Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95923 | Target Info | |||
| Target Name | Lysophosphatidate-3 receptor (LPAR3) | ||||
| Synonyms |
Lysophosphatidic acid receptor Edg7; Lysophosphatidic acid receptor 3; LPAR3; LPA3; LPA receptor 3
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| Target Type | Clinical trial Target | ||||
| Gene Name | LPAR3 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
LPA2 antagonist 1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256470; VC-6664; BCP11072; BDBM50373826; MFCD25976928; ZINC29126798; NCGC00390601-01; HY-18075
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
7-Methyl-N-[(2S)-1-[4-(2-methylphenyl)piperazin-1-yl]propan-2-yl]thieno[3,2-d]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404452; BDBM50373817
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(3R)-1-Fluoro-3-hydroxy-4-[(E)-octadec-9-enoyl]oxybutyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370500
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| Activity |
EC50 ~ 500000 nM
|
[2] | |||
| Compound Name |
[(3S)-1,1-Difluoro-3-hydroxy-4-[(E)-octadec-9-enoyl]oxybutyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426633
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| Activity |
EC50 ~ 500000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41. | ||||
| REF 2 | Structure-activity relationships of fluorinated lysophosphatidic acid analogues. J Med Chem. 2005 May 5;48(9):3319-27. | ||||
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