Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86192 | Target Info | |||
| Target Name | Voltage-gated potassium channel Kv7 (KCNQ) | ||||
| Synonyms |
Voltage-gated potassium channel subunit Kv7; Potassium voltage-gated channel subfamily KQT; Kv7; KVLQT; KQT-like; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT; IKs producing slow voltage-gated potassium channel alpha subunit KvLQT
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| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6H-Pyrimido[5,4-b][1,4]oxazin-7(8H)-one, 2-[[[trans-4-[(1R)-1-amino-2-(7-fluoro-2-oxo-1(2H)-quinoxalinyl)ethyl]cyclohexyl]amino]methyl]-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355573; SCHEMBL1375934; SCHEMBL1375938; BDBM50023589; SB19220
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| Activity | Voltage-gated potassium channel subunit Kv7.1 |
IC50 > 333000 nM
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[1] | ||
| Compound Name |
1-[(2S)-2-Amino-2-[(1r,4S)-4-[({3-oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-6-yl}methyl)amino]cyclohexyl]ethyl]-7-methoxy-1,2-dihydro-1,5-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355575; SCHEMBL1375971; SCHEMBL1375976; BDBM50023582; SB19210
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| Activity | Voltage-gated potassium channel subunit Kv7.1 |
IC50 > 333000 nM
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[1] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa. Bioorg Med Chem. 2014 Oct 1;22(19):5392-409. | ||||
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