Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T93653 | Target Info | |||
| Target Name | Cathepsin V (CTSV) | ||||
| Synonyms |
UNQ268/PRO305; Cathepsin U; Cathepsin L2; CTSU; CTSL2; CATL2
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CTSV | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Nitro-2-(4-phenylmethoxyanilino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042453; BDBM50385983
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Methoxy-2-(3-nitro-4-phenylmethoxyanilino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042455; BDBM50385985
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Anilino-3-methoxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042456; SCHEMBL11541393; BDBM50385986
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-((4-Methoxyphenyl)amino)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
2-[(4-methoxyphenyl)amino]benzoic acid; 2-(4-Methoxyanilino)benzoic acid; N-p-Anisylanthranilic acid; Anthranilic acid, N-p-anisyl-; N-(4-Metenyl)anthranilic acid; Anthranilic acid, N-(4-methoxyphenyl)-; N-(4-Methoxyphenyl)anthranilic acid; 2-(4-Methoxyphenylamino)Benzoic Acid; Benzoic acid,2-[(4-methoxyphenyl)amino]-; MLS000775662; SMR000370544; BRN 0654162; 2-(4-METHOXY-PHENYLAMINO)-BENZOICACID; Cambridge id 5482951; 2-(p-anisidino)benzoic acid; Oprea1_042911; 3-14-00-00911 (Beilstein Handbook Reference); SCHEMBL355486; cid_202918; CHEMBL1596993; BDBM69369; CTK4B9608; DTXSID40159203; HMS2663N15; ZINC241322; 2-(4-Methoxyanilino)benzoic acid #; 6263AA; ANW-63980; MFCD00477471; N-(p-methoxyphenyl) anthranilic acid; AKOS001047469; MCULE-8579305485; NE24349; VZ23399; NCGC00246065-01; 2-[(4-Methoxyphenyl)amino]-benzoic acid; DA-17888; 4'-Methoxy-diphenylamine-2-carboxylic acid; FT-0753846; UNM000011032801; 2-(4-METHOXY-PHENYLAMINO)BENZOIC ACID; EN300-40218; AB00086706-01; SR-01000393543; J-006631; SR-01000393543-1; Z56903876
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Methoxy-2-(3-methoxy-4-phenylmethoxyanilino)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2042462; BDBM50385963
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
9-(3,5-Difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL567134; MLS002471787; SCHEMBL3353019; HMS2198O14; BDBM50303441; NCGC00182110-01; NCGC00182110-02; SMR001395200; Q27165373; 9-(3,5-difluorophenyl)-6-(ethylamino)purine-2-carbonitrile; 9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-carbonitrile
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| Activity |
IC50 = 70794.58 nM
|
[2] | |||
| Compound Name |
5-((2,3-Dimethylphenoxy)methyl)-3-methyloxazolidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397973; SCHEMBL3958229; BDBM50201707; 5-[(2,3-dimethylphenoxy)methyl]-3-methyl-1,3-oxazolidin-2-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3R,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230479; SCHEMBL3961271; BDBM50201706; trans-4-(2,3-dimethylphenoxy)-3-hydroxypiperidine
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3S,4R)-4-(2,3-Dimethylphenoxy)piperidin-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL441907; SCHEMBL3959125; BDBM50201704; (3S,4R)-4-(2,3-Dimethylphenoxy)-3-piperidinol; UNII-LHH887104B component ZHFIAFNZGWCLHU-WCQYABFASA-N
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1r)-1-{[5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-2,2-dimethylpropyl(1S)-1-[oxo(1h-pyrazol-5-ylamino)acetyl]pentylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186149; SCHEMBL6616610; BDBM50169491
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| Activity |
IC50 = 230000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V. Eur J Med Chem. 2012 Aug;54:10-21. | ||||
| REF 2 | Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14;53(1):52-60. | ||||
| REF 3 | Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1254-9. | ||||
| REF 4 | P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg Med Chem Lett. 2005 Aug 1;15(15):3540-6. | ||||
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