Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68706 | Target Info | |||
| Target Name | Dibasic-processing enzyme (Furin) | ||||
| Synonyms |
Paired basic amino acid residuecleaving enzyme; Paired basic amino acid residue-cleaving enzyme; PCSK3; PACE; FUR; Dibasicprocessing enzyme
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| Target Type | Preclinical Target | ||||
| Gene Name | FURIN | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 17 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(2-Methoxyethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL611079; BI-90H9; BDBM50310148
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Triazole, 7b
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL472074; BDBM29302
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-(3,4-Dimethoxyphenethyl)-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL599111; BI-90H10; BDBM50310146
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
5-(5-Nitrothiazol-2-ylthio)-N-propyl-1,3,4-thiadiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL609039; BI-90H6; BDBM50310142
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Sec-Butyl-5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL599518; BI-98A10; BDBM50310147
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Triazole, 3j
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448771; SCHEMBL4789242; BDBM29292
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Halicin
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Investigative | Compound Info | ||
| Synonyms |
SU 3327; SU3327; 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine; SU-3327; 2-Amino-5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazole; 5-(5-Nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine; 5-[(5-nitro-1,3-thiazol-2-yl)thio]-1,3,4-thiadiazol-2-amine; CHEMBL510038; SCHEMBL8044196; BDBM29315; CTK8G3223; GTPL10703; DTXSID70474254; 2-amino-1,3,4-thiadiazole, 9; HMS3414C07; HMS3678C07; BCP32078; ZINC8716875; AKOS016368573; compound 9 [PMID: 19271755]; DB15624; SU3327; SU-3327; HY-107597; B7444; CS-0028934; EC-000.2369; JNK Inhibitor XIII - CAS 40045-50-9; 5-(5-Nitrothiazole-2-ylthio)-1,3,4-thiadiazole-2-amine; 5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
5-Methoxy-2-(5-nitrothiazol-2-ylthio)benzo[d]thiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL474804; BI-87D11; BDBM50257103
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
2-(5-Nitrothiazol-2-ylthio)benzo[d]thiazole
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Investigative | Compound Info | ||
| Synonyms |
BI-87G3; CHEMBL493539; JNK Inhibitor XI; JNK Inhibitor XI, BI-87G3; SCHEMBL20142744; BDBM50257184; ZINC40429498; BI-87G3, >=98% (HPLC); J-014468; 2-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3-benzothiazole
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
Dithioether 1,3,4-thiadiazole, 8f
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503022; SCHEMBL11430427; BDBM29313; 2,5-bis[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazole
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
[(1S,2S,4R,5R)-2,4-Bis(diaminomethylideneamino)-5-[[2-(diaminomethylideneamino)phenyl]carbamoyloxy]cyclohexyl] N-[2-(diaminomethylideneamino)phenyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL508352; BDBM50279636; (1R,3S,4S,6R)-4,6-diguanidinocyclohexane-1,3-diyl bis(2-guanidinophenylcarbamate)
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| Activity |
Ki = 100000 nM
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[4] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bis-(3-guanidino-pyridin-4-yloxy)-cyclohexyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL519572; SCHEMBL13333012; BDBM50279612
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| Activity |
Ki = 100000 nM
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[4] | |||
| Compound Name |
2-[(1S,2S,4R,5R)-2,4-Bis[(2-amino-3H-benzimidazol-5-yl)oxy]-5-(diaminomethylideneamino)cyclohexyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL488574; BDBM50279634; 1,1''-((1R,3S,4S,6R)-4,6-bis(2-amino-1H-benzo[d]imidazol-6-yloxy)cyclohexane-1,3-diyl)diguanidine
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| Activity |
Ki = 100000 nM
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[4] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bis-(3-guanidino-pyridin-2-yloxy)-cyclohexyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487333; BDBM50279611
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| Activity |
Ki = 100000 nM
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[4] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bis-(2-guanidino-phenoxy)-cyclohexyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487131; BDBM50279610
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| Activity |
Ki = 100000 nM
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[4] | |||
| Compound Name |
2-[(1R,2R,4S,5S)-5-(Diaminomethylideneamino)-2,4-dipyridin-2-yloxycyclohexyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL261020; BDBM50279635; 1,1''-((1R,3S,4S,6R)-4,6-bis(pyridin-2-yloxy)cyclohexane-1,3-diyl)diguanidine
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| Activity |
Ki = 100000 nM
|
[4] | |||
| Compound Name |
{[4-(N''-Carbamimidoylhydrazinecarbonyl)phenyl]formohydrazido}methanimidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644909; BDBM50333194
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| Activity |
Ki = 173000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 15 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(1-Phenylethylidene)hydrazinecarboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1644904; NSC627227; 2-(1-phenylethylideneamino)guanidine; NSC67022; Acetophenonaminoguanidine; MLS001047470; SCHEMBL12217973; SCHEMBL18725202; MRKZNCISKCWGLP-KPKJPENVSA-; REGID_for_CID_5916478; HMS1666J01; ZINC5412146; BDBM50333198; NSC-67022; STK526310; AKOS005459835; NSC-627227; 1-[(E)-1-phenylethylideneamino]guanidine; SMR000427857; (2E)-2-(1-phenylethylidene)hydrazinecarboximidamide
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| Activity |
Ki = 273000 nM
|
[5] | |||
| Compound Name |
Benzoylamino-guanidine
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Investigative | Compound Info | ||
| Synonyms |
2-Benzoylhydrazinecarboximidamide; CHEMBL1644905; Benzamidoguanidin; N-(diaminomethylideneamino)benzamide; NSC96972; 1-benzamidoguanidine; 2-(Benzoylamino)guanidine; Benzoic acid 2-amidinohydrazide; SCHEMBL4041579; N'-amidinobenzoic acid hydrazide; DTXSID90958006; (phenylformohydrazido)methanimidamide; ZINC1627097; AHO101337; BDBM50333199; NSC-96972; AKOS003403204; MCULE-1826343026; N-Carbamimidoylbenzenecarbohydrazonic acid
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| Activity |
Ki = 376000 nM
|
[5] | |||
| Compound Name |
2-Benzylidenehydrazinecarboximidamide
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Investigative | Compound Info | ||
| Synonyms |
1-[(phenylmethylidene)amino]guanidine; Benzalaminoguanidine; MLS000532721; CHEMBL1183425; SMR000140159; (2E)-2-benzylidenehydrazinecarboximidamide hydrobromide; 2-[(E)-benzylideneamino]guanidine; benzaldehyde diaminomethylenehydrazone; Benzalaminoguanidin; NSC302362; NSC 302362; Hydrazinecarboximidamide, 2-(phenylmethylene)-; 2-[(E)-benzalamino]guanidine; Hydrazinecarboximidamide, 2-(phenylmethylene)- (9CI); BDBM96604; cid_9568045; HMS1645H16; HMS1666H01; ALBB-022837; ZINC6060677; BDBM50333189; AKOS001016988; NE23974; NSC-302362; 2-[(E)-(phenylmethylene)amino]guanidine; NCGC00245713-01; NCGC00245713-02; 2-[(E)-(phenylmethylidene)amino]guanidine; T5777; EN300-60707; AB00456456-03; 2-[(E)-1-phenylmethylidene]-1-hydrazinecarboximidamide; F0266-1568; hydrazinecarboximidamide, 2-(phenylmethylene)-, (2E)-, hydrobromide
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| Activity |
Ki > 500000 nM
|
[5] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-5-Guanidino-4-(4-guanidino-naphthalen-1-yloxy)-2-(4-guanidino-phenoxy)-cyclohexyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL488769; BDBM50279582
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| Activity |
Ki = 6025595.86 nM
|
[4] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bis-(4-guanidino-phenoxy)-cyclohexyl]-guanidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485694; BDBM50279584; ZINC58549725; NCGC00476187-01; 1,1'-((1R,3S,4S,6R)-4,6-Bis(4-guanidinophenoxy)cyclohexane-1,3-diyl)diguanidine
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| Activity |
Ki = 12022644.35 nM
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[4] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-2-(2-Amino-4-guanidino-phenoxy)-5-guanidino-4-(4-guanidino-naphthalen-1-yloxy)-cyclohexyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL522615; BDBM50279581
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| Activity |
Ki = 21877616.24 nM
|
[4] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bis-(5-guanidino-pyridin-2-yloxy)-cyclohexyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487946; SCHEMBL15176998; BDBM50279605
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| Activity |
Ki = 41686938.35 nM
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[4] | |||
| Compound Name |
1-[(1~{r},2~{r},4~{s},5~{s})-2,4-Bis(4-Carbamimidamidophenoxy)-5-[(4-Carbamimidamidophenyl)amino]cyclohexyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL506022; BDBM50279606; 1N
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| Activity |
Ki = 45708818.96 nM
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[4] | |||
| Compound Name |
N-[(1S,2S,4R,5R)-5-Guanidino-2,4-bis-(4-guanidino-naphthalen-1-yloxy)-cyclohexyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL505581; BDBM50279583
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| Activity |
Ki = 69183097.09 nM
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[4] | |||
| Compound Name |
N-{4-[(1S,2S,4R,5R)-2,4-Diguanidino-5-(4-guanidino-phenoxy)-cyclohexyloxy]-3-guanidino-phenyl}-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL490273; BDBM50279559
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| Activity |
Ki = 89125093.81 nM
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[4] | |||
| Compound Name |
1-[(1R,2R,4S,5S)-5-Carbamimidamido-2,4-bis(2,4-dicarbamimidamidophenoxy)cyclohexyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL205548; BDBM50241035
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| Activity |
Ki = 169824365.3 nM
|
[4] | |||
| Compound Name |
N-{4-[(1S,2S,4R,5R)-2,4-Diguanidino-5-(4-guanidino-naphthalen-1-yloxy)-cyclohexyloxy]-3-guanidino-phenyl}-guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448513; BDBM50279560
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| Activity |
Ki = 407380277.8 nM
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[4] | |||
| Compound Name |
1-[(1R,2R,4S,5S)-5-[(4-Carbamimidamidonaphthalen-1-yl)amino]-2,4-bis[(4-carbamimidamidonaphthalen-1-yl)oxy]cyclohexyl]guanidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL451882; BDBM50279607
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| Activity |
Ki = 426579518.8 nM
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[4] | |||
| Compound Name |
(1S,2S,4R,5R)-2,4-Dicarbamimidamido-5-{[(3-carbamimidamidophenyl)carbamoyl]oxy}cyclohexyl N-(3-carbamimidamidophenyl)carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL506831; BDBM50279609
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| Activity |
Ki = 562341325.2 nM
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[4] | |||
| Compound Name |
(1S,2S,4R,5R)-2,4-Dicarbamimidamido-5-{[(4-carbamimidamidophenyl)carbamoyl]oxy}cyclohexyl N-(4-carbamimidamidophenyl)carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL451430; BDBM50279608
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| Activity |
Ki = 812830516.2 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2010 Jan 15;18(2):590-6. | ||||
| REF 2 | Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase. J Med Chem. 2009 Apr 9;52(7):1943-52. | ||||
| REF 3 | Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors. Bioorg Med Chem. 2009 Apr 1;17(7):2712-7. | ||||
| REF 4 | Modeling the activity of furin inhibitors using artificial neural network. Eur J Med Chem. 2009 Apr;44(4):1664-73. | ||||
| REF 5 | New furin inhibitors based on weakly basic amidinohydrazones. Bioorg Med Chem Lett. 2011 Jan 15;21(2):836-40. | ||||
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