Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82467 | Target Info | |||
| Target Name | ATPase family AAA domain containing 2 (ATAD2) | ||||
| Synonyms |
PRO2000; L16; ATPase family AAA domain-containing protein 2; ANCCA; AAA nuclear coregulator cancer-associated protein
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| Target Type | Literature-reported Target | ||||
| Gene Name | ATAD2 | ||||
| Biochemical Class | Acid anhydride hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
NI-57
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752151; 1883548-89-7; 4-Cyano-~{n}-(1,3-Dimethyl-2-Oxidanylidene-Quinolin-6-Yl)-2-Methoxy-Benzenesulfonamide; GTPL8573; SCHEMBL17560720; MolPort-039-101-322; NI 57; EX-A1876; BDBM50157570; ZINC254286814; AKOS027470204; NCGC00483115-01; NI-57, > HY-19537; CS-0015636; 4-cyano-N-(1,3-dimethyl-2-oxoquinolin-6-yl)-2-methoxybenzenesulfonamide; 4-cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzenesulfonamide
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
3-Methyl-8-((8-methyl-8-azabicyclooctan-3-yl)amino)-1,7-naphthyridin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586717; CHEMBL3586718; BDBM50096311; BDBM50096319; FZB
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| Activity |
IC50 = 50118.72 nM
|
[2] | |||
| Compound Name |
3-Methyl-5-(2-methylpyridin-3-yl)-8-(piperidin-4-ylamino)-1H-1,7-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3585450; BDBM50096316
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| Activity |
IC50 = 50118.72 nM
|
[3] | |||
| Compound Name |
3-Methyl-8-(piperidin-4-ylmethylamino)-1H-1,7-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586707; BDBM50093454
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| Activity |
IC50 = 50118.72 nM
|
[3] | |||
| Compound Name |
8-[[(1S,3S)-3-Aminocyclohexyl]amino]-3-methyl-1H-1,7-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586710; BDBM50093457
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| Activity |
IC50 = 50118.72 nM
|
[3] | |||
| Compound Name |
3-Methyl-8-(3-dimethylaminopropylamino)pyrido[3,4-b]pyridine-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586698; BDBM50093444
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| Activity |
IC50 = 63095.73 nM
|
[3] | |||
| Compound Name |
3-Methyl-8-[[(3S,4S)-3-(oxan-4-ylmethoxy)piperidin-4-yl]amino]-1H-1,7-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590395; BDBM50098330
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| Activity |
IC50 = 63095.73 nM
|
[4] | |||
| Compound Name |
3-Methyl-8-[[(3R)-pyrrolidin-3-yl]amino]-1H-1,7-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586702; BDBM50093449
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| Activity |
IC50 = 79432.82 nM
|
[3] | |||
| Compound Name |
CCOc1ccc(cc1-c1cn(C)c(=O)c2ccc(cc12)-c1cnn(C)c1)S(=O)(=O)CC
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3787482; SCHEMBL16650764; BDBM50158627; 4-(2-ethoxy-5-ethylsulfonylphenyl)-2-methyl-6-(1-methylpyrazol-4-yl)isoquinolin-1-one
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| Activity |
IC50 ~ 80000 nM
|
[5] | |||
| Compound Name |
3-Methyl-8-(3-hydroxypropylamino)quinoline-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586692; BDBM50093465
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
NI-42; CHEMBL4102050; NI 42; 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzenesulfonamide; SCHEMBL17576473; BDBM50249810; AKOS027470288; ZINC427298343; BP-25364; NI-42, >=98% (HPLC); HY-101121; CS-0020882; J3.613.254J; N-(1,2-Dihydro-1,3-dimethyl-2-oxoquinoline-6-yl)-4-cyanobenzenesulfonamide
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-Cyano-N-(1,3-diethyl-2-oxoquinolin-6-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059509; BDBM50249797
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Methyl-8-(2-hydroxyethylamino)quinoline-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586691; BDBM50093464
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(2-Oxo-3-methyl-1,2-dihydroquinoline-8-ylamino)propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586695; BDBM50093468
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
3-Butyl-8-[(6-Butyl-5,7-Dimethyl-[1,2,4]triazolo[1,5-A]pyrimidin-2-Yl)sulfanylmethyl]-7-Ethyl-Purine-2,6-Dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3774931; SCHEMBL19066319; BDBM50150069; ZINC68716836; AKOS008738479; MCULE-3915679099; J3.601.437G; Q27455888; Z642854042
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
3-Methyl-8-[[(3R)-piperidin-3-yl]amino]-1H-1,7-naphthyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586709; BDBM50093456
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
8-{[2-(Dimethylamino)ethyl]amino}-3-Methyl-1,2-Dihydroquinolin-2-One
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586689; BDBM50093462; Q27461784; 3-Methyl-8-(2-dimethylaminoethylamino)quinoline-2(1H)-one; JTF
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-8-(2-methoxyethylamino)quinoline-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586694; BDBM50093467
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
1-Methyl-2-quinolone
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Investigative | Compound Info | ||
| Synonyms |
1-METHYL-2-QUINOLINONE; 1-METHYLQUINOLIN-2(1H)-ONE; N-Methylcarbostyril; 1-methylquinolin-2-one; 1-Methyl-2(1H)-quinolinone; 2(1H)-Quinolinone, 1-methyl-; 1-Methylcarbostyril; Carbostyril, 1-methyl-; 1-Methyl-2(1H)-quinolone; 1-methyl-1,2-dihydroquinolin-2-one; UNII-UQ470VV48X; 2(1H)-Quinolinone, methyl-; MLS002637847; CHEMBL216146; UQ470VV48X; MFCD00024051; 1-methylhydroquinolin-2-one; NSC 5873; N-methyl-2-quinolone; PubChem15912; AI3-24119; 1-methyl-quinolin-2-one; N-Methyl-quinolin-2-one; C3b N-Methyl-2-quinolone; 2-Hydroxy-1-methylquinoline; ACMC-1BH74; 1-methyl-1H-quinolin-2-one; SCHEMBL248619; DTXSID1060552; Carbostyril, 1-methyl- (8CI); CTK2I8695; QYEMNJMSULGQRD-UHFFFAOYSA-; NSC5873; HMS3604D09; ZINC336851; ALBB-032305; NSC-5873; BBL019043; BDBM50157646; SBB087359; STK736383; AKOS000276919; CS-W023164; DB04580; HR-0330; MCULE-8485036701; SMR001547359; DB-053678; ST4129070; FT-0632523; H2834; 606M439; A832822; AO-840/40233519; Q27095322; F3308-4039
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
3-Methyl-8-(propylamino)quinoline-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586690; BDBM50093463
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-8-(2-piperidin-3-ylethylamino)-1H-1,7-naphthyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586706; BDBM50093453
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-8-(2-piperidin-4-ylethylamino)-1H-1,7-naphthyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586705; BDBM50093452
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Methyl-8-(1H-imidazole-2-ylmethylamino)quinoline-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586693; BDBM50093466
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8-[[3-(Dimethylamino)-2,2-dimethylpropyl]amino]-3-methyl-1H-1,7-naphthyridin-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586708; BDBM50093455
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Methyl-8-(2-dimethylaminoethylamino)pyrido[3,4-b]pyridine-2(1H)-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3586696; BDBM50093469
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| Activity |
IC50 = 501187.23 nM
|
[3] | |||
| Compound Name |
3-Methylquinolin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
3-METHYLQUINOLIN-2-ONE; 3-methyl-1,2-dihydroquinolin-2-one; 3-Methylcarbostyril; 2-Hydroxy-3-methylquinoline; 3-methylquinolin-2-ol; 3-Methyl-2-quinolinone; 2(1H)-Quinolinone, 3-methyl-; 3-Methyl-2-oxo-1,2-dihydroquinoline; 3-methyl-1H-quinolin-2-one; Quinolinol, methyl-; 3-methyl-2-quinolone; 3-Methyl-quinolin-2-ol; 3-Methylhydroquinolin-2-one; CHEMBL3586688; Carbostyril, 3-methyl-; methylquinolone; methylhydroxyquinoline; ACMC-20malf; SCHEMBL248620; 3-Methyl-2(1H)-quinolinone; 2(1H)-Quinolinone,3-methyl-; CTK0D6805; CTK4F9277; 3-Methyl-2(1H)-quinolinone #; DTXSID90949939; ANW-64695; BDBM50096297; STL572712; ZB0690; ZINC16343284; AKOS006289779; AKOS017405187; MCULE-8040173784; NE53507; AS-37316; DB-081650; FT-0760991; C06345; Q27461644; Z1863617777
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| Activity |
IC50 > 1000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins. J Med Chem. 2017 Aug 24;60(16):6998-7011. | ||||
| REF 2 | Aiming to Miss a Moving Target: Bromo and Extra Terminal Domain (BET) Selectivity in Constrained ATAD2 Inhibitors. J Med Chem. 2018 Sep 27;61(18):8321-8336. | ||||
| REF 3 | Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors. J Med Chem. 2015 Jul 23;58(14):5649-73. | ||||
| REF 4 | Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors. J Med Chem. 2015 Aug 13;58(15):6151-78. | ||||
| REF 5 | Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1811-1816. | ||||
| REF 6 | Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60(2):668-680. | ||||
| REF 7 | Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins. J Med Chem. 2016 Feb 25;59(4):1634-41. | ||||
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