Binding Site Information of Target

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T01283 Target Info
Target Name Tumor susceptibility gene protein 101 (TSG101)
Synonyms Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Target Type Clinical trial Target
Gene Name TSG101
Biochemical Class Ubiquitin-conjugating enzyme
UniProt ID
TS101_HUMAN
Drug Binding Sites of Target  Top
Ligand Name: 4-methoxy-1-(5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)-3,5-dimethyl-2-(sulfanylmethyl)pyridin-1-ium Ligand Info
Structure Description Solution-state NMR structural ensemble of human Tsg101 UEV in complex with tenatoprazole PDB:5VKG
Method Solution NMR Resolution N.A. Mutation Yes [1]
PDB Sequence
AVSESQLKKM
11
VSKYKYRDLT
21
VRETVNVITL
31
YKDLKPVLDS
41
YVFNDGSSRE
51

LMNLTGTIPV
61
PYRGNTYNIP
71
ICLWLLDTYP
81
YNPPICFVKP
91
TSSMTIKTGK
101

HVDANGKIYL
111
PYLHEWKHPQ
121
SDLLGLIQVM
131
IVVFGDEPPV
141
FSRP
Residue
Distance (Å)
ASP40
2.295
SER41
2.453
TYR42
3.767
VAL43
3.810
THR56
1.918
Residue
Distance (Å)
GLY57
4.851
PRO71
4.883
CYS73
2.028
TRP75
3.136
LYS90
1.760
References  Top
REF 1 Tsg101 chaperone function revealed by HIV-1 assembly inhibitors. Nat Commun. 2017 Nov 9;8(1):1391.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.