Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95947 | Target Info | |||
| Target Name | Acid-sensing ion channel 3 (ASIC3) | ||||
| Synonyms |
hTNaC1; hASIC3; Testis sodium channel 1; TNAC1; SLNAC1; Neuronal amiloride-sensitive cation channel 3; Amiloride-sensitive cation channel 3; ASIC3; ACCN3
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| Target Type | Literature-reported Target | ||||
| Gene Name | ASIC3 | ||||
| Biochemical Class | Amiloride-sensitive sodium channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 15 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tert-butyl 7-[2-[2-(aminomethyl)-3-chloro-1-benzothiophen-6-yl]ethynyl]-3,4-dihydro-1H-isoquinoline-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800429; BDBM50348105
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
[3-Chloro-6-[2-[2-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-isoquinolin-7-yl]ethynyl]-1-benzothiophen-2-yl]methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800435; BDBM50348109
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
2-(3-Chloro-5-methylphenyl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL563745; BDBM50296576
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| Activity |
IC50 = 51000 nM
|
[2] | |||
| Compound Name |
2-(3-Bromo-5-fluorophenyl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL556428; BDBM50296570
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| Activity |
IC50 = 59000 nM
|
[2] | |||
| Compound Name |
2-(3,5-Dibromophenyl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL571680; BDBM50296571
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| Activity |
IC50 = 59000 nM
|
[2] | |||
| Compound Name |
2-(3-(Benzylamino)-5-chlorophenyl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL561796; BDBM50296575
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| Activity |
IC50 = 77000 nM
|
[2] | |||
| Compound Name |
2-(3-Amino-5-chlorophenyl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL549580; BDBM50296573
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| Activity |
IC50 = 95000 nM
|
[2] | |||
| Compound Name |
Benzo[b]thiophen-2-ylmethanamine
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Investigative | Compound Info | ||
| Synonyms |
1-benzothiophen-2-ylmethylamine; Benzo[b]thiophene-2-methanamine; 1-benzothiophen-2-ylmethanamine; c-benzo[b]thiophen-2-yl-methylamine; 2-(aminomethyl)benzo[b]thiophene; CHEMBL1770735; 1-benzothiophene-2-yl methylamine; Benzo(b)thiophene-2-methylamine; Benzo[b]thiophene-2-methylamine; benzo[b]thiophen-2-ylmethylamine; NSC40287; ChemDiv2_001947; Oprea1_679404; Oprea1_824414; SCHEMBL240588; 1-Benzothiophen-2ylmethylamine; CTK2F4790; KS-00003KNK; ZINC64943; DTXSID50285047; 2-(Aminomethyl)[1]benzothiophene; (1-benzothiophen-2-yl)methanamine; HMS1374I11; ALBB-015187; C-Benzo[b]thiophen-2-ylmethylamine; ANW-47376; BDBM50342656; MFCD00965305; NSC-40287; SBB087727; STK064350; 1-(1-benzothiophen-2-yl)methanamine; AKOS001688870; FS-2137; MCULE-9651554232; SDCCGMLS-0065963.P001; VZ21167; BR-30075; AB0025948; DB-015189; 1-benzothiophen-2-ylmethylamine, AldrichCPR; AM20040912; FT-0607370; W7515; EN300-55374; S-4913; 314B438; J-519699; 1-(1-BENZOTHIEN-2-YL)METHANAMINE HYDROCHLORIDE
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| Activity |
IC50 = 97000 nM
|
[3] | |||
| Compound Name |
2-((5-Methoxy-1H-indol-3-yl)methyl)-6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770747; BDBM50342644
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| Activity |
IC50 = 103000 nM
|
[3] | |||
| Compound Name |
2-(3-Chloro-5-((phenylamino)methyl)phenyl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL551066; BDBM50296574
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| Activity |
IC50 = 114000 nM
|
[2] | |||
| Compound Name |
6-Phenylpyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
4-Amino-6-phenylpyrimidine; 4-Pyrimidinamine, 6-phenyl-; 6-phenyl-4-pyrimidinamine; CHEMBL1770733; MFCD00234634; 6-amino-4-phenylpyrimidine; 6-phenylpyrimidin-4-ylamine; 4-Pyrimidinamine,6-phenyl-; 6-phenylpyrimidine-4-ylamine; SCHEMBL558453; CTK4H2209; DTXSID50355799; ZINC331251; 4121AB; BDBM50342654; SBB070166; AKOS011057297; KS-00000A85; AK-92998; AS-43634; QC-10209; SC-53053; SY033915; DB-006647; CS-0045907; FT-0600213; W-3953; 435A298; A822185; A822281; AC-907/25005026; F1967-6951
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| Activity |
IC50 = 130000 nM
|
[3] | |||
| Compound Name |
2-(3,5-Dichlorophenyl)-1H-indole-5-carboximidamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563997; SCHEMBL3011394; BDBM50296565
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| Activity |
IC50 = 133000 nM
|
[2] | |||
| Compound Name |
2-(2,3,5-Trichlorophenyl)-1H-indole-5-carboximidamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561129; BDBM50296566
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| Activity |
IC50 = 135000 nM
|
[2] | |||
| Compound Name |
4-(1H-Imidazol-4-YL)-benzylamine
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Investigative | Compound Info | ||
| Synonyms |
(4-(1H-IMIDAZOL-4-YL)PHENYL)METHANAMINE; 4-(1H-imidazol-4-yl)benzylamine; CHEMBL1770737; [4-(1H-imidazol-5-yl)phenyl]methanamine; [4-(1H-imidazol-4-yl)phenyl]methanamine; SCHEMBL22654521; CTK5G0704; DTXSID40652401; 2424AJ; BDBM50342658; ZINC22015956; AKOS006293879; AB28028; Benzenemethanamine,4-(1H-imidazol-5-yl)-; DB-077867; 1-[4-(1H-Imidazol-5-yl)phenyl]methanamine; FT-0695598; Z-6804
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| Activity |
IC50 = 160000 nM
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[3] | |||
| Compound Name |
(3-Methoxy-pyridin-2-yl)-(6-methyl-pyridin-2-yl)-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL196536; SCHEMBL5582792; BDBM50171068; DB-094321; N-(3-methoxypyridin-2-yl)-6-methylpyridin-2-amine
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| Activity |
IC50 = 190000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 9 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(3,5-Dichloro-4-cyanophenyl)-1H-indole-5-carboximidamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564749; BDBM50296567
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| Activity |
IC50 = 272000 nM
|
[2] | |||
| Compound Name |
2-(3-Chloro-5-fluorophenyl)-1H-indole-5-carboximidamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561130; BDBM50296569
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| Activity |
IC50 = 278000 nM
|
[2] | |||
| Compound Name |
2-(2,6-Dichloropyridin-4-yl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL552410; BDBM50296568
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| Activity |
IC50 = 291000 nM
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[2] | |||
| Compound Name |
1,3-Benzothiazol-2-ylmethylamine
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Investigative | Compound Info | ||
| Synonyms |
Benzo[d]thiazol-2-ylmethanamine; 1,3-Benzothiazol-2-ylmethanamine; 2-Benzothiazolemethanamine; 1-(1,3-benzothiazol-2-yl)methanamine; (1,3-benzothiazol-2-ylmethyl)amine; CHEMBL1770734; benzothiazol-2-ylmethylamine; NSC509752; 2-aminomethylbenzothiazole; ACMC-209h7a; Benzothiazole-2-methanamine; SCHEMBL244775; C-Benzothiazol-2-ylmethylamine; (Benzothiazole-2-yl)methylamine; CTK4I5820; KS-00000QXX; DTXSID40325542; ZINC158627; ALBB-005900; (1,3-benzothiazol-2-yl)methanamine; 1,3-Benzothiazol-2-ylmethanamine #; ANW-26564; BDBM50342655; MFCD06660504; SBB046625; STK503606; AKOS000117373; MCULE-3961966867; NSC-509752; SDCCGMLS-0065937.P001; AK123577; AM803885; BS-13363; SC-49534; BB 0216352; FT-0694483; ST45136457; EN300-10829; K-8783; Q27452867
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| Activity |
IC50 = 363000 nM
|
[3] | |||
| Compound Name |
2-(3-Fluoro-5-methoxyphenyl)-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL561328; BDBM50296572
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| Activity |
IC50 = 374000 nM
|
[2] | |||
| Compound Name |
4-(1H-Imidazol-4-yl)aniline
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Investigative | Compound Info | ||
| Synonyms |
4-(1H-imidazol-5-yl)aniline; benzenamine, 4-(1H-imidazol-5-yl)-; CHEMBL1770736; Benzenamine, 4-(1H-imidazol-4-yl)-; EC-000.1685; 4-imidazol-4-ylphenylamine; 4-(imidazol-4-yl)-aniline; Oprea1_670733; SCHEMBL1283665; SCHEMBL17782163; 4(5)-(4-aminophenyl)imidazole; 4-(1H-imidazol-4-yl)-aniline; CTK1C2002; DTXSID90358688; 5-(4-Aminophenyl)-3H-imidazole; 4-(1H-imidazol-4-yl)phenylamine; 4-(p-aminophenyl)-1-H-imidazole; 4-(3H-Imidazol-4-yl)phenylamine; 4-(4-aminophenyl)-1-H-imidazole; ZINC6550129; 4-(4-amino phenyl)-1-H-imidazole; BBL028494; BDBM50342657; MFCD00297065; SBB076566; STK836236; AKOS000117850; MCULE-7178530908; AS-10664; DA-07247; BB 0219904; BB 0258960; FT-0677170; Z-2056; F2124-0456
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| Activity |
IC50 = 430000 nM
|
[3] | |||
| Compound Name |
6-Bromo-1,2,3,4-tetrahydroisoquinoline
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Investigative | Compound Info | ||
| Synonyms |
Isoquinoline, 6-bromo-1,2,3,4-tetrahydro-; 6-BROMO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE; MFCD07374370; CHEMBL1770731; ACMC-20ailv; SCHEMBL505055; 6-BROMO-1,2,3,4-TETRA HYDRO ISO QUINOLINE; AMOT0184; CTK1A1283; DTXSID40579124; ACT10842; BCP07129; ANW-75041; BDBM50342652; ZINC34753957; 6-Bromo-1,2,3,4-tetrahydroisoquin; AKOS013709659; CCG-357927; CS-W019599; FS-2827; MCULE-5978633680; PB30910; KS-000002G7; 1,2,3,4-Tetrahydro-6-bromoisoquinoline; AK-25184; BC005059; BR-25184; SC-14805; SY009647; 3-AMINO-2-METHYL BENZOTRIFLUORIDE?; AB0023561; AM20050217; FT-0645397; W4639; A25880; S-4856; W-206778; 6-bromo-1,2,3,4-tetrahydroisoquinoline,hydrochloride; Z1741974551
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| Activity |
IC50 = 701000 nM
|
[3] | |||
| Compound Name |
2-Amino-6-phenylpyridine
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Investigative | Compound Info | ||
| Synonyms |
6-phenylpyridin-2-amine; 6-PHENYL-PYRIDIN-2-YLAMINE; 6-Phenyl-2-pyridinamine; 6-Amino-2-phenylpyridine; CHEMBL1671950; 2-PYRIDINAMINE, 6-PHENYL-; PubChem19484; 6-phenyl-2-pyridylamine; 6-phenylpyridin-2-ylamine; 2-Pyridinamine,6-phenyl-; 6-Phenyl-2-pyridinamine #; AC-907/25005118; 2-?Amino-?6-?phenylpyridine; Pyridine, 2-amino-6-phenyl-; SCHEMBL1039866; CTK4I1860; DTXSID00344633; KS-00000K3O; ANW-48088; BDBM50342653; MFCD00234719; SBB088426; ZINC19801045; AKOS000276751; AB05274; CS-W019779; FS-3372; WT82495; 6-phenyl-pyridin-2-ylamine, AldrichCPR; AK-41465; BR-41465; SC-82099; AB0024688; BB 0260402; FT-0611216; W6009; S-3825; A824729; Q-103095
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| Activity |
IC50 = 763000 nM
|
[3] | |||
| Compound Name |
2-Phenyl-1H-indole-5-carboximidamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL25811; SCHEMBL13208176; 2-Phenyl-1H-indole-5-carboxamidine; BDBM50287160
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| Activity |
IC50 = 2765000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of non-amidine inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorg Med Chem Lett. 2011 Jul 15;21(14):4255-8. | ||||
| REF 2 | Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorg Med Chem Lett. 2009 Aug 1;19(15):4059-63. | ||||
| REF 3 | High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors. Bioorg Med Chem Lett. 2011 May 1;21(9):2646-9. | ||||
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