Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67231 | Target Info | |||
| Target Name | Endopeptidase S1P (MBTPS1) | ||||
| Synonyms |
Subtilisin/kexin-isozyme-1; Subtilisin/kexin-isozyme 1; Site-1 protease; SKI1; SKI-1; S1P; Membrane-bound transcription factor site-1 protease; KIAA0091
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| Target Type | Literature-reported Target | ||||
| Gene Name | MBTPS1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[[2-[2-[[2-[2-[[(1S)-1-Carboxy-2-methylpropyl]amino]-2-oxoethoxy]phenyl]diazenyl]phenoxy]acetyl]amino]-3-methylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171759; BDBM50378790
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| Activity |
Ki = 75000 nM
|
[1] | |||
| Compound Name |
Benzyl (2S)-3-methyl-2-[[2-[2-[[2-[2-[[(2S)-3-methyl-1-oxo-1-phenylmethoxybutan-2-yl]amino]-2-oxoethoxy]phenyl]diazenyl]phenoxy]acetyl]amino]butanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170116; BDBM50378788
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| Activity |
Ki = 125000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[2-[2-[[2-[2-[[(2S)-1-[[(1S)-1-Carboxy-2-phenylethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethoxy]phenyl]diazenyl]phenoxy]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170298; BDBM50378793
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| Activity |
Ki = 140000 nM
|
[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[[2-[2-[[2-[2-[[(1S)-1-Carboxy-2-phenylethyl]amino]-2-oxoethoxy]phenyl]diazenyl]phenoxy]acetyl]amino]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170119; BDBM50378791
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| Activity |
Ki = 225000 nM
|
[1] | |||
| Compound Name |
2-[[2-[2-[[2-[2-(Carboxymethylamino)-2-oxoethoxy]phenyl]diazenyl]phenoxy]acetyl]amino]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1170606; BDBM50378792
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| Activity |
Ki = 265000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | C(2)-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3977-81. | ||||
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