Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84703 | Target Info | |||
| Target Name | BDNF/NT-3 growth factors receptor (TrkB) | ||||
| Synonyms |
Tropomyosin-related kinase B; TrkB tyrosine kinase; Trk-B; TRKB; Neurotrophic tyrosine kinase receptor type 2; GP145-TrkB
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| Target Type | Successful Target | ||||
| Gene Name | NTRK2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
NVP-TAE684
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Investigative | Compound Info | ||
| Synonyms |
761439-42-3; NVP-TAE684; NVP-TAE 684; TAE684; TAE-684; 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine; TAE684 (NVP-TAE684); TAE 684; UNII-EH1713MN4K; CHEMBL509032; EH1713MN4K; 5-Chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-2,4-pyrimidinediamine; C30H40ClN7O3S
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| Activity |
IC50 = 422000 nM
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[1] | |||
| Compound Name |
2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629013; GTPL9989; SCHEMBL22137472; BDBM50128294; AKOS032960466; compound 11 [PMID: 26431428]; Q27455367; 2-(1-Cyclopentyl-5-(1-(oxetane-3-yl)-4-piperidinyl)-1H-pyrazole-3-ylamino)pyridine-4-carbonitrile
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| Activity |
IC50 = 1190000 nM
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[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5. | ||||
| REF 2 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 22;58(20):8182-99. | ||||
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