Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T83982 | Target Info | |||
| Target Name | Ubiquitin isopeptidase Y (USP8) | ||||
| Synonyms |
hUBPy; Ubiquitin-specific-processing protease 8; Ubiquitin thioesterase 8; Ubiquitin carboxyl-terminal hydrolase 8; UBPY; KIAA0055; Deubiquitinating enzyme 8
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| Target Type | Preclinical Target | ||||
| Gene Name | USP8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
GRL-0667
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Investigative | Compound Info | ||
| Synonyms |
BDBM50007789; CHEMBL1173044; GRM; Q27460878; SCHEMBL7938638
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(3-Fluorophenyl)methyl]-1-[(1r)-1-Naphthalen-1-Ylethyl]piperidine-4-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233815; GTPL10748; BDBM50007791; compound 3k [PMID: 24568342]; Q27465268; N-(3-Fluorobenzyl)-1-[(R)-1-(1-naphthyl)ethyl]piperidine-4-carboxamide; (R)-N-(3-Fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamide; N-(3-fluorobenzyl)-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chebi:149900
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233809; N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide; BDBM50007788; N-[3-(Acetylamino)benzyl]-1-[(R)-1-(1-naphthyl)ethyl]piperidine-4-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(4-Fluorophenyl)methyl]-1-[(1r)-1-Naphthalen-1-Ylethyl]piperidine-4-Carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233814; BDBM50007790; Q27464305; N-(4-Fluorobenzyl)-1-[(R)-1-(1-naphthyl)ethyl]piperidine-4-carboxamide; (R)-N-(4-Fluorobenzyl)-1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamide; N-(4-fluorobenzyl)-1-[(1R)-1-(naphthalen-1-yl)ethyl]piperidine-4-carboxamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4129140
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3709928; BDBM50271098; 3-acetyl-2-(4-bromophenyl)-1-[2-(3,4-dichlorophenyl)ethyl]-4-hydroxy-2H-pyrrol-5-one
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| Activity |
IC50 > 200000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. J Med Chem. 2014 Mar 27;57(6):2393-412. | ||||
| REF 2 | Chemical Approaches to Intervening in Ubiquitin Specific Protease 7 (USP7) Function for Oncology and Immune Oncology Therapies. J Med Chem. 2018 Jan 25;61(2):422-443. | ||||
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