Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T78319 | Target Info | |||
| Target Name | Extracellular matrix receptor III (CD44) | ||||
| Synonyms |
Phagocytic glycoprotein I; Phagocytic glycoprotein 1; PGP-I; PGP-1; MIC4; MDU3; MDU2; LHR; Hyaluronate receptor; Hermes antigen; Heparan sulfate proteoglycan; HUTCH-I; GP90 lymphocyte homing/adhesion receptor; Extracellular matrix receptor-III; Epican; ECMR-III; CDw44; CD44 antigen
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| Target Type | Clinical trial Target | ||||
| Gene Name | CD44 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chebi:153927
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237621; BDBM50008910; GlcNAc(b1-4)GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)GlcNAc(b1-4)GlcA(b1-3)GlcNAc(b1-4)b-GlcA
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| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R,5R,6R)-3-[(2S,3R,4R,5S,6R)-3-Acetamido-4-[(2R,3R,4R,5S,6S)-5-[(2S,3R,4R,5S,6R)-3-acetamido-4-[(2R,3R,4R,5S,6S)-5-[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-carboxy-3,4-dihydroxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-carboxy-3,4-dihydroxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237620; BDBM50008909
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| Activity |
IC50 = 108000 nM
|
[1] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1,2,3,4-tetrahydroisoquinoline
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Investigative | Compound Info | ||
| Synonyms |
1,2,3,4-Tetrahydroisoquinoline; 91-21-4; Tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-isoquinoline; ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-; 1,2,3,4-Tetrahydro isoquinoline; EINECS 202-050-0; NSC 15312; 1,2,3,4-Tetrahydro-2-isoquinoline; 1,2,3,4-Tetrahydro-2-azanaphthalene; BRN 0116156; UNII-56W89FBX3E; CHEMBL14346; AI3-15931; 56W89FBX3E; UWYZHKAOTLEWKK-UHFFFAOYSA-N; MFCD00006896; 1,2,3,4-Tetrahydroisoquinoline, 95%; 3,4-dihydro-1H-isoquinoline; tetrahydroisoquinolin; tetrahyroisoquinoline; tetrahydro-isoquinoline; PubChem7253; AC1L1NVS
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| Activity |
IC50 = 27000000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R,5R,6R)-3-[(2S,3R,4R,5S,6R)-3-Acetamido-4-[(2R,3R,4R,5S,6S)-5-[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-carboxy-3,4-dihydroxyoxan-2-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237619; BDBM50008908
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| Activity |
IC50 = 1320000 nM
|
[1] | |||
| Compound Name |
2-[(4-Methyl-1h-Imidazol-5-Yl)methyl]-1,2,3,4-Tetrahydroisoquinolin-8-Amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237627; BDBM50008917; Q27453083; 2-(4-Methyl-1H-imidazole-5-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-8-amine-; 2L2
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| Activity |
IC50 = 3500000 nM
|
[1] | |||
| Compound Name |
1,2,3,4-Tetrahydroisoquinolin-5-amine
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Investigative | Compound Info | ||
| Synonyms |
5-Amino-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-5-YLAMINE; CHEMBL3237624; 5-AMINO-1,2,3,4-TERAHYDROISOQUINOLINE; 5-ISOQUINOLINAMINE, 1,2,3,4-TETRAHYDRO-; 5-1,2,3,4-tetrahydroisoquinolylamine; 1,2,3,4-Tetrahydro-5-aminoisoquinoline; SCHEMBL329571; DTXSID50584421; ACT10600; KS-00003T1N; BDBM50008914; MFCD02684185; SBB051997; ZINC12958084; AKOS006348055; AB12578; VQ10251; TS-01948; 5-Amino-1,2,3,4-tetrahydro-isoquinoline; FT-0619955; ST50949501; Z-4776; 5-Amino-1,2,3,4-tetrahydroisoquinoline, 98%; J-003347; Q27452716; F1967-3213
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| Activity |
IC50 = 6700000 nM
|
[1] | |||
| Compound Name |
2-[(4-Methyl-1h-Imidazol-5-Yl)methyl]-1,2,3,4-Tetrahydroisoquinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3237626; BDBM50008916; AKOS033179733; MCULE-7233398006; Q27453082
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| Activity |
IC50 = 14100000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Fragment-based identification of an inducible binding site on cell surface receptor CD44 for the design of protein-carbohydrate interaction inhibitors. J Med Chem. 2014 Mar 27;57(6):2714-25. | ||||
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