Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T97071 | Target Info | |||
| Target Name | Glutamate carboxypeptidase II (GCPII) | ||||
| Synonyms |
Pteroylpoly-gamma-glutamate carboxypeptidase; Prostate-specific membrane antigen; PSMA; PSM; NAALADase I; NAALAD1; N-acetylated-alpha-linked acidic dipeptidase I; Membrane glutamate carboxypeptidase; MGCP; Glutamate carboxypeptidase 2; GIG27; Folylpoly-gamma-glutamate carboxypeptidase; Folate hydrolase 1; FOLH; FGCP; Cell growth-inhibiting gene 27 protein
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | FOLH1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 11 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-WILLARDIINE
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(S)-WILLARDIINE; Willardiine; S(-)-Willardiine; 21416-43-3; 3-(Uracil-1-yl)-L-alanine; (-)-Willardiine; CHEMBL122005; CHEBI:15851; 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine; HWD; 2-AMINO-3-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID; 1mqj; 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)alanine; AC1L98KY; Lopac0_001219; SCHEMBL401191; SCHEMBL13319907; BDBM17661; CTK5H8581; MolPort-003-959-938; ZINC901774; 96108-98-4; 2990AH; AKOS006281897; DB04129; CCG-205293; CS-3618; NCGC00094464-03; HY-12499; EU-0101219; C03584
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
Glutamine Hydroxamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
glutamine hydroxamate; N-Hydroxy-L-glutamine; 1955-67-5; Glutamyl-gamma-hydroxamate; gamma-Glutamyl hydroxamate; Glutamate-gamma-hydroxamate; L-gamma-Glutamyl hydroxamate; Glutamate-gamma-hydroxamic acid; Glutamic acid gamma-monohydroxamate; CHEMBL63893; CHEBI:75305; HGA; Glunhoh; Amino acid hydroxamates L-glutamic acid gamma- monohydroxamate; AC1L9MTD; gamma-glutamylhydroxylamine; SCHEMBL4321249; L-Glutamic acid -monohydroxamate; L-Glutamic acid gamma-hydroxamate; ZINC2522574; FCH838713; BDBM50129196; L-glutamic acid gamma-hydr
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[[(3R,5S)-1-[(4S)-4-Amino-4-carboxybutanoyl]-5-carboxypyrrolidin-3-yl]oxy-hydroxyphosphoryl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427436; BDBM50088186
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[[[(3R,5S)-1-[(4S)-4-(6-Aminohexanoylamino)-4-carboxybutanoyl]-5-carboxypyrrolidin-3-yl]oxy-hydroxyphosphoryl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427438; BDBM50088188
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[3] | |||
| Compound Name |
(R)-3-Acetylamino-N-hydroxy-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294281; BDBM50129203
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Hydroxy-L-asparagine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
L-Aspartic acid beta-hydroxamate; beta-L-aspartylhydroxamic acid; beta-L-Aspartylhydroxamate; beta-aspartohydroxamic acid; CHEMBL63902; L-Asparaginsaeure-4-hydroxyamid; (2S)-2-amino-4-(hydroxyamino)-4-oxobutanoic acid; beta-Aspartylhydroxamate; L-Asparagine, N-hydroxy-; Aspartate-beta-hydroxamate; beta-Aspartylhydroxamic acid; Aspartic acid beta-hydroxamate; D-Aspartic acid beta-hydroxamate; L-Aspartylhydroxamate; N-Hydroxy-DL-asparagine; N(4)-hydroxy-L-asparagine; SCHEMBL10596071; ZINC2545150; BDBM50129194; AKOS006273241; DL-Aspartic acid beta-hydroxamate monohydrate; C03124; (2S)-2-amino-3-(hydroxycarbamoyl)propanoic acid; Q27123606; L-Aspartic acid beta-hydroxamate, serine racemase inhibitor; (2S)-2-amino-4-(hydroxyamino)-4-oxobutanoic acidN(4)-hydroxy-L-asparagine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
n-Hydroxy-d-asparagine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL413963; N-D-beta-Aspartylhydroxylamine; Aspartic acid, .beta.-hydroxamate; ZINC2010556; BDBM50129198; (R)-2-Amino-N-hydroxy-succinamic acid; (2R)-2-amino-4-(hydroxyamino)-4-oxo-butanoic acid; Q27465314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(S)-3-Acetylamino-N-hydroxy-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65072; BDBM50129201
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[2-(2-Benzoyloxymethyl-3-benzyl-4-oxo-azetidin-1-yl)-2-oxo-ethyl]-benzoic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL285618; BDBM50099210
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-[(1-Benzoyl-3alpha-benzyl-4-oxoazetidine-2alpha-yl)methoxycarbonyl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL36215; BDBM50099207; Terephthalic acid mono-(1-benzoyl-3-benzyl-4-oxo-azetidin-2-ylmethyl) ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S)-2-[[[(3S,5R)-1-[(4S)-4-(6-Aminohexanoylamino)-4-carboxybutanoyl]-5-carboxypyrrolidin-3-yl]oxy-hydroxyphosphoryl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427439; BDBM50088189
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 11 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Glutamic Acid
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 428000 nM
|
[1] | |||
| Compound Name |
L-serine-O-phosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Phosphoserine; O-phospho-L-serine; Dexfosfoserine; phosphoserine; 407-41-0; L-O-Phosphoserine; Fosforina; O-Phosphoserine; L-SOP; L-Phosphoserine; PHOSPHONOSERINE; 3-phosphoserine; L-Serine O-phosphate; Dexfosfoserine [INN]; Phosphatidalserine; 3-O-Phosphoserine; H-Ser(PO3H2)-OH; O-phosphono-L-serine; serine, O-phosphono-; (+)-L-Serine dihydrogen phosphate (ester); L-Seryl phosphate; UNII-VI4F0K069V; L-3-Phosphoserine; L-O-Serine phosphate; L-Serinephosphoric acid; H-Ser(PO)-OH; L-2-amino-3-hydroxypropanoic acid 3-phosphate; LSOP; Phosphonoserine
Click to Show/Hide
|
||||
| Activity |
IC50 = 523000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[[(3S,5R)-1-[(4S)-4-Amino-4-carboxybutanoyl]-5-carboxypyrrolidin-3-yl]oxy-hydroxyphosphoryl]amino]pentanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3427437; BDBM50088187
Click to Show/Hide
|
||||
| Activity |
IC50 = 357000 nM
|
[3] | |||
| Compound Name |
L-Serine O-sulfate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Serine O-sulfate; O-Sulfo-L-Serine; H-SER(SO3H)-OH; sulfoserine; O-sulfonato-L-serine; L-Serine, O-sulfo-; UNII-81K4VO7FNP; 81K4VO7FNP; (S)-2-Amino-3-(sulfooxy)propanoic acid; L-serine O-(hydrogen sulfate); (2S)-2-amino-3-(sulfooxy)propanoic acid; C3H7NO6S; l-serine-o-sulfate; (2S)-2-amino-3-sulfooxypropanoic acid; L-SOS; CHEMBL28885; SCHEMBL4314030; BDBM17663; CTK2F6092; DTXSID80211652; ZINC4095907; L-Serine, hydrogen sulfate (ester); 7239AH; KM0646; MFCD00672378; AKOS006271404; DB03497; AS-46936; C02703; Q27098248; UNII-63CV1GEK3Y component LFZGUGJDVUUGLK-REOHCLBHSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 = 438000 nM
|
[1] | |||
| Compound Name |
(S)-3-(2-Carboxy-2-(3-(1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)ethyl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596429; BDBM50304743
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[5] | |||
| Compound Name |
(S)-2-(3-((S)-1-Methoxy-4-methyl-1-oxopentan-2-yl)ureido)-4-(methylthio)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596184; BDBM50304745
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[5] | |||
| Compound Name |
(S)-3-(3-Hydroxyphenyl)-2-(3-(1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595742; BDBM50304741
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[5] | |||
| Compound Name |
(S)-2-(3-((S)-1-Carboxy-2-(1H-indol-3-yl)ethyl)ureido)-4-methylpentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605939; BDBM50304747
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[5] | |||
| Compound Name |
(S)-2-(3-Hydroxyphenyl)-2-(3-(1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596194; BDBM50304709
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[5] | |||
| Compound Name |
(S)-2-(3-(Carboxy(3-hydroxyphenyl)methyl)ureido)-4-methylpentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL596204; BDBM50304710
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[5] | |||
| Compound Name |
(S)-2-(4-Fluoro-3-methoxyphenyl)-2-(3-(1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608131; BDBM50304721
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II. J Med Chem. 2007 Jul 12;50(14):3267-73. | ||||
| REF 2 | Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2097-100. | ||||
| REF 3 | Synthesis and evaluation of constrained phosphoramidate inhibitors of prostate-specific membrane antigen. Bioorg Med Chem Lett. 2015 Jun 15;25(12):2536-9. | ||||
| REF 4 | Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen. J Med Chem. 2001 May 10;44(10):1491-508. | ||||
| REF 5 | Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. Bioorg Med Chem Lett. 2010 Jan 1;20(1):392-7. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.