Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T77796 | Target Info | |||
| Target Name | Thyrotropin-releasing hormone receptor (TRHR) | ||||
| Synonyms |
Thyroliberin receptor; TRH-R
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| Target Type | Successful Target | ||||
| Gene Name | TRHR | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-1-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-2-[[(1S)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389955; BDBM50196453
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-N-[(2S)-3-(1-Benzylimidazol-4-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389037; BDBM50196458
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(1R)-3-Oxocyclopentane-1-carbonyl]-2-propyl-L-histidyl-L-prolinamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL374625; CTK3H3032; DTXSID60658940; BDBM50196448; L-Prolinamide, N-[[(1R)-3-oxocyclopentyl]carbonyl]-2-propyl-L-histidyl-
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(2-cyclohexyl-1H-imidazol-5-yl)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL437735; BDBM50196447
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S)-3-(2-Cyclohexyl-1H-imidazol-5-yl)-2-[[(1S)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376135; BDBM50196452
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S)-3-(2-Cyclohexyl-1H-imidazol-5-yl)-2-[[(1R)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375196; BDBM50196454
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S)-2-[[(1S)-3-Oxocyclopentanecarbonyl]amino]-3-(2-propan-2-yl-1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388350; BDBM50196455
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-1-oxo-3-(2-propan-2-yl-1H-imidazol-5-yl)propan-2-yl]-6-oxopiperidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388812; BDBM50196456
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(1S)-3-Oxocyclopentane-1-carbonyl]-2-propyl-L-histidyl-L-prolinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224715; CTK3H3029; DTXSID20658941; BDBM50196460; L-Prolinamide, N-[[(1S)-3-oxocyclopentyl]carbonyl]-2-propyl-L-histidyl-
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S)-2-[[(1R)-3-Oxocyclopentanecarbonyl]amino]-3-(2-propan-2-yl-1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223876; BDBM50196450
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|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-N-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224655; BDBM50196459
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[(2S)-3-(2-Tert-butyl-1H-imidazol-5-yl)-2-[[(1R)-3-oxocyclopentanecarbonyl]amino]propanoyl]pyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389858; BDBM50196461
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|
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Modifications of the pyroglutamic acid and histidine residues in thyrotropin-releasing hormone (TRH) yield analogs with selectivity for TRH receptor type 2 over type 1. Bioorg Med Chem. 2007 Jan 1;15(1):433-43. | ||||
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