Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83145 | Target Info | |||
| Target Name | Nuclear factor NF-kappa-B (NFKB) | ||||
| Synonyms |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells; DNA-binding factor KBF
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| Target Type | Successful Target | ||||
| Gene Name | NFKB1; NFKB2; RELA; RELB; REL | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 19 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1E,6E)-1,7-Bis(3-fluoro-4-hydroxy-5-methoxyphenyl)hepta-1,6-diene-3,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290185; BDBM50020587
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Ethyl-2-(3,4,5-trimethoxyphenyl)-7-methoxy-2H-1-benzopyran-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123165
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Tetrahydrocurcumin
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Investigative | Compound Info | ||
| Synonyms |
1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione; Sabiwhite; Tetrahydrodiferuloylmethane; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione; 3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-; UNII-00U0645U03; CHEMBL318743; MFCD04152347; NSC687845; 00U0645U03; NSC 687845; Tetrahydrocucumin; 3,5-Heptamedopme. 1,7-bis(hydroxy-3methoxyphenyl)heptane; EC 609-201-3; THC (Tetra Hydro Curcumin); SCHEMBL284877; KS-00000IDE; DTXSID30865801; BCP18621; HY-N0893; ZINC4649679; BDBM50059985; s3917; Tetrahydrocurcumin, >=96% (HPLC); AKOS015999950; Tetrahydrocurcumin, analytical standard; CCG-268326; CS-3739; NSC-687845; VN10058; AC-24240; AK-47436; AS-13957; SY047647; AB0024474; FT-0674986; W5754; 062T041; J-504043; Q27135730; 1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione; 1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-heptane-3,5-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Isopropyl-2-(3,4,5-trimethoxyphenyl)-7-methoxy-2H-1-benzopyran-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124000
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-Methyl-2-(3,4,5-trimethoxyphenyl)-7-methoxy-2H-1-benzopyran-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL121115
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenyl)-7-methoxy-2H-1-benzopyran-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL121138; SCHEMBL7975488
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-[(E)-2-[3-[(E)-2-[4-Hydroxy-3-methoxy-5-(3-methylbut-2-enyl)phenyl]ethenyl]-1H-pyrazol-5-yl]ethenyl]-2-methoxy-6-(3-methylbut-2-enyl)phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3290441; BDBM50020589; 4,4'-[1H-Pyrazole-3,5-diylbis(1,2-ethenediyl)]bis(2-prenyl-6-methoxyphenol)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenyl)-7-methoxy-2H-1-benzopyran-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123362; SCHEMBL7962069; 7-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-chromene-3-carboxylic acid
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| Activity |
IC50 ~ 50000 nM
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[2] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenyl)-7-methoxy-2H-1-benzopyran-3-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123887; SCHEMBL7961876; [7-methoxy-2-(3,4,5-trimethoxyphenyl)-2H-chromen-3-yl]methanol
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N,N-Dimethyl 2-(3,4,5-trimethoxyphenyl)-7-methoxy-2H-1-benzopyran-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331471
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1,7-Bis[3-methoxy-4-hydroxy-5-(3-methyl-2-butenyl)phenyl]-1,6-heptadiene-3,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2392187; Diprenylcurcumin; BDBM50020590
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(3,4,5-Trimethoxyphenyl)-3-(piperidinocarbonyl)-7-methoxy-2H-1-benzopyran
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL330872
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Tert-butyl N-(4-oxocyclopent-2-en-1-yl)carbamate
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Investigative | Compound Info | ||
| Synonyms |
tert-Butyl (4-oxocyclopent-2-en-1-yl)carbamate; Carbamic acid, (4-oxo-2-cyclopenten-1-yl)-, 1,1-dimethylethyl ester (9CI); SCHEMBL5600252; CHEMBL3902610; CTK8J8893; MFCD09954963; 1-(Boc-amino)-4-oxocyclopent-2-ene; SB23022; KS-0000080D; AS-50685; CS-0048065; 4-(tert-Butyloxycarbonylamino)-2-cyclopentene-1-one
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| Activity |
IC50 = 52000 nM
|
[3] | |||
| Compound Name |
N-(3,4-Dihydro-2H-benzo[h]chromen-2-ylmethyl)-3,5-bis(trifluoromethyl)aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3260931
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| Activity |
IC50 = 56300 nM
|
[4] | |||
| Compound Name |
N-(3,4-Dihydro-2H-benzo[h]chromen-2-ylmethyl)-3-methylbutanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3260935
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| Activity |
IC50 = 56300 nM
|
[4] | |||
| Compound Name |
4-Anilinocyclopent-2-enone
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Investigative | Compound Info | ||
| Synonyms |
4-anilinocyclopent-2-en-1-one; CHEMBL3935371; SCHEMBL14586688; 4-Anilino-2-cyclopentene-1-one
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| Activity |
IC50 = 57000 nM
|
[3] | |||
| Compound Name |
N-[3,5-Bis(trifluoromethyl)phenyl]-3,4-dihydro-2H-benzo[h]chromene-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3260925
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| Activity |
IC50 = 63800 nM
|
[4] | |||
| Compound Name |
[(5R,5As,9R,9aR,9bR)-9,9b-dihydroxy-6,6,9a-trimethyl-1-oxo-3,5,5a,7,8,9-hexahydrobenzo[e][2]benzofuran-5-yl] hexanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3261196; BDBM50016099
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|
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| Activity |
IC50 = 68400 nM
|
[5] | |||
| Compound Name |
N-(3,5-Dichlorophenyl)-3,4-dihydro-2H-benzo[h]chromene-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3260922
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| Activity |
IC50 = 96700 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem. 2014 Jul 10;57(13):5638-48. | ||||
| REF 2 | Novel chromene derivatives as TNF-alpha inhibitors. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3647-50. | ||||
| REF 3 | WO patent application no. 2004013077A2, IMPROVEMENTS IN PHARMACEUTICALLY USEFUL COMPOUNDS | ||||
| REF 4 | Design and synthesis of 3,4-dihydro-2H-benzo[h]chromene derivatives as potential NF-B inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2404-7. | ||||
| REF 5 | Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species. Bioorg Med Chem. 2014 Jun 1;22(11):2912-8. | ||||
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