Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84160 | Target Info | |||
| Target Name | 5-HT 3 receptor (5HT3R) | ||||
| Synonyms |
5-hydroxytryptamine receptor type 3; 5-hydroxytryptamine receptor 3; 5-HT3R; 5-HT3 receptor; 5-HT-3
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nicotine
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Approved | Compound Info | ||
| Synonyms |
Habitrol; Micotine; NCT; NICOTINE AND SALTS; Nicoderm Patch; Nicotina [Italian]; Nicotine Patch; Nicotine [USAN]; Nicotine replacement patch; Nicotine solution; Nictoine patch; Nikotin [German]; Nikotyna [Polish]; Transdermal Nicotine; Nicotine [UN1654] [Poison]; ENT 3,424; Habitrol (TN); Nicorette (TN); Nicotine (USP); Nicotine (compounds related to); Nicotine [BSI:ISO]; L(-)-nicotine; Beta-Pyridyl-alpha-N-methyl pyrrolidine; (-)-Nicotine solution; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; (S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; (S)-(-)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-Nicotine; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(N-Methylpyrollidino)pyridine; 3-(N-Methylpyrrolidino)pyridine; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
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| Activity |
Ki = 71000 nM
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[1] | |||
| Compound Name |
7-Methoxy-4-[4-(4-pyrazol-1-ylbutyl)piperazin-1-yl]pyrrolo[1,2-a]quinoxaline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL415933; BDBM50408150
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
7-[4-[(4-Fluorophenyl)methyl]piperazin-1-yl]-10-methyl-2,8,13-triazatricyclo[7.4.0.02,6]trideca-1(13),3,5,7,9,11-hexaene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL298649; SCHEMBL8570048; BDBM50408176
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| References | Top | ||||
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| REF 1 | The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21. | ||||
| REF 2 | Novel and selective partial agonists of 5-HT3 receptors. 2. Synthesis and biological evaluation of piperazinopyridopyrrolopyrazines, piperazinopyrroloquinoxalines, and piperazinopyridopyrroloquinoxalines. J Med Chem. 1997 Jun 6;40(12):1808-19. | ||||
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