Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T92494 | Target Info | |||
| Target Name | Eukaryotic elongation factor 2 kinase (eEF-2K) | ||||
| Synonyms |
eEF-2K; eEF-2 kinase; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
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|
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| Target Type | Successful Target | ||||
| Gene Name | EEF2K | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4159250
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284583
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4169836
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284565
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4175938
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Investigative | Compound Info | ||
| Synonyms |
BDBM50284561
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4167655
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284569
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4167115
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284577
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Phenyl-3-[(phenylsulfonyl)amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4177312; Oprea1_472067; Oprea1_477749; CTK7J1806; BDBM50284579; STK981694; AKOS001780535; AKOS017269394; MCULE-9919563052
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4172081
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284570
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4163026
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284557
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4169490
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284582
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4164776
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284765
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(2-Methoxybenzoyl)amino]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4170518; CTK7B0535; BDBM50284742; AKOS000127395
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4160702
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284558
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-{[(4-Tert-butylphenyl)sulfonyl]amino}-3-phenylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4163235; Oprea1_266842; Oprea1_539169; BDBM50284910; STK981692; AKOS001618178; MCULE-1609505398; EU-0074297
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(3-Bromophenyl)formamido]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4174994; BDBM50284548; AKOS000176861; AKOS017276869; Z98660440
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4161520
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284791
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-[(3-Nitrophenyl)sulfonylamino]-3-phenylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4161570; 3-{[(3-nitrophenyl)sulfonyl]amino}-3-phenylpropanoic acid; SCHEMBL7140434; BDBM50284767; STK981693; MCULE-8478632194; EU-0004391; SR-01000427464; SR-01000427464-1
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4161882
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284573
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4168729
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50284572
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis and structure-activity relationship of a focused library of -phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer. Eur J Med Chem. 2018 Jan 1;143:402-418. | ||||
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