Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T96435 | Target Info | |||
| Target Name | Sentrin specific protease-1 (SENP1) | ||||
| Synonyms |
Sentrin/SUMO-specific protease SENP1; Sentrin-specific protease 1
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| Target Type | Literature-reported Target | ||||
| Gene Name | SENP1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[2-(4-Chlorophenyl)-2-oxoethyl] 4-[(3,4-dimethoxybenzoyl)amino]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159855; Oprea1_595427; BDBM50394463
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
[2-(4-Chlorophenyl)-2-oxoethyl] 4-[(3,4-diethoxybenzoyl)amino]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159856; BDBM50394462
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
[2-(4-Chlorophenyl)-2-oxoethyl] 4-[(3-aminobenzoyl)amino]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159854; BDBM50394461
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
[2-(4-Chlorophenyl)-2-oxoethyl] 4-[(3-hydroxybenzoyl)amino]benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159852; BDBM50394460
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Tert-butyl N-[3-[[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamoyl]phenyl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910014; BDBM50355871
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Benzyl N-[2-oxo-1-(2-oxoethyl)-3H-1,4-benzodiazepin-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910021; BDBM50355878
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-Acetamido-N-[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910015; BDBM50355872
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Benzyl N-[1-(2-hydroxyethyl)-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910019; BDBM50355876
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Tert-butyl N-[4-[[2-oxo-1-(2-oxoethyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamoyl]phenyl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910012; BDBM50355869
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Benzyl N-[2-oxo-1-(3-oxopropyl)-5-phenyl-3H-1,4-benzodiazepin-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910020; BDBM50355877
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6867-70. | ||||
| REF 2 | Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6389-92. | ||||
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