Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83391 | Target Info | |||
| Target Name | Fructose-1,6-bisphosphatase (FBP) | ||||
| Synonyms |
FBPase; D-fructose-1,6-bisphosphate 1-phosphohydrolase
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | FBP1; FBP2 | ||||
| Biochemical Class | Phosphoric monoester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 68 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(3-Methoxyphenyl)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127636; BDBM50449179
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
7-Nitro-4-(3-nitroanilino)-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127766; BDBM50449185
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
7-Nitro-4-phenyl-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127635; BDBM50449180
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
[5-(6-Chloro-9-phenethyl-9H-purin-8-yl)-furan-2-yl]-phosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515436; BDBM50277465
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 50000 nM
|
[2] | ||
| Compound Name |
4-(4-Chloroanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127765; BDBM50449186
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(3-Chloroanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127764; BDBM50449187
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
N-(5-Chlorobenzo[d]oxazol-2-yl)butane-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205376; BDBM50181354
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[3] | ||
| Compound Name |
[5-(6-Methylamino-9-phenethyl-9H-purin-8-yl)-furan-2-yl]-phosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL515243; BDBM50277464
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 50000 nM
|
[2] | ||
| Compound Name |
3-(2-Carboxyethyl)-1-(cyclopropylmethyl)-7-nitroindole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393939; BDBM50101425
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[4] | ||
| Compound Name |
4-(3-Aminoanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127632; BDBM50449183
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-Anilino-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127756; BDBM50449191
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(3-Chlorophenyl)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127637; BDBM50449178
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
7-Nitro-4-[3-(trifluoromethyl)phenyl]-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127642; BDBM50449174
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
2,5-Dichloro-N-(4-iodobenzo[d]oxazol-2-yl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203628; BDBM50181361
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[3] | ||
| Compound Name |
2,6-Dichloro-N-(5-chlorobenzo[d]oxazol-2-yl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380739; BDBM50181348
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[3] | ||
| Compound Name |
2-Chloro-N-(5-chlorobenzo[d]oxazol-2-yl)-6-methylbenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382861; BDBM50181331
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[3] | ||
| Compound Name |
3-(4-Tert-butylbenzyloxy)-N-(5-chlorobenzo[d]oxazol-2-yl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382691; BDBM50181338
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[3] | ||
| Compound Name |
4-(3-Methoxy-N-propylanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127634; BDBM50449181
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(4-Chlorophenyl)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127638; BDBM50449177
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
7-Nitro-4-[4-(trifluoromethyl)phenyl]-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127743; BDBM50449173
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
N-(5-Chlorobenzo[d]oxazol-2-yl)methanesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205392; BDBM50181350
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[3] | ||
| Compound Name |
1-Benzyl-3-(2-carboxyethyl)-7-nitroindole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393940; BDBM50101424
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[4] | ||
| Compound Name |
3-(2-Carboxyethyl)-5-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950316; BDBM50364917
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[4] | ||
| Compound Name |
4-(3-Aminophenyl)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127745; BDBM50449172
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(3-Acetamidoanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127631; BDBM50449184
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|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
7-Amino-3-(2-carboxyethyl)-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393938; BDBM50101426
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[4] | ||
| Compound Name |
4-(3-Methoxy-N-methylanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127633; BDBM50449182
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(4-Cyanophenyl)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127640; BDBM50449175
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
7-Nitro-4-(3,4,5-trimethoxyanilino)-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127761; BDBM50449188
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|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(3-Cyanophenyl)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127639; BDBM50449176
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|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(4-Methoxyanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127759; BDBM50449189
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|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
4-(2-Methoxyanilino)-7-nitro-1H-indole-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127757; BDBM50449190
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
3-(2-Ethoxycarbonyl-7-nitro-1H-indol-3-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393937; BDBM50101428
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|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 50000 nM
|
[4] | ||
| Compound Name |
2,5-Dichloro-N-(4-methylbenzo[d]oxazol-2-yl)benzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204894; BDBM50181359
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 55000 nM
|
[3] | ||
| Compound Name |
{5-[6-Amino-9-(2,2-diphenyl-ethyl)-9H-purin-8-yl]-furan-2-yl}-phosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL475304; BDBM50277466
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 70000 nM
|
[2] | ||
| Compound Name |
1-Butyl-3-(m-tolylsulfonyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459134; BDBM50273273; 1-butyl-3-(3-methylphenyl)sulfonylurea
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 86763 nM
|
[5] | ||
| Compound Name |
[2-(6-Amino-9-benzyl-9H-purin-8-ylamino)-ethyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484136; SCHEMBL5361216; BDBM50277896; N9-benzyl-8-(2-phosphonoethylamino)adenine; 2-[(6-amino-9-benzylpurin-8-yl)amino]ethylphosphonic acid
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 91000 nM
|
[2] | ||
| Compound Name |
2-Amino-8H-indeno[1,2-d]thiazol-6-ylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568552; BDBM50302484
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 91900 nM
|
[6] | ||
| Compound Name |
2-(6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-9H-purin-8-ylamino)ethylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519323; BDBM50277894
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 100000 nM
|
[2] | ||
| Compound Name |
(6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-8-ylamino)methylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482951; BDBM50277858
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
3-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyltetrahydro-furan-2-yl)-9H-purin-8-yl]-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485129; BDBM50277855
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
5-(6-Amino-9-phenethyl-9H-purin-8-yl)-furan-2-carboxylic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520175; BDBM50278061
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
N-Carbamoyl-3-methylbenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593391; (3-methylphenyl)sulfonylurea; BDBM50305596
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
[5-(6-Amino-9-phenethyl-9H-purin-8-yl)-furan-2-yl]-phosphonic Acid Monoethyl Ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520176; BDBM50278064
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
Diethyl [5-(6-Amino-9-phenethyl-9H-purin-8-yl)-furan-2-yl]-phosphonate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484923; BDBM50278063
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
1-[(3-Methylbenzene)sulfonyl]-3-[2-({[(3-methylbenzene)sulfonyl]carbamoyl}amino)ethyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496654; BDBM50272868
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
Methyl 7-(3-(methylsulfonyl)ureido)heptanoylsulfamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591318; BDBM50305597
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[7] | ||
| Compound Name |
3-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyltetrahydro-furan-2-yl)-9H-purin-8-ylamino]-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519361; SCHEMBL13835142; BDBM50277857
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-8-ylamino]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485130; 8-(Carboxymethylamino)adenosine; BDBM50277856
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
1-(3-Methylphenyl)sulfonyl-3-[2-[2-[(3-methylphenyl)sulfonylcarbamoylamino]ethylamino]ethyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL458055; BDBM50273192
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
{[(6-Amino-9-phenethyl-9H-purine-8-carbonyl)-amino]-methyl}-phosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL484782; SCHEMBL5358382; BDBM50277929; [[6-amino-9-(2-phenylethyl)purine-8-carbonyl]amino]methylphosphonic acid
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 100000 nM
|
[2] | ||
| Compound Name |
3-(6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-8-ylamino)propylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520307; BDBM50277892
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
[3-(6-Amino-9-phenethyl-9H-purin-8-yl)-propyl]-phosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519996; BDBM50277968
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 100000 nM
|
[2] | ||
| Compound Name |
[1-[[6-Amino-9-(2,2-dimethylpropyl)purin-8-yl]methyl]imidazol-2-yl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL485144; BDBM50277695; {1-[6-Amino-9-(2,2-dimethyl-propyl)-9H-purin-8-ylmethyl]-1Himidazol-2-yl}-phosphonic Acid
Click to Show/Hide
|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
[(E)-3-(6-Amino-9-phenethyl-9H-purin-8-yl)-allyl]-phosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520009; BDBM50277930
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|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 100000 nM
|
[2] | ||
| Compound Name |
[2-(6-Amino-9-phenethyl-9H-purin-8-ylamino)-ethyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521165; SCHEMBL6346450; BDBM50277926; 2-[[6-amino-9-(2-phenylethyl)purin-8-yl]amino]ethylphosphonic acid
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|
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 100000 nM
|
[2] | ||
| Compound Name |
3-[(3-Methylbenzene)sulfonyl]-1-[3-({[(3-methylbenzene)sulfonyl]carbamoyl}amino)propyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL498538; BDBM50272869
Click to Show/Hide
|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[5] | ||
| Compound Name |
(E)-3-[6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyltetrahydro-furan-2-yl)-9H-purin-8-yl]-acrylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519202; BDBM50277854
Click to Show/Hide
|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
|
[2] | ||
| Compound Name |
2-(6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-8-ylamino)ethylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483163; SCHEMBL5369521; 8-(2-phosphonoethylamino)-adenosine; BDBM50277891
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|
||||
| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 100000 nM
|
[2] | ||
| Compound Name |
2-(6-Amino-9H-purin-8-ylamino)ethylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483356; BDBM50277895
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 ~ 100000 nM
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[2] | ||
| Compound Name |
(2-Amino-8H-indeno[1,2-d]thiazol-6-yloxy)methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL567315; BDBM50302498; 6-[(Dihydroxyphosphinyl)methoxy]-8H-indeno[1,2-d]thiazole-2-amine
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 112000 nM
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[6] | ||
| Compound Name |
(2-Amino-8H-indeno[1,2-d]thiazol-5-yloxy)methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL577282; BDBM50302499; 5-[(Dihydroxyphosphinyl)methoxy]-8H-indeno[1,2-d]thiazole-2-amine
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 112000 nM
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[6] | ||
| Compound Name |
2-Amino-4,5-dihydronaphtho[1,2-d]thiazol-7-yl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL566049; BDBM50302494
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 112000 nM
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[6] | ||
| Compound Name |
1-Butyl-3-(3-chlorophenylsulfonyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456984; Benzenesulfonamide, N-[(butylamino)carbonyl]-3-chloro-; BDBM50273272; ZINC36395652; AKOS034315041; MCULE-1777907660; 1-butyl-3-(3-chlorophenyl)sulfonylurea; 3-butyl-1-(3-chlorobenzenesulfonyl)urea; Z425552742
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 134180 nM
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[5] | ||
| Compound Name |
2-(6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-8-ylamino)ethyl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL483355; BDBM50277893
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 140000 nM
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[2] | ||
| Compound Name |
[2-(6-Amino-9-phenethyl-9H-purin-8-ylsulfanyl)-ethyl]-phosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL484160; BDBM50277969
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 145000 nM
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[2] | ||
| Compound Name |
2-Amino-8H-indeno[1,2-d]thiazol-6-yl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL566670; BDBM50302491
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 146000 nM
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[6] | ||
| Compound Name |
5-(6-Amino-9-phenethyl-9H-purin-8-yl)-furan-2-sulfonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL484922; BDBM50278062
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 150000 nM
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[2] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 14 non binders) | Download | Top | |||
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| Compound Name |
1-(3-Chlorophenylsulfonyl)-3-propylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456992; BDBM50273270; 1-(3-chlorophenyl)sulfonyl-3-propylurea
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 234231 nM
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[5] | ||
| Compound Name |
[5-(6-Dimethylamino-9-phenethyl-9H-purin-8-yl)-furan-2-yl]-phosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL520489; BDBM50278065
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 250000 nM
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[2] | ||
| Compound Name |
1-(3-Chlorophenylsulfonyl)-3-(2-(methylthio)ethyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL500269; BDBM50273275
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 277143 nM
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[5] | ||
| Compound Name |
2-Amino-8H-indeno[1,2-d]thiazol-5-yl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL568771; BDBM50302492
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 307000 nM
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[6] | ||
| Compound Name |
Urea, 1-propyl-3-(m-tolylsulfonyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL505578; 1-propyl-3-(m-tolylsulfonyl)urea; N-propyl-N'-(toluene-3-sulfonyl)-urea; BRN 3328135; 1-Propyl-3-(m-tolylsulfonyl)-urea; 4-11-00-00238 (Beilstein Handbook Reference); CTK8H7099; DTXSID40177503; BDBM50273271
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 320180 nM
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[5] | ||
| Compound Name |
2-Amino-4,5-dihydronaphtho[1,2-d]thiazol-9-yl dihydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL576125; BDBM50302496
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 335000 nM
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[6] | ||
| Compound Name |
2-Amino-4,5-dihydronaphtho[1,2-d]thiazol-9-ylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL577500; BDBM50302489
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 354000 nM
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[6] | ||
| Compound Name |
2-Amino-4,5-dihydronaphtho[1,2-d]thiazol-7-ylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL567511; BDBM50302487
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 354000 nM
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[6] | ||
| Compound Name |
(+)-Usnic acid
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Investigative | Compound Info | ||
| Synonyms |
2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzofuran-1-one; CHEMBL242022; Usninsaure; SCHEMBL1767536; US9273021, Usnic Acid; 2,6-diacetyl-3,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-1(9bH)-one; CHEMBL1314537; BDBM209638; MFCD00065294; AKOS000281081; AKOS030500799; MCULE-7220578322; VC30491; NCGC00160165-01; DB-050340; FT-0636008; Q425335; (+)-2,6-Diacetyl-1,7,9-trihydroxy-8,9b-dimethyldibenzofuran-3(9bH)-one; 2,6-Diacetyl-3,7,9-trihydroxy-8,9b-dimethyl-9bH-dibenzofuran-1-one (Usnic acid)
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 = 371000 nM
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[8] | ||
| Compound Name |
{[(6-Amino-9-phenethyl-9H-purin-8-ylmethyl)-amino]-methyl}-phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL484774; BDBM50277928
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 > 500000 nM
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[2] | ||
| Compound Name |
[3-(6-Amino-9-phenethyl-9H-purin-8-yl)-propyl]-phosphinic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL521504; BDBM50278021
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 > 1000000 nM
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[2] | ||
| Compound Name |
[2-(6-Amino-9-phenethyl-9H-purin-8-yl)-1-methyl-ethyl]-phosphinic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448582; BDBM50278022
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 > 1000000 nM
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[2] | ||
| Compound Name |
[2-(6-Amino-9-phenethyl-9H-purin-8-yl)-ethoxy]-phosphinic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482991; BDBM50278023
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 > 1000000 nM
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[2] | ||
| Compound Name |
[2-(6-Amino-9-phenethyl-9H-purine-8-sulfonyl)-ethyl]-phosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL485009; BDBM50277970
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| Activity | Fructose-1,6-bisphosphatase 1 |
IC50 > 1000000 nM
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[2] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem. 2014 Mar 15;22(6):1850-62. | ||||
| REF 2 | Fructose-1,6-bisphosphatase inhibitors. 1. Purine phosphonic acids as novel AMP mimics. J Med Chem. 2009 May 14;52(9):2880-98. | ||||
| REF 3 | Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10. | ||||
| REF 4 | Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Eur J Med Chem. 2015 Jan 27;90:394-405. | ||||
| REF 5 | Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4708-12. | ||||
| REF 6 | Synthesis, SAR, and X-ray structure of tricyclic compounds as potent FBPase inhibitors. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5909-12. | ||||
| REF 7 | Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes. Bioorg Med Chem Lett. 2010 Jan 15;20(2):594-9 | ||||
| REF 8 | US patent application no. 9273021B2, Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof | ||||
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