Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84621 | Target Info | |||
| Target Name | Steroid 11-beta-hydroxylase (CYP11B1) | ||||
| Synonyms |
S11BH; P450C11; P-450c11; CYPXIB1; CYP11B1
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| Target Type | Successful Target | ||||
| Gene Name | CYP11B1 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
VOROZOLE
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
Vorozole; Rivizor; 129731-10-8; R-83842; UNII-1E2S9YXV2A; 1E2S9YXV2A; Vorozol [INN-Spanish]; Vorozolum [INN-Latin]; (+)-Vorozole; CCRIS 7482; Vorozolum; Vorozol; Rivizor (TN); 6-[(S)-(4-chlorophenyl)-(1,2,4-triazol-1-yl)methyl]-1-methylbenzotriazole; Vorozole (USAN/INN); AC1OCF4T; (S)-VOROZOLE; SCHEMBL4554; Vorozole [USAN:INN:BAN]; CHEMBL224060; DTXSID20156230; (+)-(S)-6-(p-Chloro-alpha-1H-1,2,4-triazol-1-ylbenzyl)-1-methyl-1H-benzotriazole; CHEBI:135387; 1H-Benzotriazole, 6-((4-chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl)-1-methyl
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| Activity |
IC50 = 95000 nM
|
[1] | |||
| Compound Name |
6-Methoxy-1-(4-pyridyl)-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL294361; BDBM50035204; 4-(6-Methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)-pyridine; 4-(6-methoxy-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-1-yl)pyridine
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| Activity |
IC50 = 75000 nM
|
[1] | |||
| Compound Name |
1-(4-Pyridyl)-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL304583; BDBM50035208; 1-Pyridin-4-yl-1a,2,3,7b-tetrahydro-1H-cyclopropa[a]naphthalen-6-ol
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| Activity |
IC50 = 76000 nM
|
[1] | |||
| Compound Name |
CID 71621803
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077246; SCHEMBL15018509; BDBM50268690
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pyridyl-substituted tetrahydrocyclopropa[a]naphthalenes: highly active and selective inhibitors of P450 arom. J Med Chem. 1995 Jun 9;38(12):2103-11. | ||||
| REF 2 | Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248. | ||||
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