Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02546 | Target Info | |||
| Target Name | Voltage-gated sodium channel alpha Nav1.4 (SCN4A) | ||||
| Synonyms | Voltage-gated sodium channel subunit alpha Nav1.4; Sodium channel protein type IV subunit alpha; Sodium channel protein skeletal muscle subunit alpha; SkM1; SCN4A | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | SCN4A | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | Ligand Info | |||||
| Structure Description | Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1 | PDB:6AGF | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
VVRRGAIKVL
128 IHALFSMFIM138 ITILTNCVFM148 TMSDPPPWSK158 NVEYTFTGIY168 TFESLIKILA 178 RGFCVDDFTF188 LRDPWNWLDF198 SVIMMAYLTE208 FVDLGNISAL218 RTFRVLRALK 228 TITVIPGLKT238 IVGALIQSVK248 KLSDVMILTV258 FCLSVFALVG268 LQLFMGNLRQ 278 KCVRWPPPFD337 WDAYISDEGN347 FYFLEGSNDA357 LLCGNSSDAG367 HCPEGYECIK 377 TGRNPNYGYT387 SYDTFSWAFL397 ALFRLMTQDY407 WENLFQLTLR417 AAGKTYMIFF 427 VVIIFLGSFY437 LINLILAVVA447 MAYAEQNEAT457 LAEDKENCCA562 PWLKFKNIIH 572 LIVMDPFVDL582 GITICIVLNT592 LFMAMEHYPM602 TEHFDNVLTV612 GNLVFTGIFT 622 AEMVLKLIAM632 DPYEYFQQGW642 NIFDSIIVTL652 SLVELGLANV662 QGLSVLRSFR 672 LLRVFKLAKS682 WPTLNMLIKI692 IGNSVGALGN702 LTLVLAIIVF712 IFAVVGMQLF 722 GKSYKECVCK732 IALDCNLPRW742 HMHDFFHSFL752 IVFRILCGEW762 IETMWDCMEV 772 AGQAMCLTVF782 LMVMVIGNLV792 VLNLFLALLL802 SSFSGKKWWT1019 LRRACFKIVE 1029 HNWFETFIVF1039 MILLSSGALA1049 FEDIYIEQRR1059 VIRTILEYAD1069 KVFTYIFIME 1079 MLLKWVAYGF1089 KVYFTNAWCW1099 LDFLIVDVSI1109 ISLVANWLGY1119 SELGPIKSLR 1129 TLRALRPLRA1139 LSRFEGMRVV1149 VNALLGAIPS1159 IMNVLLVCLI1169 FWLIFSIMGV 1179 NLFAGKFYYC1189 INTTTSERFD1199 ISEVNNKSEC1209 ESLMHTGQVR1219 WLNVKVNYDN 1229 VGLGYLSLLQ1239 VATFKGWMDI1249 MYAAVDSREK1259 EEQPQYEVNL1269 YMYLYFVIFI 1279 IFGSFFTLNL1289 FIGVIIDNFN1299 QQKKKLGGKD1309 IFMTEEQKKY1319 YNAMKKLGSK 1329 KPQKPIPRPQ1339 NKIQGMVYDL1349 VTKQAFDITI1359 MILICLNMVT1369 MMVETDNQSQ 1379 LKVDILYNIN1389 MIFIIIFTGE1399 CVLKMLALRQ1409 YYFTVGWNIF1419 DFVVVILSIV 1429 GLALSDLIQK1439 YFVSPTLFRV1449 IRLARIGRVL1459 RLIRGAKGIR1469 TLLFALMMSL 1479 PALFNIGLLL1489 FLVMFIYSIF1499 GMSNFAYVKK1509 ESGIDDMFNF1519 ETFGNSIICL 1529 FEITTSAGWD1539 GLLNPILNSG1549 PPDCDPNLEN1559 PGTSVKGDCG1569 NPSIGICFFC 1579 SYIIISFLIV1589 VNMYIAIILE1599 NFNVATEE
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| Ligand Name: 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine | Ligand Info | |||||
| Structure Description | Structure of the human voltage-gated sodium channel Nav1.4 in complex with beta1 | PDB:6AGF | ||||
| Method | Electron microscopy | Resolution | 3.20 Å | Mutation | No | [1] |
| PDB Sequence |
VVRRGAIKVL
128 IHALFSMFIM138 ITILTNCVFM148 TMSDPPPWSK158 NVEYTFTGIY168 TFESLIKILA 178 RGFCVDDFTF188 LRDPWNWLDF198 SVIMMAYLTE208 FVDLGNISAL218 RTFRVLRALK 228 TITVIPGLKT238 IVGALIQSVK248 KLSDVMILTV258 FCLSVFALVG268 LQLFMGNLRQ 278 KCVRWPPPFD337 WDAYISDEGN347 FYFLEGSNDA357 LLCGNSSDAG367 HCPEGYECIK 377 TGRNPNYGYT387 SYDTFSWAFL397 ALFRLMTQDY407 WENLFQLTLR417 AAGKTYMIFF 427 VVIIFLGSFY437 LINLILAVVA447 MAYAEQNEAT457 LAEDKENCCA562 PWLKFKNIIH 572 LIVMDPFVDL582 GITICIVLNT592 LFMAMEHYPM602 TEHFDNVLTV612 GNLVFTGIFT 622 AEMVLKLIAM632 DPYEYFQQGW642 NIFDSIIVTL652 SLVELGLANV662 QGLSVLRSFR 672 LLRVFKLAKS682 WPTLNMLIKI692 IGNSVGALGN702 LTLVLAIIVF712 IFAVVGMQLF 722 GKSYKECVCK732 IALDCNLPRW742 HMHDFFHSFL752 IVFRILCGEW762 IETMWDCMEV 772 AGQAMCLTVF782 LMVMVIGNLV792 VLNLFLALLL802 SSFSGKKWWT1019 LRRACFKIVE 1029 HNWFETFIVF1039 MILLSSGALA1049 FEDIYIEQRR1059 VIRTILEYAD1069 KVFTYIFIME 1079 MLLKWVAYGF1089 KVYFTNAWCW1099 LDFLIVDVSI1109 ISLVANWLGY1119 SELGPIKSLR 1129 TLRALRPLRA1139 LSRFEGMRVV1149 VNALLGAIPS1159 IMNVLLVCLI1169 FWLIFSIMGV 1179 NLFAGKFYYC1189 INTTTSERFD1199 ISEVNNKSEC1209 ESLMHTGQVR1219 WLNVKVNYDN 1229 VGLGYLSLLQ1239 VATFKGWMDI1249 MYAAVDSREK1259 EEQPQYEVNL1269 YMYLYFVIFI 1279 IFGSFFTLNL1289 FIGVIIDNFN1299 QQKKKLGGKD1309 IFMTEEQKKY1319 YNAMKKLGSK 1329 KPQKPIPRPQ1339 NKIQGMVYDL1349 VTKQAFDITI1359 MILICLNMVT1369 MMVETDNQSQ 1379 LKVDILYNIN1389 MIFIIIFTGE1399 CVLKMLALRQ1409 YYFTVGWNIF1419 DFVVVILSIV 1429 GLALSDLIQK1439 YFVSPTLFRV1449 IRLARIGRVL1459 RLIRGAKGIR1469 TLLFALMMSL 1479 PALFNIGLLL1489 FLVMFIYSIF1499 GMSNFAYVKK1509 ESGIDDMFNF1519 ETFGNSIICL 1529 FEITTSAGWD1539 GLLNPILNSG1549 PPDCDPNLEN1559 PGTSVKGDCG1569 NPSIGICFFC 1579 SYIIISFLIV1589 VNMYIAIILE1599 NFNVATEE
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LEU142
3.705
CYS145
3.898
VAL146
4.568
THR149
3.573
MET150
3.916
SER151
4.165
VAL247
3.783
LYS248
3.573
LEU250
3.501
SER251
3.660
MET254
3.683
ILE255
3.840
THR257
4.307
VAL258
4.625
LEU261
4.658
TYR384
3.713
GLY385
4.277
TYR386
4.091
SER393
3.521
TRP394
3.351
PHE396
3.680
LEU397
3.855
PHE400
3.911
MET403
3.895
THR404
4.143
GLN405
4.061
ILE439
3.979
ILE442
3.745
LEU443
3.779
SER696
3.770
THR704
3.369
LEU707
3.389
ALA708
4.257
ILE709
4.127
PHE712
3.749
ASP746
4.128
PHE747
4.254
PHE748
4.032
PHE751
3.964
PHE755
4.069
LEU758
4.282
CYS759
4.127
GLN775
3.424
ALA776
4.363
LEU779
4.279
THR780
3.920
LEU783
3.797
MET786
4.742
VAL787
3.961
ASN790
3.398
LEU791
3.775
VAL793
3.785
LEU794
3.624
LEU796
3.707
PHE797
4.215
ILE1160
3.825
VAL1163
4.378
LEU1164
3.722
CYS1167
3.616
LEU1168
4.445
TRP1171
4.058
ASN1229
4.971
GLY1231
3.279
LEU1232
3.374
TYR1234
4.036
LEU1235
4.093
LEU1238
4.255
ALA1241
3.643
THR1242
4.394
PHE1243
4.206
TYR1270
4.221
LEU1273
3.750
VAL1276
4.177
ILE1277
4.236
ILE1279
3.807
ILE1280
3.687
GLY1282
4.207
SER1283
3.969
PHE1284
4.079
PHE1285
4.028
THR1286
3.528
LEU1287
3.747
PHE1290
3.456
THR1533
4.941
THR1534
4.212
SER1535
4.303
SER1548
4.709
PRO1571
3.709
SER1572
2.904
ILE1575
4.129
CYS1576
3.696
CYS1579
4.104
SER1580
4.189
ILE1582
4.063
ILE1583
3.703
ILE1584
3.926
PHE1586
3.932
LEU1587
3.680
TYR1593
4.620
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure of the human voltage-gated sodium channel Na(v)1.4 in complex with beta1. Science. 2018 Oct 19;362(6412):eaau2486. | ||||
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