Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T89515 | Target Info | |||
| Target Name | Polypeptide deformylase (PDF) | ||||
| Synonyms |
PDF
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| Target Type | Successful Target | ||||
| Gene Name | |||||
| Biochemical Class | CH-NH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Benzoyl-benzofuran-4,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807943; SCHEMBL290186; 3-benzoyl-1-benzofuran-4,5-dione; BDBM50349078
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| Activity |
IC50 = 59000 nM
|
[1] | |||
| Compound Name |
6,7-Dibromo-3-(4-methoxybenzoyl)-1-benzofuran-4,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807951; SCHEMBL290072; BDBM50349086
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| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
2-[2-Oxo-2-(hydroxyamino)ethylidene]-3-butyl-2,3-dihydrobenzothiazole 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL323389; BDBM50132674; 2-[3-Butyl-1,1-dioxo-1,3-dihydro-1lambda*6*-benzothiazol-(2Z)-ylidene]-N-hydroxy-acetamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Butyl-2,3-dihydrobenzothiazole-2-ylideneacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL113143; BDBM50132671; [3-Butyl-3H-benzothiazol-(2Z)-ylidene]-acetic acid
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[3-Ethyl-3H-benzothiazol-(2Z)-ylidene]-N-hydroxy-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL112788; BDBM50132673; N-Hydroxy-2-(3-ethyl-2,3-dihydrobenzothiazole-2-ylidene)acetamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(1-Benzenesulfonyl-5-bromo-2-methyl-1H-indol-3-ylmethyl)-N-hydroxyformamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220027; SCHEMBL5187671; BDBM50201878; N-[[1-(benzenesulfonyl)-5-bromo-2-methylindol-3-yl]methyl]-N-hydroxyformamide
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| Activity |
IC50 = 200000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(6-Bromo-1H-indol-3-yl)-3-(hydroxyamino)propan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219438; BDBM50201873
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|
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| Activity |
IC50 = 250000 nM
|
[3] | |||
| Compound Name |
1-(5-Bromo-1H-indol-3-yl)-3-(hydroxyamino)propan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216480; BDBM50201870
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|
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| Activity |
IC50 = 360000 nM
|
[3] | |||
| Compound Name |
2-(5-Bromo-2-methyl-1H-indolyl)-N-hydroxyacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219460; BDBM50201872
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|
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| Activity |
IC50 = 450000 nM
|
[3] | |||
| Compound Name |
1-(5-Chloro-1H-indol-3-yl)-3-(hydroxyamino)propan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373863; BDBM50201876
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|
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| Activity |
IC50 = 600000 nM
|
[3] | |||
| Compound Name |
1-(4-Fluoro-1H-indol-3-yl)-3-(hydroxyamino)propan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373862; BDBM50201871
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|
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| Activity |
IC50 = 700000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4528-32. | ||||
| REF 2 | Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3273-6. | ||||
| REF 3 | Discovery and refinement of a new structural class of potent peptide deformylase inhibitors. J Med Chem. 2007 Jan 11;50(1):10-20. | ||||
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