Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T68782 | Target Info | |||
| Target Name | Prostaglandin D2 receptor (PTGDR) | ||||
| Synonyms |
Prostanoid DP receptor; PGD2 receptor; PGD receptor
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| Target Type | Clinical trial Target | ||||
| Gene Name | PTGDR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(5-Methyl-6-(4-(methylsulfonyl)benzyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684727; SCHEMBL10074104; BDBM50338158
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(5-Methyl-6-(4-(methylsulfonyl)phenylsulfonyl)-6H-thieno[2,3-b]pyrrol-4-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684721; SCHEMBL400709; BDBM50338152; 2-[5-methyl-6-(4-methylsulfonylphenyl)sulfonylthieno[2,3-b]pyrrol-4-yl]acetic acid
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[6-[[4-[Cyclohexyl(methyl)sulfamoyl]phenyl]methyl]-5-methylthieno[2,3-b]pyrrol-4-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684726; BDBM50338157; 2-(6-(4-(N-cyclohexyl-N-methylsulfamoyl)benzyl)-5-methyl-6H-thieno[2,3-b]pyrrol-4-yl)acetic acid
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(6-(2-Chloro-4-(methylsulfonyl)benzyl)-5-methyl-6H-thieno[2,3-b]pyrrol-4-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1684728; BDBM50338159
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Schembl20719106
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770317; BDBM50384443; 5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione
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| Activity |
IC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
(R)-2-(8-(4-Fluoro-N-methylphenylsulfonamido)-6,7,8,9-tetrahydro-5H-pyrido[3,2-b]indol-5-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL550465; SCHEMBL2516080; BDBM50296983
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(6R)-6-[(4-Fluorophenyl)sulfonyl-methylamino]-5,6,7,8-tetrahydropyrido[3,4-b]indol-9-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL550868; BDBM50296984; (R)-2-(6-(4-fluoro-N-methylphenylsulfonamido)-7,8-dihydro-5H-pyrido[3,4-b]indol-9(6H)-yl)acetic acid
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-Bromo-2-(1-phenylpyrazole-4-carbonyl)phenoxy]acetic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217053; SCHEMBL1994430; CTK3C5717; DTXSID10469987; BDBM50200271; 4-bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxyacetic acid; 2-(4-Bromo-2-(1-phenyl-1H-pyrazole-4-carbonyl)phenoxy)acetic acid; Acetic acid, [4-bromo-2-[(1-phenyl-1H-pyrazol-4-yl)carbonyl]phenoxy]-
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(2-Benzhydryl-4-(4-chlorophenyl)thiazol-5-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL590582; SCHEMBL5056677; 2-[2-benzhydryl-4-(4-chlorophenyl)-1,3-thiazol-5-yl]acetic Acid; BDBM50309273
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| Activity |
IC50 = 100000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Thienopyrrole acetic acids as antagonists of the CRTH2 receptor. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1861-4 | ||||
| REF 2 | Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1(7):316-20. | ||||
| REF 3 | Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. | ||||
| REF 4 | Novel selective orally active CRTH2 antagonists for allergic inflammation developed from in silico derived hits. J Med Chem. 2006 Nov 16;49(23):6638-41. | ||||
| REF 5 | Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1181-5. | ||||
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