Binding Site Information of Target

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Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T00895 Target Info
Target Name Protein kinase C epsilon (PRKCE)
Synonyms Protein kinase C epsilon type; PKCE; PKC epsilon; NPKC-epsilon
Target Type Successful Target
Gene Name PRKCE
Biochemical Class Kinase
UniProt ID
KPCE_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: adenosine diphosphate Ligand Info
Structure Description Structure of a peptide-substrate bound to PKCiota core kinase domain PDB:5LIH
Method X-ray diffraction Resolution 3.25 Å Mutation No [1]
PDB Sequence
RMRPFKRQGS
11
VRR
Residue
Distance (Å)
ARG8
2.753
Residue
Distance (Å)
Ligand Name: Phosphonothreonine Ligand Info
Structure Description Structure of a peptide-substrate bound to PKCiota core kinase domain PDB:5LIH
Method X-ray diffraction Resolution 3.25 Å Mutation No [1]
PDB Sequence
RMRPFKRQGS
11
VRR
Residue
Distance (Å)
ARG13
3.199
Residue
Distance (Å)
ARG14
4.580
Ligand Name: Aluminum fluoride Ligand Info
Structure Description Structure of a peptide-substrate bound to PKCiota core kinase domain PDB:5LIH
Method X-ray diffraction Resolution 3.25 Å Mutation No [1]
PDB Sequence
RMRPFKRQGS
11
VRR
Click to Show 3D Structure of This Binding Site
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Residue
Distance (Å)
GLN9
4.481
GLY10
3.489
Residue
Distance (Å)
SER11
2.624
References  Top
REF 1 aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization. Dev Cell. 2016 Aug 22;38(4):384-98.

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