790; BDBM171395; US9085576, 29
Click to Show/Hide
|
||||
| Activity |
IC50 = 462460 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-methylphenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688719; SCHEMBL16042762; BDBM171661; US9085576, 295
Click to Show/Hide
|
||||
| Activity |
IC50 = 464360 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683909; SCHEMBL16044614; BDBM171529; US9085576, 163
Click to Show/Hide
|
||||
| Activity |
IC50 = 464440 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-chloro-3-methylimidazo[1,2-a]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688631; SCHEMBL16042408; BDBM171566; US9085576, 200
Click to Show/Hide
|
||||
| Activity |
IC50 = 464930 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688723; SCHEMBL16044965; BDBM171665; US9085576, 299
Click to Show/Hide
|
||||
| Activity |
IC50 = 465440 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-ethynylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688736; SCHEMBL16041471; BDBM171679; US9085576, 313
Click to Show/Hide
|
||||
| Activity |
IC50 = 466880 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683852; SCHEMBL16077268; BDBM171462; US9085576, 96
Click to Show/Hide
|
||||
| Activity |
IC50 = 467370 nM
|
[5] | |||
| Compound Name |
(8R)-8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-5,6,7,8-tetrahydroquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688827; SCHEMBL16041927; BDBM171778; US9085576, 403
Click to Show/Hide
|
||||
| Activity |
IC50 = 468840 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[5-[(2-Bromopyridin-4-yl)amino]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979965; SCHEMBL15991180; BDBM214816; US9296734, 17
Click to Show/Hide
|
||||
| Activity |
IC50 = 469000 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-7'-(3,6-dihydro-2H-pyran-5-yl)spiro[5H-1,3-oxazole-4,9'-xanthene]-2'-yl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3809662; BDBM50172102
Click to Show/Hide
|
||||
| Activity |
IC50 = 470000 nM
|
[41] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683869; SCHEMBL16043733; BDBM171483; US9085576, 117
Click to Show/Hide
|
||||
| Activity |
IC50 = 471710 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683862; SCHEMBL16041351; BDBM171474; US9085576, 108
Click to Show/Hide
|
||||
| Activity |
IC50 = 471870 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chlorothiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688611; SCHEMBL16042038; BDBM171545; US9085576, 179
Click to Show/Hide
|
||||
| Activity |
IC50 = 474390 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683824; SCHEMBL16041422; BDBM171434; US9085576, 68
Click to Show/Hide
|
||||
| Activity |
IC50 = 476180 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-(difluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688819; SCHEMBL16077328; BDBM171769; US9085576, 395
Click to Show/Hide
|
||||
| Activity |
IC50 = 476950 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dichloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683827; SCHEMBL16041360; BDBM171437; US9085576, 71
Click to Show/Hide
|
||||
| Activity |
IC50 = 477760 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
US9296759, 58; CHEMBL3981595; BDBM220805
Click to Show/Hide
|
||||
| Activity |
IC50 = 480000 nM
|
[24] | |||
| Compound Name |
Chembl4294221
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 = 480000 nM
|
[25] | |||
| Compound Name |
N-[(4S)-2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
US9296759, 58; CHEMBL3959153; SCHEMBL16109580; BDBM220766
Click to Show/Hide
|
||||
| Activity |
IC50 = 480000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methoxypropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688675; SCHEMBL16041384; BDBM171613; US9085576, 247
Click to Show/Hide
|
||||
| Activity |
IC50 = 486400 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965367; SCHEMBL15991346; BDBM215014; US9296734, 206
Click to Show/Hide
|
||||
| Activity |
IC50 = 487900 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(trifluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]phenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688639; SCHEMBL16077279; BDBM171574; US9085576, 208
Click to Show/Hide
|
||||
| Activity |
IC50 = 489480 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(methylamino)pyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693254; BDBM171814; US9085576, 439
Click to Show/Hide
|
||||
| Activity |
IC50 = 489920 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chloro-5-fluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683887; SCHEMBL16077272; BDBM171502; US9085576, 136
Click to Show/Hide
|
||||
| Activity |
IC50 = 490740 nM
|
[5] | |||
| Compound Name |
N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902829; SCHEMBL15991015; BDBM214884; US9296734, 85
Click to Show/Hide
|
||||
| Activity |
IC50 = 492000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-3,5-dichloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683886; SCHEMBL16042193; BDBM171501; US9085576, 135
Click to Show/Hide
|
||||
| Activity |
IC50 = 493690 nM
|
[5] | |||
| Compound Name |
3-{2-[(5-Aminopentyl)amino]-2-oxoethoxy}-5-({[1-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl phenylmethanesulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
oxyacetamide 5; CHEMBL426717; SCHEMBL4586113; BDBM16046; L-124,671; Q27453495
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[47] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688641; SCHEMBL16045265; BDBM171576; BDBM171582; US9085576, 210; US9085576, 216
Click to Show/Hide
|
||||
| Activity |
IC50 = 500140 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688790; SCHEMBL16077314; BDBM171737; US9085576, 447
Click to Show/Hide
|
||||
| Activity |
IC50 = 500520 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688653; SCHEMBL16043937; BDBM171590; US9085576, 224
Click to Show/Hide
|
||||
| Activity |
IC50 = 509920 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(cyclopropylmethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915529; SCHEMBL15990976; BDBM214998; US9296734, 191
Click to Show/Hide
|
||||
| Activity |
IC50 = 510800 nM
|
[13] | |||
| Compound Name |
N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-3,5-dichloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688754; SCHEMBL16040710; BDBM171698; US9085576, 328
Click to Show/Hide
|
||||
| Activity |
IC50 = 511670 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethyl)-2-methylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683903; SCHEMBL16041576; BDBM171520; US9085576, 154
Click to Show/Hide
|
||||
| Activity |
IC50 = 514640 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethyl)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688632; SCHEMBL16042836; BDBM171567; US9085576, 201
Click to Show/Hide
|
||||
| Activity |
IC50 = 515090 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943009; SCHEMBL15991138; BDBM215032; US9296734, 224
Click to Show/Hide
|
||||
| Activity |
IC50 = 515200 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683800; SCHEMBL16077257; BDBM171406; US9085576, 40
Click to Show/Hide
|
||||
| Activity |
IC50 = 516140 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688743; SCHEMBL16041883; BDBM171687; US9085576, 443
Click to Show/Hide
|
||||
| Activity |
IC50 = 517380 nM
|
[5] | |||
| Compound Name |
N-[2-Amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955960; BDBM220835; US9296759, 100
Click to Show/Hide
|
||||
| Activity |
IC50 = 517700 nM
|
[24] | |||
| Compound Name |
(4S,6S)-4-(2,3-Difluoro-5-((2-methoxypyrido[3,4-b]pyrazin-5-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899306; SCHEMBL15991060; BDBM214985; US9296734, 178
Click to Show/Hide
|
||||
| Activity |
IC50 = 519000 nM
|
[13] | |||
| Compound Name |
N-[6-[(1R,2S,6R)-4-Amino-2-methyl-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoropyridin-2-yl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688748; SCHEMBL16041594; BDBM171692; US9085576, 322
Click to Show/Hide
|
||||
| Activity |
IC50 = 521420 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683796; SCHEMBL16077258; BDBM171402; US9085576, 36
Click to Show/Hide
|
||||
| Activity |
IC50 = 526500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683892; SCHEMBL16045631; BDBM171509; US9085576, 143
Click to Show/Hide
|
||||
| Activity |
IC50 = 529160 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloro-3-(hydroxymethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693236; SCHEMBL16041842; BDBM171795; US9085576, 420
Click to Show/Hide
|
||||
| Activity |
IC50 = 532830 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-cyanothiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688610; SCHEMBL16043343; BDBM171544; US9085576, 178
Click to Show/Hide
|
||||
| Activity |
IC50 = 534110 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688700; SCHEMBL16041232; BDBM171640; US9085576, 274
Click to Show/Hide
|
||||
| Activity |
IC50 = 537750 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683888; SCHEMBL16042421; BDBM171503; US9085576, 137; US9085576, 139
Click to Show/Hide
|
||||
| Activity |
IC50 = 539090 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688652; SCHEMBL16041877; BDBM171589; US9085576, 223
Click to Show/Hide
|
||||
| Activity |
IC50 = 541280 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979143; SCHEMBL15991357; BDBM215020; US9296734, 212
Click to Show/Hide
|
||||
| Activity |
IC50 = 554000 nM
|
[13] | |||
| Compound Name |
(1R,5S,6R)-5-(Difluoromethyl)-5-[2-fluoro-5-[[(7R)-3-isocyano-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl]amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688825; BDBM171776; US9085576, 401
Click to Show/Hide
|
||||
| Activity |
IC50 = 555020 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688738; SCHEMBL16041644; BDBM171681; US9085576, 315
Click to Show/Hide
|
||||
| Activity |
IC50 = 556390 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[5-(4-Bromopyridin-2-yl)oxy-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3954714; SCHEMBL15990836; BDBM214893; US9296734, 93
Click to Show/Hide
|
||||
| Activity |
IC50 = 557000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-3-chloro-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683884; SCHEMBL16040821; BDBM171499; US9085576, 133
Click to Show/Hide
|
||||
| Activity |
IC50 = 558460 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methylsulfonylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688614; SCHEMBL16041580; BDBM171548; US9085576, 182
Click to Show/Hide
|
||||
| Activity |
IC50 = 565490 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964029; SCHEMBL15991526; BDBM215040; US9296734, 232
Click to Show/Hide
|
||||
| Activity |
IC50 = 568100 nM
|
[13] | |||
| Compound Name |
N-[2-Amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-thiazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950477; BDBM220848; US9296759, 111
Click to Show/Hide
|
||||
| Activity |
IC50 = 569000 nM
|
[24] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683845; SCHEMBL16041910; BDBM171455; US9085576, 89
Click to Show/Hide
|
||||
| Activity |
IC50 = 574200 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-chloro-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683813; SCHEMBL16077263; BDBM171419; US9085576, 53
Click to Show/Hide
|
||||
| Activity |
IC50 = 577310 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[2-(1H-indol-4-yl)ethynyl]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943708; SCHEMBL15991111; BDBM214931; US9296734, 130
Click to Show/Hide
|
||||
| Activity |
IC50 = 578000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chlorothiophene-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688613; SCHEMBL16040474; BDBM171547; US9085576, 181
Click to Show/Hide
|
||||
| Activity |
IC50 = 580110 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-thiazol-4-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683915; SCHEMBL16041459; BDBM171535; US9085576, 169
Click to Show/Hide
|
||||
| Activity |
IC50 = 581850 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688660; SCHEMBL16042597; BDBM171598; US9085576, 232
Click to Show/Hide
|
||||
| Activity |
IC50 = 587650 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688623; SCHEMBL16044940; BDBM171558; US9085576, 192
Click to Show/Hide
|
||||
| Activity |
IC50 = 590780 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-(1,3-oxazol-4-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683856; SCHEMBL16041863; BDBM171468; US9085576, 102
Click to Show/Hide
|
||||
| Activity |
IC50 = 591850 nM
|
[5] | |||
| Compound Name |
Schembl20590941
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693239; BDBM171798; US9085576, 423
Click to Show/Hide
|
||||
| Activity |
IC50 = 591980 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683803; SCHEMBL16040485; BDBM171409; US9085576, 43
Click to Show/Hide
|
||||
| Activity |
IC50 = 595960 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[2-Fluoro-5-[(5-fluoro-3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688768; SCHEMBL16077300; BDBM171714; US9085576, 344
Click to Show/Hide
|
||||
| Activity |
IC50 = 596190 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(7-methoxypyrido[3,2-d]pyrimidin-4-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688787; SCHEMBL16077316; BDBM171734; US9085576, 364
Click to Show/Hide
|
||||
| Activity |
IC50 = 596240 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-(difluoromethyl)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3905422; SCHEMBL15991362; BDBM215019; US9296734, 211
Click to Show/Hide
|
||||
| Activity |
IC50 = 604000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[5-[2-[5-(Difluoromethoxy)pyridin-2-yl]ethynyl]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940730; SCHEMBL15990723; BDBM214928; US9296734, 127
Click to Show/Hide
|
||||
| Activity |
IC50 = 605000 nM
|
[13] | |||
| Compound Name |
N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908288; SCHEMBL15991001; BDBM214886; US9296734, 87
Click to Show/Hide
|
||||
| Activity |
IC50 = 609000 nM
|
[13] | |||
| Compound Name |
[4-[3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-2-(5-fluoropyridin-3-yl)phenyl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693248; BDBM171808; US9085576, 433
Click to Show/Hide
|
||||
| Activity |
IC50 = 612810 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4,5-difluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683866; SCHEMBL16044067; BDBM171479; US9085576, 113
Click to Show/Hide
|
||||
| Activity |
IC50 > 618000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963645; SCHEMBL15990824; BDBM215017; US9296734, 209
Click to Show/Hide
|
||||
| Activity |
IC50 = 622000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683794; SCHEMBL16077255; BDBM171400; US9085576, 34
Click to Show/Hide
|
||||
| Activity |
IC50 = 622600 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930009; SCHEMBL15990768; BDBM215003; US9296734, 196
Click to Show/Hide
|
||||
| Activity |
IC50 = 627600 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966537; SCHEMBL15991155; BDBM215025
Click to Show/Hide
|
||||
| Activity |
IC50 = 634000 nM
|
[13] | |||
| Compound Name |
N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-5-bromo-3-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930808; SCHEMBL15990812; BDBM214885; US9296734, 86
Click to Show/Hide
|
||||
| Activity |
IC50 = 636000 nM
|
[13] | |||
| Compound Name |
Chembl4289749
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 = 640000 nM
|
[25] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(oxan-4-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693228; SCHEMBL16041850; BDBM171787; US9085576, 412
Click to Show/Hide
|
||||
| Activity |
IC50 = 640340 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688696; SCHEMBL16041854; BDBM171636; US9085576, 270
Click to Show/Hide
|
||||
| Activity |
IC50 = 646370 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688707; SCHEMBL16040831; BDBM171648; US9085576, 282
Click to Show/Hide
|
||||
| Activity |
IC50 = 649740 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-4-methylsulfanylphenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683891; SCHEMBL18707850; BDBM171507; US9085576, 141
Click to Show/Hide
|
||||
| Activity |
IC50 = 654540 nM
|
[5] | |||
| Compound Name |
8-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoroanilino]-1,7-naphthyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688789; SCHEMBL16077320; BDBM171736; US9085576, 446
Click to Show/Hide
|
||||
| Activity |
IC50 = 657710 nM
|
[5] | |||
| Compound Name |
N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-3-chloro-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934414; SCHEMBL15991477; BDBM214879; US9296734, 80
Click to Show/Hide
|
||||
| Activity |
IC50 = 658000 nM
|
[13] | |||
| Compound Name |
6-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-3-chloro-5H-pyrrolo[3,4-b]pyridin-7(6H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693252; SCHEMBL16042341; BDBM171812; US9085576, 437
Click to Show/Hide
|
||||
| Activity |
IC50 = 659310 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683889; SCHEMBL16040332; BDBM171504; US9085576, 138
Click to Show/Hide
|
||||
| Activity |
IC50 = 662080 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]phenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972761; SCHEMBL15991087; BDBM214949; US9296734, 144
Click to Show/Hide
|
||||
| Activity |
IC50 = 665000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3912808; SCHEMBL15991612; BDBM214828; US9296734, 28
Click to Show/Hide
|
||||
| Activity |
IC50 = 666000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-2-(2-methoxyethoxy)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688683; SCHEMBL16040628; BDBM171621; US9085576, 255
Click to Show/Hide
|
||||
| Activity |
IC50 = 666150 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-methoxypyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688618; SCHEMBL16044984; BDBM171553; US9085576, 187
Click to Show/Hide
|
||||
| Activity |
IC50 = 667110 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-[(1R)-1-cyanoethoxy]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688687; SCHEMBL16077287; BDBM171625; US9085576, 259
Click to Show/Hide
|
||||
| Activity |
IC50 = 668250 nM
|
[5] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloropicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683832; SCHEMBL16042373; BDBM171442; US9085576, 76
Click to Show/Hide
|
||||
| Activity |
IC50 = 684310 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-methylphenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688718; SCHEMBL16041383; BDBM171660; US9085576, 294
Click to Show/Hide
|
||||
| Activity |
IC50 = 684340 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688716; SCHEMBL16041923; BDBM171658; US9085576, 292
Click to Show/Hide
|
||||
| Activity |
IC50 = 689700 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyano-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688822; SCHEMBL16041181; BDBM171772; US9085576, 398
Click to Show/Hide
|
||||
| Activity |
IC50 = 690320 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688650; SCHEMBL16040722; BDBM171586; US9085576, 220; US9085576, 225
Click to Show/Hide
|
||||
| Activity |
IC50 = 690710 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683833; SCHEMBL16041664; BDBM171443; US9085576, 77
Click to Show/Hide
|
||||
| Activity |
IC50 = 697750 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-chloro-3-propan-2-ylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688714; SCHEMBL16043963; BDBM171655; US9085576, 289
Click to Show/Hide
|
||||
| Activity |
IC50 = 699950 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688627; SCHEMBL16043763; BDBM171562; US9085576, 196
Click to Show/Hide
|
||||
| Activity |
IC50 = 703110 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-propan-2-yloxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683896; SCHEMBL16042041; BDBM171513; US9085576, 147
Click to Show/Hide
|
||||
| Activity |
IC50 = 706050 nM
|
[5] | |||
| Compound Name |
N-[6-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoropyridin-2-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3939817; SCHEMBL15991378; BDBM214887; US9296734, 88
Click to Show/Hide
|
||||
| Activity |
IC50 = 712000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-methoxy-3-methylpyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688725; SCHEMBL16041815; BDBM171667; US9085576, 301
Click to Show/Hide
|
||||
| Activity |
IC50 = 714940 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-methylphenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688695; SCHEMBL16026314; BDBM171635; US9085576, 269
Click to Show/Hide
|
||||
| Activity |
IC50 = 715760 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[2-(1H-indol-6-yl)ethynyl]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952431; SCHEMBL15991295; BDBM214933; US9296734, 132
Click to Show/Hide
|
||||
| Activity |
IC50 = 721000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-6-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688711; SCHEMBL16040648; BDBM171652; US9085576, 286
Click to Show/Hide
|
||||
| Activity |
IC50 = 724590 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-[3-Chloro-2-fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688779; SCHEMBL16042425; BDBM171726; US9085576, 356
Click to Show/Hide
|
||||
| Activity |
IC50 = 725380 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-cyano-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683883; SCHEMBL16042466; BDBM171498; US9085576, 132
Click to Show/Hide
|
||||
| Activity |
IC50 = 725410 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-cyano-3-(dimethylamino)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688814; SCHEMBL16041673; BDBM171763; US9085576, 389
Click to Show/Hide
|
||||
| Activity |
IC50 = 732460 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925742; SCHEMBL15991056; BDBM214977; US9296734, 170
Click to Show/Hide
|
||||
| Activity |
IC50 = 733000 nM
|
[13] | |||
| Compound Name |
(4S,6S)-4-[3-[(3-Chloro-1,7-naphthyridin-8-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909033; SCHEMBL15991167; BDBM214951; US9296734, 146
Click to Show/Hide
|
||||
| Activity |
IC50 = 733000 nM
|
[13] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloro-3-(methoxymethyl) picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683802; SCHEMBL16043490; BDBM171408; US9085576, 42
Click to Show/Hide
|
||||
| Activity |
IC50 = 735560 nM
|
[5] | |||
| Compound Name |
(1R,2S,6R)-2-(Difluoromethyl)-2-[2-fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-5-oxa-3-azabicyclo[4.1.0]hept-3-en-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688772; SCHEMBL16077301; BDBM171718; US9085576, 348
Click to Show/Hide
|
||||
| Activity |
IC50 = 738320 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-chloro-4-fluorophenyl]-5-bromopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950109; SCHEMBL15991416; BDBM215021; US9296734, 213
Click to Show/Hide
|
||||
| Activity |
IC50 = 739000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(cyclopropylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693231; SCHEMBL16041230; BDBM171790; US9085576, 415
Click to Show/Hide
|
||||
| Activity |
IC50 = 747300 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-[2-(3-methyloxetan-3-yl)ethynyl]pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693226; SCHEMBL16047900; BDBM171784; US9085576, 409
Click to Show/Hide
|
||||
| Activity |
IC50 = 748150 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688709; SCHEMBL16041605; BDBM171650; US9085576, 284
Click to Show/Hide
|
||||
| Activity |
IC50 = 752050 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dimethylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688616; SCHEMBL16042916; BDBM171551; US9085576, 185
Click to Show/Hide
|
||||
| Activity |
IC50 = 752560 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-(6-fluoroquinazolin-2-yl)phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952357; SCHEMBL15990780; BDBM214915; US9296734, 114
Click to Show/Hide
|
||||
| Activity |
IC50 = 758000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688626; SCHEMBL16040624; BDBM171561; US9085576, 195
Click to Show/Hide
|
||||
| Activity |
IC50 = 759190 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913544; SCHEMBL15991659; BDBM215008; US9296734, 201
Click to Show/Hide
|
||||
| Activity |
IC50 = 761600 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chlorothiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688609; SCHEMBL16043943; BDBM171543; US9085576, 177
Click to Show/Hide
|
||||
| Activity |
IC50 = 762010 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyrimidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683857; SCHEMBL16041274; BDBM171469; US9085576, 103
Click to Show/Hide
|
||||
| Activity |
IC50 = 762630 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-oxazol-2-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683913; SCHEMBL16041485; BDBM171533; US9085576, 167
Click to Show/Hide
|
||||
| Activity |
IC50 = 767260 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(difluoromethyl)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688617; SCHEMBL16041935; BDBM171552; US9085576, 186
Click to Show/Hide
|
||||
| Activity |
IC50 = 767700 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-fluoro-4-methoxyphenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683895; SCHEMBL16044074; BDBM171512; US9085576, 146
Click to Show/Hide
|
||||
| Activity |
IC50 = 768310 nM
|
[5] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683848; SCHEMBL16043711; BDBM171458; US9085576, 92
Click to Show/Hide
|
||||
| Activity |
IC50 = 769500 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-methyl-5-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688620; SCHEMBL16042954; BDBM171555; US9085576, 189
Click to Show/Hide
|
||||
| Activity |
IC50 = 770000 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957027; SCHEMBL15991313; BDBM215036; US9296734, 228
Click to Show/Hide
|
||||
| Activity |
IC50 = 775000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3971569; SCHEMBL15991865; BDBM215034; US9296734, 226
Click to Show/Hide
|
||||
| Activity |
IC50 = 780500 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924515; SCHEMBL15990696; BDBM214996; US9296734, 189
Click to Show/Hide
|
||||
| Activity |
IC50 = 783800 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]phenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693253; SCHEMBL16041811; BDBM171813; US9085576, 438
Click to Show/Hide
|
||||
| Activity |
IC50 = 792770 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl)benzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586138
Click to Show/Hide
|
||||
| Activity |
IC50 = 797000 nM
|
[34] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-chloropyridine-2-carbothioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894515; SCHEMBL15991263; BDBM214890; US9296734, 91
Click to Show/Hide
|
||||
| Activity |
IC50 = 805000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-4-(2-cyclopropylethynyl)-3,6-dihydro-2H-pyridine-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930667; SCHEMBL15990846; BDBM214925; US9296734, 124
Click to Show/Hide
|
||||
| Activity |
IC50 = 810000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluoro-5-methylphenyl]-5-chloro-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688726; SCHEMBL16042918; BDBM171668; US9085576, 302
Click to Show/Hide
|
||||
| Activity |
IC50 = 810690 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688636; SCHEMBL16042448; BDBM171571; US9085576, 205
Click to Show/Hide
|
||||
| Activity |
IC50 = 820880 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683823; SCHEMBL16041472; BDBM171432; US9085576, 66
Click to Show/Hide
|
||||
| Activity |
IC50 = 825020 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-4-methylsulfonylphenyl]-5-chloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693240; BDBM171799; US9085576, 424
Click to Show/Hide
|
||||
| Activity |
IC50 = 831860 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980634; SCHEMBL15990960; BDBM215031; US9296734, 223
Click to Show/Hide
|
||||
| Activity |
IC50 = 832900 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-chloro-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688721; SCHEMBL16040702; BDBM171663; US9085576, 297
Click to Show/Hide
|
||||
| Activity |
IC50 = 834640 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-methylthiophene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683922; SCHEMBL16041602; BDBM171542; US9085576, 176
Click to Show/Hide
|
||||
| Activity |
IC50 = 834710 nM
|
[5] | |||
| Compound Name |
(1R,5S,6R)-5-[2-Chloro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688783; BDBM171730; US9085576, 360
Click to Show/Hide
|
||||
| Activity |
IC50 = 843040 nM
|
[5] | |||
| Compound Name |
N-[5-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-6-fluoropyridin-3-yl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3969602; SCHEMBL15991383; BDBM214871; US9296734, 72
Click to Show/Hide
|
||||
| Activity |
IC50 = 844000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-oxazol-5-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683917; SCHEMBL16041387; BDBM171537; US9085576, 171
Click to Show/Hide
|
||||
| Activity |
IC50 = 845840 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-[(2R)-but-3-yn-2-yl]oxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683897; SCHEMBL16043481; BDBM171514; US9085576, 148
Click to Show/Hide
|
||||
| Activity |
IC50 = 848580 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3,5-dichloropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688624; SCHEMBL16041256; BDBM171559; US9085576, 193
Click to Show/Hide
|
||||
| Activity |
IC50 = 875420 nM
|
[5] | |||
| Compound Name |
(4S,6S)-4-[2-Fluoro-5-[(3-fluoropyridin-2-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985831; SCHEMBL15990869; BDBM214813; US9296734, 14
Click to Show/Hide
|
||||
| Activity |
IC50 = 879000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-(fluoromethoxy)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688615; SCHEMBL16041461; BDBM171549; US9085576, 183
Click to Show/Hide
|
||||
| Activity |
IC50 = 882020 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(cyclopentylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693234; SCHEMBL16041288; BDBM171793; US9085576, 418
Click to Show/Hide
|
||||
| Activity |
IC50 = 890720 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-cyano-3-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683842; SCHEMBL16041866; BDBM171452; US9085576, 86
Click to Show/Hide
|
||||
| Activity |
IC50 = 891600 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chloro-5-fluorophenyl]-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683904; SCHEMBL16041818; BDBM171522; US9085576, 156
Click to Show/Hide
|
||||
| Activity |
IC50 = 896760 nM
|
[5] | |||
| Compound Name |
N-(6-((4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-fluoropyridin-2-yl)-5-cyano-3-methylpicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926112; SCHEMBL15990871; BDBM214883; US9296734, 84
Click to Show/Hide
|
||||
| Activity |
IC50 = 900000 nM
|
[13] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-isocyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903133; BDBM214970; US9296734, 163
Click to Show/Hide
|
||||
| Activity |
IC50 = 901000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1S,2R,6S)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688703; SCHEMBL16041926; BDBM171644; US9085576, 278
Click to Show/Hide
|
||||
| Activity |
IC50 = 904390 nM
|
[5] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloro-3-methoxypicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683789; SCHEMBL16906364; BDBM171394; US9085576, 28
Click to Show/Hide
|
||||
| Activity |
IC50 = 907850 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-5-chloro-4-fluorophenyl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683846; SCHEMBL16040644; BDBM171456; US9085576, 90
Click to Show/Hide
|
||||
| Activity |
IC50 = 913000 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-prop-2-enoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693230; SCHEMBL16049052; BDBM171789; US9085576, 414
Click to Show/Hide
|
||||
| Activity |
IC50 = 924060 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-(1,3-oxazol-4-ylmethoxy)pyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683920; SCHEMBL16041996; BDBM171540; US9085576, 174
Click to Show/Hide
|
||||
| Activity |
IC50 = 925020 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-bromo-3-fluoropyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919193; SCHEMBL16002802; BDBM215049; US9296734, 240
Click to Show/Hide
|
||||
| Activity |
IC50 = 928000 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688643; SCHEMBL16044641; BDBM171578; US9085576, 212
Click to Show/Hide
|
||||
| Activity |
IC50 = 928320 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-2,4-difluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683835; SCHEMBL16041394; BDBM171445; US9085576, 79
Click to Show/Hide
|
||||
| Activity |
IC50 = 941650 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683910; SCHEMBL16041392; BDBM171530; US9085576, 164
Click to Show/Hide
|
||||
| Activity |
IC50 = 949930 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-3-chloro-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688657; SCHEMBL16041349; BDBM171595; US9085576, 229
Click to Show/Hide
|
||||
| Activity |
IC50 = 956160 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chlorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688640; SCHEMBL16077278; BDBM171575; US9085576, 209
Click to Show/Hide
|
||||
| Activity |
IC50 = 958310 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-but-2-ynoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3688630; SCHEMBL16041399; BDBM171565; US9085576, 199
Click to Show/Hide
|
||||
| Activity |
IC50 = 958610 nM
|
[5] | |||
| Compound Name |
N-(3-((1R,5S,6R)-3-Amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-2,4,6-trifluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3693255; SCHEMBL16041013; BDBM171815; US9085576, 451
Click to Show/Hide
|
||||
| Activity |
IC50 = 959560 nM
|
[5] | |||
| Compound Name |
N-(2-Amino-3'-cyclopropylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-methoxypyrazine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893589; BDBM220814; US9296759, 80
Click to Show/Hide
|
||||
| Activity |
IC50 = 962700 nM
|
[24] | |||
| Compound Name |
N-[3-[(1S,5R,6S)-3-Amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683807; SCHEMBL16077259; BDBM171413; US9085576, 47
Click to Show/Hide
|
||||
| Activity |
IC50 = 967700 nM
|
[5] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(difluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-fluorophenyl]-5-methoxypyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683881; SCHEMBL16041390; BDBM171496; US9085576, 130
Click to Show/Hide
|
||||
| Activity |
IC50 = 987710 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-(difluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942544; SCHEMBL15991079; BDBM215029; US9296734, 221
Click to Show/Hide
|
||||
| Activity |
IC50 = 991700 nM
|
[13] | |||
| Compound Name |
N-[3-[(1R,2S,6R)-4-Amino-2-(fluoromethyl)-5-oxa-3-azabicyclo[4.1.0]hept-3-en-2-yl]-4-chlorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3683878; SCHEMBL16043397; BDBM171493; US9085576, 127
Click to Show/Hide
|
||||
| Activity |
IC50 = 996820 nM
|
[5] | |||
| Compound Name |
N-[3-[(4S,6S)-2-Amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(difluoromethyl)pyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944430; SCHEMBL15991556; BDBM215007; US9296734, 200
Click to Show/Hide
|
||||
| Activity |
IC50 = 997300 nM
|
[13] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
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