Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T70490 | Target Info | |||
| Target Name | Dipeptidyl peptidase I (CTSC) | ||||
| Synonyms |
Dipeptidyl transferase; Dipeptidyl peptidase 1; DPPI; DPP-I; Cysteine protease dipeptidyl peptidase I; Cathepsin J; Cathepsin C; CPPI
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| Target Type | Clinical trial Target | ||||
| Gene Name | CTSC | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 11 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[(2-Cyanopyrimidin-4-Yl)methyl]-3-[2-(3,5-Dichlorophenyl)-2-Methylpropanoyl]-4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354494; BDBM50042857; Q27454172
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| Activity |
IC50 = 66000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[2-(3,5-Dichlorophenyl)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354497; BDBM50042854
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397973; SCHEMBL3958229; BDBM50201707; 5-[(2,3-dimethylphenoxy)methyl]-3-methyl-1,3-oxazolidin-2-one
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230479; SCHEMBL3961271; BDBM50201706; trans-4-(2,3-dimethylphenoxy)-3-hydroxypiperidine
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[2-(3,5-Dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354496; BDBM50042855
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[2-(dimethylamino)ethoxy]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354493; BDBM50042858
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-(3,5-Dichlorophenyl)-N-[(3S)-1-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354499; BDBM50042851
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441907; SCHEMBL3959125; BDBM50201704; (3S,4R)-4-(2,3-Dimethylphenoxy)-3-piperidinol; UNII-LHH887104B component ZHFIAFNZGWCLHU-WCQYABFASA-N
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[2-(Cyanomethylamino)-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354492; BDBM50042850
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[(2S)-2-(3,5-Dichlorophenyl)-2-(ethylamino)acetyl]amino]-3,3-dimethyl-N-[2-[[(E)-3-methylsulfonylprop-2-enyl]amino]-2-oxoethyl]butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354498; BDBM50042852
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Amino-N-(1-benzyl-3-methanesulfonyl-allyl)-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL13279; BDBM50026018
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|
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| Activity |
Ki = 180000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(2-Amino-acetylamino)-5-phenyl-pent-2-enoic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL13352; BDBM50026015
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|
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| Activity |
Ki = 220000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(2-Aminoacetyl)amino]-3-phenylpropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
Gly-Phe-NH2; L-Phenylalaninamide, glycyl-; CHEMBL378267; glycylphenylalaninamide; Glycyl-L-phenylalaninamid; SCHEMBL1329814; CTK0E8425; DTXSID60426348; ZINC1605336; BDBM50026027; (S)-2-(2-Aminoacetamido)-3-phenylpropanamide; 2-(2-Amino-acetylamino)-3-phenyl-propionamide
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| Activity |
Ki = 6200000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-based design and optimization of potent inhibitors of the adenoviral protease. Bioorg Med Chem Lett. 2015 Feb 1;25(3):438-43. | ||||
| REF 2 | Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1254-9. | ||||
| REF 3 | Carboxyl-modified amino acids and peptides as protease inhibitors. J Med Chem. 1986 Jan;29(1):104-11. | ||||
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