Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69563 | Target Info | |||
| Target Name | Oxalosuccinate decarboxylase (IDH1) | ||||
| Synonyms |
PICD; NADP(+)-specific ICDH; Isocitrate dehydrogenase [NADP] cytoplasmic; IDP; IDH; Cytosolic NADP-isocitrate dehydrogenase
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|
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| Target Type | Successful Target | ||||
| Gene Name | IDH1 | ||||
| Biochemical Class | Short-chain dehydrogenases reductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 106 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ciclopirox
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|
Approved | Compound Info | ||
| Synonyms |
Ciclopiroxum; Cyclopirox; Cyclopyroxolamine; Loprox; Penlac; Stieprox; Terit; Ciclopirox Olamin; Ciclopirox gel; Loprox Gel; Loprox Shampoo; Loprox cream; Penlac nail lacquer; HOE 296b; Batrafen (TN); Ciclopirox-Olamin; Ciclopiroxum [INN-Latin]; Dafnegin-CSC; HOE-296; HOE-296b; Loprox (TN); Penlac (TN); Stieprox (TN); Ciclopirox (USP/INN); Ciclopirox [USAN:BAN:INN]; (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone); 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone; 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone; 6-Cyclohexyl-1-hydroxy-4-methyl-2-(1H)-pyridone; 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H)-pyridinone; 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one; 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(5E)-3-Methyl-5-(pyridin-4-ylmethylidene)-2-sulfanylideneimidazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605395; BDBM50111975
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
4-[(1R)-1-Hydroxyethyl]-3-[2-[1-(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111104; BDBM247894; US9434719, 112
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Chembl4280797
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|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6-Phenyl-4-methyl-1-hydroxypyridin-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386130; SCHEMBL11851322; BDBM50434273; 1-hydroxy-4-methyl-6-phenylpyridin-2-one
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
(S)-4-Isopropyl-3-(2-((S)-1-(piperidin-4-yl)ethylamino)pyrimidin-4-yl)oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3682020; SCHEMBL14831070; BDBM146350; US8957068, 476; (S)-4-isopropyl-3-[2-((S)-1-piperidin-4-yl-ethylamino)-pyrimidin-4-yl]-oxazolidin-2-one; (4S)-3-[2-[[(1S)-1-piperidin-4-ylethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[2-(1-Adamantylmethylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672189; SCHEMBL14846971; BDBM146061; US8957068, 96
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(5E)-5-[(2-Bromopyridin-4-yl)methylidene]-2-sulfanylideneimidazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605398; BDBM50111979
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4293250
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|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Hydroxy-6-(1-phenylethyl)pyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343431; BDBM50029638
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(4S)-3-[5-Chloro-2-[[(1S)-1-naphthalen-2-ylethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672201; SCHEMBL14846978; BDBM146073; US8957068, 108
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-[(4E)-4-[(6-Methoxypyridin-3-yl)methylidene]-5-oxo-2-sulfanylideneimidazolidin-1-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605385; BDBM50111797
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
5-[(E)-(2-Amino-5-oxo-1H-imidazol-4-ylidene)methyl]-1H-pyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605405; BDBM50112071
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-3-{2-[(S)-1-(1-Cyclobutyl-piperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-4-isopropyl-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3682021; SCHEMBL14831073; BDBM146351; US8957068, 477
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-3-[2-[1-(Furan-2-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677189; SCHEMBL14846829; BDBM146313; US8957068, 419; US8957068, 420
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[2-[1-[5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-yl]ethylamino]pyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4114157; BDBM247889; US9434719, 102
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-[(E)-(2-Methylsulfanyl-5-oxo-1H-imidazol-4-ylidene)methyl]-1H-pyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605406; BDBM50112096
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
4,5-Dihydroxy-2-benzylpyrimidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570807; SCHEMBL1585413; BDBM50029549; 2-benzyl-5-hydroxy-1H-pyrimidin-6-one
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Thioxo-5-(2-methoxypyridine-5-ylmethylene)thiazolidine-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605401; BDBM50111982
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(5E)-5-(3,4-Dimethoxybenzylidene)-2-mercapto-3-phenyl-3,5-dihydro-4H-imidazol-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605372; ALBB-008450; BDBM50114021; STK505424; ZINC13603295; AKOS000532042; AKOS003406014; (5E)-5-(3,4-dimethoxybenzylidene)-3-phenyl-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(4S)-4-Propan-2-yl-3-[2-[[(1R)-1-(3-propyl-1,2,4-oxadiazol-5-yl)ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3682140; SCHEMBL19178180; BDBM47150; US8957068, 369
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-3-[2-[1-(4-Ethyl-1,2,4-triazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677158; SCHEMBL14846731; BDBM146281; US8957068, 353; US8957068, 354
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
6-Benzyl-1-hydroxy-4-propan-2-ylpyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386129; BDBM50434274
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[(4E)-5-Oxo-4-[(6-oxo-1H-pyridin-3-yl)methylidene]-2-sulfanylideneimidazolidin-1-yl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605386; BDBM50111798
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
1-Hydroxy-5-phenylpyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574580; 1-HYDROXY-5-PHENYLPYRIDIN-2(1H)-ONE; SCHEMBL1585628; 1-hydroxy-5-phenyl-pyridin-2-one; BDBM50335486; ZINC45286533
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|
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| Activity |
Ki = 50000 nM
|
[1] | |||
| Compound Name |
(5E)-3-Benzyl-5-(pyridin-3-ylmethylidene)-2-sulfanylideneimidazolidin-4-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605376; BDBM50111788
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
Metipirox
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|
Investigative | Compound Info | ||
| Synonyms |
UNII-IE9M6JG949; IE9M6JG949; Metipiroxum; Metipirox [INN]; 1-Hydroxy-4,6-dimethyl-2(1H)-pyridon; 1-hydroxy-4,6-dimethylpyridin-2-one; 2(1H)-Pyridone, 1-hydroxy-4,6-dimethyl-; SCHEMBL794955; CHEMBL2104878; DTXSID50183579; BDBM50029642; AKOS006274256; 1-Hydroxy-4,6-dimethyl-2(1H)-pyridone; 1-hydroxy-4,6-dimethyl-1,2-dihydropyridin-2-one; Q27280682
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(4S)-4-Propan-2-yl-3-[2-[[(1S)-1-(2H-tetrazol-5-yl)ethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677063; SCHEMBL14846845; BDBM146182; US8957068, 234
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
1-Hydroxy-3-benzylimidazol-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574581; SCHEMBL10077158; 1-benzyl-3-hydroxyimidazol-2-one; BDBM50029552
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(4S)-3-[2-[1-(1-Benzyltriazol-4-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3682025; SCHEMBL14846840; BDBM146355; US8957068, 481; US8957068, 482
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-3-[2-[1-(1-Ethylpyrazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677168; SCHEMBL14846717; BDBM146291; US8957068, 375; US8957068, 376
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4R)-4-Benzyl-3-[2-(cyclopropylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676994; SCHEMBL14846946; BDBM146108; US8957068, 143
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Chembl4279183
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Benzyl-1-hydroxy-2H-pyridin-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386125; BDBM50434276
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|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[2-[1-(5-Benzyl-1,2,4-oxadiazol-3-yl)ethylamino]-5-fluoropyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4113072; BDBM247896; US9434719, 116
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(4S)-3-[2-[1-(3-Methyl-1,2,4-oxadiazol-5-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677164; SCHEMBL14846733; BDBM146287; US8957068, 365; US8957068, 366
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-[(1R)-1-Hydroxyethyl]-3-[2-[1-[3-(2-phenoxyethyl)-1,2,4-oxadiazol-5-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107669; BDBM247886; US9434719, 96
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[2-(Cyclopentylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672110; SCHEMBL14846867; BDBM145981; US8957068, 16
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Streptpyrone A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343469; 6-benzyl-4-methylpyran-2-one; SCHEMBL11857671; BDBM50029554
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
6-Benzyl-1-Hydroxy-4-Methylpyridin-2(1h)-One
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Investigative | Compound Info | ||
| Synonyms |
SYC 435; TC-E 5008; CHEMBL2386126; 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone; 1-Hydroxy-4-methyl-6-benzyl-2(1H)-pyridone; SCHEMBL10723992; SYC-435; BDBM50434278; ZINC34100965; AKOS027470164; 6-benzyl-1-hydroxy-4-methylpyridin-2-one; Q27451898
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4282653
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|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
C1=CC(=O)N(O)C(C=2C=CC=CC=2)=C1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343430; SCHEMBL16113539; BDBM50029636
Click to Show/Hide
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4289867
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-Benzyl-1-hydroxy-6-oxopyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343428; BDBM50029627
Click to Show/Hide
|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(5E)-5-[(6-Oxo-1H-pyridin-3-yl)methylidene]imidazolidine-2,4-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605404; BDBM50112061
Click to Show/Hide
|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
1-Hydroxy-5-(3-phenylpropyl)pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343425; BDBM50029634
Click to Show/Hide
|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4291032
Click to Show/Hide
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1,4-Dihydroxy-6-benzyl-2(1H)-pyridone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343439; BDBM50029557
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Hydroxy-5-(2-phenylethyl)pyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343424; BDBM50029633
Click to Show/Hide
|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(4R,5S)-4-Methyl-5-phenyl-3-[2-[[(1S)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672113; SCHEMBL14846861; BDBM145984; US8957068, 19
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[2-(1-Phenylethylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672096; SCHEMBL14846963; BDBM145967; US8957068, 2
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
6-Benzyl-1-hydroxypyridin-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2386128; BDBM50434275; 1-Hydroxy-6-benzyl-2(1H)-pyridone
Click to Show/Hide
|
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl4280398
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-4-Isopropyl-3-{2-[(S)-1-(1-isopropyl-piperidin-4-yl)-ethylamino]-pyrimidin-4-yl}-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3682022; SCHEMBL14833732; BDBM146352; US8957068, 478
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4R)-4-Benzyl-3-[2-(cyclopentylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672112; SCHEMBL14846858; BDBM145983; US8957068, 18
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-3-[2-[[(2S)-1-Hydroxypropan-2-yl]amino]pyrimidin-4-yl]-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677008; SCHEMBL14846632; BDBM146122; US8957068, 157
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-[(1R)-1-Hydroxyethyl]-3-[2-[1-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112998; BDBM247890; US9434719, 104
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-[(1-Hydroxy-4-methyl-6-oxopyridin-2-yl)methyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343451; BDBM50029474
Click to Show/Hide
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||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(4S)-4-Propan-2-yl-3-[2-[1-[1-(pyridine-4-carbonyl)piperidin-4-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3682023; SCHEMBL14846689; BDBM146353; US8957068, 479
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Chembl4294325
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(4S)-4-Propan-2-yl-3-[2-[1-[1-(pyridine-3-carbonyl)piperidin-4-yl]ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3682024; SCHEMBL14847088; BDBM146354; US8957068, 480
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[2-[1-(5-Benzyl-1,2,4-oxadiazol-3-yl)ethylamino]pyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4110975; BDBM247895; US9434719, 114
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(4S,5R)-4-Methyl-5-phenyl-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672120; SCHEMBL14846869; BDBM145991; US8957068, 26
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-4-Benzhydryl-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672114; SCHEMBL14846864; BDBM145985; US8957068, 20
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4R)-4-Benzyl-3-[2-(cycloheptylamino)pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3676995; SCHEMBL14846951; BDBM146109; US8957068, 144
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(5E)-3-Benzyl-5-[(6-methoxypyridin-3-yl)methylidene]-2-sulfanylideneimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605377; BDBM50111789
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(4S,5R)-4,5-Diphenyl-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672132; SCHEMBL14847065; BDBM146003; US8957068, 38
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-4-Isopropyl-3-(2-(2,2,2-trifluoro-1-phenylethylamino)pyrimidin-4-yl)oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677021; SCHEMBL14832193; BDBM146135; BDBM146339; US8957068, 170; US8957068, 462; US8957068, 463; (4S)-4-propan-2-yl-3-[2-[(2,2,2-trifluoro-1-phenylethyl)amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(5E)-5-[(3,4-Dimethoxyphenyl)methylidene]-3-[(4-methoxyphenyl)methyl]-2-sulfanylideneimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605373; BDBM50114020
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(4S)-4-Propan-2-yl-3-[2-[1-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)ethylamino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677161; SCHEMBL14846732; SCHEMBL19179063; BDBM146284; US8957068, 359; US8957068, 360
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(5E)-3-Benzyl-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylideneimidazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605371; BDBM50114022
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(5E)-5-[(6-Methoxypyridin-3-yl)methylidene]imidazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605403; BDBM50112052
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
N,1-Dihydroxy-6-oxopyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343427; BDBM50029628
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
N,1-Dihydroxy-6-oxopyridine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343434; BDBM50029556
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl 11-(1H-indol-3-yl)-3-methyl-1-oxo-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4217951; HMS1616N22; BDBM50453424; STK403905; AKOS000664473; AKOS022008267; MCULE-3206603176; AE-848/42025028
Click to Show/Hide
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||||
| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
(4S)-3-[2-[1-(2-Ethyl-1,2,4-triazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677157; SCHEMBL14846727; BDBM146280; US8957068, 351; US8957068, 352
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-3-[2-[1-(5-Methyl-1,3,4-oxadiazol-2-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677154; SCHEMBL14846729; BDBM146277; US8957068, 345; US8957068, 346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[(E)-(1-Methyl-5-oxo-2-sulfanylideneimidazolidin-4-ylidene)methyl]-1H-pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3605392; BDBM50111895
Click to Show/Hide
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||||
| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
6-Benzyl-4-methylpyran-2-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343470; BDBM50029555
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(4S)-3-[2-[1-(4-Methyl-1,2,4-triazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677155; SCHEMBL15960211; BDBM146278; US8957068, 347; US8957068, 348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4R)-4-(2-Methylpropyl)-3-[2-[[(1R)-1-phenylethyl]amino]pyrimidin-4-yl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672139; SCHEMBL14847070; BDBM146010; US8957068, 45
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
N-(1-Hydroxy-6-oxopyridin-3-yl)-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3343429; BDBM50029635
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4286444
Click to Show/Hide
|
Investigative | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(4S)-3-[2-[1-(2-Ethylpyrazol-3-yl)ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3677194; SCHEMBL15960232; BDBM146318; US8957068, 428; US8957068, 429
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4S)-3-[2-[1-[4-(4-Methylpiperazin-1-yl)phenyl]ethylamino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672152; SCHEMBL15960157; BDBM146023; US8957068, 58
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(4R)-3-[2-[1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]ethylamino]-5-fluoropyrimidin-4-yl]-4-[(1R)-1-hydroxyethyl]-1,3-oxazolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111529; SCHEMBL16089205; BDBM247596; US9434719, 191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(3-Fluoro-N-(2-thiophen-2-ylacetyl)anilino)-2-(2-methylphenyl)-N-piperidin-4-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180737
Click to Show/Hide
|
||||
| Activity |
IC50 = 53100 nM
|
[8] | |||
| Compound Name |
NS(=O)(=O)c1ccc(Cc2c(nn(-c3nc(cs3)C(O)=O)c2-c2cccnc2)-c2ccccc2)cc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066429; SCHEMBL17900303; BDBM50250650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
2-[3-Phenyl-4-[(4-sulfamoylphenyl)methyl]pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090794; SCHEMBL17895507; BDBM50250647
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
NS(=O)(=O)c1ccc(Nc2cn(nc2-c2cccc(c2)-c2ccccc2)-c2nc(cs2)C(O)=O)cc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076027; SCHEMBL17900241; BDBM50250649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
Nc1c(Cc2ccc(cc2)S(N)(=O)=O)c(nn1-c1nc(cs1)C(O)=O)-c1cccc(c1)-c1ccccc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075666; SCHEMBL17900203; BDBM50250667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
2-[5-[3-(2-Fluorophenyl)phenyl]-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099443; SCHEMBL17900190; BDBM50250646
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
2-[5-(3-Bromophenyl)-3-oxo-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-2-yl]-1,3-thiazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084774; SCHEMBL17900258; BDBM50250644
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
NS(=O)(=O)c1ccc(Cc2cn(nc2-c2ccc(F)c(F)c2)-c2nc(cs2)C(O)=O)cc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069796; SCHEMBL17900205; BDBM50250675
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
(R)-3-((2-Chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(R)-GNE-140; GNE-140; R-GNE-140; 2003234-63-5 (R-isomer); inhibitor GNE-140; CHEMBL4065858; SCHEMBL19972989; BDBM197160; EX-A1474; s6675; CS-7646; HY-100742A; GNE-140 (6); BS-15887; AK00798569; J3.623.769D; Q27460797
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
2-{3-(3,4-Difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076973; 9Y7; SCHEMBL17895396; BDBM50250674
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
NS(=O)(=O)c1ccc(Cc2c(nn(-c3nc(cs3)C(O)=O)c2C2CC2)-c2ccccc2)cc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090677; SCHEMBL17900227; BDBM50250653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
NS(=O)(=O)c1ccc(Nc2cn(nc2-c2ccccc2)-c2nc(cs2)C(O)=O)cc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076958; SCHEMBL17895575; BDBM50250676
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
{4-[4-({3-[(2-Methyl-1,3-benzothiazol-6-YL)amino]-3-oxopropyl}amino)-4-oxobutyl]benzyl}propanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AZ-33; LDHA Inhibitor, 33; LDHA Inhibitor 33; CHEMBL2059811; BDBM86137; EX-A797; AZ-33(AZ33); BCP16056; MFCD29913759; ZINC84690296; AKOS026751498; AZ-33;AZ 33; LDHA Inhibitor 33; DB-104096; A13341; J-690146; Q27451388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
NS(=O)(=O)c1ccc(Cc2c(nn(-c3nc(cs3)C(O)=O)c2-c2ccncc2)-c2ccccc2)cc1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092360; SCHEMBL17900166; BDBM50250651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluo
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GSK2837808A; GSK 2837808A; CHEMBL3335794; SCHEMBL15054502; BCP31884; BDBM50103568; GSK-2837808A; s8590; ZINC98210307; AKOS024458530; CS-6944; NCGC00355875-03; NCGC00355875-05; HY-100681; GSK-2837808A; GSK 2837808A; GSK2837808; GSK-2837808; GSK 2837808
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 57000 nM
|
[9] | |||
| Compound Name |
N-Cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-o-tolylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AGI-5198; IDH-C35; AGI-5198(IDH C35); CHEMBL2180727; AGI5198; AGI-5198 (IDH-C35); MLS006010252; GTPL9240; SCHEMBL15118942; C27H31FN4O2; AOB5947; DTXSID30718166; EX-A171; QCR-214; HMS3653K15; HMS3865J13; AGI 5198; BCP07382; BDBM50400272; MFCD24848688; s7185; AKOS026674117; CCG-269371; CS-1429; SB19576; KS-0000000N; NCGC00347934-01; NCGC00347934-09; AK198943; BS-14968; DA-35355; HY-18082; SMR004701328; AB0032505; FT-0768624; SW220036-1; X5817; W-6035; Q27074345; S900006220
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-Cyclohexyl-2-(3-fluoro-N-(2-indol-1-ylacetyl)anilino)-2-(2-methylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180729; SCHEMBL10183920; BDBM50400270
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-Cyclohexyl-2-[3-fluoro-N-(2-thiophen-2-ylethyl)anilino]-2-(2-methylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180753
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-Cyclohexyl-2-(3-fluoro-N-[2-(2-methylbenzimidazol-1-yl)acetyl]anilino)-2-(2-methylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180728; SCHEMBL10183228; BDBM50400271
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)ethyl]-N-(3-fluorophenyl)-2-thiophen-2-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2180752
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. J Med Chem. 2014 Oct 23;57(20):8307-18. | ||||
| REF 2 | Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J Med Chem. 2015 Sep 10;58(17):6899-6908. | ||||
| REF 3 | US patent application no. 9434719B2, 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH | ||||
| REF 4 | Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4 H-pyran-4-one derivatives as antiglioma agents. Medchemcomm. 2018 Jan 19;9(3):471-476. | ||||
| REF 5 | Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett. 2013 Jun 13;4(6):542-546. | ||||
| REF 6 | US patent application no. 8957068B2, 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH | ||||
| REF 7 | Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening. Bioorg Med Chem Lett. 2018 Feb 1;28(3):388-393. | ||||
| REF 8 | Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo. ACS Med Chem Lett. 2012 Sep 17;3(10):850-5. | ||||
| REF 9 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017 Nov 22;60(22):9184-9204. | ||||
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