Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83198 | Target Info | |||
| Target Name | Cysteines of Keap1 (KEAP1 Cysteines) | ||||
| Synonyms |
Kelch-like protein 19-Cysteines; Kelch-like ECH-associated protein 1-Cysteines; KLHL19-Cysteines; KIAA0132-Cysteines; INrf2-Cysteines; Cytosolic inhibitor of Nrf2-Cysteines
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| Target Type | Clinical trial Target | ||||
| Gene Name | KEAP1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(4-Chlorophenyl)-3-(1-methylbenzotriazol-5-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3819386; BDBM50180853
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| Activity |
IC50 = 61000 nM
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[1] | |||
| Compound Name |
Chembl4162919
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Investigative | Compound Info | ||
| Activity |
IC50 = 69700 nM
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[2] | |||
| Compound Name |
2-({5-[(2,4-Dimethylphenyl)sulfonyl]-6-Oxo-1,6-Dihydropyrimidin-2-Yl}sulfanyl)-N-[2-(Trifluoromethyl)phenyl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402206; BDBM50120421; MCULE-8022045809; Q27454740; 4ID
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| Activity |
IC50 = 118000 nM
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[3] | |||
| Compound Name |
Chembl4238271
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Investigative | Compound Info | ||
| Synonyms |
BDBM50462210
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| Activity |
Ki = 151500 nM
|
[4] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ethyl 2-[[4-[(2-ethoxy-2-oxoethyl)-(4-methoxyphenyl)sulfonylamino]naphthalen-1-yl]-(4-methoxyphenyl)sulfonylamino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3632707; BDBM50130547
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| Activity |
IC50 > 250000 nM
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[5] | |||
| Compound Name |
3-(4-Chlorophenyl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
3-(4-Chlorophenyl)propionic acid; Benzenepropanoic acid, 4-chloro-; 4-chlorophenylpropionic acid; 3-(4-chlorophenyl)-propionic acid; MFCD00016555; 4-Chlorobenzenepropanoic acid; 3-(4-Chloro-phenyl)-propionic acid; UNII-EU6X3MW040; EU6X3MW040; CHEMBL3819037; p-Chlorohydrocinnamic acid; 4-CHLOROHYDROCINNAMIC ACID; p-Chlorhydrozimtsaure; PubChem12507; ACMC-1CMDB; KSC494I8J; SCHEMBL349314; b-(p-chlorophenyl)propionic acid; CTK3J4484; 3-(p-chlorophenyl)propionic acid; DTXSID90174022; 3-(p-chlorophenyl) propionic acid; ZINC129056; ALBB-029466; KS-00000N5J; 3-(4-Chlorophenyl)propanoic acid #; ANW-23951; BBL022568; BDBM50180854; SBB010179; STK397363; 4-CHLORO-BENZENEPROPANOIC ACID; AKOS000112333; AB01196; CS-W007646; MCULE-1600813005; 3-(4-Chlorophenyl)propionic acid, 97%; AK-25565; AS-12445; SC-16870; SY003370; BETA-(P-CHLOROPHENYL)PROPIONIC ACID; AB0000740; DB-021649; ST4134001; FT-0633981; EN300-24304; C-5364; 493C658; AE-641/00345037; J-510685; Q27465198; Z188924002
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| Activity |
IC50 > 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem. 2016 Apr 28;59(8):3991-4006. | ||||
| REF 2 | Small molecules inhibiting Keap1-Nrf2 protein-protein interactions: a novel approach to activate Nrf2 function. Medchemcomm. 2016 Nov 17;8(2):286-294. | ||||
| REF 3 | Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. Bioorg Med Chem. 2013 Jul 15;21(14):4011-9. | ||||
| REF 4 | Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2728-2731. | ||||
| REF 5 | Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators. Eur J Med Chem. 2015 Oct 20;103:252-68. | ||||
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