Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T86679 | Target Info | |||
| Target Name | Adenosine A2b receptor (ADORA2B) | ||||
| Synonyms |
Adenosine receptor A2b; A2b Adenosine receptor
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| Target Type | Successful Target | ||||
| Gene Name | ADORA2B | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 73 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL61259; 9-Ethyl-8-phenylethynyl-9H-purin-6-ylamine; 8-phenylethynyl-9-ethyladenine; BDBM50102169
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[4-(Furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575605; BDBM50298514
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(1-Cyclohexyl-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258505; BDBM50327338
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(3-Ethyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258730; BDBM50327341
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-Chlorophenyl)-N-[4-(furan-2-yl)-11-methyl-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL573594; BDBM50298546
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(4-(Quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258731; SCHEMBL3306156; BDBM50327342; 2-[[2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid; 2-{[4-(Quinoxalin-6-yl)-1-(2-methylphenyl)-1H-pyrazol-5-yl]amino}benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Chloro-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258283; SCHEMBL1819219; BDBM50327334; 5-chloro-2-[[5-methyl-2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(1-(2-Ethylphenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258621; SCHEMBL1819035; BDBM50327339; 2-[[2-(2-ethylphenyl)-5-methyl-4-quinoxalin-6-ylpyrazol-3-yl]amino]-5-methoxybenzoic acid; 2-{[4-(Quinoxalin-6-yl)-1-(2-ethylphenyl)-3-methyl-1H-pyrazol-5-yl]amino}-5-methoxybenzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[11-Ethyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572653; BDBM50298539
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(3-Chlorophenyl)-N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL576017; BDBM50298513
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
2-(4-Fluorophenyl)-N-[4-(furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574484; BDBM50298516
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-(1-(2-Chlorophenyl)-3-methyl-4-(quinoxalin-6-yl)-1H-pyrazol-5-ylamino)-5-methoxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258506; SCHEMBL3306001; BDBM50327323; 2-[[2-(2-chlorophenyl)-5-methyl-4-quinoxalin-6-ylpyrazol-3-yl]amino]-5-methoxybenzoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(3-Methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258396; SCHEMBL3305031; BDBM50327336; 2-[[5-methyl-2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[4-(Furan-2-yl)-11-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-2-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575205; BDBM50298542
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
5-Methyl-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258284; SCHEMBL3302210; BDBM50327335; 5-methyl-2-[[5-methyl-2-(2-methylphenyl)-4-quinoxalin-6-ylpyrazol-3-yl]amino]benzoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-(4-(8-Fluoroquinoxalin-6-yl)-3-methyl-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258850; SCHEMBL1819029; BDBM50327343; 2-[[4-(8-fluoroquinoxalin-6-yl)-5-methyl-2-(2-methylphenyl)pyrazol-3-yl]amino]benzoic acid; 2-{[4-(8-Fluoroquinoxalin-6-yl)-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl]amino}benzoic acid
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-Methoxy-2-(3-methyl-4-(quinoxalin-6-yl)-1-o-tolyl-1H-pyrazol-5-ylamino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258170; BDBM50327333
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-[11-Ethyl-4-(furan-2-yl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-(4-phenylphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572654; BDBM50298545
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(6-Amino-9H-purin-9-yl)-N-cyclopentyl-1-deoxyribofuranuronamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2070508; BRN 0587969; Adenosine-5'-(N-cyclopentyl)carboxamide; Ribofuranuronamide, 1-(6-amino-9H-purin-9-yl)-N-cyclopentyl-1-deoxy-; BDBM50389799; 5'-Oxo-5'-(cyclopentylamino)-5'-deoxyadenosine
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|
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| Activity |
EC50 = 54000 nM
|
[4] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[(3,5-Dimethylpyrazol-1-yl)methyl]-5-[6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094884; BDBM50247448
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-(4-Chloro-2-fluoroanilino)-2-(3,5-dimethylphenyl)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4105044; BDBM50247443
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[2-Chloro-6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067452; BDBM50247458
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5S)-2-[2-Chloro-6-(4-chloro-2-fluoroanilino)purin-9-yl]-5-(chloromethyl)oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080383; BDBM50247452
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[2-Chloro-6-(4-chloro-2-fluoroanilino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078360; BDBM50247446
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[2-(3,5-Dimethylphenyl)-6-[[(3R)-oxolan-3-yl]amino]purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087198; BDBM50247444
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
Ethyl 6-amino-2-(2-phenylethyl)pyrazolo[3,4-d]pyrimidine-4-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3410301; BDBM50072934
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| Activity |
Ki = 60000 nM
|
[6] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-(2-Bicyclo[2.2.1]heptanylamino)-2-(3,5-dimethylphenyl)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097343; BDBM50247445
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-(4-Chloro-2-fluoroanilino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102630; BDBM50247447
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|
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-(Cyclopentylamino)purin-9-yl]-5-[(3,5-dimethylpyrazol-1-yl)methyl]oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059994; BDBM50247451
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| Activity |
EC50 ~ 60000 nM
|
[5] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-oxo-4H-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927633; BDBM50360193
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|
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[4-(Furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-naphthalen-1-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335950; BDBM50133368
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-diphenylethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927447; BDBM50360187
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088770; BDBM50315592; 2-(2-Furyl)-5-phenoxy 7-phenylacetylamino-[1,2,4]triazolo[1,5-a]-[1,3,5]triazine
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-dimethylpropan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927628; BDBM50360188
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|
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-(4-nitrophenyl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927439; BDBM50360212
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-Amino-8-(2-phenylethynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350497; 8-phenylethynyladenosine; 8-(phenylethynyl)adenosine; CHEMBL611516; SCHEMBL4378434; BDBM50366687
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| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089799; BDBM50315601
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(3R,4S,5R)-2-[6-(Ethylamino)-2-(2-phenylethynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL607759; BDBM50370121
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| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[2-[(3R)-3-hydroxy-3-phenylprop-1-ynyl]-6-(methylamino)purin-9-yl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL410115; BDBM50003277
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| Activity |
EC50 = 100000 nM
|
[9] | |||
| Compound Name |
N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089113; BDBM50315598; 5-Dimethylamino-2-(2-furyl)-7-phenylacetylamino-[1,2,4]triazolo[1,5-a]-[1,3,5]triazine
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
CID 9819926
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2261343; SCHEMBL6661352; BDBM50487261; (2S,3S,4R,5R)-2-(fluoromethyl)-5-[6-(oxan-4-ylamino)purin-9-yl]oxolane-3,4-diol
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-methylsulfanyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2,2-diphenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090125; BDBM50315585; 7-Diphenyl-acetylamino-2-(2-furyl)-5-methylthio[1,2,4]-triazolo[1,5-a]-[1,3,5]triazine
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-phenylethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927436; BDBM50360209
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-(5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl)-3-p-tolylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089480; BDBM50315602
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-(4-methoxyphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089463; BDBM50315599; 5-Dimethylamino-2-(2-furyl)-7-[4-(methoxyphenyl)-acetyl]amino-[1,2,4]triazolo[1,5-a]-[1,3,5]triazine
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-methylsulfanyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]hexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092579; BDBM50315588; 2-(2-Furyl)-5-methylthio-7-n-pentylcarbonylamino-[1,2,4]-triazolo[1,5-a]-[1,3,5]triazine
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| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]pentan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927435; BDBM50360208
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|
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-naphthalen-1-ylmethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927441; BDBM50360180
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
8-(1-Hexynyl)adenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2181966; BDBM50397720; Adenosine, 8-(1-hexynyl)-; CHEMBL610640; BDBM50366688; (2R,3R,4S,5R)-2-(6-amino-8-hex-1-ynylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
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||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-(Ethylamino)-2-hex-1-ynylpurin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437842; BDBM50003272
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| Activity |
EC50 = 100000 nM
|
[9] | |||
| Compound Name |
2-(1-Hexynyl)adenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319387; adenosine, 2-(1-hexynyl)-; SCHEMBL5359016; CTK5G8155; BDBM50119168; (2R,3R,4S,5R)-2-(6-amino-2-hex-1-ynylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-2-(hex-1-ynyl)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-2-(hex-1-ynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(6-Amino-2-hex-1-ynyl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
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| Activity |
EC50 = 100000 nM
|
[9] | |||
| Compound Name |
N-[4-(Furan-2-yl)-11-(3-phenylpropyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(12),2,4,7,9-pentaen-7-yl]-2-(4-phenylphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572602; BDBM50298509
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||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[2-(2-phenylethynyl)-6-(propan-2-ylamino)purin-9-yl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113551
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||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[2-Hex-1-ynyl-6-(propan-2-ylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL261623; BDBM50003270
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||||
| Activity |
EC50 = 100000 nM
|
[9] | |||
| Compound Name |
5-N-(2-Aminoethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1926693
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-methylsulfanyl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-phenylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090126; BDBM50315586; 2-(2-Furyl)-5-methylthio-7-phenylacetylamino[1,2,4]-triazolo[1,5-a]-[1,3,5]triazine
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Tert-butyl N-[2-[[2-(furan-2-yl)-5-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethylamino]-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]amino]ethyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927425; BDBM50360195
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-(methylamino)-2-(phenylethynyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574597; SCHEMBL19464857; BDBM50299698; Adenosine, N-methyl-2-(phenylethynyl)-
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||||
| Activity |
EC50 = 100000 nM
|
[9] | |||
| Compound Name |
8-(3-Phenyl-3-oxo-1-propenyl)adenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350496; CHEMBL610346; BDBM50366686; Adenosine, 8-[(1E)-3-oxo-3-phenyl-1-propenyl]-
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2-(4-methoxyphenyl)acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089438; BDBM50315593; 2-(2-Furyl)-7-[4-(methoxyphenyl)acetyl]amino-5-phenoxy[1,2,4]triazolo[1,5-a]-[1,3,5]triazine
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-3,3-dimethylbutan-1-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927629; BDBM50360189
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2,2-dichloroethanone
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927438; BDBM50360211
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Methyl 4-[4-[7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-4-oxobutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927437; BDBM50360210
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2,2-diphenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092870; BDBM50315591; 7-Diphenylacetylamino-2-(2-furyl)-5-phenoxy[1,2,4]-triazolo[1,5-a]-[1,3,5]triazine
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]hexanamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089798; BDBM50315600; 5-Dimethylamino-2-(2-furyl)-7-n-pentylcarbonylamino-[1,2,4]triazolo[1,5-a]-[1,3,5]triazine
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-2-(4-chlorophenyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927442; BDBM50360181
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[2-(Furan-2-yl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]hexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089439; BDBM50315594; 2-(2-Furyl)-7-n-pentylcarbonylamino-5-phenoxy[1,2,4]-triazolo[1,5-a]-[1,3,5]triazine
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
[4-[7-Amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl]piperazin-1-yl]-phenylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927440; BDBM50360213
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||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-N,7-N-Bis(2-aminoethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[5-(Dimethylamino)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl]-2,2-diphenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089112; BDBM50315597; 5-Dimethylamino-7-diphenylacetylamino-2-(2-furyl)-[1,2,4]triazolo[1,5-a]-[1,3,5]triazine
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Amino-2-(phenylethynyl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375190; Adenosine, 2-(phenylethynyl)-; 2-(Phenylethynyl)adenosine; CTK3I1645; DTXSID70437329; BDBM50205709; (3R,4S,5R)-2-((R)-6-amino-2-phenylethynyl-9H-purin-3-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
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||||
| Activity |
EC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[(1R)-2alpha-(Benzyloxy)cyclopentane-1beta-yl]-5'-oxo-5'-(ethylamino)-5'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770679; BDBM50149598; J3.605.582K
Click to Show/Hide
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||||
| Activity |
EC50 = 125892.54 nM
|
[11] | |||
| Compound Name |
4-(6-Cyclopentylamino-purin-9-yl)-1-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL27952; BDBM50088424; (1R,2R,3S,4R,5S)-4-(6-Cyclopentylamino-purin-9-yl)-1-hydroxymethyl-bicyclo[3.1.0]hexane-2,3-diol
Click to Show/Hide
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||||
| Activity |
Ki = 139000 nM
|
[12] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S,3S,4R,5R)-N-Ethyl-3,4-dihydroxy-5-[6-[[(1R,2R)-2-hydroxycyclopentyl]amino]purin-9-yl]oxolane-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770310; BDBM50149599
Click to Show/Hide
|
||||
| Activity |
EC50 = 331131.12 nM
|
[11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1931-4. | ||||
| REF 2 | Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites. Bioorg Med Chem. 2009 Jul 15;17(14):5259-74. | ||||
| REF 3 | Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5891-4. | ||||
| REF 4 | 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors. J Med Chem. 1999 Apr 22;42(8):1384-92. | ||||
| REF 5 | Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A 1 Adenosine Receptor Agonists. J Med Chem. 2018 Jan 11;61(1):305-318. | ||||
| REF 6 | A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists. Eur J Med Chem. 2015 Mar 6;92:784-98. | ||||
| REF 7 | Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility. J Med Chem. 2011 Feb 10;54(3):877-89. | ||||
| REF 8 | Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process. Bioorg Med Chem. 2010 Apr 1;18(7):2524-36. | ||||
| REF 9 | N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands. J Med Chem. 2002 Jul 18;45(15):3271-9. | ||||
| REF 10 | Potent, Selective Adenosine A1 Agonists as Potential Analgesics. Med Chem Res. 2004;13:88-98. | ||||
| REF 11 | Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity. J Med Chem. 2016 Feb 11;59(3):947-64. | ||||
| REF 12 | Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. J Med Chem. 2000 Jun 1;43(11):2196-203. | ||||
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