Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67619 | Target Info | |||
| Target Name | RAC-alpha serine/threonine-protein kinase (AKT1) | ||||
| Synonyms |
RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; PKB alpha
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | AKT1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 162 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Niclosamide
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
Click to Show/Hide
|
||||
| Activity |
IC50 = 59400 nM
|
[1] | |||
| Compound Name |
ABT-869
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
Linifanib; ABT 869; S1003_Selleck; AL-39324; RG-3635; ABT869, Linifanib, AL-39324, RG3635; N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea; N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Genistein
Click to Show/Hide
|
Phase 2/3 | Compound Info | ||
| Synonyms |
Bonistein; GEN; Genestein; Genisteol; Genisterin; Prunetol; Sophoricol; Differenol A; G 6649; G10000; IN1327; NPI 031L; STO514; TNP00151; GENISTEIN (ENDOCRINE DISRUPTER); Lactoferrin-genistein; PTI G4660 (Genistein); PTI-G4660; SIPI 807-1; C.I. 75610; SIPI-9764-I; ENDOCRINE DISRUPTOR (GENISTEIN) (SEE ALSO GENISTEIN (446-72-0)); 4 inverted exclamation marka,5,7-Trihydroxyisoflavone; ,5,7-Trihydroxyisoflavone; 4',5, 7-Trihydroxyisoflavone; 4',5,7-Trihydroxy isoflavone; 4',5,7-Trihydroxyisoflavone; 4,5,7-Trihydroxyiso-flavone; 4,6,7-Trihydroxyisoflavone; 5,7,4'-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 70000 nM
|
[3] | |||
| Compound Name |
BMS-509744
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BMS-509744; 439575-02-7; BMS 509744; CHEMBL209148; N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3,3-dimethylbutan-2-ylamino)methyl]benzamide; GTPL9994; SCHEMBL14460651; KS-00001CVA; CHEBI:91404; MolPort-039-101-283; C32H41N5O4S2; BMS509744; BDBM50186460; 3499AH; compound 3 [PMID:16682193]; AKOS025142036; NCGC00229512-02; NCGC00229512-01
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
U0126
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
U0126; 109511-58-2; U-0126; U 0126; 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene; UNII-8027P94HLL; CHEBI:64208; 8027P94HLL; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile; FT-1069-1; 218601-62-8; Succinonitrile, bis(amino(o-aminophenylthio)methylene)-; Butanedinitrile, bis(amino((2-aminophenyl)thio)methylene)-; C18H16N6S2; (2z)-Bis{amino[(2-Aminophenyl)sulfanyl]methylidene}butanedinitrile; (2Z,3Z)-bis{amino[(2-aminophenyl)sulfanyl]methylene}succinonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[5] | |||
| Compound Name |
AM7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrimidone, 22; AM 7; AM-7
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Ro-4396686
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5809947; CHEMBL606964
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125000 nM
|
[7] | |||
| Compound Name |
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL357756; CHEMBL3822972; BDBM206104; DB-085143; US9255110, 17
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
p38 MAP Kinase Inhibitor IX
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259922; Kinome_3519; SCHEMBL16576573; CTK8G2239; BDBM50376226; 4-methyl-N-(1,2-oxazol-3-yl)-3-[(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
6-Chloro-5-[(3,5-dimethylphenyl)sulfanyl]-1H-indazole-4,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221222; CTK3H4898; DTXSID40658867; BDBM50195184; 6-chloro-5-(3,5-dimethylphenylthio)-1H-indazole-4,7-dione; 1H-Indazole-4,7-dione, 6-chloro-5-[(3,5-dimethylphenyl)thio]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
3-(5-Chloro-2-{[1-(dimethylamino)propan-2-yl]oxy}phenyl)-1-(5-cyanopyrazin-2-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
urea-based inhibitor 2d; A-690002; CHEMBL425904; SCHEMBL5865729; BDBM14829; 1-[5-chloro-2-[1-(dimethylamino)propan-2-yloxy]phenyl]-3-(5-cyanopyrazin-2-yl)urea; (+/-)1-[5-Chloro-2-(2-dimethylamino-1-methyl-ethyloxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
WYE-354; WYE 354; pyrazolo pyrimidine, 19; cc-506; MLS006011008; SCHEMBL300431; CHEMBL561708; GTPL9361; WYE354; BDBM35587; DTXSID00657912; C24H29N7O5; HMS3654N09; BCP02898; ZINC43013490; CCG-264882; CS-0183; SB19260; NCGC00242484-01; NCGC00242484-02; NCGC00242484-09; AC-28454; AS-55957; HY-12034; SMR004702806; BCP0726000260; DB-059456; FT-0675866; S1266; SW219671-1; X7422; W-5702; J-001552; J-514253; BRD-K77008974-001-01-6; Q27166532; mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
N-[4-(1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593946; N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)acetamide; Oprea1_858091; SCHEMBL288427; ZINC68398; BDBM50304370; AKOS000650091; MCULE-5354564551
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
1-{1-[(4-{5-[(4-Hydroxyphenyl)methyl]-6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl}phenyl)methyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazinone 14d; CHEMBL3143723; BDBM15157
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779202; SCHEMBL897210; BDBM50344664; 6,6-dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
(R)-3-(6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)acrylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602471; BDBM50306677
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
N-(4-(N-1,3,4-Thiadiazol-2-ylsulfamoyl)phenyl)-2-(2-(2-methoxyethoxy)ethoxy)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611216; SCHEMBL11891687; BDBM50304371
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[13] | |||
| Compound Name |
5-[[4-[(4-Aminophenyl)sulfonylamino]phenyl]sulfonylamino]-1,3,4-thiadiazole-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL328336; CHEMBL3910424; BDBM223485; US9320734, 456
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
6-Chloro-5-(4-fluoroanilino)-1H-indazole-4,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223410; CTK3H4904; DTXSID80658861; BDBM50195191; 6-chloro-5-((4-fluorophenyl)amino)-1h-indazole-4,7-dione; 6-chloro-5-(4-fluorophenylamino)-1H-indazole-4,7-dione; 1H-Indazole-4,7-dione, 6-chloro-5-[(4-fluorophenyl)amino]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
CID 49806721
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
4-Hexyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1685047; SCHEMBL283518; BDBM50338947
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[13] | |||
| Compound Name |
4-Amino-n-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-amino-N-(1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide; CHEMBL286737; NSC35261; SCHEMBL282714; DTXSID50873827; ZINC1667535; 2-Sulfanilamido-1,3,4-thiadiazole; BDBM50034417; NSC-35261; AKOS000205626; NE45475; DS-010280; A1-13781; 4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamide; Benzenesulfonamide,4-amino-n-1,3,4-thiadiazol-2-yl-; Benzenesulfonamide, 4-amino-N-1,3,4-thiadiazol-2-yl-; N-(1,3,4-Thiadiazole-2-yl)-4-aminobenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[13] | |||
| Compound Name |
1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081198; SCHEMBL5480112; BDBM50312153
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[17] | |||
| Compound Name |
1-Phenyl-4-methoxy-2-butene-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099613; BDBM50444879; ZINC103230557; (E)-4-methoxy-1-phenylbut-2-en-1-one; (2E)-4-methoxy-1-phenyl-2-buten-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[18] | |||
| Compound Name |
4-Butyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1685046; SCHEMBL282536; BDBM50338946
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[13] | |||
| Compound Name |
N-{4-[(2,6-Dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}furan-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)-2-furamide; SMR000060020; Oprea1_193777; MLS000081953; MLS000879870; SCHEMBL328331; ARONIS007031; CHEMBL1533790; REGID_for_CID_1241577; BDBM223483; HMS2429C22; ZINC1045347; CCG-55610; STL070905; AKOS000496890; MCULE-2815604861; KS-00003Z76; AB00426477-10; US9320734, 445; SR-01000644627-1; Z56761936; F0016-0866; N-(4-(N-(2,6-dimethoxypyrimidin-4-yl)sulfamoyl)phenyl)furan-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
5-(8-Quinolylsulfonylamino)-1,3,4-thiadiazole-2-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC699000; CHEMBL1994702; SCHEMBL10108478; BDBM223475; ZINC3923941; AKOS024355645; MCULE-7128935002; NSC-699000; NCI60_035403; ST50983081; US9320734, 345; 5-[(8-quinolylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide; N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)-8-quinolinesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
1H-Indazole-4,7-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376871; SCHEMBL4951467; CTK3H4907; DTXSID70596920; BDBM50195194; ZINC40762769; AKOS006353049; MB14896; CS-0110433
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
6-Chloro-5-(3,5-difluoroanilino)-1H-indazole-4,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223464; CTK3H4903; DTXSID40658862; BDBM50195185; 6-chloro-5-(3,5-difluorophenylamino)-1H-indazole-4,7-dione; 1H-Indazole-4,7-dione, 6-chloro-5-[(3,5-difluorophenyl)amino]-; 6-chloro-5-((3,5-difluorophenyl)amino)-1h-indazole-4,7-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
1-(1-{[4-(5-Benzyl-6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl)phenyl]methyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazinone 14c; SCHEMBL3979061; CHEMBL3143722; BDBM15155
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
2-(6-((R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL602472; BDBM50306684; CH-5234152
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[16] | |||
| Compound Name |
3-[3-({5-[(E)-2-(Pyridin-4-yl)ethenyl]pyridin-3-yl}oxy)propyl]-1H-indole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205836; BDBM15093; trans-bispyridinylethylene analog 7b
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[19] | |||
| Compound Name |
(2S)-1-[(2S)-2-[(2-Acetamidoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-[4-[[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]-2-methylanilino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505490
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[20] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[21] | |||
| Compound Name |
1-[1-({4-[5-(Butan-2-yl)-6-oxo-3-phenyl-1,6-dihydropyrazin-2-yl]phenyl}methyl)piperidin-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazinone 14e; SCHEMBL2439485; SCHEMBL3979847; CHEMBL3143721; BDBM15159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
2-[2-(3-Acetamidophenyl)tetrazol-5-yl]sulfanyl-N-(thiophen-2-ylmethyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915460; Oprea1_174720; SCHEMBL15037550; ZINC4324656; BDBM50358103; CCG-40721; MCULE-3925219236; SR-01000630846-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[22] | |||
| Compound Name |
1-[1-({4-[6-(2-Methylpropyl)-5-oxo-3-phenyl-4,5-dihydropyrazin-2-yl]phenyl}methyl)piperidin-4-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362016; pyrazinone 13f; SCHEMBL2437301; SCHEMBL2439564; BDBM15160
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
N-(2,6-Dimethoxypyrimidin-4-yl)-4-(furan-2-ylamino)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL328335; CHEMBL3987198; BDBM223473; US9320734, 444
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
2-{[2-(Anilinocarbonyl)anilino]carbonyl}benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CDS1_004013; CBMicro_017517; Oprea1_549009; Oprea1_675014; MLS001178709; DivK1c_005053; SCHEMBL328588; ARONIS017135; CHEMBL1733315; BDBM223481; HMS2805A20; ZINC668345; CCG-6196; KS-000049MM; STK003244; AKOS000483615; MCULE-5623236718; SMR000477052; ST034079; BIM-0017468.P001; AB00080778-01; AN-329/10742058; SR-01000405841; US9320734, 439; SR-01000405841-1; 2-{[2-(phenylcarbamoyl)phenyl]carbamoyl}benzoic acid; 2-({[2-(anilinocarbonyl)phenyl]amino}carbonyl)benzoic acid; 2-{N-[2-(N-phenylcarbamoyl)phenyl]carbamoyl}benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
Acetamide, N-(4-(((2,6-dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-[4-[(2,6-dimethoxypyrimidin-4-yl)sulfamoyl]phenyl]acetamide; UNII-9K98HZI4W8; 9K98HZI4W8; N-{4-[(2,6-dimethoxypyrimidin-4-yl)sulfamoyl]phenyl}acetamide; N-(4-(((2,6-Dimethoxy-4-pyrimidinyl)amino)sulfonyl)phenyl)acetamide; Sulfadimethoxine N4-Acetate; N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)acetamide; N4-Acetylsulphadimethoxine; Oprea1_011961; Oprea1_678202; MLS000123077; CHEMBL1349361; CTK1H2935; DTXSID10204077; BDBM223484; HMS2438L15; ZINC826341; N-[4-(2,6-Dimethoxy-pyrimidin-4-ylsulfamoyl)-phenyl]-acetamide; MFCD00580046; STK834145; AKOS000747068; MCULE-8706179642; NCGC00245475-01; SMR000123686; N4-Acetylsulfadimethoxine, analytical standard; US9320734, 450; N4-Acetyl-N1-(4,6-dimethoxy-2-pyrimidinyl)sulfanilamide; N-[4-(2,6-Dimethoxypyrimidin-4-ylsulfamoyl)phenyl]acetamide; 4-Acetylamino-N-(4,6-dimethoxy-pyrimidin-2-yl)benzenesulfonamide; N-(p-(2,6-Dimethoxy-4-pyrimidinylaminosulfonyl)phenyl)acetamide; N-(4-([(2,6-Dimethoxy-4-pyrimidinyl)amino]sulfonyl)phenyl)acetamide #
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-acetamido-N-(4-{[(1S)-2-methyl-1-{[(1S)-1-{[2-(naphthalen-2-yl)ethyl]carbamoyl}-2-phenylethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246327; BDBM50204353
Click to Show/Hide
|
||||
| Activity |
IC50 = 51000 nM
|
[23] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 22ea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444400; BDBM31451
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[20] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}-N-(4-{[(1S)-1-{[(1S)-1-(hexylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396589; BDBM50204357
Click to Show/Hide
|
||||
| Activity |
IC50 = 52000 nM
|
[23] | |||
| Compound Name |
Artocarpesin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915458; 2',4',5,7-Tetrahydroxy-6-(3-methyl-2-butenyl)flavone; 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)chromen-4-one; NSC710343; CTK4G7464; DTXSID30327994; ZINC1658458; BDBM50358100; LMPK12110892; NSC-710343; NCI60_038828; FT-0721720; Flavone,4',5,7-tetrahydroxy-6-(3-methyl-2-butenyl)-; 4H-1-Benzopyran-4-one,4-dihydroxyphenyl)-5,7-dihydroxy-6-(3-methyl-2-butenyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 54480 nM
|
[22] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 21be
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448003; BDBM31440
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[20] | |||
| Compound Name |
Tert-butyl (1-(4-(9H-benzo[f]pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)benzoyl)piperidin-4-yl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3684519; SCHEMBL12195927; BDBM103233; US8541407, 210
Click to Show/Hide
|
||||
| Activity |
IC50 = 56000 nM
|
[24] | |||
| Compound Name |
5-(Benzylamino)quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960835; SCHEMBL15054726; BDBM181344; US9139568, 97
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[25] | |||
| Compound Name |
N-[(S)-1-((S)-1-Benzylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-4-[(tert-butylcarbamoyl-methyl)-(5-guanidino-pentanoyl)-amino]-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391132; BDBM50204329
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[23] | |||
| Compound Name |
3-[3-[(2-Methoxyphenyl)methyl]imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177841; BDBM50397807
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[26] | |||
| Compound Name |
3-[5-[(E)-(2-Amino-3,7-dicyano-4,6-dimethyl-cyclopenta[b]pyridin-5-ylidene)methyl]-2-furyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL193261; SCHEMBL6742722; SMSF0011413; ZINC2121591; AKOS000610351; CB12779; BIM-0009727.P001
Click to Show/Hide
|
||||
| Activity |
IC50 = 60200 nM
|
[27] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}-N-(4-{[(1S)-2-methyl-1-{[(1S)-1-{[2-(naphthalen-1-yl)ethyl]carbamoyl}-2-phenylethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269433; BDBM50204348
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[23] | |||
| Compound Name |
N12C3=CC=CC=C3N(C)C3=CC=CC=C3C2=NN=C1C1=CC=C(C=CC=C2)C2=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2510200; CHEMBL3679723; BDBM103037; US8541407, 14
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[24] | |||
| Compound Name |
5-(Pyridin-3-ylmethylamino)quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972029; SCHEMBL15054362; BDBM181309; US9139568, 62
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[25] | |||
| Compound Name |
C1CC(N)Ccn1C(=O)C1=CC=C(C=2N3C4=CC=CN=C4NC4=CC=CC=C4C3=NN=2)C=C1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2504922; CHEMBL3684520; BDBM103234; US8541407, 211
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[24] | |||
| Compound Name |
N-(4-Methoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036868; BDBM50385177
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[28] | |||
| Compound Name |
N-((S)-1-((S)-1-(Benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-guanidinobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393645; BDBM50204339
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[23] | |||
| Compound Name |
(2S)-1-[(2S)-2-[(2-Acetamidoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-[4-[[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]-3-naphthalen-1-ylanilino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL507059
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[20] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 22da
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL451291; BDBM31450
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[20] | |||
| Compound Name |
(2S)-N-[(1S)-1-(Benzylcarbamoyl)-2-phenylethyl]-2-({4-[(2S)-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}propanamido]phenyl}formamido)-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396644; BDBM50204336
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[23] | |||
| Compound Name |
3-Methyl-4-phenyl-1H-pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Methyl-4-phenylpyrazole; 5-methyl-4-phenyl-1H-pyrazole; 3-Methyl-4-phenylpyrazol; CHEMBL228114; MFCD00051752; ACMC-1BRBB; Maybridge1_003313; 5-methyl-4-phenylpyrazole; pyrazole-based inhibitor 1; SCHEMBL105178; 3-methyl-4-phenyl-1H-pyrazol; 4-Phenyl-5-methyl-1H-pyrazole; BDBM16211; CTK3J4384; HMS550O13; DTXSID90160349; 1H-Pyrazole,3-methyl-4-phenyl-; 3-Methyl-4-phenyl-1H-pyrazole #; ALBB-006850; KS-00000NO5; ZINC4692749; 6627AA; ANW-72592; SBB048410; STK504166; AKOS000265029; AKOS015899729; AS06545; CM10492; CS-W016200; MCULE-1577784164; 3-METHYL-4-PHENYL-2H-PYRAZOLE; AK-33201; CD 09292; DB-063215; 3-Methyl-4-phenyl-1H-pyrazole, AldrichCPR; FT-0616095; ST50824692; Y-8098; 12T-0222; J-512860; J-640176; J-800178; Q27460932
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[29] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 22ca
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469523; BDBM31449
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[20] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 21ba
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444649; BDBM31436
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[20] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 21bd
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510540; BDBM31439
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[20] | |||
| Compound Name |
(E)-1-[2,4-Dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(3-hydroxyphenyl)prop-2-en-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1915456; BDBM50358098
Click to Show/Hide
|
||||
| Activity |
IC50 = 85900 nM
|
[22] | |||
| Compound Name |
4-[2-(4-Methylphenyl)-5-(piperidin-4-ylmethoxy)pyridin-3-yl]benzenecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759201; BDBM50142238; 8WC
Click to Show/Hide
|
||||
| Activity |
IC50 = 87600 nM
|
[30] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-acetamido-N-(4-{[(1S)-2-methyl-1-{[(1S)-1-{[2-(naphthalen-1-yl)ethyl]carbamoyl}-2-phenylethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246537; BDBM50204354
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[23] | |||
| Compound Name |
6-Phenyl-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL262623; Kinome_3598; BDBM50376344
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[31] | |||
| Compound Name |
(2S)-N-(4-{[(1S)-1-{[(1S)-1-{[2-(4-Benzylpiperidin-1-yl)ethyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437188; BDBM50204346
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[23] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 21aa
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513216; BDBM31435
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[20] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}-N-(4-{[(1S)-2-methyl-1-{[(1S)-1-{[(4-pentylphenyl)methyl]carbamoyl}-2-phenylethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397075; BDBM50204335
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[23] | |||
| Compound Name |
Chembl4170467
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50449753
Click to Show/Hide
|
||||
| Activity |
IC50 = 98330 nM
|
[32] | |||
| Compound Name |
Tert-butyl N-[benzyl-(2-chloroacetyl)amino]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298610; BDBM50022560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
3-Methyl-4-(2-phenoxyacetamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199759; BDBM50175252
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL456294; Calicoferol I; USFQLAVWHQCNDG-AYEIPMSGSA-; BDBM50358248; LMST03020180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
Calicoferol E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL456936; (8S)-3-hydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-one; BDBM50358246; LMST03020157
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-(4-methylphenyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036726; BDBM50385172
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
6-Phenyl-7,8-dihydro-9H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259380; BDBM50376351
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
6-(3-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263902; BDBM50376350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036728; BDBM50385170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-(2-Methoxyethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611079; BI-90H9; BDBM50310148
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Cyclapolin 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin-9; CHEMBL476124; 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide; 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide; SCHEMBL5055142; CTK8I6133; AOB5979; ZINC2577648; BDBM50263697; AKOS024457436; HY-15159; CS-0003792; 7-Nitro-5-(trifluoromethyl)-2-Benzothiazolecarboxamide 3-oxide; 2-(aminocarbonyl)-7-nitro-5-(trifluoromethyl)-1,3-benzothiazol-3-ium-3-olate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-(3,4-Dimethoxyphenethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599111; BI-90H10; BDBM50310146
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
7-[[(1R,2S,4Ar,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-5-methoxy-2-methyl-1,3-benzoxazol-6-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109402; BDBM50446565
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
5-[4-(3,4-Difluorophenyl)piperazin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932697; SCHEMBL15060295; BDBM181339; US9139568, 92
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-(2-chloroethylamino)-1-oxo-3-phenylpropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298515; BDBM50022558
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
Tert-butyl N-[(2S)-3-oxo-1-phenylpentan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2603668; CHEMBL3358446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
5-[3-(Aminomethyl)piperidin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3947957; SCHEMBL15073448; BDBM181303; US9139568, 56
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[4-(3-Chlorophenyl)piperazin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943330; SCHEMBL15059846; BDBM181343; US9139568, 96
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[3-Fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AMG-51; pyrimidone, 51; AMG51; CHEMBL453737; SCHEMBL2868963; AMG-51;AMG 51; BDBM24769; SYN1111; C34H33F2N5O5; BCP21618; ZINC43178754; NCGC00263201-01; NCGC00263201-02; AS-16255
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-[4-(5-Chloro-2-methylphenyl)piperazin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3969122; SCHEMBL15060158; BDBM181358; US9139568, 111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[2-Phenylethyl-[(3R)-piperidin-3-yl]amino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4108594; SCHEMBL16163311; BDBM181352; US9139568, 105
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL609039; BI-90H6; BDBM50310142
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-(2-iodoethylamino)-1-oxo-3-phenylpropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298513; BDBM50022552
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
5-[(2-Phenyl-2-piperazin-1-ylethyl)amino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931144; SCHEMBL15055213; BDBM181316; US9139568, 69
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
3-[[4-(1-Methylbenzimidazol-2-yl)pyrimidin-2-yl]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036870; BDBM50385178
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Methyl 3-(piperidin-1-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200348; BDBM50175233
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
2,3,6,8-Tetrahydroxy-1-methylxanthone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Anomalin A; CHEMBL454440; 2,3,6,8-tetrahydroxy-1-methylxanthen-9-one; DTXSID601017507; BDBM50350424; ZINC14761282; MCULE-3078868213; NCGC00381290-01!2,3,6,8-tetrahydroxy-1-methylxanthen-9-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
5-[4-(3-Chloro-4-fluorophenyl)piperazin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906249; SCHEMBL15060401; BDBM181341; US9139568, 94
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[4-(3,4-Dichlorophenyl)piperazin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911505; SCHEMBL15059364; BDBM181357; US9139568, 110
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Calicoferol C
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515982; BDBM50358249
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
5-[[(3R)-Pyrrolidin-3-yl]methylamino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4110740; SCHEMBL15054993; BDBM181307; US9139568, 60
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Tert-butyl N-[(2S)-1-(2-bromoethylamino)-1-oxo-3-phenylpropan-2-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298514; BDBM50022557
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201511; SCHEMBL1155440; BDBM47167; CTK3C7420; DTXSID40468140; US8957103, Z1; 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-; 3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407532; BDBM50376348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N-Sec-Butyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL599518; BI-98A10; BDBM50310147
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Calicoferol B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL464351; BDBM50358250
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
Astrogorgiadiol B
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ASTROGORGIADIOL; (8S,9R)-9,10-seco-1,3,5(10)-cholestatriene-3,9-diol; LMST03020242; CHEMBL517956; SCHEMBL4865385; BDBM50358247
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407265; BDBM50376347
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
4-(1-Methylbenzimidazol-2-yl)-N-phenylpyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036725; BDBM50385171
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-(2-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371695; BDBM50175235
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
5-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919249; SCHEMBL15060311; BDBM181337; US9139568, 90
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[[1-(3-Methylphenyl)piperidin-4-yl]amino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921030; SCHEMBL15073694; BDBM181304; US9139568, 57
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin 1; 2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-3-oxide; SCHEMBL5062617; CHEMBL1222044; CTK2H1083; DTXSID10429521; 7-nitro-3-oxido-5-(trifluoromethylsulfanyl)-1,3-benzothiazol-3-ium-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(3S,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338335; BDBM50431025
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-Methoxy-5-[[4-(1-methylbenzimidazol-2-yl)pyrimidin-2-yl]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036866; BDBM50385175; NSC-750416
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
5-[[2-(3-Chlorophenyl)-2-(dimethylamino)ethyl]amino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908671; SCHEMBL15055282; BDBM181315; US9139568, 68
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[2-(3,4-Dichlorophenyl)ethylamino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902499; SCHEMBL15055419; BDBM181351; US9139568, 104
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-(4-Phenylbutylamino)quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932743; SCHEMBL15055454; BDBM181349; US9139568, 102
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
6-(3-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259381; BDBM50376346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(3R,5E)-1-Methyl-3-(pyridin-2-ylmethyl)-5-(pyridin-2-ylmethylidene)piperidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2338334; BDBM50431026
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
4-[[4-(1-Methylbenzimidazol-2-yl)pyrimidin-2-yl]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036869; BDBM50385174
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
6-(4-Methylphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL405233; BDBM50376349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
Calicoferol A
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(22E)-(8S)-3-hydroxy-9,10-seco-1,3,5(10),22-cholestatetraen-9-one; LMST03020605; CHEMBL518060; BDBM50358244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
5-[4-(4-Fluorophenyl)piperazin-1-yl]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923951; SCHEMBL15060296; BDBM181355; US9139568, 108
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
6-(4-Chlorophenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL260620; BDBM50376345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
5-(3-Hydroxy-3-phenylpyrrolidin-1-yl)quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890779; SCHEMBL15057666; BDBM181313; US9139568, 66
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-(2-((3-(Dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yl)oxy)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-MT-63; 2-(Methylamino)triazine 63; CHEMBL373882; SCHEMBL1264383; BDBM15000
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[42] | |||
| Compound Name |
5-(3-Phenylmethoxypyrrolidin-1-yl)quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945508; SCHEMBL15054652; BDBM181312; US9139568, 65
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
2-Chloro-4-[[4-(1-methylbenzimidazol-2-yl)pyrimidin-2-yl]amino]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036865; BDBM50385179
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-(3-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199657; BDBM50175253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
5-[(1-Methylpyrrolidin-3-yl)amino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948835; SCHEMBL15055191; BDBM181305; US9139568, 58
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
4-(1H-Indole-4-ylamino)-5-[3-[2-(4-methylpiperazino)ethoxy]phenyl]pyridine-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467321; SCHEMBL2971392; BDBM29824; 4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 12d; 4-(1H-indol-4-ylamino)-5-[3-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]pyridine-3-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
N-(4-Ethoxyphenyl)-4-(1-methylbenzimidazol-2-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036867; BDBM50385176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d]-[1]benzazepin-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603463; BDBM50308188; NSC-743304
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Methyl 3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200586; SCHEMBL14163466; BDBM50175248; ZINC28564886
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
1,3-Dimethyl-7-(1-methylbenzimidazol-2-yl)pyrido[2,3-d]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2036871; BDBM50385180
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
4-(4-Chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199658; BDBM50175244
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
N'-Acryloyl-N'-benzylhydrazinecarboxylic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298928; BDBM50022563; ZINC169325681; A1-04053; N'-Acryloyl-N'-benzyl-hydrazinecarboxylic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
5-[[(3S)-Pyrrolidin-3-yl]methylamino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942427; SCHEMBL15054836; BDBM181308; US9139568, 61
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Rel-Astrogorgol F
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922224; BDBM50358243
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
4(3H)-Pyrimidinone,2-[(4-fluorophenyl)amino]-5-[5-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]-2-pyridinyl]-3-methyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrimidone, 62; CHEMBL447602; SCHEMBL13511902; BDBM24772; ZINC43202030
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
24-Exomethylenecalicoferol E
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922225; BDBM50358245
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
Methyl 2-(5-carbamoyl-3-methyl-1H-thieno[2,3-c]pyrazol-4-ylamino)-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370199; BDBM50175250
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
5-[[4-[3-(Trifluoromethoxy)phenyl]pyrrolidin-3-yl]amino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896544; SCHEMBL15055417; BDBM181319; US9139568, 72
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Norlichexanthone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one; 9H-xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; CHEMBL466154; 1,3,6-trihydroxy-8-methylxanthen-9-one; 1,3,6-trihydroxy-8-methyl-xanthen-9-one; 3,6,8-Trihydroxy-1-methylxanthone; Fusarindin; AC1NQYTV; Xanthen-9-one, 1,3,6-trihydroxy-8-methyl-; C10087; ACon0_000599; ACon1_001113; CTK4E4931; DTXSID20174777; 1,3,6-trihydroxy-8-methylxanthone; ZINC5765089; BDBM50350423; AKOS000365318; MCULE-8777096541; NCGC00169665-01; W2650; 1,3,6-Trihydroxy-8-methyl-9H-xanthen-9-one #; BRD-K97951054-001-01-6; Q27107546; NCGC00169665-03!1,3,6-trihydroxy-8-methylxanthen-9-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-acetamido-N-(4-{[(1S)-2-methyl-1-{[(1S)-1-{[(4-pentylphenyl)methyl]carbamoyl}-2-phenylethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394250; BDBM50204352
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[23] | |||
| Compound Name |
Quinazolin-7-yl, 15a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501390; BDBM31453
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[20] | |||
| Compound Name |
(2S)-N-(4-{[(1S)-1-{[(1S)-1-(Benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)-5-carbamimidamido-2-acetamidopentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245659; BDBM50204350
Click to Show/Hide
|
||||
| Activity |
IC50 = 119000 nM
|
[23] | |||
| Compound Name |
N-((S)-1-((S)-1-(Benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(2-guanidinoethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248369; BDBM50204347
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[23] | |||
| Compound Name |
4-[5-[(E)-(2-Amino-3,7-dicyano-4,6-dimethylcyclopenta[b]pyridin-5-ylidene)methyl]furan-2-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365978; ZINC1833348
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[27] | |||
| Compound Name |
Indole-aryl scaffold, 36a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471216; BDBM31457
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[20] | |||
| Compound Name |
4-Phenyl-1H-pyrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Phenylpyrazole; 1H-Pyrazole, 4-phenyl-; Pyrazole, 4-phenyl-; 4-(C6H5)-pyrazole; CHEMBL390066; MFCD00462204; 4-Phenyl-1H-pyrazole #; pyrazole-based inhibitor 5; SCHEMBL82741; JMC514968 Compound 35; BDBM16215; CTK0H9678; DTXSID80144491; ABLOCK AB-12-2432; BCP09906; KS-00000P6I; ZINC3164652; AKOS005198822; AB06118; AS06546; CM10493; CS-W022231; MCULE-5589155043; NCGC00333584-01; AK-30224; BS-13375; SY028300; AB0134942; DB-058747; FT-0646841; EN300-07023; K-0273; AB01329407-02; J-515933; Z56940955
Click to Show/Hide
|
||||
| Activity |
IC50 = 135000 nM
|
[29] | |||
| Compound Name |
Chembl4168160
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50449752
Click to Show/Hide
|
||||
| Activity |
IC50 = 138330 nM
|
[32] | |||
| Compound Name |
Desmethylxanthohumol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466143; Demethylxanthohumol; MEGxp0_001775; ACon1_001231; ZINC5158935; BDBM50358099; NCGC00169552-01; HY-122966; CS-0090765; J3.588.293F; C16416; Q27149540; 1-(2,4,6-Trihydroxy-3-prenylphenyl)-3-(4-hydroxyphenyl)acrylaldehyde
Click to Show/Hide
|
||||
| Activity |
IC50 = 143900 nM
|
[22] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 21bc
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499846; BDBM31438
Click to Show/Hide
|
||||
| Activity |
IC50 = 152000 nM
|
[20] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 22ba
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457309; BDBM31448
Click to Show/Hide
|
||||
| Activity |
IC50 = 158000 nM
|
[20] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-acetamido-N-(4-{[(1S)-1-{[(1S)-1-(hexylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391793; BDBM50204345
Click to Show/Hide
|
||||
| Activity |
IC50 = 163000 nM
|
[23] | |||
| Compound Name |
4-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-2-phenylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505303
Click to Show/Hide
|
||||
| Activity |
IC50 = 173000 nM
|
[20] | |||
| Compound Name |
3-(4-Tert-butylphenyl)-2-pyridin-3-ylimidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177844; BDBM50397806
Click to Show/Hide
|
||||
| Activity |
IC50 = 185000 nM
|
[26] | |||
| Compound Name |
N-(4-{[(1S)-1-{[(1S)-1-(Benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)-5-carbamimidamidopentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396530; BDBM50204333
Click to Show/Hide
|
||||
| Activity |
IC50 = 193000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 27 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Phenylaminoethyl guanidine deriv., 21bb
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL446065; BDBM31437
Click to Show/Hide
|
||||
| Activity |
IC50 = 215000 nM
|
[20] | |||
| Compound Name |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-[2-(carboxyamino)acetamido]pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-carbamoylpropanamido]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231257; BDBM50204340
Click to Show/Hide
|
||||
| Activity |
IC50 = 229000 nM
|
[23] | |||
| Compound Name |
Quinazolin-6-yl, 15b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471217; BDBM31454
Click to Show/Hide
|
||||
| Activity |
IC50 = 232000 nM
|
[20] | |||
| Compound Name |
(2S)-N-[(1S,2R)-1-{[(1S,2R)-1-{[(1S)-1-{[(1S)-1-(Benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-2-hydroxypropyl]-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245933; BDBM50204331
Click to Show/Hide
|
||||
| Activity |
IC50 = 239000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[(2R)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-sulfanylpropanamido]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437388; BDBM50204355
Click to Show/Hide
|
||||
| Activity |
IC50 = 241000 nM
|
[23] | |||
| Compound Name |
2-[4-(3-Phenylquinoxalin-2-yl)phenyl]propan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Akt-I-1,2; alpha,alpha-Dimethyl-4-(3-phenyl-2-quinoxalinyl)benzenemethanamine; 2,3-diphenylquinoxaline 1; CHEMBL362455; SCHEMBL4605370; BDBM15148; DTXSID00431315; BCPP000420; ZINC14957904; BCP9000267; NCGC00345823-01; NCGC00345823-02; DB-070790; FT-0747552; 382D488
Click to Show/Hide
|
||||
| Activity |
IC50 > 250000 nM
|
[45] | |||
| Compound Name |
Phenylaminoethyl guanidine deriv., 22aa
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL457630; BDBM31447
Click to Show/Hide
|
||||
| Activity |
IC50 = 253000 nM
|
[20] | |||
| Compound Name |
4-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-3-phenylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444220
Click to Show/Hide
|
||||
| Activity |
IC50 = 288000 nM
|
[20] | |||
| Compound Name |
3-[6-Bromo-3-(4-tert-butylphenyl)imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177845; SCHEMBL2191936; BDBM50397802
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
3-(4-Tert-butylphenyl)-2-pyridin-4-ylimidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177839; BDBM50397805
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
6-Bromo-3-[(2-methoxyphenyl)methyl]-2-pyridin-4-ylimidazo[4,5-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177843; BDBM50397803
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
3-[3-(3-Tert-butylphenyl)imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177846; BDBM50397801
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
3-[6-Bromo-3-[(2-methoxyphenyl)methyl]imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177842; BDBM50397804
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[26] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}-N-(4-{[(1S)-1-{[(1S)-1-{[3-(3-acetamidophenoxy)propyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395678; BDBM50204337
Click to Show/Hide
|
||||
| Activity |
IC50 = 322000 nM
|
[23] | |||
| Compound Name |
N-[(S)-1-((S)-1-Benzylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-4-(2-guanidino-ethylamino)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245587; BDBM50204343
Click to Show/Hide
|
||||
| Activity |
IC50 = 390000 nM
|
[23] | |||
| Compound Name |
7-Azaindole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Pyrrolo[2,3-b]pyridine; 1,7-Diazaindene; 7H-Pyrrolo[2,3-b]pyridine; 7-Aza-1-pyrindine; 1,7-Dideazapurine; 1H-PYRROLO(2,3-b)PYRIDINE; MFCD00005606; pyrrolo[2,3-b]pyridine; 7-aza-indole; UNII-QX4465NR9T; 7H-Pyrrolo(2,3-b)pyridine; 7-Azaindole, 98%; 1 h-pyrrolo[2,3:b]pyridine; QX4465NR9T; Pyrrolo(2,3-b)pyridine; WLN: T56 BM INJ; EINECS 205-981-0; NSC 67063; 7-azaindol; 7-aza indole; pyrrolo[b]pyridine; zlchem 221; PubChem7679; ACMC-20lk5f; ACMC-1CKM0; pyrrolo[2,3-b]-pyridine; NCIOpen2_000707; SCHEMBL17837; KSC202K2D; 1-H-pyrrolo[2,3-b]pyridine; 1H-pyrrolo(2,3-b)-pyridine; CHEMBL389685; DTXSID3075046; BDBM16223; CTK1A2521; CTK2J8336; ZLC0029; WT674; ACN-S002680; ACT02468; ALBB-006259; BCP26852; CS-B0516; KS-000002OI; NSC67063; NSC77951; STR01850; ANW-26142; BBL008683; HTS000456; MFCD00075874; NSC-67063; NSC-77951; SBB004295; SC1771; STK503791; ZINC15442276; AKOS000446848; AC-1215; AS07114; CM14215; LS21042; MCULE-6621126582; PB32078; PS-4533; QC-3424; NCGC00188278-01; AK-26735; BR-26735; SC-03043; SY001940; AB0005988; DB-016106; AM20070247; FT-0604377; P1117; ST51044413; EN300-25796; A-9500; C-8859; Z-9562; 38720-EP2272517A1; 38720-EP2292615A1; 38720-EP2295433A2; 38720-EP2303879A1; 38720-EP2311837A1; 72278-EP2272517A1; 72278-EP2308867A2; 72278-EP2308870A2; 271A636; 271-63-6 7-azaindole; Q27287542; F0001-0881
Click to Show/Hide
|
||||
| Activity |
IC50 > 398107.17 nM
|
[46] | |||
| Compound Name |
1H-Indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
INDAZOLE; 1H-Benzopyrazole; 2H-indazole; Isoindazole; 2-Azaindole; 1,2-Diazaindene; 1,2-Benzodiazole; 1H-indazol; Benzopyrazole; Azaindole; UNII-7C4VQE5C03; 1,2-Benzopyrazole; MFCD00005691; 7C4VQE5C03; Indazole, 96%; WLN: T56 BMNJ; 1,2-Diazaindene (VAN); EINECS 205-978-4; NSC 26336; indazol; 2-Azoindole; 1-H-indazole; Indazole, 5; Indazole, 6; NSC90357; BENZPYRAZOL; zlchem 598; ACMC-20aixv; Indazole, 98%; PubChem15665; SCHEMBL6295; KSC205O5T; CHEMBL86795; SCHEMBL3056528; SCHEMBL5376344; SCHEMBL5376627; SCHEMBL5376678; SCHEMBL5379372; SCHEMBL5383265; DTXSID4075374; SCHEMBL17515466; BDBM24627; CTK0J2806; CTK1A5759; ZLD0045; ACT05802; BCP27336; NSC26336; ANW-75473; MFCD20483705; NSC-26336; NSC-90357; RW3869; SBB040063; STL371246; ZINC16052862; AKOS000271187; CS-W008689; LS20969; MCULE-6962938625; PB23156; PS-4750; VZ21733; AK-49124; BR-49124; SC-27069; SY001125; AB0015286; DB-024400; A5299; AM20060873; BB 0219702; FT-0607899; FT-0627194; I0278; ST50177678; EN300-44212; KS-00000729; 6945-EP2270010A1; 6945-EP2272517A1; 6945-EP2272813A2; 6945-EP2272828A1; 6945-EP2272832A1; 6945-EP2275395A2; 6945-EP2275401A1; 6945-EP2275404A1; 6945-EP2275412A1; 6945-EP2277858A1; 6945-EP2280000A1; 6945-EP2280012A2; 6945-EP2281563A1; 6945-EP2281818A1; 6945-EP2284157A1; 6945-EP2284920A1; 6945-EP2285783A1; 6945-EP2289890A1; 6945-EP2292586A2; 6945-EP2292592A1; 6945-EP2292604A2; 6945-EP2292611A1; 6945-EP2295412A1; 6945-EP2295413A1; 6945-EP2295429A1; 6945-EP2295432A1; 6945-EP2295433A2; 6945-EP2295550A2; 6945-EP2298738A1; 6945-EP2298767A1; 6945-EP2298770A1; 6945-EP2301923A1; 6945-EP2301937A1; 6945-EP2305250A1; 6945-EP2305648A1; 6945-EP2305651A1; 6945-EP2305675A1; 6945-EP2308510A1; 6945-EP2308562A2; 6945-EP2308840A1; 6945-EP2308848A1; 6945-EP2308854A1; 6945-EP2311824A1; 6945-EP2311825A1; 6945-EP2314575A1; 6945-EP2316459A1; 6945-EP2316470A2; 6945-EP2316832A1; 6945-EP2316833A1; 6945-EP2371811A2; 6945-EP2372804A1; 6945-EP2378585A1; B-1767; 38318-EP2295433A2; 38318-EP2303878A1; 38318-EP2311837A1; 53182-EP2292630A1; 53182-EP2305651A1; 53182-EP2308854A1; 90623-EP2270505A1; 90623-EP2272972A1; 90623-EP2272973A1; 90623-EP2275411A2; 90623-EP2277872A1; 90623-EP2281815A1; 90623-EP2292606A1; 90623-EP2295413A1; 90623-EP2295429A1; 90623-EP2305219A1; 90623-EP2305640A2; AB00376876-02; 103668-EP2300437A1; 271I443; AC-907/25014165; Q417106; J-504679; F0918-7060; F1918-0009; Z276614452
Click to Show/Hide
|
||||
| Activity |
IC50 > 398107.17 nM
|
[46] | |||
| Compound Name |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]propanamido]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245918; BDBM50204342
Click to Show/Hide
|
||||
| Activity |
IC50 = 409000 nM
|
[23] | |||
| Compound Name |
(2S)-N-[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-(Benzylcarbamoyl)-2-phenylethyl]carbamoyl}-2-methylpropyl]carbamoyl}ethyl]carbamoyl}ethyl]-5-carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246137; BDBM50204351
Click to Show/Hide
|
||||
| Activity |
IC50 = 438000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-methylbutanamido]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269244; BDBM50204328
Click to Show/Hide
|
||||
| Activity |
IC50 = 445000 nM
|
[23] | |||
| Compound Name |
(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}-N-(4-{[(1S)-2-methyl-1-{[(1S)-2-phenyl-1-{[2-(piperidin-1-yl)ethyl]carbamoyl}ethyl]carbamoyl}propyl]carbamoyl}phenyl)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246330; BDBM50204349
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-(1H-imidazol-5-yl)propanamido]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394715; BDBM50204341
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-phenylpropanamido]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391820; BDBM50204356
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(2S)-N-[(1S)-1-(Benzylcarbamoyl)-2-phenylethyl]-2-({4-[(2S)-2-{[(2S)-1-[(2S)-2-(2-acetamidoacetamido)propanoyl]pyrrolidin-2-yl]formamido}propanamido]phenyl}formamido)-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394041; BDBM50204358
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
N-((S)-1-((S)-1-(Benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-4-(guanidinomethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245987; BDBM50204330
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Compound Name |
(2S)-1-[(2S)-2-[(2-Acetamidoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2S)-1-[4-[[(2S)-1-[[(2S)-1-(benzylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]-2-phenylanilino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486269
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[20] | |||
| Compound Name |
(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S,3R)-2-[(2S)-5-Carbamimidamido-2-{[(2S)-1-[(2S)-5-carbamimidamido-2-(2-acetamidoacetamido)pentanoyl]pyrrolidin-2-yl]formamido}pentanamido]-3-hydroxybutanamido]-3-hydroxybutanamido]-3-(1H-indol-3-yl)propanamido]-3-phenylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437750; BDBM50204334
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[23] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9. | ||||
| REF 2 | Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted ... J Med Chem. 2007 Apr 5;50(7):1584-97. | ||||
| REF 3 | Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J Med Chem. 2006 Jun 29;49(13):3800-8. | ||||
| REF 4 | Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3706-12. | ||||
| REF 5 | Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105. | ||||
| REF 6 | Design, synthesis, and biological evaluation of potent c-Met inhibitors. J Med Chem. 2008 Sep 25;51(18):5766-79. | ||||
| REF 7 | Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3. | ||||
| REF 8 | Identification of a selective inhibitor of transforming growth factor -activated kinase 1 by biosensor-based screening of focused libraries. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1031-1036. | ||||
| REF 9 | Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2652-7. | ||||
| REF 10 | Synthesis and biological evaluation of 5-arylamino-6-chloro-1H-indazole-4,7-diones as inhibitors of protein kinase B/Akt. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6001-5. | ||||
| REF 11 | 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities. J Med Chem. 2005 May 5;48(9):3118-21. | ||||
| REF 12 | ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6. | ||||
| REF 13 | US patent application no. 9320734B2, Small molecule inhibitors of the pleckstrin homology domain and methods for using same | ||||
| REF 14 | Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4. | ||||
| REF 15 | 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors. J Med Chem. 2011 Sep 22;54(18):6286-94. | ||||
| REF 16 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 17 | Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6991-5. | ||||
| REF 18 | Preparation and evaluation of deconstruction analogues of 7-deoxykalafungin as AKT kinase inhibitors. Bioorg Med Chem Lett. 2014 Jan 1;24(1):271-4. | ||||
| REF 19 | Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1679-85. | ||||
| REF 20 | Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents. Bioorg Med Chem. 2009 Feb 15;17(4):1764-71. | ||||
| REF 21 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 22 | Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors. Eur J Med Chem. 2011 Dec;46(12):5949-58. | ||||
| REF 23 | Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics. Bioorg Med Chem Lett. 2007 Apr 1;17(7):2068-73. | ||||
| REF 24 | US patent application no. 8541407B2, Substituted benzo-pyrido-triazolo-diazepine compounds | ||||
| REF 25 | US patent application no. 9139568B2, Heterocyclic carboxamides as modulators of kinase activity | ||||
| REF 26 | Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. J Med Chem. 2012 Jun 14;55(11):5291-310. | ||||
| REF 27 | 5-Substituted [1]pyrindine derivatives with antiproliferative activity. Eur J Med Chem. 2010 Mar;45(3):896-901. | ||||
| REF 28 | 2-Anilino-4-(benzimidazol-2-yl)pyrimidines--a multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines. Eur J Med Chem. 2012 Jul;53:254-63. | ||||
| REF 29 | Recent developments in fragment-based drug discovery. J Med Chem. 2008 Jul 10;51(13):3661-80. | ||||
| REF 30 | 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2016 Jan 14;59(1):253-263. | ||||
| REF 31 | Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2691-5. | ||||
| REF 32 | Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors. Eur J Med Chem. 2018 Jul 15;155:905-924. | ||||
| REF 33 | Phenylalanine-Based Inactivator of AKT Kinase: Design, Synthesis, and Biological Evaluation. ACS Med Chem Lett. 2014 Mar 7;5(5):462-7. | ||||
| REF 34 | Scaffold oriented synthesis. Part 1: Design, preparation, and biological evaluation of thienopyrazoles as kinase inhibitors. Bioorg Med Chem Lett. 2006 Jan 1;16(1):96-9. | ||||
| REF 35 | 9,10-secosteroids, protein kinase inhibitors from the Chinese gorgonian Astrogorgia sp. Bioorg Med Chem. 2011 Nov 15;19(22):6873-80. | ||||
| REF 36 | Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. | ||||
| REF 37 | Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. | ||||
| REF 38 | Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia. J Nat Prod. 2014 Feb 28;77(2):218-26. | ||||
| REF 39 | Arthrinins A-D: novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp. Bioorg Med Chem. 2011 Aug 1;19(15):4644-51. | ||||
| REF 40 | Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor. J Med Chem. 2006 Dec 14;49(25):7549-53. | ||||
| REF 41 | Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties. J Med Chem. 2013 May 9;56(9):3456-66. | ||||
| REF 42 | Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50(4):611-26. | ||||
| REF 43 | Synthesis and PKCtheta inhibitory activity of a series of 4-indolylamino-5-phenyl-3-pyridinecarbonitriles. Bioorg Med Chem Lett. 2009 May 1;19(9):2461-3. | ||||
| REF 44 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 45 | 2013 Philip S. Portoghese Medicinal Chemistry Lectureship: drug discovery targeting allosteric sites. J Med Chem. 2014 Sep 25;57(18):7485-98. | ||||
| REF 46 | Selectivity of kinase inhibitor fragments. J Med Chem. 2011 Jul 28;54(14):5131-43. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.