Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93509 | Target Info | |||
| Target Name | Calcitonin gene-related peptide 1 (CALCA) | ||||
| Synonyms |
Calcitonin gene-related peptide I; CGRP-I; CALCA; CALC1; Alpha-type CGRP
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| Target Type | Clinical trial Target | ||||
| Gene Name | CALCA | ||||
| Biochemical Class | Cytotoxic amylin family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Telcagepant
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|
Phase 2 | Compound Info | ||
| Synonyms |
MK 0974; MK0974; N7R; MK-0974; Telcagepant (USAN); N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Bromo-N-[(3,5-difluorophenyl)methyl]-6-(1,1-dioxothiazinan-2-yl)-3-methoxypyridine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910948; BDBM50356293
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[4-Bromo-5-hydroxy-6-[(3,5-difluorobenzyl)carbamoyl]-2-pyridinyl]tetrahydro-2H-1,2-thiazine 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910947; SCHEMBL2250995; BDBM50356278; 4-Bromo-N-(3,5-difluorobenzyl)-6-(1,1-dioxido-1,2-thiazinan-2-yl)-3-hydroxypyridine-2-carboxamide; 4-bromo-N-[(3,5-difluorophenyl)methyl]-6-(1,1-dioxothiazinan-2-yl)-3-hydroxypyridine-2-carboxamide
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
5-(1,1-Dioxothiazinan-2-yl)-N-[(4-fluorophenyl)methyl]-1,6-naphthyridine-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910942; BDBM50356288
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[(3,5-Difluorophenyl)methyl]-5-(1,1-dioxothiazinan-2-yl)-8-hydroxyquinoline-7-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910944; BDBM50356290
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(3,5-Difluorophenyl)methyl 5-(1,1-dioxothiazinan-2-yl)-8-hydroxy-1,6-naphthyridine-7-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910945; BDBM50356291
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of a novel RAMP-independent CGRP receptor antagonist. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6705-8. | ||||
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