Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95399 | Target Info | |||
| Target Name | Myophosphorylase (PYGM) | ||||
| Synonyms |
Glycogen phosphorylase, muscle form; Myophosphorylase
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| Target Type | Discontinued Target | ||||
| Gene Name | PYGM | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID28870136-Compound-52
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Patented | Compound Info | ||
| Activity |
IC50 = 114000 nM
|
[1] | |||
| Compound Name |
4-[2-[(3-Methoxybenzoyl)amino]phenoxy]phthalic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL118313; SCHEMBL6431378; BDBM50149299; 4-[2-(3-Methoxy-benzoylamino)-phenoxy]-phthalic acid
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
4-[2-[(3-Acetylbenzoyl)amino]phenoxy]phthalic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331779; SCHEMBL6432203; BDBM50149317; 4-[2-(3-Acetyl-benzoylamino)-phenoxy]-phthalic acid
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| Activity |
IC50 = 50000 nM
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[2] | |||
| Compound Name |
4-(2-Benzamidophenoxy)phthalic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL422431; SCHEMBL6431208; ZINC3202584; BDBM50149305; STK295562; AKOS003244763; MCULE-8578706350; 4-(2-Benzoylamino-phenoxy)-phthalic acid; 4-{2-[(phenylcarbonyl)amino]phenoxy}benzene-1,2-dicarboxylic acid
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(5S,7S,8S,9S,10S)-8,9,10-Trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3351144; BDBM50215446
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| Activity |
Ki = 105000 nM
|
[3] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[2-(3-Carboxy-benzoylamino)-phenoxy]-phthalic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL331056; BDBM50149296
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| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
5-Ethynyl-1-(beta-D-Glucopyranosyl)pyrimidine-2,4(1h,3h)-Dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2041078; BDBM50386283; ZINC84671503; Q27459043
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| Activity |
IC50 = 291400 nM
|
[4] | |||
| Compound Name |
(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-6-[(2R,3S,4R,5R,6R)-6-[(2R,3S,4R,5R,6R)-6-[(2R,3S,4R,5R,6R)-6-[(2R,3S,4R,5R,6R)-4,5-Dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
Maltoheptaose; CHEMBL3322298; D-maltoheptaose; Maltohexaose DP7; PubChem24242; Maltoheptaose, >=60% (HPLC); BDBM50056222; MFCD00064605; 3,4-(DIBENZYLOXY)PHENETHYLAMINEHYDROCHLORIDE; Glc(a1-4)Glc(a1-4)Glc(a1-4)Glc(a1-4)Glc(a1-4)Glc(a1-4)Glc
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| Activity |
Ki = 1000000 nM
|
[5] | |||
| Compound Name |
alpha-D-Glucose
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Investigative | Compound Info | ||
| Synonyms |
alpha-D-Glucopyranose; alpha-Dextrose; alpha-glucose; Glucopyranose, alpha-D-; alpha-D-Glc; a-D-Glucopyranose; UNII-5J5I9EB41E; Grape sugar; glucoses; 5J5I9EB41E; CHEMBL423707; D-gluose; alpha-D-glucose, Phase I; alpha-D-glucose, Phase II; Blood sugar; alpha-D-glucopyranose, Phase I; alpha-D-glucopyranose, Phase II; .alpha.-D-Glucose; alpha-D(+)-Glucose, 99+%, anhydrous; D-Glucose-5-C-tD-glucose [MeSH: Glucose]; D-(+)-Glucose, anhydrous; a-Dextrose; a-Glucose; DextroseAnhydrate; alpha-delta-Glucose; EINECS 207-757-8; alpha-d(+)-glucose; I+/--D-Glucose; 1,3-alpha-D-Glucan; 1,6-alpha-D-Glucan; alpha-delta-Glucopyranose; Glucose,standard solution; Dextrin from corn, p.a.; bmse000015; bmse000791; bmse000797; bmse000855; Epitope ID:144998; MolMap_000023; Alpha-D-Glucose, Anhydrous; SCHEMBL6222; (1->3)-alpha-D-glucan; (1->4)-alpha-D-glucan; (1->6)-alpha-D-glucan; (1,6-alpha-D-Glucosyl)n; MLS006011570; Glucose, p.a., ACS reagent; (1->3)-alpha-D-glucopyranan; (1->4)-alpha-D-glucopyranan; Dextrin from potato starch, CP; [alpha-D-Glucosyl-(1,3)]n; D-(+)-Glucose, AR, anhydrous; DTXSID30197710; [alpha-D-Glucosyl-(1,3)]n+1; alpha-D-Glucose, anhydrous, 96%; CMC_6867; Dextrin from corn, Type I, powder; ZINC3861213; D-(+) Glucose, analytical standard; D-(+)-Glucose, analytical standard; alpha-D-glucose; D-glucose; glucose; BDBM50351158; s6028; Glucose stock solution, 1000 mg/dL; AKOS015950677; D-(+)-Glucose, >=99% (GC); MCULE-3846926665; NCGC00160621-01; NCGC00160621-03; AC-15067; BS-17112; SC-46961; SMR004703328; D-(+)-Glucose, >=99.5% (GC); HY-128417; CS-0099249; Dextrin from potato starch, for microbiology; Dextrin from potato starch, Type IV, powder; D-(+)-Glucose, LR, anhydrous, >=99.5%; D-(+)-Glucose, tested according to Ph.Eur.; alpha-D-Glucose, SAJ first grade, >=98.0%; C00267; D-(+)-Glucose, BioXtra, >=99.5% (GC); alpha-D-Glucose, SAJ special grade, >=98.0%; D-Glucose (Dextrose), NIST(R) SRM(R) 917C; W-204032; D-(+)-Glucose, Vetec(TM) reagent grade, >=99.5%; Q23905965; Z1258578367; 074AD9E3-1FC7-485C-8A50-2B653D501E5B; D-(+)-Glucose, 99.9 atom % 16O, 99.9 atom % 12C
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| Activity |
Ki = 1700000 nM
|
[5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4944-8. | ||||
| REF 2 | Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site. J Med Chem. 2004 Jul 1;47(14):3537-45. | ||||
| REF 3 | Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin. Bioorg Med Chem Lett. 1999 May 17;9(10):1385-90. | ||||
| REF 4 | The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment. Eur J Med Chem. 2012 Aug;54:740-9. | ||||
| REF 5 | Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl--d-glucopyranosylamines. Bioorg Med Chem. 2014 Sep 1;22(17):4810-25. | ||||
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