Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T85605 | Target Info | |||
| Target Name | 5-HT receptor (5HTR) | ||||
| Synonyms |
5-Hydroxytryptamine receptor
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Methylthiodimethyltryptamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL285355; 4-Methylthio-dimethyltryptamine; 1H-Indole-3-ethanamine, N,N-dimethyl-4-(methylthio)-; DTXSID80146551; N,N-dimethyl-2-(4-methylsulfanyl-1H-indol-3-yl)ethanamine; ZINC3650189; BDBM50224305
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| Activity |
IC50 = 151000 nM
|
[1] | |||
| Compound Name |
4-(1H-Imidazol-2-ylmethyl)benzene-1,2-diol;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL15228; BDBM50022536
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| Activity |
IC50 = 162181.01 nM
|
[2] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Schembl20970979
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL368261; BDBM50224304; ZINC28008288; N-[2-(5H-[1,3]dioxolo[4,5-f]indol-7-yl)ethyl]-N-propan-2-ylpropan-2-amine
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| Activity |
IC50 = 933000 nM
|
[1] | |||
| Compound Name |
4-[Hydroxy(1H-imidazol-2-yl)methyl]benzene-1,2-diol;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL14837; BDBM50022596
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| Activity |
IC50 = 2.29E+12 nM
|
[2] | |||
| Compound Name |
4-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-5-fluorobenzene-1,2-diol;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL14508; BDBM50022537
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| Activity |
IC50 = 3.63E+13 nM
|
[2] | |||
| Compound Name |
5-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-fluorobenzene-1,2-diol;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL14651; BDBM50022538
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| Activity |
IC50 = 5.50E+13 nM
|
[2] | |||
| Compound Name |
4-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-3-fluorobenzene-1,2-diol;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL14982; BDBM50022539
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| Activity |
IC50 = 6.46E+13 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationships in potentially hallucinogenic N,N-dialkyltryptamines substituted in the benzene moiety. J Med Chem. 1982 Aug;25(8):908-13. | ||||
| REF 2 | Synthesis and alpha 2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogues in human platelets. J Med Chem. 1990 Apr;33(4):1138-44. | ||||
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