Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82028 | Target Info | |||
| Target Name | Sodium/hydrogen exchanger 1 (SLC9A1) | ||||
| Synonyms |
Solute carrier family 9 member 1; Na+/H+ antiporter, amiloride-sensitive; Na(+)Sodium/hydrogen exchanger 1/H(+) exchanger 1; Na(+)/H(+) exchanger 1; Na(+)/H(+) antiporter, amiloride-sensitive; NHE1; NHE-1; Myocardial Na+/H+ exchanger; APNH1; APNH
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| Target Type | Clinical trial Target | ||||
| Gene Name | SLC9A1 | ||||
| Biochemical Class | Monovalent cation:proton antiporter-1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 22 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Amiloride
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Approved | Compound Info | ||
| Synonyms |
Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)
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| Activity |
IC50 = 60000 nM
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[1] | |||
| Compound Name |
1-(Phenylsulfonyl)-1H-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
1-(benzenesulfonyl)benzotriazole; CHEMBL4095965; 1-(Phenylsulfonyl)-1H-benzo[d][1,2,3]triazole; ACMC-1AQY8; CBChromo1_000098; N-Phenylsulfonylbenzotriazol; (phenylsulfonyl)benzotriazole; CBDivE_009281; SCHEMBL2491809; CTK4I4219; 1-phenylsulfonyl-1h-benzotriazole; DTXSID90353734; ZINC198598; BDBM50234598; STK093470; AKOS000733950; CCG-277047; MCULE-9282718432; 1H-Benzotriazole, 1-(phenylsulfonyl)-; 1-(Phenylsulfonyl)-1H-benzotriazole, 97%; 1-(phenylsulfonyl)-1H-1,2,3-benzotriazole; 1H-1,2,3-benzotriazol-1-yl phenyl sulfone; ST45150456; AE-848/32960029; BRD-K70982938-001-02-2
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| Activity |
IC50 = 50890 nM
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[2] | |||
| Compound Name |
1-Benzoyl-1H-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
(1H-Benzo[d][1,2,3]triazol-1-yl)(phenyl)methanone; benzotriazol-1-yl(phenyl)methanone; Benzotriazol-1-yl-phenyl-methanone; MLS000529214; SMR000121689; 1-Benzoylbenzotriazole; 1H-Benzotriazole, 1-benzoyl-; Methanone,1H-benzotriazol-1-ylphenyl-; N-Benzoylbenzotriazolen; 1-benzoyl-1H-benzotrizole; benzotriazolyl phenyl ketone; cid_570059; SCHEMBL2493561; CHEMBL1288725; 1-benzotriazolyl(phenyl)methanone; BDBM32701; CTK4I6028; DTXSID30341099; HMS1693P08; ZINC101721; 1-Benzoyl-1H-benzotriazole, 97%; MFCD00451114; STK018512; 1H-benzotriazol-1-yl(phenyl)methanone; AKOS000673400; MCULE-9739030857; 1-Benzoyl-1H-1,2,3-benzotriazole #; 1-BENZOYL-1H-BENZOTRIZOLE 97; SC-65910; ST010702; 1H-1,2,3-benzotriazol-1-yl(phenyl)methanone; SR-01000393867; SR-01000393867-1; BRD-K38804290-001-08-8
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| Activity |
IC50 = 51570 nM
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[2] | |||
| Compound Name |
1-Heptyl-1H-1,2,3-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082866; SCHEMBL8633983; BDBM50234612; ZINC106866428
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| Activity |
IC50 = 59230 nM
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[2] | |||
| Compound Name |
1-Hexylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072374; 1-(n-hexyl)benzotriazole; 1-Hexyl-1H-benzotriazole; SCHEMBL461412; DTXSID40876887; 1-hexyl-1h-1,2,3-benzotriazole; BDBM50234601
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| Activity |
IC50 = 60590 nM
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[2] | |||
| Compound Name |
1-Pentyl-1H-1,2,3-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557236; 1-pentylbenzotriazole; 1-Pentyl-1H-benzotriazole; 1-PENTABENZOTRIAZOLE; SCHEMBL462848; DTXSID00876484; BDBM50234602; 1-pentyl-1h-benzo[d][1,2,3]triazole
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| Activity |
IC50 = 63470 nM
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[2] | |||
| Compound Name |
1-[(2,4-Dichlorophenyl)methyl]benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074684; Cambridge id 6499148; ZINC450466; BDBM50234616; CCG-290029; MCULE-7593800174; Benzotriazole, 1-(2,4-dichlorobenzyl)-; 1-(2,4-Dichlorobenzyl)-1H-1,2,3-benzotriazole #
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| Activity |
IC50 = 65140 nM
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[2] | |||
| Compound Name |
1-Butyl-1H-benzo[d][1,2,3]triazole
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Investigative | Compound Info | ||
| Synonyms |
1-butylbenzotriazole; 1-n-Butylbenzotriazole; 1-Butyl benzotriazole; CHEMBL425230; 1-butyl-1H-1,2,3-benzotriazole; BUTYL BENZOTRIAZOLE; 1-butyl-1H-benzotriazole; SCHEMBL1834794; CTK2H5560; DTXSID90402877; ZINC5468108; ANW-46487; BDBM50234604; MFCD01249642; AKOS003644565; AS-57777; CS-0061500; FT-0694342; W8004
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| Activity |
IC50 = 68110 nM
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[2] | |||
| Compound Name |
1-(3-Chloropropyl)-1H-1,2,3-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084954; 1-(3-chloropropyl)benzotriazole; SCHEMBL318888; BDBM50234614; 1-(3-chloropropyl)-1H-benzotriazole; 1-(3-chloropropyl)-1H-benzo[d][1,2,3]triazole
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| Activity |
IC50 = 69750 nM
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[2] | |||
| Compound Name |
1-Propylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
1-Propyl-1H-1,2,3-benzotriazole; CHEMBL204234; 1-propyl-1H-benzotriazole; SCHEMBL283896; ZINC5311330; BDBM50234610
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| Activity |
IC50 = 72380 nM
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[2] | |||
| Compound Name |
1-Benzyl-1H-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
1-Benzyl-1H-benzo[d][1,2,3]triazole; 1-Benzylbenzotriazole; 1-Benzyl-1H-1,2,3-benzotriazole; 1H-Benzotriazole, 1-benzyl-; 1H-Benzotriazole, 1-(phenylmethyl)-; 1-Benzyl-1,2,3-benzotriazole; CHEMBL1884989; [phenylmethyl]-1H-benzotriazole; (Phenylmethyl)-1H-benzotriazole; benzyl-1H-benzotriazole; MLS001008592; SCHEMBL2734889; DTXSID90334583; HMS2841L14; 1-(Phenylmethyl)-1H-benzotriazole; ALBB-032313; ZINC2913586; BDBM50234596; MFCD00227101; AKOS003644443; 1-Benzyl-1H-1,2,3-benzotriazole #; DS-9242; MCULE-7622325307; KS-00000S77; AK149946; DA-05647; SMR000495838; FT-0750583
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| Activity |
IC50 = 72510 nM
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[2] | |||
| Compound Name |
1-Ethylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
1-ethyl-1H-1,2,3-benzotriazole; 1H-BENZOTRIAZOLE, 1-ETHYL-; 1-ETHYL-1H-BENZOTRIAZOLE; 1H-Benzotriazole,1-ethyl-; CHEMBL4097403; BRN 0127548; Benzotriazole, 1-ethyl- (6CI); SCHEMBL45852; 4-26-00-00096 (Beilstein Handbook Reference); CTK4D2186; DTXSID40168032; ZINC2018370; BDBM50234606; 1H-1,2,3-benzotriazole, 1-ethyl-
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| Activity |
IC50 = 86480 nM
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[2] | |||
| Compound Name |
1-Methylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
1-Methyl-1H-benzotriazole; 1-Methyl-1H-benzo[d][1,2,3]triazole; 1H-Benzotriazole, 1-methyl-; 1-Methyl-1,2,3-benzotriazole; BRN 0118900; CHEMBL3086212; 1-Methyl-1H-1,2,3-benzotriazole; MFCD00014572; 1H-1,2,3-benzotriazole, 1-methyl-; Q63408764; EINECS 236-401-4; NSC 11743; NSC11743; Cobratec TT-100; ACMC-1BNUD; 3-N-methyl benzotriazole; 1H-Benzotriazole, 1-methyl; 1H-Benzotriazole,1-methyl-; 1-Methyl-1,3-benzotriazole; KSC492S9H; SCHEMBL170155; WLN: T56 BNNNJ B1; CTK3J2993; DTXSID40158150; ZINC405132; ALBB-027917; BCP20547; KS-000011VZ; 6097AA; ANW-19563; BDBM50234617; NSC-11743; STK364417; AKOS003644485; 1-Methyl-1H-1,2,3-benzotriazole #; CM11059; MCULE-5663090989; VZ21545; AC-24250; AS-10388; DB-019265; CS-0132322; FT-0608022; M2121; ST50411460; A806625; J-006391
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| Activity |
IC50 = 97100 nM
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[2] | |||
| Compound Name |
(3R)-1-[(1S,2S)-4,6-Dichloro-1-[4-(3,5-dimethyl-1,2,4-triazol-4-yl)-2-fluorophenoxy]-2,3-dihydro-1H-inden-2-yl]pyrrolidin-3-ol;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892788; BDBM50196789
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
2-Butyl-2H-benzo[d][1,2,3]triazole
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Investigative | Compound Info | ||
| Synonyms |
2-butylbenzotriazole; CHEMBL4072288; 2-Butyl-2H-benzotriazole; SCHEMBL9222921; 2-butyl-2H-1,2,3-benzotriazole; ZINC5310512; BDBM50234603; MFCD00962172; AKOS022184248; AS-61889; CS-0059973
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| Activity |
IC50 = 101120 nM
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[2] | |||
| Compound Name |
2-(3-Chloropropyl)benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063302; SCHEMBL9039241; BDBM50234615
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| Activity |
IC50 = 115250 nM
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[2] | |||
| Compound Name |
2-Propylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087253; 2-Propyl-2H-benzotriazole; SCHEMBL6229314; BDBM50234605
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| Activity |
IC50 = 135000 nM
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[2] | |||
| Compound Name |
2-Hexylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
2-Hexyl-2H-benzotriazole; CHEMBL4093129; 2-Hexyl-2H-1,2,3-benzotriazole; SCHEMBL17528648; ZINC5308762; BDBM50234600
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| Activity |
IC50 = 154670 nM
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[2] | |||
| Compound Name |
2-Heptylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100842; BDBM50234599
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| Activity |
IC50 = 156540 nM
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[2] | |||
| Compound Name |
2-Methylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
2-Methyl-2H-benzotriazole; 2H-Benzotriazole, 2-methyl-; 2-Methyl-2H-1,2,3-benzotriazole; 2-Methyl-2H-benzo[d][1,2,3]triazole; CHEMBL4068558; NSC11744; 2-N-methyl benzotriazole; 2H-Benzotriazole,2-methyl-; SCHEMBL822547; 2-Methyl-1,2,3-benzotriazole; 2METHYL-2H-BENZOTRIAZOLE; SCHEMBL11938122; CTK4D2185; DTXSID80168031; ALBB-032316; ZINC1718550; BDBM50234608; MFCD00464868; NSC-11744; AKOS006272796; 2-Methyl-2H-1,2,3-benzotriazole #; 2H-1,2,3-benzotriazole, 2-methyl-; FT-0691796
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| Activity |
IC50 = 177000 nM
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[2] | |||
| Compound Name |
2-Pentyl-2H-benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085368; SCHEMBL169024; BDBM50234611
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| Activity |
IC50 = 191230 nM
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[2] | |||
| Compound Name |
1H-Benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
Benzotriazole; 2H-Benzotriazole; 1H-Benzo[d][1,2,3]triazole; 1,2,3-BENZOTRIAZOLE; 1H-1,2,3-Benzotriazole; Azimidobenzene; Aziminobenzene; Benztriazole; Benzisotriazole; Benzene azimide; 2,3-Diazaindole; Cobratec #99; 1,2-Aminoazophenylene; Cobratec 99; 1,2,3-Triaza-1H-indene; 1,2,3-Triazaindene; 1,2,-Aminozophenylene; NCI-C03521; NSC-3058; 1,2,3-1h-benzotriazole; U-6233; UNII-86110UXM5Y; 1,2,3-Benztriazole; MFCD00005699; 2H-benzo[d][1,2,3]triazole; 86110UXM5Y; 1H-Benzotriazol; DSSTox_CID_147; 1H-Benzotriazole, 99%; DSSTox_RID_75400; DSSTox_GSID_20147; Benzotriazole (VAN); benzotriazol; CCRIS 78; Pseudoazimidobenzene; Cobratec 35G; HSDB 4143; 1,2,3-Benzotriazole,1H-benzo[d][1,2,3]triazole; EINECS 202-394-1; azaindazole; BRN 0112133; aza-indazole; AI3-15984; 1 h-benzotriazole; 1,3-Triazaindene; 1,3-Benzotriazole; Cobratec No. 99; 1,2-Aminozophenylene; PubChem16004; ACMC-209ruz; 1H-1,3-Benzotriazole; 1,3-Triaza-1H-indene; 1H-Benzotriazole (VAN8C; EC 202-394-1; WLN: T56 BMNNJ; SCHEMBL8956; 1,2,3-Benzotriazole(BTA); 4-26-00-00093 (Beilstein Handbook Reference); KSC486M6D; MLS002302971; CHEMBL84963; 1H-benzo-[1,2,3]triazole; DTXSID6020147; BDBM36293; CTK1A4424; CTK3I6661; NSC3058; Benzotriazole, analytical standard; HMS3091M10; ZINC332008; Benzotriazole, reagent grade, 97%; CS-D1407; KS-00000K8O; STR01561; Tox21_201501; Tox21_302934; ANW-40377; BDBM50234613; SBB060070; STL281967; Benzotriazole, ReagentPlus(R), 99%; 1H-Benzotriazole, >=98.0% (N); AKOS000119181; AKOS025396849; MCULE-2848618742; PS-3644; NCGC00091322-01; NCGC00091322-02; NCGC00091322-03; NCGC00256574-01; NCGC00259052-01; AK-44446; BP-21454; SC-15698; SMR001252218; AB0008382; DB-022595; B0094; BB 0243857; FT-0606217; FT-0698151; ST51046317; Benzotriazole, Vetec(TM) reagent grade, 98%; 3334-EP2270010A1; 3334-EP2270113A1; 3334-EP2272828A1; 3334-EP2272935A1; 3334-EP2280000A1; 3334-EP2281563A1; 3334-EP2281818A1; 3334-EP2284920A1; 3334-EP2289883A1; 3334-EP2292586A2; 3334-EP2292593A2; 3334-EP2292597A1; 3334-EP2292611A1; 3334-EP2298753A1; 3334-EP2301918A1; 3334-EP2301921A1; 3334-EP2301924A1; 3334-EP2301926A1; 3334-EP2305651A1; 3334-EP2308562A2; 3334-EP2308839A1; 3334-EP2308840A1; 3334-EP2308849A1; 3334-EP2308850A1; 3334-EP2308854A1; 3334-EP2314575A1; 3334-EP2315502A1; 3334-EP2316459A1; 3334-EP2371811A2; 3334-EP2372804A1; 3334-EP2377847A1; 3334-EP2378585A1; Z-2915; 22608-EP2315502A1; 81449-EP2275411A2; 81449-EP2305687A1; AB00374479-06; AC-907/34124039; Q220672; W-100172; Z57127352; F2190-0645
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| Activity |
IC50 = 192680 nM
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[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Ethylbenzotriazole
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Investigative | Compound Info | ||
| Synonyms |
2-Ethyl-2H-benzotriazole; CHEMBL4079373; 2H-Benzotriazole, 2-ethyl-; SCHEMBL6229399; CTK8H1853; DTXSID50343494; ZINC5341916; BDBM50234597; 2-Ethyl-2H-1,2,3-benzotriazole #
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| Activity |
IC50 = 355000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous ... J Biol Chem. 2007 Jul 6;282(27):19716-27. | ||||
| REF 2 | Sodium hydrogen exchanger inhibitory activity of benzotriazole derivatives. Eur J Med Chem. 2017 Jan 27;126:183-189. | ||||
| REF 3 | Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na +/H + Exchanger Type 3 (NHE3). J Med Chem. 2016 Oct 13;59(19):8812-8829. | ||||
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