Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T81358 | Target Info | |||
| Target Name | CDC7-related kinase (CDC7) | ||||
| Synonyms |
huCdc7; HsCdc7; Cell division cycle 7related protein kinase; Cell division cycle 7-related protein kinase; CDC7related kinase; CDC7L1
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CDC7 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-[5-(Benzylamino)-1,3,4-oxadiazol-2-yl]-3H-1,3-benzoxazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093060; BDBM50443664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Benzyl-5-([1,3]thiazolo[5,4-c]pyridin-2-yl)-1,3,4-oxadiazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093057; BDBM50443667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(2-Aminopyridin-4-yl)indole-6-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348180; BDBM50432339
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-(1H-Indol-1-yl)pyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348176; SCHEMBL9377410; 4-indol-1-ylpyrimidin-2-amine; BDBM50432338
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Pyrimidinamine, 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348170; BDBM50432337
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Pyrimidinamine, 4-(6-chloro-1H-pyrrolo[3,2-c]pyridin-1-yl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2346665; BDBM50432340
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-[5-(Benzylamino)-1,3,4-oxadiazol-2-yl]-1,3-dihydroindol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093061; BDBM50443663
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
8-Bromo-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-7-methyl-3H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030384; SCHEMBL1850483; BDBM50383741; 8-bromo-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-7-methyl-1H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 104000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
8-Bromo-2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}-6-methyl[1]benzofuro[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030380; SCHEMBL1853828; BDBM50383720; 8-bromo-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-6-methyl-1H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 1350000 nM
|
[3] | |||
| Compound Name |
8-Bromo-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-9-methoxy-3H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030381; SCHEMBL1850185; BDBM50383721; 8-bromo-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-9-methoxy-1H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 3000000 nM
|
[3] | |||
| Compound Name |
8-Bromo-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-7-methoxy-3H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030385; SCHEMBL1851310; BDBM50383724; 8-bromo-2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-7-methoxy-1H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 3000000 nM
|
[3] | |||
| Compound Name |
2-{[(3S)-3-Hydroxypyrrolidin-1-yl]methyl}[1]benzofuro[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030377; SCHEMBL1852454; BDBM50383717; 2-[[(3S)-3-hydroxypyrrolidin-1-yl]methyl]-1H-[1]benzofuro[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 3000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The optimization of aminooxadiazoles as orally active inhibitors of Cdc7. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6396-400. | ||||
| REF 2 | N-substituted azaindoles as potent inhibitors of Cdc7 kinase. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2056-60. | ||||
| REF 3 | Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.