Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93266 | Target Info | |||
| Target Name | Hyperpolarization cyclic nucleotide-gated channel 1 (HCN1) | ||||
| Synonyms |
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Brain cyclic nucleotide-gated channel 1; BCNG1; BCNG-1
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| Target Type | Literature-reported Target | ||||
| Gene Name | HCN1 | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Methoxy-N-[(2-piperidin-1-yl-1,3-dihydroinden-2-yl)methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823675; BDBM50419061
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| Activity |
IC50 = 50118.72 nM
|
[1] | |||
| Compound Name |
3-Methoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823669; BDBM50419057
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| Activity |
IC50 = 63095.73 nM
|
[1] | |||
| Compound Name |
2-Methyl-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823678; BDBM50419063
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| Activity |
IC50 = 63095.73 nM
|
[1] | |||
| Compound Name |
4-Methoxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823670; BDBM50419058
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-Ethoxy-N-[[1-(4-phenylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823884; BDBM50419073
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| Activity |
IC50 ~ 199526.23 nM
|
[1] | |||
| Compound Name |
2-Ethyl-N-[[1-(4-propan-2-ylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823877; BDBM50419082
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| Activity |
IC50 ~ 199526.23 nM
|
[1] | |||
| Compound Name |
2-Chloro-N-[[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823679; BDBM50419081; MCULE-4962371646
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| Activity |
IC50 ~ 199526.23 nM
|
[1] | |||
| Compound Name |
2-Hydroxy-N-[[2-(4-methylpiperazin-1-yl)-1,3-dihydroinden-2-yl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823672; BDBM50419059
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| Activity |
IC50 ~ 199526.23 nM
|
[1] | |||
| Compound Name |
2-Methoxy-N-[2-(4-methylpiperazin-1-yl)ethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823890; SCHEMBL15825898; BDBM50419077; ZINC22830029; AKOS004075417
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| Activity |
IC50 ~ 199526.23 nM
|
[1] | |||
| Compound Name |
2-Methoxy-N-[(1-morpholin-4-ylcyclohexyl)methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1332972; HMS1853M19; BDBM50419072; STL202395; ZINC19902148; AKOS002244663; MCULE-3926575372; NCGC00118793-01; D335-0521; 2-methoxy-N-{[1-(morpholin-4-yl)cyclohexyl]methyl}benzamide
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| Activity |
IC50 ~ 199526.23 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of a novel series of selective HCN1 blockers. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5197-201. | ||||
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