Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T75797 | Target Info | |||
| Target Name | Prostaglandin F2-alpha receptor (PTGFR) | ||||
| Synonyms |
Prostanoid FP receptor; PGF2-alpha receptor; PGF2 alpha receptor; PGF receptor; FP prostanoid receptor; FP prostaglandin receptor
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| Target Type | Successful Target | ||||
| Gene Name | PTGFR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL423815; 3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid; SCHEMBL7922112; SCHEMBL7922115; BDBM50097792; 2-(2-Naphthylmethyl)benzeneacrylic acid; (E)-3-(2-Naphthalen-2-ylmethyl-phenyl)-acrylic acid
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| Activity |
Ki = 69000 nM
|
[1] | |||
| Compound Name |
2-[1-[2-(N-Benzoyl-4-methylanilino)ethyl]piperidin-4-yl]oxyacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793911; BDBM50163296
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
2-[1-[2-[N-(1,3-Benzodioxole-5-carbonyl)-4-methylanilino]ethyl]piperidin-4-yl]oxyacetic acid;hydrate;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3798917; BDBM50167257
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
Schembl20719106
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770317; BDBM50384443; 5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione
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| Activity |
IC50 ~ 50118.72 nM
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[4] | |||
| Compound Name |
(Z)-7-[(1R,2R,3R,6S)-2-[(E,3S)-4-(3-Chlorophenoxy)-3-hydroxybut-1-enyl]-3,6-dihydroxycyclohexyl]hept-5-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL428794; 7-{2-[4-(3-Chloro-phenoxy)-3-hydroxy-but-1-enyl]-3,6-dihydroxy-cyclohexyl}-hept-5-enoic acid; BDBM50091622
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| Activity |
Ki = 56000 nM
|
[5] | |||
| Compound Name |
(E)-3-[2-(2,4-Dichloro-benzyl)-phenyl]-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL350832; BDBM50097791; 2-(2,4-Dichlorobenzyl)benzeneacrylic acid
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| Activity |
Ki = 63000 nM
|
[1] | |||
| Compound Name |
(E)-3-[2-(4-Methylsulfanyl-benzyl)-phenyl]-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL165010; SCHEMBL7929810; SCHEMBL7929816; (E)-3-[2-[(4-methylsulfanylphenyl)methyl]phenyl]prop-2-enoic Acid; BDBM50097794; 2-[4-(Methylthio)benzyl]benzeneacrylic acid
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| Activity |
Ki ~ 83000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry. Bioorg Med Chem Lett. 2001 Mar 12;11(5):747-9. | ||||
| REF 2 | Piperidine derivatives as nonprostanoid IP receptor agonists. Bioorg Med Chem Lett. 2016 May 1;26(9):2360-4. | ||||
| REF 3 | Piperidine derivatives as nonprostanoid IP receptor agonists 2. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2886-2889. | ||||
| REF 4 | Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1(7):316-20. | ||||
| REF 5 | Synthesis and biological activity of a novel 11a-homo (cyclohexyl) prostaglandin. J Med Chem. 2000 Sep 7;43(18):3400-7. | ||||
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