Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92308 | Target Info | |||
| Target Name | DNA [cytosine-5]-methyltransferase (DNMT) | ||||
| Synonyms |
DNA MTase
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|
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| Target Type | Successful Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 38 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID27376512-Compound-Figure3CN
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|
Patented | Compound Info | ||
| Activity | DNA [cytosine-5]-methyltransferase 1 |
EC50 = 100000 nM
|
[1] | ||
| Compound Name |
UNC0642
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|
Investigative | Compound Info | ||
| Synonyms |
1481677-78-4; UNC 0642; UNC-0642; CHEMBL2441082; 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine; Barrett; GTPL7017; SCHEMBL17372593; AOB2595; MolPort-035-765-953; EX-A2241; BCP08266; ZINC96285772; BDBM50442103; AKOS024458509; SB19046; CS-5269; NCGC00189140-01; NCGC00189140-02; AS-16721; HY-13980; BC600721; AK547424; UNC0642, > KB-146019; J-008448
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
GSK343
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|
Investigative | Compound Info | ||
| Synonyms |
compound 6 [PMID 24900432]; GSK 343
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3A |
IC50 ~ 100000 nM
|
[3] | ||
| DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2R,3S)-3-(1H-Indol-3-ylmethyl)-1-(naphthalene-2-carbonyl)pyrrolidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109076; BDBM50495478
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 50000 nM
|
[4] | ||
| Compound Name |
1-(2-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)ethyl)-3-ethylurea
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|
Investigative | Compound Info | ||
| Synonyms |
DS-437; CHEMBL3577854; EX-A3697; BDBM50089221; HY-124131; CS-0084441
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3A |
IC50 ~ 50000 nM
|
[5] | ||
| DNA [cytosine-5]-methyltransferase 3B |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
7-[5-(2-Acetamidoethyl)-2-hydroxyphenyl]-3,5,6-trihydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3414632; BDBM50075185
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3A |
IC50 = 50000 nM
|
[6] | ||
| Compound Name |
(S)-2-Amino-4-(((2s,3s,4r,5r)-5-(6-(3-Chlorobenzylamino)-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydrofuran-2-Yl)methylthio)butanoic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1230055; BDBM50470562; Q27453570; 36A
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
Ki ~ 50000 nM
|
[7] | ||
| Compound Name |
N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385821; SCHEMBL3657042; BDBM50448487
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 52000 nM
|
[8] | ||
| Compound Name |
(2S,4R)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)pyrrolidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563230; BDBM50294558
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3B |
IC50 = 54000 nM
|
[9] | ||
| DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-Amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564768; SCHEMBL5052442; BDBM50294486
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3B |
IC50 = 57200 nM
|
[10] | ||
| Compound Name |
2-Amino-4-(((2S,3S,4R,5R)-5-(6-(benzylamino)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556265; BDBM50294492
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 61000 nM
|
[10] | ||
| Compound Name |
4-({[2-(2-Furylmethyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]carbonyl}amino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922548; AN-979/41971108; HMS1599E18; ZINC692812; BDBM50206866; STK276873; AKOS003344826; MCULE-9783439994; SR-01000286985; SR-01000286985-1
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3A |
IC50 = 64000 nM
|
[11] | ||
| Compound Name |
(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-(((1R,2S)-2-aminocyclopentylthio)methyl)tetrahydrofuran-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559281; BDBM50294570
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3B |
IC50 = 66000 nM
|
[9] | ||
| DNA [cytosine-5]-methyltransferase 1 |
IC50 = 94000 nM
|
[9] | |||
| Compound Name |
4-[(2-Amino-6-methylpyrimidin-4-yl)amino]-N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126652; BDBM50448488
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 68000 nM
|
[8] | ||
| Compound Name |
C(CNc1ncnc2cc(OCC3CCN(CCNc4ccnc5ccccc45)CC3)ccc12)Nc1ccccc1
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100095; SCHEMBL16585772
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
EC50 = 73000 nM
|
[1] | ||
| Compound Name |
(2R,3S)-1-Benzoyl-3-(1H-indol-3-ylmethyl)pyrrolidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109078; BDBM50495476
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 73000 nM
|
[4] | ||
| Compound Name |
2-Amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560165; BDBM50294489
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 75000 nM
|
[10] | ||
| Compound Name |
(2S,3R)-1-(2,4-Dinitrophenylthio)-3-[(1H-indole-3-yl)methyl]pyrrolidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109079; BDBM50495480
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 80000 nM
|
[4] | ||
| Compound Name |
(2S,3R)-1-Benzoyl-3-(1H-indole-3-ylmethyl)pyrrolidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109077; BDBM50495481
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 98000 nM
|
[4] | ||
| Compound Name |
(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-(((S)-pyrrolidin-2-ylmethylthio)methyl)tetrahydrofuran-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563782; BDBM50294568
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3B |
IC50 = 100000 nM
|
[9] | ||
| Compound Name |
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
UNC0379; UNC-0379; CHEMBL3318285; UNC 0379; 6,7-Dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine; C23H35N5O2; CS-3345; HY-12335; SCHEMBL22568439; AOB6365; EX-A461; SYN5081; BCP10429; KS-00000T5A; 3362AH; BDBM50051117; MFCD28167817; s7570; ZINC98214604; AKOS025404942; UNC 0379;UNC-0379; CCG-268809; SB19349; NCGC00384189-06; NCGC00384189-10; AK174945; AS-16447; DA-43617; B8009; FT-0699830; A14320; UNC0379 trifluoroacetate salt, >=98% (HPLC)
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[12] | ||
| Compound Name |
7-Methyl-3-[2-(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl]-[1,2,4]triazolo[4,3-a]pyridine
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|
Investigative | Compound Info | ||
| Synonyms |
NSC303530; NSC-303530; CHEMBL382617; NCIStruc1_000837; NCIStruc2_000846; DTXSID40316430; ZINC1567332; BDBM50180789; CCG-36738; NCGC00014676; NCI303530; NCGC00014676-02; NCGC00097779-01; NCI60_002562; 1,2-bis(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethane
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 100000 nM
|
[13] | ||
| Compound Name |
(2S,4R)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)piperidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551787; BDBM50294560
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | ||
| Compound Name |
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
GSK926; CHEMBL2204998; SCHEMBL2590353; BDBM50400779
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3A |
IC50 ~ 100000 nM
|
[3] | ||
| DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(2S,4S)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)-1-methylpyrrolidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558883; BDBM50294563
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | ||
| Compound Name |
Chembl4282866
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50470498; ZINC38895935; AT-096/43397269; 4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-diethylbenzenesulfonamide
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
N-[(6-Methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2204997; SCHEMBL12180659; BDBM50400781
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3A |
IC50 ~ 100000 nM
|
[3] | ||
| DNA [cytosine-5]-methyltransferase 1 |
IC50 = 121000 nM
|
[3] | |||
| Compound Name |
Methyl 2-[[2-[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl]amino]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
PRMT5-IN-C17; ZINC00659298; ChemDiv1_002844; Oprea1_645106; CHEMBL4092336; HMS595B06; ZINC5455374; STK346078; AKOS000421473; AKOS000830714; MCULE-9755352312; AG-690/12869587; SR-01000429953; SR-01000429953-1; Z16078172; methyl 2-({[(5-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoate; methyl 2-({[(6-methoxy-1H-benzimidazol-2-yl)sulfanyl]acetyl}amino)benzoate; methyl 2-{2-[(6-methoxy-1H-1,3-benzodiazol-2-yl)sulfanyl]acetamido}benzoate
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
(2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((azetidin-3-ylthio)methyl)tetrahydrofuran-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539449; BDBM50294571
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3B |
IC50 ~ 100000 nM
|
[9] | ||
| Compound Name |
(2R,4S)-4-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)piperidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563888; BDBM50294561
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 ~ 100000 nM
|
[9] | ||
| DNA [cytosine-5]-methyltransferase 3B |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S,3R)-1-(2-Naphthoyl)-3-(1H-indole-3-ylmethyl)pyrrolidine-2-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109075; BDBM50495482
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 128000 nM
|
[4] | ||
| Compound Name |
5'-{[(3s)-3-Amino-3-Carboxypropyl][2-(1-Benzothiophen-3-Yl)ethyl]amino}-5'-Deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018855; BDBM50381263; Q27451529
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 132000 nM
|
[16] | ||
| Compound Name |
N,N-Dimethyl-1-[3-(4-nitrophenyl)-4,5-dihydro-1,2-oxazol-5-yl]methanamine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916517; BDBM50357280
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 150000 nM
|
[6] | ||
| Compound Name |
(5S)-2-(4-Nitrophenyl)-5-(pyrrolidin-1-ylmethyl)-4,5-dihydro-1,3-oxazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403716; BDBM50075194
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 150000 nM
|
[6] | ||
| Compound Name |
2-Amino-4-(((2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(phenylamino)-9H-purin-9-yl)-tetrahydrofuran-2-yl)methylthio)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549412; BDBM50294491
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 154000 nM
|
[10] | ||
| Compound Name |
4-Amino-N-(4-((2-amino-6-methylpyrimidin-4-yl)amino)phenyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126654; SCHEMBL12240376; BDBM50448490; ZINC98086055; AKOS024261046
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 173000 nM
|
[8] | ||
| Compound Name |
N-[2-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126647; BDBM50448483
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 174000 nM
|
[8] | ||
| Compound Name |
(2R,3S,4R,5R)-2-(2-Amino-3-cyclohexylpropyl)-5-(6-aminopurin-9-yl)oxolane-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263626; SCHEMBL16486898; BDBM50010380
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 179000 nM
|
[17] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 15 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Procainamide
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|
Approved | Compound Info | ||
| Synonyms |
Biocoryl; Novocainamid; Novocainamide; Novocamid; Procainamida; Procainamidum; Procamide; Procan; Procanbid; Procapan; Pronestyl; Novocaine amide; Procaine amide; P-Aminobenzoic diethylaminoethylamide; Procainamida [INN-Spanish]; Procainamide (INN); Procainamide [INN:BAN]; Procainamidum [INN-Latin]; Procan (TN); Procanbid (TN); Procapan (free base); Pronestyl (TN); Pronestyl-Sr; P-Amino-N-(2-diethylaminoethyl)benzamide; Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-(9CI); 2-Diethylaminoethylamid kyseliny p-aminobenzoove; 2-Diethylaminoethylamid kyseliny p-aminobenzoove [Czech]; 4-Amino-N-(2-(Diethylamino)Ethyl)Benzamide Sulfate; 4-Amino-N-(2-(diethylamino)ethyl)benzamide; 4-Amino-N-[2-(diethylamino)ethyl]benzamide; 4-amino-N-(2-diethylaminoethyl)-benzamide; 4-amino-N-(2-diethylaminoethyl)benzamide
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 > 500000 nM
|
[6] | ||
| Compound Name |
1-((2-(1H-Indol-3-yl)ethyl)amino)-3-(9H-carbazol-9-yl)-propan-2-ol
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|
Investigative | Compound Info | ||
| Synonyms |
DC_05; DC-05; CHEMBL3358015; C25H25N3O; AOB6967; SYN5082; BDBM50031317; AKOS002242638; AKOS016316322; NCGC00402253-02; AS-16448; DC_05, >=98% (HPLC); HY-12746; ST50753266; 1-carbazol-9-yl-3-[(2-indol-3-ylethyl)amino]propan-2-ol; 1-carbazol-9-yl-3-[2-(1H-indol-3-yl)ethylamino]propan-2-ol; 1-(9H-Carbazole-9-yl)-3-[[2-(1H-indole-3-yl)ethyl]amino]-2-propanol
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3A |
IC50 > 200000 nM
|
[18] | ||
| DNA [cytosine-5]-methyltransferase 3B |
IC50 > 200000 nM
|
[18] | |||
| Compound Name |
2-Amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-(methylthio)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558406; BDBM50294490
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 216000 nM
|
[10] | ||
| DNA [cytosine-5]-methyltransferase 3B |
IC50 = 500000 nM
|
[10] | |||
| Compound Name |
(2S)-3-(1-Benzothiophen-3-yl)-2-(1,3-dioxoisoindol-2-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109080; BDBM50495483
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|
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 230000 nM
|
[4] | ||
| Compound Name |
2-Amino-4-(((2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558882; SCHEMBL5056803; BDBM50294487
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|
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| Activity | DNA [cytosine-5]-methyltransferase 3B |
IC50 = 256000 nM
|
[10] | ||
| Compound Name |
N-[4-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126645; BDBM50448485
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 265000 nM
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[8] | ||
| Compound Name |
4-[5-[(Dimethylamino)methyl]-4,5-dihydro-1,2-oxazol-3-yl]aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916669; BDBM50357281
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 270000 nM
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[19] | ||
| Compound Name |
S-Nebularinehomocysteine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL563570; BDBM50294479; (2S)-2-amino-4-[[(2S,3S,4R,5R)-3,4-dihydroxy-5-purin-9-yloxolan-2-yl]methylsulfanyl]butanoic acid
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 300000 nM
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[10] | ||
| Compound Name |
N(4)-Adenosyl-N(4)-methyl-2,4-diaminobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
UNII-AC4E80KX81; AC4E80KX81; CHEMBL1235825; S-5'-AZAMETHIONINE-5'-DEOXYADENOSINE; Adomdb; 5'-{[(3s)-3-amino-3-carboxypropyl](methyl)amino}-5'-deoxyadenosine; aza-AdoMet; 5'-[N-[(3S)-3-AMINO-3-CARBOXYPROPYL]-N-METHYLAMINO]-5'-DEOXYADENOSINE; SCHEMBL4319361; CTK4A7499; DTXSID10920563; Adenosine,5'-[[(3S)-3-amino-3-carboxypropyl]methylamino]-5'-deoxy- (9CI); BDBM50381264; DB03458; 3-[Methyl(5'-adenosyl)aminomethyl]alanine; Q27094385
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 302000 nM
|
[16] | ||
| Compound Name |
5-Methyl-3-[(4-nitrophenyl)methyl]-3a,4,6,6a-tetrahydropyrrolo[3,4-d][1,2]oxazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916683; BDBM50357284
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 310000 nM
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[19] | ||
| Compound Name |
N-Phthalyl-L-tryptophan
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Investigative | Compound Info | ||
| Synonyms |
RG108; RG-108; RG 108; CHEMBL1564869; (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid; C19H14N2O4; (2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid; (2S)-2-(1,3-dioxo-2-isoindolyl)-3-(1H-indol-3-yl)propanoic acid; (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid.; NSC-401077; MFCD08705332; (s)-N-phthaloyltryptophan; NCIStruc1_001775; NCIStruc2_000834; SCHEMBL164192; 2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid; KS-00000XHZ; ZINC84613; AOB6949; SYN3037; DTXSID801017660; HMS3651D15; RG 108,N-Phthalyl-L-tryptophan; BCP06930; EX-A2208; 2683AH; BDBM50389497; CCG-37087; NCGC00014891; NCI401077; s2821; AKOS024457533; CS-1248; SB19339; NCGC00014891-02; NCGC00014891-03; NCGC00097992-01; AC-32704; HY-13642; AB0064932; P2023; SW219042-1; W-5383; BRD-K89391146-001-01-5; Q27166807; (2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 390000 nM
|
[6] | ||
| Compound Name |
4-(5-Methyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d][1,2]oxazol-3-yl)aniline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916680; BDBM50357283
Click to Show/Hide
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 570000 nM
|
[19] | ||
| Compound Name |
S-Inosyl-L-homocysteine
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Investigative | Compound Info | ||
| Synonyms |
S-inosinylhomocysteine; CHEMBL559715; S-(5'-deoxyinosin-5'-yl)-L-homocysteine; SCHEMBL3515045; BDBM50294480; C03431; Q27102172
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 > 1000000 nM
|
[10] | ||
| DNA [cytosine-5]-methyltransferase 3B |
IC50 > 1000000 nM
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[10] | |||
| Compound Name |
3-[(4-Methoxyphenyl)methyl]-5-methyl-3a,4,6,6a-tetrahydropyrrolo[3,4-d][1,2]oxazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916684; BDBM50357285
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 1130000 nM
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[19] | ||
| Compound Name |
N,N-Dimethyl-1-[3-[(4-nitrophenyl)methyl]-4,5-dihydro-1,2-oxazol-5-yl]methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1916672; BDBM50357282
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| Activity | DNA [cytosine-5]-methyltransferase 1 |
IC50 = 1600000 nM
|
[19] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Rational Design of Bisubstrate-Type Analogues as Inhibitors of DNA Methyltransferases in Cancer Cells. J Med Chem. 2017 Jun 8;60(11):4665-4679. | ||||
| REF 2 | Discovery of Reversible DNA Methyltransferase and Lysine Methyltransferase G9a Inhibitors with Antitumoral in Vivo Efficacy. J Med Chem. 2018 Aug 9;61(15):6518-6545. | ||||
| REF 3 | Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6. | ||||
| REF 4 | Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1. J Med Chem. 2014 Jan 23;57(2):421-34. | ||||
| REF 5 | Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett. 2015 Mar 2;6(4):408-12. | ||||
| REF 6 | Targeting DNA methylation with small molecules: what's next?. J Med Chem. 2015 Mar 26;58(6):2569-83. | ||||
| REF 7 | Design, synthesis and in vitro anti-Zika virus evaluation of novel Sinefungin derivatives. Eur J Med Chem. 2018 Sep 5;157:994-1004. | ||||
| REF 8 | Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J Med Chem. 2014 Feb 13;57(3):701-13. | ||||
| REF 9 | Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6. | ||||
| REF 10 | SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51. | ||||
| REF 11 | Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays. Bioorg Med Chem Lett. 2017 Jan 15;27(2):342-346. | ||||
| REF 12 | Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem. 2014 Aug 14;57(15):6822-33. | ||||
| REF 13 | Discovery of two novel, small-molecule inhibitors of DNA methylation. J Med Chem. 2006 Jan 26;49(2):678-83. | ||||
| REF 14 | Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening. Eur J Med Chem. 2018 Sep 5;157:867-876. | ||||
| REF 15 | Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem. 2017 Jul 27;60(14):6289-6304. | ||||
| REF 16 | Development of rationally designed DNA N6 adenine methyltransferase inhibitors. Bioorg Med Chem Lett. 2012 May 1;22(9):3079-82. | ||||
| REF 17 | Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2. ACS Med Chem Lett. 2014 Jan 31;5(4):293-7. | ||||
| REF 18 | Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-41. | ||||
| REF 19 | Synthesis and biochemical evaluation of (2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors. J Med Chem. 2011 Nov 10;54(21):7663-77. | ||||
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