Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00494 | Target Info | |||
| Target Name | ATP-binding cassette transporter A1 (ABCA1) | ||||
| Synonyms | Cholesterol mobilizing transporter ABCA1; Cholesterol efflux regulatory protein; CERP; ATP-binding cassette transporter (ABCA1) transmembrane protein; ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ABC1; ABC-1 | ||||
| Target Type | Successful Target | ||||
| Gene Name | ABCA1 | ||||
| Biochemical Class | ABC transporter | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Adenosine triphosphate | Ligand Info | |||||
| Structure Description | The structure of ATP-bound ABCA1 | PDB:7TBW | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
CWPQLRLLLW
12 KNLTFRRRQT22 CQLLLEVAWP32 LFIFLILISV42 RLSYPPYEQH52 ECHFPNKAMP 62 SAGTLPWVQG72 IICNANNPCF82 RYPTPGEAPG92 VVGNFNKSIV102 ARLFSDARRL 112 LLYSQKDTSM122 KDMRKVLRTL132 QQIKKSSSKS200 EEMIQLGDQE210 VSELCGLPRE 220 KLAAAERVLR230 SNMDILKPIL240 RTLNSTSPFP250 SKELAEATKT260 LLHSLGTLAQ 270 ELFSMRSWSD280 MRQEVMFLTS296 STQIYQAVSR306 IVCGHTPYCN356 DLMKNLESSP 366 LSRIIWKALK376 PLLVGKILYT386 PDTPATRQVM396 AEVNKTFQEL406 AVFHDLEGMW 416 EELSPKIWTF426 MENSQEMDLV436 RMLLDSRDND446 HFWEQQLDGL456 DWTAQDIVAF 466 LAKHPVYTWR485 EAFNETNQAI495 RTISRFMECV505 NLNKLEPIAT515 EVWLINKSME 525 LLDERKFWAG535 IVFTGITPGS545 IELPHHVKYK555 IRMDIDNVER565 TNKIKDGYWD 575 PGPRADPFED585 MRYVWGGFAY595 LQDVVEQAII605 RVLTGTEKKT615 GVYMQQMPYP 625 CYVDDIFLRV635 MSRSMPLFMT645 LAWIYSVAVI655 IKGIVYEKEA665 RLKETMRIMG 675 LDNSILWFSW685 FISSLIPLLV695 SAGLLVVILK705 LGNLLPYSDP715 SVVFVFLSVF 725 AVVTILQCFL735 ISTLFSRANL745 AAACGGIIYF755 TLYLPYVLCV765 AWRDYVGFTL 775 KIFASLLSPV785 AFGFGCEYFA795 LFEEQGIGVQ805 WDNLFESPVE815 EDGFNLTTSV 825 SMMLFDTFLY835 GVMTWYIEAV845 FPGQYGIPRP855 WYFPCEPTHL895 KLGVSIQNLV 905 KVYRDGMKVA915 VDGLALNFYE925 GQITSFLGHN935 GAGKTTTMSI945 LTGLFPPTSG 955 TAYILGKDIR965 SEMSTIRQNL975 GVCPQHNVLF985 DMLTVEEHIW995 FYARLKGLSE 1005 KHVKAEMEQM1015 ALDVGLPSSK1025 LKSKTSQLSG1035 GMQRKLSVAL1045 AFVGGSKVVI 1055 LDQPTAGVDP1065 YSRRGIWELL1075 LKYRQGRTII1085 LSTHHMDEAD1095 VLGDRIAIIS 1105 HGKLCCVGSS1115 LFLKNQLGTG1125 YYLTLVKSAI1183 SNLIRKHVSE1193 ARLVEDIGHE 1203 LTYVLPAFVE1220 LFHEIDDRIS1235 SYGISETTLE1245 EIFLKVAEES1255 GKGSYQVKGW 1322 KLTQQQFVAL1332 LWKRLLIARR1342 SRKGFFAQIV1352 LPAVFVCIAL1362 VFSLIVPPFG 1372 KYPSLELQPW1382 MYNEQYTFVS1392 NDAPEDTGTL1402 ELLNALTKDP1412 GFGTRCMEGN 1422 PIPDTPCQAG1432 EEEWTTAPVP1442 QTIMDLFQNG1452 NWTMQNPSPA1462 CQCSKMLPVC 1477 PPGAGGLPPP1487 QRKQNTADIL1497 QDLTGRNISD1507 YLVKTYVQII1517 AKSLKNKIWV 1527 NEFRYGGFSL1537 GVSNPSQEVN1552 DAIKQMKKHL1562 KLAKDSSADR1572 FLNSLGRFMT 1582 GLDTKNNVKV1592 WFNNKGWHAI1602 SSFLNVINNA1612 ILRANLQKGE1622 NPSHYGITAF 1632 NHPLNLTKQQ1642 LSEVALMTTS1652 VDVLVSICVI1662 FAMSFVPASF1672 VVFLIQERVS 1682 KAKHLQFISG1692 VKPVIYWLSN1702 FVWDMCNYVV1712 PATLVIIIFI1722 CFQQKSYVSS 1732 TNLPVLALLL1742 LLYGWSITPL1752 MYPASFVFKI1762 PSTAYVVLTS1772 VNLFIGINGS 1782 VATFVLELFT1792 DNKLNNINDI1802 LKSVFLIFPH1812 FCLGRGLIDM1822 VKNQAMADAL 1832 ERVSPLSWDL1848 VGRNLFAMAV1858 EGVVFFLITV1868 LIQYRFFIDE1891 DEDVRRERQR 1901 ILDGGGQNDI1911 LEIKELTKIY1921 RRKRKPAVDR1931 ICVGIPPGEC1941 FGLLGVNGAG 1951 KSSTFKMLTG1961 DTTVTRGDAF1971 LNKNSILSNI1981 HEVHQNMGYC1991 PQFDAITELL 2001 TGREHVEFFA2011 LLRGVPEKEV2021 GKVGEWAIRK2031 LGLVKYGEKY2041 AGNYSGGNKR 2051 KLSTAMALIG2061 GPPVVFLDQP2071 TTGMDPKARR2081 FLWNCALSVV2091 KEGRSVVLTS 2101 HSMEECEALC2111 TRMAIMVNGR2121 FRCLGSVQHL2131 KNRFGDGYTI2141 VVRIDLKPVQ 2156 DFFGLAFPGS2166 VLKEKHRNML2176 QYQLPSSLSS2186 LARIFSILSQ2196 SKKRLHIEDY 2206 SVSQTTLDQV2216 FVNFAKDQ
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TYR908
3.648
ASP910
3.086
LYS913
3.207
ALA915
3.874
GLY933
4.354
HIS934
3.932
ASN935
2.411
GLY936
3.425
ALA937
4.161
GLY938
3.076
LYS939
2.527
THR940
2.533
THR941
3.493
GLN980
2.742
LYS1025
3.106
GLN1032
1.296
SER1034
3.248
GLY1035
3.958
GLY1036
3.336
MET1037
4.445
ASP1057
4.966
GLN1058
3.964
GLY1062
3.839
HIS1089
2.575
TYR1921
3.593
LYS1924
2.849
ALA1928
4.056
GLY1946
4.886
VAL1947
4.284
ASN1948
2.861
GLY1949
3.371
ALA1950
4.236
GLY1951
3.181
LYS1952
2.963
SER1953
2.561
SER1954
2.840
THR1955
4.902
GLN1993
2.875
TYR2037
3.931
LYS2040
4.963
ASN2044
3.043
TYR2045
4.678
SER2046
3.231
GLY2047
3.144
GLY2048
2.580
ASN2049
4.905
GLN2070
2.791
GLY2074
2.852
MET2075
4.617
HIS2102
3.315
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| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | The structure of ATP-bound ABCA1 | PDB:7TBW | ||||
| Method | Electron microscopy | Resolution | 3.10 Å | Mutation | Yes | [1] |
| PDB Sequence |
CWPQLRLLLW
12 KNLTFRRRQT22 CQLLLEVAWP32 LFIFLILISV42 RLSYPPYEQH52 ECHFPNKAMP 62 SAGTLPWVQG72 IICNANNPCF82 RYPTPGEAPG92 VVGNFNKSIV102 ARLFSDARRL 112 LLYSQKDTSM122 KDMRKVLRTL132 QQIKKSSSKS200 EEMIQLGDQE210 VSELCGLPRE 220 KLAAAERVLR230 SNMDILKPIL240 RTLNSTSPFP250 SKELAEATKT260 LLHSLGTLAQ 270 ELFSMRSWSD280 MRQEVMFLTS296 STQIYQAVSR306 IVCGHTPYCN356 DLMKNLESSP 366 LSRIIWKALK376 PLLVGKILYT386 PDTPATRQVM396 AEVNKTFQEL406 AVFHDLEGMW 416 EELSPKIWTF426 MENSQEMDLV436 RMLLDSRDND446 HFWEQQLDGL456 DWTAQDIVAF 466 LAKHPVYTWR485 EAFNETNQAI495 RTISRFMECV505 NLNKLEPIAT515 EVWLINKSME 525 LLDERKFWAG535 IVFTGITPGS545 IELPHHVKYK555 IRMDIDNVER565 TNKIKDGYWD 575 PGPRADPFED585 MRYVWGGFAY595 LQDVVEQAII605 RVLTGTEKKT615 GVYMQQMPYP 625 CYVDDIFLRV635 MSRSMPLFMT645 LAWIYSVAVI655 IKGIVYEKEA665 RLKETMRIMG 675 LDNSILWFSW685 FISSLIPLLV695 SAGLLVVILK705 LGNLLPYSDP715 SVVFVFLSVF 725 AVVTILQCFL735 ISTLFSRANL745 AAACGGIIYF755 TLYLPYVLCV765 AWRDYVGFTL 775 KIFASLLSPV785 AFGFGCEYFA795 LFEEQGIGVQ805 WDNLFESPVE815 EDGFNLTTSV 825 SMMLFDTFLY835 GVMTWYIEAV845 FPGQYGIPRP855 WYFPCEPTHL895 KLGVSIQNLV 905 KVYRDGMKVA915 VDGLALNFYE925 GQITSFLGHN935 GAGKTTTMSI945 LTGLFPPTSG 955 TAYILGKDIR965 SEMSTIRQNL975 GVCPQHNVLF985 DMLTVEEHIW995 FYARLKGLSE 1005 KHVKAEMEQM1015 ALDVGLPSSK1025 LKSKTSQLSG1035 GMQRKLSVAL1045 AFVGGSKVVI 1055 LDQPTAGVDP1065 YSRRGIWELL1075 LKYRQGRTII1085 LSTHHMDEAD1095 VLGDRIAIIS 1105 HGKLCCVGSS1115 LFLKNQLGTG1125 YYLTLVKSAI1183 SNLIRKHVSE1193 ARLVEDIGHE 1203 LTYVLPAFVE1220 LFHEIDDRIS1235 SYGISETTLE1245 EIFLKVAEES1255 GKGSYQVKGW 1322 KLTQQQFVAL1332 LWKRLLIARR1342 SRKGFFAQIV1352 LPAVFVCIAL1362 VFSLIVPPFG 1372 KYPSLELQPW1382 MYNEQYTFVS1392 NDAPEDTGTL1402 ELLNALTKDP1412 GFGTRCMEGN 1422 PIPDTPCQAG1432 EEEWTTAPVP1442 QTIMDLFQNG1452 NWTMQNPSPA1462 CQCSKMLPVC 1477 PPGAGGLPPP1487 QRKQNTADIL1497 QDLTGRNISD1507 YLVKTYVQII1517 AKSLKNKIWV 1527 NEFRYGGFSL1537 GVSNPSQEVN1552 DAIKQMKKHL1562 KLAKDSSADR1572 FLNSLGRFMT 1582 GLDTKNNVKV1592 WFNNKGWHAI1602 SSFLNVINNA1612 ILRANLQKGE1622 NPSHYGITAF 1632 NHPLNLTKQQ1642 LSEVALMTTS1652 VDVLVSICVI1662 FAMSFVPASF1672 VVFLIQERVS 1682 KAKHLQFISG1692 VKPVIYWLSN1702 FVWDMCNYVV1712 PATLVIIIFI1722 CFQQKSYVSS 1732 TNLPVLALLL1742 LLYGWSITPL1752 MYPASFVFKI1762 PSTAYVVLTS1772 VNLFIGINGS 1782 VATFVLELFT1792 DNKLNNINDI1802 LKSVFLIFPH1812 FCLGRGLIDM1822 VKNQAMADAL 1832 ERVSPLSWDL1848 VGRNLFAMAV1858 EGVVFFLITV1868 LIQYRFFIDE1891 DEDVRRERQR 1901 ILDGGGQNDI1911 LEIKELTKIY1921 RRKRKPAVDR1931 ICVGIPPGEC1941 FGLLGVNGAG 1951 KSSTFKMLTG1961 DTTVTRGDAF1971 LNKNSILSNI1981 HEVHQNMGYC1991 PQFDAITELL 2001 TGREHVEFFA2011 LLRGVPEKEV2021 GKVGEWAIRK2031 LGLVKYGEKY2041 AGNYSGGNKR 2051 KLSTAMALIG2061 GPPVVFLDQP2071 TTGMDPKARR2081 FLWNCALSVV2091 KEGRSVVLTS 2101 HSMEECEALC2111 TRMAIMVNGR2121 FRCLGSVQHL2131 KNRFGDGYTI2141 VVRIDLKPVQ 2156 DFFGLAFPGS2166 VLKEKHRNML2176 QYQLPSSLSS2186 LARIFSILSQ2196 SKKRLHIEDY 2206 SVSQTTLDQV2216 FVNFAKDQ
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states. Nat Cardiovasc Res. 2022;1(3):238-245. | ||||
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